• 대한물리의학회지
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• 제9권3호
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• pp.301-305
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• 2014

PURPOSE: The purpose of this study was to determine the optimal thresholds of serum lipid level related to hypertension according to age in Korean adults. METHODS: In total, 564 adults who visited the health examine center in general hospital were included. The blood pressure and lipid profiles of low density lipoprotein cholesterol(LDL), high density lipoprotein cholesterol (HDL), triglyceride(TG) were measured. Receiver operating characteristic (ROC) curve were used to establish optimal thresholds between blood pressure and lipid profiles. RESULTS: The optimal TG cutoff value were 110.50(mg/dl) in the 18-39 and 81.50(mg/dl) in the 40-59 age group, and optimal cutoff value of LDL were 126.50(mg/dl) in the 40-59 age group and 111.00(mg/dl) in the 60 and over age group. There was a negative correlation between HDL and hypertension, a higher HDL decreased hypertension. The optimal cutoff value of HDL was 49.50(mg/dl) in the 18-39 age group. CONCLUSION: The thresholds of hypertension were lower in LDL and TG with aging. This result indicated that elderly people needs to concern more about their lipid profiles to maintain healthy cardiovascular function.

• Journal of Nutrition and Health
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• 제36권7호
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• pp.667-674
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• 2003

The study was performed to investigate the effects of isoflavone and/or grape seed oil supplementation on serum and liver lipid profiles and bone strength in ovariectomized female rats. Female Spraque-Dawley rats were assigned into 4 groups of ovariectomized (O), isoflavone (0.085 mg/100 g b.w/day) in ovariectomized rats, grape seed oil in ovariectomized rats and isoflavone and/or grape seed oil in ovariectomized rats. After 8 weeks, biochemical profiles of serum, liver and bone were analyzed. Total food intakes, body weight gains and FER (food efficiency ratio) were not statistically significantly different among groups. Total cholesterol, triglyceride and LDL-cholesterol levels in serum were decreased by fed of isoflavone and/or grape seed oils. However, crude lipid and total cholesterol contents in liver were not affect of isoflavone and/or grape seed oil. The hepatic glutathione contents were increased by isoflavone and/or grape seed oil fed. The hepatic glutathione-S-transferase activity in isoflavone and/or grape seed oil supplemented groups were higher than that O group. Bone (scapular and femur bone) dry weight, femur of max weight and bending strength were no significant difference among groups. Our finding suggest that isoflavone/grape seed oils might have potential role for serum lipid profiles improvement and bone strength in vivo.

• Journal of Nutrition and Health
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• 제35권8호
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• pp.854-862
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• 2002

In the present study, we investigated the effects of chronic green tea consumption on the serum lipid profiles of 92 subjects (mean age: 59.5 $\pm$ 8.9, men: 41, women:51) living in a green tea cultivation village. The anthropometric and biochemical blood indices were measured, and nutritional intakes were assessed using 24-h recall method. Also, we administered a questionnaire regarding green tea consumption. The subjects were divided into three groups based on the period of green tea consumption (0, < 10 year, and $\geq$ 10 year). There were no significant differences in age, anthropometric indices (Wt, Ht, BMI, Body fat, LBM), and nutritional intakes among the groups. Serum LDL-cholesterol concentration was significantly lower in the $\geq$ 10 year group compared with the other groups (p < 0.05). Also, the LDL/HDL-cholesterol ratio was significantly lower in the $\geq$ 10 year group compared with the other groups (p < 0.05). The frequency of subjects with a normal range of serum LDL-cholesterol concentration (< 200 mg/dl) was significantly higher in the $\geq$ 10 year group compared with the other groups (p < 0.05). These results imply positive effects of chronic green tea consumption on blood lipid profiles, which requires confirmation in further studies.

• 생명과학회지
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• 제15권5호
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• pp.763-766
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• 2005

이상의 결과를 통하여 볼 때, 1년간의 규칙적인 운동은 남성 치매환자의 일상생활도 향상에 매우 효과적임을 알 수 있었고, TC, TC, LDL-C을 감소시키고 HDL-C을 증가시킴으로써 결과적으로 동맥경화와 심장병을 방지할 뿐만 아니라 독립적이고도 책임 있는 일상생활을 통해 치매환자의 삶의 질을 높이는데 큰 도움을 줄 것으로 기대된다.

• Journal of Nutrition and Health
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• 제38권1호
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• pp.11-19
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• 2005

There has been increasing research interests that green vegetables play beneficial roles in human health. This study was performed to investigate the effects of freeze-dried green vegetable extract of Angelica keiskei Koidz (A) and Brassica oleracea acephala (B) on lipid profiles and antioxidant status in rats. Seven-weeks old male Sprague Dawley rats were divided into 6 groups and fed diets containing 5% A & B and 0.5% cholesterol (cho) for 8 weeks [Control Diet (C) & C + chol (CC), A & A + chol (AC), B & B + chol (BC)]. Lipid profiles and antioxidant status were determined by enzyme assay methods. The serum levels of [LDL + VLDLJ-cholesterol of the rats fed vegetable extract diets A and B were significantly lower than that of group C and the ratios of HDL/[LDL + VLDL] were significantly higher in groups A and B. Addition of cholesterol in the diet, however, abolished this effect. The Brassica oleracea acephala juice lowered serum TG level even when cholesterol was added to the diet. Serum total antioxidant status(TAS) were significantly higher in groups A and B as compared to the control group and the ratios of [GSH-Px +Catalase]/total-SOD in the liver were also significantly higher in groups A and B indicating that H202 produced be efficiently removed. In conclusion, freeze-dried green vegetable extract diets (A and B) improved serum lipid profiles by increasing the HDL/[LDL + VLDL〕 ratio and exerted favorable influences on antioxidant systems by improving total antioxidant status (TAS) in serum and by significantly increasing the ratio of [GSH-Px + Catalase]/total-SOD in the liver.

• Preventive Nutrition and Food Science
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• 제3권1호
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• pp.71-76
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• 1998

This study investigated the effect of regular exercise on serum lipid profiles and carnitine levels in college students. Daily nutrient intake, anthropometry , serum lipid, and carnitine profiles in serum and urine were evaluated prior to beginning the study and after 35 days of treadmill running for 30 minutes per day. The results obtained were summarized as follows : 1) Concentrations of total lipid and Triglyceride in serum were decreased by regular exercise in female subjects but unaffected in males. 2) Serum LDL-cholesterol was significantly decreased, but total cholesterol and HDL-cholesterol in serum were not affected in both male and female subjects. 3) nonesterified carnitinem, acid-insoluble acylcarnitine, and total carnitine levels in serum were not affected, but acid-soluble acylcarnitine level was increased by regular exercise in both subjects. 4) Urinary excretionof the acid-soluble acylcarnitine level was increased by regular exercise -training. These results suggest that regular exercise -training has different effects on serum lipid oxidation via carnitine metabolism in this condition.

• Clinical Nutrition Research
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• 제13권1호
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• pp.74-87
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• 2024

Since the effects of cinnamon supplementation on lipid profiles are still controversial, this study conducted a meta-analysis of randomized controlled trials to assess the effect of cinnamon supplementation on lipid profiles. The study was designed and conducted according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statements. A systematic and comprehensive search was performed in several databases from inception up to 11 November 2023. The meta-analysis on the impact of Cinnamon on lipid profiles indicates a non-significant overall effect on low-density lipoprotein (weighted mean differences [WMD], -2.48; 95% confidence interval [CI], -9.70, 4.72). However, significant reductions are seen with doses < 500 mg/day (-10.26), and non-significant increases with doses ≥ 500 mg/day (1.18). The overall effect on high-density lipoprotein is non-significant (WMD, 3.97; 95% CI, -7.877, 15.831), showing varying responses at different doses. Triglycerides exhibit a significant overall reduction (WMD, -6.88; 95% CI, -12.62, -1.15), particularly in the < 500 mg/day group. The overall effect on cholesterol is non-significant (WMD, -4.314; 95% CI, -15.011, 6.384), with diverse responses at different doses. High heterogeneity underlines the importance of standardized study designs and further exploration of dosage-specific effects. Findings from this study suggest that cinnamon supplements might be beneficial to modulate the blood lipid profile.

• Journal of Preventive Medicine and Public Health
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• 제36권1호
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• pp.24-32
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• 2003

Objectives : To identify the psychosocial well-being status in a rural community, and examine the association between the psychosocial well-being status and adverse lipid profile. Method : In 2001, we surveyed 575 subjects in Yangpyoung, Kyounggido, including medical examination, fasting-blood sample and questionnaires for the psychosocial well-being status, socioeconomic position and behavioral risk factors. The logistic regression analysis was used to examine explanatory factors of the psychosocial well-being status, and association between the psychosocial well-being status and adverse lipid profiles. Result : The association between the psychosocial well-being status and adverse lipid profiles was not strong. The total cholesterol and triglyceridelevels were associated with psychosocial well-being. The adjusted odds ratio for moderate psychosocial well-being relating to total cholesterol was 1.90 (95%CI, 0.82-4.04), but that for triglyceride was 0.65 (95%CI, 0.36-1.21). The HDL-Cholesterol and LOL-Cholesterol level were not associated with the psychosocial well-being status. Conclusion : The total cholesterol and psychosocial well-being status were weakly associated, but the between the psychosocial well-being status and adverse lipid profiles were not consistent.

• Nutrition Research and Practice
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• 제6권3호
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• pp.195-200
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• 2012

The purpose of this study was to investigate the effects of ${\alpha}$-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4 weeks of feeding, rats on the HFD were divided into three groups by randomized block design; the first group received the high-fat-diet (n = 10), and the second group received the HFD administered with 0.25% ${\alpha}$-lipoic acid (0.25LA), and the third group received the high-fat diet with 0.5% ${\alpha}$-lipoic acid (0.5LA). The high fat diet with ${\alpha}$-lipoic acid supplemented groups had significantly inhibited body weight gain, compared to that in the HFD group (P < 0.05). Organ weights of rats were also significantly reduced in liver, kidney, spleen, and visible fat tissues in rats supplemented with ${\alpha}$-lipoic acid (P < 0.05). Significant differences in plasma lipid profiles, such as total lipids, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, were observed between the HFD and 0.5LA groups. The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with ${\alpha}$-lipoic acid supplementation in a dose-dependent manner (P < 0.05). Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with ${\alpha}$-lipoic acid in a dose-dependent manner (P < 0.05), whereas liver triglyceride content was not affected. In conclusion, ${\alpha}$-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats.

• Bulletin of the Korean Chemical Society
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• 제34권7호
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• pp.2143-2147
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• 2013

Matrix assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is a very effective method for lipid mass fingerprinting. However, MALDI MS suffered from spectral complexities, differential ionization efficiencies, and poor reproducibility when analyzing complex lipid mixtures without prior separation steps. Here, we aimed to find optimal MALDI sample preparation methods which enable selective or class-wide mass fingerprinting of two totally different lipid classes. In order to achieve this, various matrices with additives were tested against the mixture of phosphatidylcholine (PC) and cerebrosides (Cers) which are abundant in animal brain tissues and also of great interests in disease biology. Our results showed that, from complex lipid mixtures, 2,4,6-trihydroxyacetophenone (THAP) with $NaNO_3$ was a useful MALDI matrix for the class-wide fingerprinting of PC and Cers. In contrast, THAP efficiently generated PC-focused profiles and graphene oxide (GO) with $NaNO_3$ provided Cer-only profiles with reduced spectral complexity.