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The Effect of Isoflavone and/or Grape Seed Oil Supplementation on Blood Lipid Profiles and Bone Strength in Ovariectomized Female Rats  

정혜경 (호서대학교 자연과학부 식품영양전공)
최창숙 (호서대학교 자연과학부 식품영양전공)
이지현 (호서대학교 자연과학부 식품영양전공)
박원종 (공주대학교 산업과학대학 식품공학과)
강명화 (호서대학교 자연과학부 식품영양전공)
Publication Information
Journal of Nutrition and Health / v.36, no.7, 2003 , pp. 667-674 More about this Journal
Abstract
The study was performed to investigate the effects of isoflavone and/or grape seed oil supplementation on serum and liver lipid profiles and bone strength in ovariectomized female rats. Female Spraque-Dawley rats were assigned into 4 groups of ovariectomized (O), isoflavone (0.085 mg/100 g b.w/day) in ovariectomized rats, grape seed oil in ovariectomized rats and isoflavone and/or grape seed oil in ovariectomized rats. After 8 weeks, biochemical profiles of serum, liver and bone were analyzed. Total food intakes, body weight gains and FER (food efficiency ratio) were not statistically significantly different among groups. Total cholesterol, triglyceride and LDL-cholesterol levels in serum were decreased by fed of isoflavone and/or grape seed oils. However, crude lipid and total cholesterol contents in liver were not affect of isoflavone and/or grape seed oil. The hepatic glutathione contents were increased by isoflavone and/or grape seed oil fed. The hepatic glutathione-S-transferase activity in isoflavone and/or grape seed oil supplemented groups were higher than that O group. Bone (scapular and femur bone) dry weight, femur of max weight and bending strength were no significant difference among groups. Our finding suggest that isoflavone/grape seed oils might have potential role for serum lipid profiles improvement and bone strength in vivo.
Keywords
isoflavone; grape seed oil; GSH; GST; ovariectomized rat;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 The effects of estrogen depletion and isoflavone on bone metabolism in rats /
[ Deyhim,F.;Stoecker,B.J.;Brusewitz,G.H.;Arjmandi,B.H. ] / Nutrition Research   DOI   ScienceOn
2 Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats /
[ Drape,C.R.;Edel,M.J.;Dick,I.M.;Randel,A.G.;Martin,G.B.;Prince,R.L. ] / J Nutr
3 The effects of dietary protein and calcium levels on calcium and bone metabolism in growing rats /
[ Chang,Y.E.;Chung,H.K.;Chang,N.S.;Lee,H.S. ] / Korean J Nutrition
4 The effect of various types of calcium sources on calcium and bone metabolism in rats /
[ Chung,H.K.;Chang,N.S.;Lee,H.S.;Chang,Y.E. ] / Korean J Nutrition   과학기술학회마을
5 Dietary soy-derived isoflavone phytoestrogen /
[ Tikkanen,M.J.;Adlercreutz,H. ] / Biochemical Pharmacology   DOI   ScienceOn
6 The effect of isoflavone on serum lipid profiles and bone markers in posmenopausal women /
[ Lee,B.S.;Won,H.J.;Lee,S.K.;Choi,Y.;Yoon,S.;Park,K.H.;Cho,D.J.;Song,C.H. ] / The Korean Society of Menopause
7 The effect of ipriflavone on postmenopausal osteoporsis /
[ Weon,Y.J.;Chung,Y.S.;Hong,K.Y.;Park,Y.K.;Kim,H.S.;Lee,J.H.;Lee,E.J.;Lim,S.K.;Kim,K.R.;Lee,H.C.;Huh,K.B. ] / J Korean Society of Endocrinology
8 Glutathione S-transferase /
[ Habig,W.H.;Pabst,M.P.;Jakoby,W.B. ] / J Biol Chem
9 In standard method chemistry /
[ Zak,B. ] / Total and free cholesterol
10 The effect of dietary calcium level on bone mineral density and bone mineral content in ovariectomized female rats /
[ Kim,K.H.;Choi,M.J.;Lee,I.K. ] / Korean J Nutrition   과학기술학회마을
11 Soy intake related menopausal symptoms, serum lipids, and bone mineral density in postmenopausal japanese women /
[ Somekawa,Y.;Chiguchi,M.;Ishibashi,T.;Aso.T. ] / Obstet Gynecol   DOI   ScienceOn
12 Proanthocyanidinrich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits /
[ Yamakoshi,J.;Kataoka,S.;Koga,T.;Ariga,T. ] / Atherosclerosis   DOI   ScienceOn
13 Quantification and physicochemical properties of grape seed lipids /
[ Kang,H.C.;Lee,S.H.;Kim,J.B. ] / J Korean Soc Agric Chem Biotechnol
14 Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge /
[ Friedwald,W.T.;Levy,R.T.;Fridrickson,D.S. ] / Clin Nutr
15 Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation model in vitro /
[ Jayaprakasha,G.K.;Shingh,R.P.;Sakariah,K.K. ] / Food Chemistry   DOI   ScienceOn
16 Effect of dietray boron supplementation and calcium levels on calcium and bone metabolism in ovariectomized femals rats /
[ Chung,H.K.;Lee,H.S.;Choe,C.S. ] / Korean J Nutrition
17 Soy isoflavones:hope or hype? /
[ Fizpatrick,L.A. ] / Maturitas
18 Lipid component and proparties of grape seed oils /
[ Hwang,J.T.;Kang,H.C.;Kim,T.S.;Park,W.J. ] / Korean J food & Nutr
19 Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats /
[ Muramatsu,K.;Fukuyo,M.;Hara,Y. ] / J Nutr Sci Vitaminol   DOI
20 Difference in effective dosage of genistein on bone and uterus in ovariectomized mice /
[ Ishimi,Y.;Arai,N.;Wang,X.;Wu,J.;Umegaki,K.;Miyaura,C.;Takeda,A.;Ikegami,S. ] / Biochemical and Biophysical Research Communication   DOI   ScienceOn
21 Estimation of plasma phosphatase by determination of hygrolyzed phenol with amino antipyrine /
[ Kind,P.R.N.;King,E.J. ] / Am J Clin Pathol
22 Effect of dietary grapeseed oil on serum lipids in spontaneously hypertensive rats /
[ Choi,H.J.;Whang,Y.H.;Pek,U.H.;Shin,H.S. ] / Korean J Nutrition   과학기술학회마을
23 An immunohistochemical study on alkaline phosphatase activity in osteoblasts cultured with isoflavone /
[ Kim,W.W.;Lee,K.S.;Lee,S.H. ] / The Korean Society of Menopause
24 The effect of dietary calcium and phosphate levels on calcium and bone metabolism in rats /
[ Chung,H.K.;Kim,J.Y.;Lee,H.S.;Kim,H.Y. ] / Korean J Nutrition   과학기술학회마을
25 Reaction of o-phtal-alaldehyde and thiols with primary amines: Fluoroscence properties of 1-alkyl(and aryl) rhio-2-alkylisoindoles /
[ Simons,S.S.;Johnson,D.F. ] / Ann Biochem   DOI   ScienceOn
26 Microsomal lipid peroxidation /
[ Buege,J.A.;Aust,S.D. ] / Methods in Enzymology   DOI
27 Role of soy isoflavones in the hypotriglyceridemic effect of soy protein in the rat /
[ Demonty,I.;Lamarche,B.;Desaies,Y.;Jacques,H. ] / J Nutritional Biochemistry   DOI   ScienceOn
28 Seed oil improve lipid metabolism and increase antioxidant potential in rats fed diets containing cholesterol /
[ Gorinstein,S.;Leontowicz,H.;Leontowicz,M.;Lojek,A.;Ciz,M.;Krzeminski,R.;Zachwieja,Z.;Jastrzebski,Z.;Delgado-Licon,E.;Marin-Belloso,O.;Trakhtenberg,S. ] / Nutrition Research   DOI   ScienceOn
29 The effect of isoflavone on lipid metabolism and Responses in SD rats /
[ Jeong,M.K.;Bang,N.H.;Seol,S.M.;Kim,W.K. ] / Korean J Nutrition   과학기술학회마을
30 Does response relationship of isoflavone supplementation on plasma lipid profiles and total antioxidant status in perimenopausal and postmenopausal women /
[ Choi,Y.;Toon,S.;Lee,M.J.;Lee,S.K.;Lee,B.S. ] / Korean J Nutrition   과학기술학회마을
31 Improved methed for increasing of the oil yields in grape seed /
[ Kang,M.H.;Chung,H.K.;Song,E.S.;Park,W.J. ] / Korean J Food Sci Technol
32 Does soybean isoflavone have adverse effects on human? /
[ Sohn,H.S.;Lee,Y.S.;Shin,H.C.;Chung,H.K. ] / Korea Soybean Digest
33 A study on hormonal changes and bone densities in Korean menopasual women /
[ Han,Y.K.;Park,W.K.;Choi,E.H.;Shin,H.H.;Kim,S.W. ] / J Korean Soc Endocrinol
34 The effect of isoflavone supplementation on bone metabolism in ovariectomized SD rats /
[ Park,Y.H.;Yoon,S.;Chung,S.Y.;Yang,S.O.;Yoo,T.M. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
35 Antiulcer activity of grape seed extract and procyanidins /
[ Saito,M.;Fosoyama,H.;Ariga,T.;Kataoka,S.;Yamaji,N. ] / J Agric Food Chem   DOI   ScienceOn
36 Effect of dietary of bone supplementation in rats during growth /
[ Chung,H.K.;Lee,H.S.;Kim,J.Y.;Kim,J.Y. ] / Korean J Nutrition
37 Antioxidant effects of dietary polymeric grape seed tannins in tissues of rats fed a high cholesterol-vitamin E-deficient diet /
[ Tebib,K.;Rouanet,J.M.;Besancon,P. ] / Food Chemistry   DOI   ScienceOn