• Journal of Korean Academy of Fundamentals of Nursing
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• v.8 no.2
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• pp.234-243
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• 2001

Purpose : To investigate the effects of exercise combined with behavior modification therapy on the degree of obesity. blood lipid level and self-esteem in obese middle aged women. Method : 18 obese middle-aged women volunteers with a BMI over 30% were assigned to exercise combined with behavior modification therapy (n=9) or to a control group(n=9). For the intervention the experiment group used walking outdoors as excercise and behavior modification therapy for 12 weeks. Result Body weight, BMI, TC, TG, LDL-C, and % TC/HDL-C were significantly decreased in experimental group. Changes in HDL-C and self-esteem were significantly increased in the experimental group. Conclusion : This study provides evidence that regular exercise combined with behavior modification is effective in changing the degree of obesity, blood lipid level and self esteem in obese middle-aged women over 12 weeks.

• The Korean Journal of Food And Nutrition
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• v.12 no.1
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• pp.20-25
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• 1999

The study was conducted to investigate the effect of cholesterol and fiber on liver lipid metabolism in rats. Male Sprague Dawley rats were administrated 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia and were fed diet containing three levels(0%, 5% and 10%) of cellulose and pec-tin respectively. The rats were sacrified after 5 weeks of feeding period. Net weight gain and feed ef-ficiency ratio were increased in 10% fiber groups as compared to those of 5% fiber groups. Feed intake did not show significancy by fiber kinds and levels. Liver and kidney weights tended to be decreased in proportion to level of fiber. Heart weight was lowered in 10% fiber groups as compared to that of 5% fi-ber groups. Liver triglyceride concentration was significantly increased in pectin groups. Total-free-cholesterol and cholesteryl ester concentrations in liver were significantly decreased by fiber and were decreased in proportion to level of fiver. Phospholipid concentration was significantly decreased by fiber and were decreased in proportion to level of fiber. Phospholipid concentration was significantly decreased in 5% cellulose group. the results indicate that 10% pectin may have beneficial roles in hypercholester-olemia.

• Journal of Nutrition and Health
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• v.27 no.10
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• pp.967-978
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• 1994

This study was done to investigate the effect of age and dietary linolenic acid content and the linolenic acid/linoleic acid(LNA/LA) ratio on the lipid metabolism and formation of PGI2 and TXA2. The male Sprague-Dawley rats were fed 6 different with 0.2, 0.4, 0.6 of LNA/LA ratio within either 8% LNA(high LNA) or 4% LNA(low LNA) of fatty acid content for different feeding period(1, 4, 12 month). The dietary fat used were sesame oil, perilla oil, soybean oil and beef tallow. The concentration of serum total lipid, total cholesterol and HDL-C were increased with aging. Triglyceride concentration was decreased in 0.2 ratio of LNA/LA. The lipid content of liver showed similar tendency to that of serum. The ratio of PGI2/TXA2 was increased in 1 month rats and antithrombotic effect was reduced significantly with increasing age. The PGI2/TXA2 ratio was tended to be higher in diet of 0.2 and 0.4 LNA/LA ratio at high LNA level and in diet of 0.6 LNA/LA ratio at low LNA level. Especially PGI2/TXA2 ratio was increased linearly with rising LNA/LA ratio at low LNA level. It seemed that the LNA content and LNA/LA ratio had interaction to increase the antithrombotic effect bychanging TXA2 synthesis. And the dietary fatty acid related effect lowering the serum and liver lipid content, excepting triglyceride, was increased when dietary n3/n6 ratio was high(0.6) at both high and low n3 level. Therefore, it could not be recommended to consume large amount of n3 fatty acid or high ratio of n3/n6 to prevent cardiovascular diseases. These results suggested that the dietary fatty acid ratio of n3/n6 could be determined based on the n-3 content of dietary fat to reduce the risk of cardiovascular disease.

• Journal of Nutrition and Health
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• v.21 no.1
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• pp.23-35
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• 1988

This study was designed to find out the effects of aerobic exercise on lipid and Ca metabolism in seven healthy college women, aged 20 to 22 years. Metabolic studies were conducted before and after a 10-weeks exercise period, during which subjects participated in the planned aerobic dance program every day except Sunday. The initial mean time engaged in the exercise was 28 minutes and it was gradually increased up to 45 minutes around the middle point of the exercise period. During both of metabolic study periods, the subjects ate experimental diets which supplied about 120g of protein and 600mg of Ca daily and during the rest of the experimental period they ate their usual diets. The use of alcoholic beverages and drugs were prohibited. The results were summarized as follows. 1) The effect of exercise on lipid metabolism. (1) Mean body weight decreased significantly after exercise(p<0.01) and it did not show a significant decline in skinfold thickness and total body fat contents. (2) Serum total cholesterol level decreased significantly after exercise(p<0.05) and TG level also tended to be lower than that of pre-exercise period. Exercise did not exert any influence on the level of serum HDL-cholesterol in this study. (3) Exercise did not alter total lipid content in feces and apparent lipid absorption rate. 2) The effect of exercise on Ca and P metabolism. (1) After exercise, focal Ca excretion was slightly reduced, however, urinary Ca excretion was not significantly changed. In the results, a slight increase was shown in body Ca retention after exercise. (2) Exercise tended to increase urinary P excretion, but neither P balance nor fecal excretion was significantly changed after exercise. (3) Bone mineral content was not affected by exercise. In summary, aerobic exercise decreased total cholesterol and TG level in serum and tended to increase body Ca retention. With the results, it can be concluded that the additional physical activities beyond the normal daily life in college women might prevent some degenerative diseases-suchas atherosclerosis and osteoporosis.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.49-65
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• 1998

Holotrichia was tested for the effects on damages of liver tissue induced by bromobenzene. Holotrichia was treated firstly into samples, and then bromobenzene intoxicated animal models were set with them. In vitro, the level of lipid peroxide in tissue of liver proportinally decreased with the level of concentration of extract prepared from Holotrichia It was much more decreased, when lipid peroxidation was induced with ferrous iron ($Fe&{+2}$). In vivo, after the extract was administered to the animal model for twenty days, the level of lipid peroxide in liver decreased compared to that of bromobenzene-treated group. The enzyme activities of epoxide hydrolase and glutathione S-transferase in liver highly increased in Holotrichia pre-medicating group compare with the group treated with only bromobenzene. And we can get the same results in the enzyme activities of superoxide dismutase, catalase and glutathione peroxidase. The level of glutathione followed by Holotrichia pre-medicationg administration, increased as highly as normal group in compare with the group treated with only bromobenzene. Also, the enzyme activities of AL T, AST and $\{gammer}-GTP$ in liver considerably decreased. In conclusion, Holotrichia recovers the damage of liver due to bromobenzene intoxication by the increased activities of lipid peroxidation and bromobenzene scavenging enzymes.

• Journal of Nutrition and Health
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• v.23 no.7
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• pp.477-491
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• 1990

To observe the effect of dietary n6 linoleic acid, n6 gamma-linolenic acid and n3 alphalinolenic acid aon plasma lipid composition and platelet aggregation, twenty college women were divided into 4 groups and treated for 2 weeks with experimental diets supplying fat at 23% cal which were different only in fatty acid composition. Dietary fat was corn oil(CO) as a source of n6 linoleic acid(LA), perilla oil(PO) for n3 alpha-linolenic acid(ALA) and evenign primrose oil(EPO) for n6 gamma-linolenic acid(GLA). Plasma cholesterol level was slightly decreased by PL(13.5g) but significantly increased by equal amount of CO. However, there was similar hypocholeaterolemic effect when double amount of CO(27.0g), was supplemented. Therefore, total fat unsaturation may be more important factor for plasma cholesterol-lowering effect than the structure of fatty acid itself. Plasma cholesterol level was not lowered by supplement of GLA in CO diet. There was similar trend in hypotriglyceridemic effect by PO and CO as in plasma cholesterol. Plasma TG level was rather increased but not significantly by GLA supplement to CO diet. Overall, plasma lipid-lowering effect was greater by ALA than LA and GLA effect was not greater than by LA. GLA supplement did not significantly improve lipid compositions to prevent against CHD. There was no significant change both in fatty acid composition in platelet and ADP-induced platelet aggregation by GLA supplement to corn oil diet and by ALA in PO diet in young women.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.5
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• pp.409-417
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• 1991

To investigate effects of chronic alcohol consumption and tocopherol on lipid peroxidation and mitochondrial respiration 48 male rats of Sprague-Dawley strain were divided into 4 groups. Each group received for 3 weeks one of 4 experimental diets: tocopherol deficient control (TDC), tocopherol deficient-ethanol (TDE), tocopherol-supplemented control (TSC) and tocopherol-supplemented-ethanol (TSE). Composition of the diets was based on the Lieber and Decarli liquid diet and $\alpha$-tocopherol was supplemented at the level of 30mg/liter of diet, and ethanol supplied 36kcal%. TDC and TSC were pair-fed to TDE and TSE, respectively. Increase of body weight of tocopherol deficient-ethanol group was the lowest and the effect was diminished with tocopherol supplementation. Respiration of liver mitochondria was depressed in ethanol-administered groups and the effect became larger with tocopherol deficiency. Hepatic lipid peroxide level was not influenced by ethanol, but hepatic tocopherol content decreased with ethanol treatment. The result indicated that, although lipid perroxide level was unchanged with chronic ethanol consumption, oxidative stress exists in tissues of rate administered ethanol and may be relieved by tocopherol supplementation.

• Journal of the Korean Applied Science and Technology
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• v.7 no.2
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• pp.55-61
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• 1990

To investigate the influence of saturated fats, ${\alpha}-linolenic$ acid, EPA and DHA on the lipid hydroperoxide concentration and fatty acid composition in liver microsomes and in plasma lipid of rabbits, the animals were fed on the perilla oil rich ${\alpha}-linolenic$ acid or sardine oil rich EPA and DHA diet for four weeks Were examined. The fatty acid composition of plasma lipid and liver microsomes of rabbits fed on the perilla oil diet was an accumulation of arachidonic acid(AA) 20:4 n-6, eicosapentaenoic acid(EPA) 20:5 n-3, and docosahexaenoic acid(DHA) 22:6 n-3, The fatty acid composition of plasma lipid and liver microsomes of rabbits fed on the sardine oil was an accumulation of ${\alpha}-linolenic$ acid(LNA) 18:3 n-3, and arachidonic acid(AA) 20:4. The p/s ratio of rabbits fed on the perilla oil diet changed from 7.4 to 2.27 for plasma lipid and 2.47 for liver microsomes. The concentration of lipid hydroperoxide was 3.48 nmol MDA/ml and 4.35 nmol MDA/ml for plasma lipid and liver microsomes, respectively, in perilla oil diet. The lipid hydroperoxide liver was 4.22 nmol MDA/ml and 67 nmol MDA/ml for plasma lipid and liver microsornes in sardine oil diet.

• The Journal of Internal Korean Medicine
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• v.21 no.3
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• pp.389-398
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• 2000

The fallowing are the results of the experimental studies of Cordyceps militaris (CM) on the penile nitric oxide synthase (NOS) activity and the level of blood testosterone in hydrocortisone acetate-treated rats. CM was tested for the effects on activity of xanthine oxidase and lipid peroxidation in penis of hydrocortisone acetate-treated rats. In vitro, CM didn't effect the levels of lipid peroxide and the activity of NOS. In the penis of hydrocortisone acetate-treated rats, lipid peroxide, the activities and ratio of type conversion of xanthine oxidase were increased but activity of NOS and content of nitrite were decreased. In vivo, after administration of CM to hydrocortisone acetate-treated rats, levels of lipid peroxide in penis was decreased. Also, the activities and ratio of type conversion of xanthine oxidase were decreased, too. The body weight and concentration of testosterone in the blood were increased. The effects of Cordyceps militalis Broth did better than the effects of Cordyceps militalls Mycelia, These results suggest that CM decrease the activities of free radical generating enzymes such as xanthine oxidase which form lipid peroxide and increase the penile NOS activity and the level of blood testosterone in hydrocortisone acetate-treated rats. Conclusively, CM is capable of improving of sexual ability in hydrocortisone acetate-treated rats.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.4
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• pp.859-867
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• 2014

This study was conducted to evaluate the optimum dietary lipid level in juvenile river puffer. Five semi-purified diets were formulated with corn oil to contain graded levels of lipid levels of 6, 9, 12, 15 and 18%. Fish averaging $8.32{\pm}0.02$ g randomly were fed the experimental diets in triplicate groups for 8 weeks. After the 8-weeks feeding trial, weight gain and specific growth rate of fish fed the 9% diet were significantly higher than those of fish fed the 15 and 18% diets (P<0.05) but there was not significantly different from that of fish fed the 6, 9 and 12% diets. Feed efficiency and protein efficiency ratio of fish fed the 6, 9 and 12% diets were significantly higher than those of fish fed the 18% diet (P<0.05). Visceralsomatic index of fish fed 18% diet was significantly higher than that of fish fed the 6% diet (P <0.05) but there was not significantly different from that of fish fed the 9, 12, 15 and 18% diets. No significant differences were observed in condition factor, hepatosomatic index and whole body composition among all the fish groups. Serum cholesterol and triglyceride fish fed of 18% diet were significantly higher than that of fish fed the other diets (P<0.05). Optimum dietary lipid levels by using broken-line model and by using second order polynomial were estimated at 7.01% and 8.98% for the maximum growth of fish respectively. Therefore, these results suggested that the optimum dietary lipid level could be greater than 7.01% but less than 8.98% for the maximum growth in juvenile river puffer.