The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Holotrichia on damages of liver tissue induced by bromobenzene in rats

제조가 Bromobenzene에 의(依)한 흰쥐의 간손상(肝損傷)에 미치는 영향(影響)

  • Han, Jeong-Hoon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Shin, Hyeon-Chul (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Kim, Jong-Dae (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center)
  • 한정훈 (동국대학교 한의과대학 내과학교실) ;
  • 신현철 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 김종대 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 신억섭 (동국대학교 의료원 약제과)
  • Published : 1998.04.30
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Abstract

Holotrichia was tested for the effects on damages of liver tissue induced by bromobenzene. Holotrichia was treated firstly into samples, and then bromobenzene intoxicated animal models were set with them. In vitro, the level of lipid peroxide in tissue of liver proportinally decreased with the level of concentration of extract prepared from Holotrichia It was much more decreased, when lipid peroxidation was induced with ferrous iron ($Fe&{+2}$). In vivo, after the extract was administered to the animal model for twenty days, the level of lipid peroxide in liver decreased compared to that of bromobenzene-treated group. The enzyme activities of epoxide hydrolase and glutathione S-transferase in liver highly increased in Holotrichia pre-medicating group compare with the group treated with only bromobenzene. And we can get the same results in the enzyme activities of superoxide dismutase, catalase and glutathione peroxidase. The level of glutathione followed by Holotrichia pre-medicationg administration, increased as highly as normal group in compare with the group treated with only bromobenzene. Also, the enzyme activities of AL T, AST and $\{gammer}-GTP$ in liver considerably decreased. In conclusion, Holotrichia recovers the damage of liver due to bromobenzene intoxication by the increased activities of lipid peroxidation and bromobenzene scavenging enzymes.

Keywords

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