• 혜화의학회지
• /
• 제25권1호
• /
• pp.133-144
• /
• 2016

Objectives : This study was aimed to investigate the effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) in a dyslipidemia animal model induced by a high-fat diet. Methods : ACLL extracts was administered at 200 mg/kg, and 400 mg/kg to Apoe mice, where arthritis was induced by high cholesterol diet. After mice were treated with GO for 4 weeks, we measured AST, ALT, BUN and lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride), atherogenic index(AI) and cardiac risk factor(CRF). Results : Serum AST, ALT, creatinine, BUN levels were not changed by ACLL extract do not show any toxic effects. Also, ACLL extract groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol, LDL cholesterol and triglyceride decrease). Conclusions : We suggest that ACLL extract may have the control effects of Dyslipidemia by improving lipid metabolism.

• Preventive Nutrition and Food Science
• /
• 제15권3호
• /
• pp.184-188
• /
• 2010

The purpose of the present study was to evaluate the effects of red pepper seeds powder on lipid metabolism in rats fed high fat high cholesterol diet. Rats were divided into five experimental groups: normal diet group, high fat high cholesterol diet group, high fat high cholesterol diet with 5% red pepper seeds powder supplemented group (SA group), high fat high cholesterol diet with 10% red pepper seeds powder supplemented group (SB group) and high fat high cholesterol diet with 15% red peeper seeds powder supplemented group (SC group). The serum triglyceride (TG) and cholesterol contents, and LDL-cholesterol and atherogenic index (AI) of the red pepper seed powder supplemented groups were significantly decreased compared to the HF group. The serum HDL-cholesterol contents of the red pepper seed powder supplemented groups were increased compared to the HF group. However, there was no significant difference in the serum HDL-cholesterol among all experimental groups. The hepatic TG and cholesterol contents of the red pepper seed powder supplemented groups were significantly decreased compared to the HF group. The fecal total cholesterol and triglyceride contents of the red pepper seeds powder supplemented groups were significantly increased compared to the HF group. These results suggest that supplementation of red pepper seed powder may have a pronounced impact on markers of lipid metabolism in serum and liver of rats fed high fat high cholesterol diets.

• 대한지역사회영양학회지
• /
• 제12권1호
• /
• pp.40-49
• /
• 2007

This study was done to investigate the health-related habits, dietary intakes and serum lipid levels in overweight and obese women by body mass index(BMI). Subjects were 137 pre-menopausal women aged 19 to 49 years. They were divided by 3 groups, overweight($23{\leqq}BMI<25$), obese($25{\leqq}BMI<30$) and morbidly obese($BMI{\geq}30$) according to their BMI. Body composition was determined by bioelectrical impedance analysis(BIA) method. Dietary intakes were examined by 3-day record method and nutrient intakes were analyzed by the Computer Aided Nutritional analysis program for professionals(CAN-pro 3.1). Serum lipid levels were measured using automatic biochemical analyzer(Selectra E). The average age, height weight and BMI of subjects were 31.7 years old, 159.3cm, 69.4kg, and $27.4kg/m^2$, respectively. Their average consumption of energy were 1712kca1 and 86.4% of estimated energy requirement(EER). Their mom ratio of carbohydrate:protein:fat was 55.2:14.6:30.2. Particularly, the fat consumption of subjects tended to be elevated with increasing BMI. There was no significant difference in nutrient intakes among 3 groups. But the mom intakes of Ca, Fe, vitamin C and Na of all the subjects were 70.1%, 81.2%, 75.7% of recommended intake(RI) and 258.9% of adequate intake(AI), respectively, The intakes of vegetables and seaweeds were significantly higher in morbidly obese group while the intake of fruits was higher in overweight group compared to the other groups. Serum lipid analysis showed that there were no significant differences in the levels of total cholesterol, triglyceride and LDL-cholesterol among the groups. But the serum HDL-cholesterol level of the overweight group was significantly higher than that of the other groups. LDL-/HDL-cholesterol ratio and AI index were significantly higher in the morbidly obese group compared to the other groups. In addition, The systolic blood pressure of morbidly obese group was significantly higher compared to the other groups. Overall data suggest that morbidly obese women have to more concern about reducing systolic blood pressure and nm lipid levels by decreasing their fat consumption and salt intakes as well as loosing body fat. In addition, all the subjects participated in this study have to be careful about their meals and health-related behaviors in order to prevent obesity-related chronic diseases.

• Clinical and Experimental Pediatrics
• /
• 제49권7호
• /
• pp.763-768
• /
• 2006

목 적 : 후두세척술을 이용하여 얻어진 LLMI로 급성세기관지염의 흡인의 위험성을 평가하고, LLMI와 기도염증세포 사이의 연관성에 대해서 연구하고자 하였다. 방 법 : RSV 세기관지염을 앓은 22명의 환아에서 급성기와 회복기에 각각 후두세척술을 시행하여 총세포수와 세포분획을 계산하였다. 한 개의 대식세포당 지질함유량은 0부터 4까지의 점수로 측정하였고, LLMI는 100개의 세포를 검사하여 400점까지 측정하였다. 결 과 : 세기관지염의 급성기에는 회복기에 비해 총세포수와 LLMI가 의미있게 증가되었다(P<0.05). 후두세척액의 중성구 백분율은 LLMI와 상관관계가 있었다(r=0.69, P<0.001). pH 양성군은 pH 음성군에 비해 후두세척액의 LLMI와 중성구 백분율이 의미있게 높았다(P<0.05). 결 론 : 본 연구는 세기관지염 시기에 일시적인 흡인의 위험이 증가한다는 것을 보여준다. 후두세척액으로 측정한 LLMI는 세기관지염 환아에서 흡인의 유용한 지표가 될 수 있다.

• 한국지역사회생활과학회지
• /
• 제19권1호
• /
• pp.113-123
• /
• 2008

This study was performed to find and compare the characteristics of dietary factors and obesity indices on serum lipid profiles using 407 healthy adult males that had physical examinations conducted at the general hospital located in Suwon. The subjects were divided 56.3% for the normal group, 16.7% for TG, 14.5% for TC and 12.5% for TC TG group, respectively. When comparing the blood lipid profiles to normal group, TC group was high in both total cholesterol and LDL-cholesterol, TG group was high in triglyceride and low in HDL-cholesterol, TC TG group was high in triglyceride, total cholesterol, LDL-cholesterol and low in HDL-cholesterol. In comparison of blood lipid profiles with normal group, among anthropometric factors, body weigh, BMI (Body Mass Index) and WHR (Waist Hip Ratio) showed significant differences. TC group was high in both total cholesterol and LDL-cholesterol, and TG group was high in triglyceride and low in HDL-cholesterol. TC TG group was high in triglyceride, total cholesterol and LDL-cholesterol, and was low in HDL-cholesterol. Body weigh of TG group was significantly higher than that of normal group (p<0.05). BMI and WHR of TG group and TC TG group were significantly higher than those of normal group (p<0.05). Total cholesterol was mainly related to the intake of animal lipids and alcoholic beverage. Serum triglyceride levels were closely related with lipid intake and high BMI in this group. In TC TG group, BMI and WHR were high. As well, serum LDL-cholesterol was high and HDL-cholesterol was low which indicates TC TG group had the most undesirable blood lipid profiles. Therefore, it may be necessary to manage BMI and WHR to prevent hyperlipidemia and obesity for adult males in Suwon.

• Preventive Nutrition and Food Science
• /
• 제16권3호
• /
• pp.202-209
• /
• 2011

This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제23권2호
• /
• pp.163-173
• /
• 2020

Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.

• 한국식품영양과학회지
• /
• 제35권5호
• /
• pp.530-535
• /
• 2006

본 연구는 다량의 당질과 단백질을 함유하고 있는 매생이가 동물의 체내 지질대사에 미치는 영향을 검토하였다. SD계 흰쥐를 기초식이군과 1% 콜레스테롤 급이군, 그리고 콜레스테롤과 동시에 5% 매생이를 급이한 매생이 급이군으로 나누어 5주간 급여하여 혈액과 간 중의 지방과 콜레스테롤 함량을 측정하고, 비만 유전자인 랩틴 단백질의 발현정도를 측정하였다. 혈청 중 중성지방과 총콜레스테롤 함량은 기초식이군에 비해 콜레스테롤 급이군에서 높게 나타났으며, 매생이 급이군은 콜레스테롤 급이군에 비해 유의하게 낮았다. 혈청 중 HDL-콜레스테롤 함량은 콜레스테롤 급이군에서 가장 낮게 나타났으나, 콜레스테롤과 함께 급이한 매생이 급이군에서는 높아지는 경향을 나타내었다. 간 중의 중성지방과 총콜레스테롤 함량 또한 콜레스테롤 급이군에 비해 매생이 급이군에서 유의적으로 낮은 경향을 나타내었다. 즉, 고콜레스테롤혈증이 유발된 흰쥐에 대한 매생이 급이가 다른 해조류와 마찬가지로 기능성 식이섬유로서 작용하여 혈청 및 간 내 콜레스테롤, 중성지질 및 LDL-콜레스테롤 농도의 저하, HDL-콜레스테롤 농도의 상승 및 동맥경화지수의 저하 등 지질개선 효과가 있는 것으로 확인되었다. 따라서, 동결건조하여 분말화시킨 매생이 자체만으로도 혈청 또는 간장에서의 지질개선 뿐만 아니라 심혈관계 질환의 치료를 목적으로 하는 식품소재로서의 활용이 가능할 것으로 생각된다.

• Journal of Nutrition and Health
• /
• 제33권5호
• /
• pp.524-531
• /
• 2000

This study was conducted to investigate the basal leptin concentrations in normal(n=17, BMI 20-25, obesity index 90-110%) and overweight(n=13, BMI > 25, obestity index > 120%) Korea young aldult males, and correlation between leptin concentrations, nutrients intake, anthropometry and other biochemical parameters. Nutritional status, serum leptin and biochemiccal parameters were evaluated based on 24hr-dietary records, anthropometric measurement and blood analysis. Obesity index were 138% and 101% in overweight and normal group, respectively. Serum leptin concentration was higher in overweight group than that in normal group (8.65$\pm$ 9.41 vs 2.06 $\pm$ 1.19, p<0.05). Serum triglyceride, HDL-cholesterol and insulin concentrations were higher in overweight group than in normal group(p<0.05). Nutrients intakes was not different between two group. The leptin concentrations were correlated with body weight(p<0.001), BMI(p<0.05), obesity index(p<0.05), waist circumference(p<0.05), animal lipid intake(p<0.05)in overweight group.

• Natural Product Sciences
• /
• 제11권4호
• /
• pp.225-228
• /
• 2005

four varieties of ground nut (Arechis hypogea) were collected from different areas of Pakistan (Tillagang, Gujar khan, Hanoi and Pipplan) from Punjab province. The oils were extracted for the evaluation of lipid. Physico-chemical values of oils were determined like refractive index, peroxide value, unsaponifiable matter, acid value, iodine value, free fatty acid and ester value. The lipid profile as indicated by GLC showed that Palmitic acid ranged from 8.2-8.8%, proportions of oleic acid and linoleic acid varied from 57.8-59.87% and 22.5-24.1% respectively. Gujar khan variety of peanut has higher % age of oil (56.79). The higher yield of oil in this variety is not at the cost of any nutritional quality of peanut oil.