• Bulletin of the Korean Mathematical Society
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• v.49 no.2
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• pp.395-409
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• 2012

In the study of homology cobordisms, knot concordance and link concordance, the following technical problem arises frequently: let ${\pi}$ be a group and let M ${\rightarrow}$ N be a homomorphism between projective $\mathbb{Z}[{\pi}]$-modules such that $\mathbb{Z}_p\;{\otimes}_{\mathbb{Z}[{\pi}]}M{\rightarrow}\mathbb{Z}_p{\otimes}_{\mathbb{Z}[{\pi}]}\;N$ is injective; for which other right $\mathbb{Z}[{\pi}]$-modules V is the induced map $V{\otimes}_{\mathbb{Z}[{\pi}]}\;M{\rightarrow}\;V{\otimes}_{\mathbb{Z}[{\pi}]}\;N$ also injective? Our main theorem gives a new criterion which combines and generalizes many previous results.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11b
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• pp.323-337
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• 2006

Recently, several studies have been carried on knowledge flow of science, technology, industry to establish STI policy. Still it is in need of studies on relationship of science-industry although there have been studied only in aspect of science-technology relationship or technology-industry relationship. This paper's purpose is to propose method to measure knowledge flow among science, technology, and industry by means of patent citation by USPTO. After gathering knowledge flow data between science and technology through mapping citing patent and cited pater, it gets knowledge flows data between technology-industry by using OTC (OECD Technology Concordance), technology-industry mapping program. Based on these knowledge flow data, it examines knowledge flow science to industry by applying overlap function that is a network link weight function.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2004.11a
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• pp.18-34
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• 2004

This paper will review data obtained primarily from our preclinical investigations that show that exposure to stress has a significant impact on drug taking. Stress increases reward associated with psychomotor stimulants, possibly through a process similar to sensitization, and a growing clinical literature indicates that there is also a link between substance abuse and stress in human addicts. One explanation for the high concordance between stress-related disorders and drug addiction is the self-medication hypothesis, which suggests that a dually-diagnosed person often uses the abused substance to cope with tension associated with life stressors or to relieve symptoms of anxiety and depression resulting from a traumatic event. However, another characteristic of drug self-administration is that drug delivery and its subsequent effects on the HPA axis are under the direct control of the individual. This controlled activation of the HPA axis may result in the production of an internal state of arousal or stimulation that is actually sought by the individual (i.e., the sensation-seeking hypothesis). During abstinence, however, exposure to stressors or drug-associated cues can stimulate the HP A axis to remind the individual about the effects of the abused substance, thus producing craving and promoting relapse. Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for addiction. Of primary importance is to reduce the impact of cocaine-associated environmental stimuli on the HPA axis so that they no longer function as triggers for relapse.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.706-710
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• 2006

Recently, several studies have been carried on knowledge flow of science, technology, industry to establish STI policy. Still it is lack of studies on relationship of science-industry although there have been studied only in aspect of science-technology relationship or technology-industry relationship. This paper's purpose is to propose method to measure knowledge flow among science, technology, and industry by means of patent citation. After gathering knowledge flow data between science and technology through mapping citing patent and cited paper, it gets knowledge flows data between technology-industry by using OTC (OECD Technology Concordance), technology-industry mapping program. Basd on 2 types of knowledge flow data, it propose method to examine knowledge flow from science to industry by applying overlap function is a network link weight function.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.5
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• pp.299-305
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• 2011

Calcineurin (CaN) is activated in diabetes and plays a role in glomerular hypertrophy and extracellular matrix (ECM) accumulation. Here, kidneys from diabetic model mice were investigated for the expression of the regulator of CaN 1 (RCAN1) isoform 4 (RCAN1.4) which had been shown to be transcriptionally upregulated by CaN activation. We found the increased immunoreactivity for RCAN1 in the glomerular cells of db/db mice and streptozotocin-induced diabetic mice. In concordance, the expression of RCAN1 protein and RCAN1.4 mRNA were elevated in the whole kidney sample from db/db mice. Interleukin-$1{\beta}$ (IL-$1{\beta}$), tumor necrosis factor-${\alpha}$, and glycated albumin (AGE-BSA) were identified as inducers of RCAN1.4 in mesangial cells. Pretreatment of cyclosporine A blocked the increases of RCAN1.4 stimulated by IL-$1{\beta}$ or AGE-BSA, suggesting that activation of CaN is required for the RCAN1.4 induction. Stable transfection of RCAN1.4 in Mes-13 mesangial cells upregulated several factors relevant to ECM production and degradation. These results suggested that RCAN1.4 might act as a link between CaN activation and ECM turnover in diabetic nephropathy.