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Cyclofarnesane sesquiterpene glucoside from the whole plant of Loranthus tanakae and its cytotoxicity ('꼬리겨우살이'(Loranthus tanakae) 전초로부터 cyclofarnesane sesquiterpene glucoside의 분리 동정 및 세포독성)

  • Joo, Sun-Woo;Kim, Hyoung-Geun;Oh, Eun-Ji;Ko, Jung-Hwan;Lee, Yeong-Geun;Kang, Se-Chan;Lee, Dae Young;Baek, Nam-In
    • Journal of Applied Biological Chemistry
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    • v.62 no.1
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    • pp.7-10
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    • 2019
  • The whole plants of Loranthus tanakae were repeatedly extracted with 80% aqueous MeOH and the concentrate was partitioned into ethyl acetate (EtOAc), n-butyl alcohol (n-BuOH) and $H_2O$ fractions. The repeated silica gel ($SiO_2$), octadecyl $SiO_2$ (ODS), and Sephadex LH-20 column chromatographies for the n-BuOH fraction led to isolation of a cyclofarnesane sesquiterpene glucoside. The chemical structure including stereo structure was determined to be a (1'R,3'S,5'R,8'S,2E,4E)-dihydrophaseic acid $3^{\prime}-O-{\beta}-{\text\tiny{D}}$-glucopyranoside on the basis of spectroscopic analyses. This compound was isolated for the first time from L. tanakae in this study. Compound 1 showed a moderate dose-dependent cytotoxicity against human Caucasian gastric adenocarcinoma cells and human hepatocyte cari-noma cells cell lines at higher than $50{\mu}g/mL$.

The Cytotoxicity of 1,3-diphenylpropenone derivatives (1,3-diphenylpropenone 유도체의 세포독성)

  • Yu, Seong-Jae;Kwon, Byung-Mok;Lee, Chong-Ock;Choi, Sang-Un;Sung, Nack-Do
    • Applied Biological Chemistry
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    • v.42 no.1
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    • pp.68-72
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    • 1999
  • The cytotoxicity of 1,3-diphenylpropenone derivatives known to inhibit the farnesyl protein transferase (FPTase) was examined against various established tumor cell line, A549 (lung cancer), SKMEL-2 (uterine cancer), HCT-15 (skin cancer), SKOV-3 (brain cancer) and XF-498 (colon cancer) of the 1,3-diphenylpropenone derivatives showing farnesyl protein transferase (FPTase) inhibition activity. And the structure-activity relationship (SAR) between structure of 1,3-diphenylpropenone derivatives as substrate and cytotoxicity was investigated by Free-Wilson analysis as well as Hansch method with tumor cell lines. From the result of Free-Wilson analyses, X-substituents on the benzoyl group have a more important role than Y-substituents on the styryl group. The 2,4-dichloro substituent, 15 and 2,4-dimethyl substituent, 16 showed the highest cytotoxicity (average pI_(50)=5.0). Particulary, the cytotoxicity of X-substituents increased with electronic effect $({\sigma})$ due to weak electron withdrawing group with optimum value $({\sigma}_{opt}=0.22{\sim}0.29})$ whereas that of Y-substituent resulted from various factors such as logP, $B_1$ and R constant.

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Quadratic Sigmoid Neural Equalizer (이차 시그모이드 신경망 등화기)

  • Choi, Soo-Yong;Ong, Sung-Hwan;You, Cheol-Woo;Hong, Dae-Sik
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.1
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    • pp.123-132
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    • 1999
  • In this paper, a quadratic sigmoid neural equalizer(QSNE) is proposed to improve the performance of conventional neural equalizer in terms of bit error probability by using a quadratic sigmoid function as the activation function of neural networks. Conventional neural equalizers which have been used to compensate for nonlinear distortions adopt the sigmoid function. In the case of sigmoid neural equalizer, each neuron has one linear decision boundary. So many neurons are required when the neural equalizer has to separate complicated structure. But in case of the proposed QSNF and quadratic sigmoid neural decision feedback equalizer(QSNDFE), each neuron separates decision region with two parallel lines. Therefore, QSNE and QSNDFE have better performance and simpler structure than the conventional neural equalizers in terms of bit error probability. When the proposed QSNDFE is applied to communication systems and digital magnetic recording systems, it is an improvement of approximately 1.5dB~8.3dB in signal to moise ratio(SNR) over the conventional decision feedback equalizer(DEF) and neural decision feedback equalizer(NDFE). As intersymbol interference(ISI) and nonlinear distortions become severer, QSNDFE shows astounding SNR shows astounding SNR performance gain over the conventional equalizers in the same bit error probability.

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Investigation of fault in the Kyungju Kaekok-ri area by 2-D Electrical Resistivity Survey (2차원 전기비저항 탐사를 이용한 경주 개곡리 지역의 단층조사)

  • Lee, Chi-Seop;Kim, Hee-Joon;Kong, Young-Sae;Lee, Jung-Mo;Chang, Tae-Woo
    • Geophysics and Geophysical Exploration
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    • v.4 no.4
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    • pp.124-132
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    • 2001
  • Electrical resistivity survey has been conducted for delineating geological fault structure in Kaekok-ri near Kyungju. In general, electrical resistivity survey has an advantage of searching buried faults and its traces compared with other geophysical survey methods. Distribution of electrical conductivity in the ground is influenced by the ratio of pores, groundwater and clay minerals. These properties are evidenced indirectly to explain for weathering condition, faults and fracture Bones. Thus the electrical resistivity survey can be an effective method to find buried faults. We have carried out two dimensional (2-D) interpretation by means of smoothness-constrained least-squares and finite element method. Field data used in this paper was acquired at Kaekok-ri, Wuedong-eup, Kyungju-si, where is Ulsan Fault and is close to the region in which debatable quaternary fault traces were found recently. The dipole-dipole array resistivity survey which could show the 2-D subsurface electrical resistivity structure, was carried out in the area with three lines. The results showed good property of fault, fracture zone and fault traces which we estimated were congruous with the results. Through this study, 2-D electrical resistivity survey interpretation for fault is useful to apply.

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Research of Electrical Safety Test Construction about Structure under 765kV Transmission Lines (765kV 송전선로 선하 건조물 전기안전 실증시험 구축 연구)

  • Mun, Seong-duk;Maeng, Jong-ho;An, Ho-sung;Ahn, Heesung;Lee, Ho-guen
    • Proceedings of the KIEE Conference
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    • 2015.07a
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    • pp.410-411
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    • 2015
  • 765kV 송전선로와 선하 건조물은 최하단 도체의 높이 28m를 적용하고 대지저항률은 $100{\Omega}m$, IEEE 변전소 설계지침인 Std-80에 따라 건조물에 접촉하는 사람의 인체저항은 $1000{\Omega}m$, 대지를 딛고 있는 사람의 한쪽 발 접지저항은 직경 8cm의 원판 접지저항을 적용한다. 이렇게 구성된 모델에서 선로중심에서 건조물까지 이격거리 변동에 따라 인체 유도전류를 측정하고자 한다. 본 연구에서는 전기안전 실증시험을 위해 765kV 가공송전선로 직하에 목조 및 샌드위치 판넬 2가지 시험용 가옥을 설치하였다. 전기설비기술기준에 의거하여 선하직하 이격거리가 28m일 때 발생할 수 있는 전자계 특성과 재질에 따른 전자계가 미치는 영향을 비교 분석하고 장기 유도장해 실측 데이터를 확보하고자 그림 1과 같이 구축 설계하였다. 이를 통해 송전선로에 의해 선로중심으로부터 구축된 모의가옥까지 이격거리에 따라 유도되는 전류를 측정하고 그 크기가 인체에 미치는 유도전류 한계치 초과 여부에 대해 검토함으로써 안전성 여부에 대해 측정 및 검토하고자 시험게획을 수립하였다. 또한 선로 고장 시 대지전위상승에 의한 선하 건조물 안정성 검토 및 낙뢰서지 유입에 의한 전기안전 시험 구성을 하였다.

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Broadband W-band Tandem coupler using MIMIC technology (MIMIC 기술을 이용한 광대역 W-band Tandem 커플러)

  • Lee, Mun-Kyo;An, Dan;Lee, Bok-Hyung;Lim, Byeong-Ok;Lee, Sang-Jin;Moon, Sung-Woon;Jun, Byoung-Chul;Kim, Yong-Hoh;Yoon, Jin-Seob;Kim, Sam-Dong;Rhee, Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.44 no.7 s.361
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    • pp.105-111
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    • 2007
  • In this paper, we designed and fabricated a 3-dB tandem coupler using air-bridge technology for millimeter-wane monolithic integrated circuits, operating at W-band($75{\sim}110\;GHz$) frequency. Tightly edge-coupled CPW line has low directivity due to different even-mode and odd-mode phase velocity. To overcome this disadvantage, a 3-dB tandem coupler which comprises the two-sectional weakly parallel-coupled lines with equal phase velocity was designed at W-band. The proposed coupler was fabricated using air-bridge technology to monolithically materialize the uniplanar coupler structure instead of conventional multilayer or wire bonded structure. From the measurements, the coupling coefficient of $2.9{\sim}3.6\;dB$ and the good phase difference of $91.2{\pm}2.9^{\circ}$ were obtained in broad frequency range of $75{\sim}100\;GHz$.

A Experimental Study on the Determination of Construction method of Controled Low-strength Material Accelerated Flow Ability Using Surplus Soil for Underground Power Line (지중송전관로용 급결 유동성 뒤채움재의 시공법 설정에 관한 실험적 연구)

  • Oh, Gi-Dae;Kim, Dae Hong
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.5 no.3
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    • pp.84-93
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    • 2010
  • Compaction of backfill material of Underground power lines is difficult, especially under pipeline. so it could cause structural problem because of low compaction efficiency. So various methods have been taken to solve the problem and one of them is CLSM(Controled low-strength material accelerated flow ability). But In other countries, these are already in progress for a long time to research and development and recently on practical steps. But, in our country, study for only general structures, not for underground power line structure that is being constructed at night rapidly. In this study, we performed property tests and indoor & outdoor test (3 cases). The tests showed flow ability reached at the limit construction(160 mm) flowability by 9 to 15 minute after starting to mix, and construction buoyant is lowering after placing CLSM by 70 % of theoretical buoyant that is calculated by unit weight of material. In this paper, we performed indoor tests and outdoor tests to estimate mechanical properties and to suggest construction method(using batch plant, setting spacer at 1.8 m and placing at 2m) for CLSM that using surplus soil. And the test showed good results for construction quality, workability and structure safety.

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Availability Evaluation of Quasi Static RTK Positioning for Construction of High Rise Buildings and Civil Structures (고가(高架)구조물의 정위치 시공을 위한 준스태틱RTK 측위의 적용성 실험)

  • Kim, In-Seop
    • Journal of Korean Society for Geospatial Information Science
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    • v.19 no.4
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    • pp.119-126
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    • 2011
  • During precise survey on the top of High rise buildings and civil structures, optical surveying equipments like a Total Station are not recommended to use because of some reasons that uneasier alignment with reflectors located at the top of building, increasing error depends on increasement of observation distance and unavailable dynamic positioning etc. Recently various GPS positioning methods have been applied to this job however almost of them are post-processing method which is required much longer time during for whole process includes stake-out, cross checking, fixing positions and final inspections. Therefore, in this study, we applied with RTK surveying system which allows stake-out and inspection in realtime to avoid delaying of construction schedule and also applied with Quasi Static RTK measurement and network adjustment to get a high accuracy within a few millimeters in structure positioning to achieve a successful management for process and quality control of the project. As a result, very high accurate surveying for structures within approx. 2mm in realtime has been achieved when surveyor conduct a network adjustment using least square method for 4 base lines created by Quasi Static RTK data and we expect this method will be applied to construction survey for high rise buildings and civil structures in the future.

Studies on the External Structure of the Cuticle of Silkworm pupa (Bombyx mori L.) (가잠용외피의 외부구조에 관한 조사연구)

  • 윤종관
    • Journal of Sericultural and Entomological Science
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    • v.20 no.2
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    • pp.10-14
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    • 1978
  • There are relatively many reports have been issued on he active movement of cuticle of larva. which tend to protect their body, however, only a few reports have been disclosed on the cuticle of pupal body except the small portion of rectangle which shown tortoise-shell shape. In this connection, many portion of the external structure of pupal cuticle has been studied and the following. results were found: 1) No. spot of rectangle which is sculptured in the surface of cuticle that born by branching. out of the development of cell in imaginal bud of antenna and head were found. However, in the compound eye of net shaped sculpture was found in the (equation omitted) shaped parts which holding. the diameter of about 8u and the surrounding area has the small bump and the one is dark brown coloured comparing with shape. 2) The sculpture shape of thorax is a little different than in the head. However, (equation omitted) portion is varies from the segment to segment. In general, it is not very clear than the compound eye in the head, the dark brown bump shape is slowly fade a from the prothorax, mesothorax to metathorax. 3) The surface of intersegment membrane is colourless or slightly yellow, and the entire surface has stripped marking with thine lines. 4) In the abdominal segment, there are many and small sculptures in net shape around the (equation omitted) shape portions. 5) The size of sculpture in (equation omitted) portion of abdomen is smaller than one in thorax, and in the same segment, the dorsal is smaller than abdomen and the rear portion of the segment is larger than the front of segment. 6) After the 7th abdominal segment, no intersegmental membrane is found and the cuticle of the external structure is the same as external structure of the segment. 7) The seta is not found in head, compound eye, antenna and wing which portions were subdivided by development of imagined bud of the cell, no seta is found in cuticle of the segment in the general cell of the larva stage and also in the dorsal and intersegmental membrane.

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A Study on the New Impedance Matching method by using Non-Symmetrical coupled Lines for MIC and MMIC (MIC와 MMIC를 위한 비대칭 결합 선로에 의한 새로운 임피던스 정합 방법에 관한 연구)

  • 강희창;진연강
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.13 no.6
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    • pp.521-528
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    • 1988
  • Into the telecommunications industry, which had been monopolistic, a few advanced countries introduced competition through 70's and 80's. And this trend is going on worldwide. The introduction of competition into the industry is made mainly in the long distance, international and enhanced market. This liberalisation results from the fundamental change of the cost function. Suggesting that the cost comprises of that of the facility sector and that of the operation sector there exists the economies of scale in the facility sector in general. The major ground for the monopolistic industrial structure in the past was the natural monopoly depending on the economies of scale. But the rapid advance of the technology by a large margin. This decrease has resulted in the change of the cost function. That is while there exists the economies of scale in the smaller production scale, the average cost increases beyond a certain scale. This means that the natural monopoly collapsed, and that the competitive structure is more efficient than the monopolistic structure. But, because there exists economies of scale in the smaller scale, the desirable number of players, which could result in efficient industry structure depends on the market size. Such correlation between technological level market size and the degree of regulation is found in the case of U.S.A., Japan and U.K., where deregulation policy of the telecommunications market has already been carried out. In U.S.A., which has the largest market and the highest technological level the degree of regulation is lowest. Also in the order of Japan and U.K. the regulation is severer. Japan and U.K. are likely to liberalize still more, as the technology advances and the market grows. This article is just the beginning of the research, and this hypothesis requires more detailed research.

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