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http://dx.doi.org/10.3839/jabc.2019.002

Cyclofarnesane sesquiterpene glucoside from the whole plant of Loranthus tanakae and its cytotoxicity  

Joo, Sun-Woo (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Kim, Hyoung-Geun (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Oh, Eun-Ji (Integrative Biosciences and Biotechnology, Postech Life Science Building)
Ko, Jung-Hwan (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Lee, Yeong-Geun (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Kang, Se-Chan (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Lee, Dae Young (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Baek, Nam-In (Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University)
Publication Information
Journal of Applied Biological Chemistry / v.62, no.1, 2019 , pp. 7-10 More about this Journal
Abstract
The whole plants of Loranthus tanakae were repeatedly extracted with 80% aqueous MeOH and the concentrate was partitioned into ethyl acetate (EtOAc), n-butyl alcohol (n-BuOH) and $H_2O$ fractions. The repeated silica gel ($SiO_2$), octadecyl $SiO_2$ (ODS), and Sephadex LH-20 column chromatographies for the n-BuOH fraction led to isolation of a cyclofarnesane sesquiterpene glucoside. The chemical structure including stereo structure was determined to be a (1'R,3'S,5'R,8'S,2E,4E)-dihydrophaseic acid $3^{\prime}-O-{\beta}-{\text\tiny{D}}$-glucopyranoside on the basis of spectroscopic analyses. This compound was isolated for the first time from L. tanakae in this study. Compound 1 showed a moderate dose-dependent cytotoxicity against human Caucasian gastric adenocarcinoma cells and human hepatocyte cari-noma cells cell lines at higher than $50{\mu}g/mL$.
Keywords
(1'R,3'S,5'R,8'S,2E,4E)-dihydrophaseic acid $3^{\prime}-O-{\beta}-{\text\tiny{D}}$-glucopyranoside; Cyclofarnesane sesquiterpene glucoside; Cytotoxicity; Loranthus tanakae; Nuclear magnetic resonance;
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