• Bulletin of the Korean Chemical Society
• /
• 제32권6호
• /
• pp.2015-2020
• /
• 2011

A series of isoxazol-indolin-2-one was designed for GSK-3${\beta}$ inhibitors as novel anticancer agents based on their binding mode analysis in GSK-3${\beta}$ crystal structure. Total 21 compounds were synthesized and evaluated for their inhibitory activity against two tumor cell lines (DU145 and HT29). Most of the synthesized compounds were potent with above 80% inhibitory activity at 100 ${\mu}M$, and several compounds were examined for inhibitory activity against GSK-3${\beta}$. Among them, 15(Z) ($R_1$=H, $R_2$=3-Cl-phenyl) was most active with 78% inhibition of tumor cell line (HT29) at 20 ${\mu}M$ and 72% inhibition of GSK-3${\beta}$ at 20 ${\mu}M$.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• 제12권2호
• /
• pp.209-218
• /
• 1994

This study aims to generate triangulated irregular network in a form of digital terrain model which is being increasingly used. In general, grid digital elevation model and triangulated irregular network are reasonable units for solving terrain problems. But, triangulated irregular network is an efficient alternative to grid digital elevation model because of their efficiency in storing data and their convenient data structure for accommodating irregularly spaced elevation data. Various methods represented for extracting triangulated irregular networks from grid digital elevation model, and then algorithm that get accurate results for triangulation with their data set was introduced. The new approach for triangulation in this study uses the Elevation and Changeable Distance criterion, and adding interpolation points and restricted constraint lines can generate triangulated irregular network which is more close to real surface. This made database efficient construction and could be used for many applications of geo-spatial information system.

• Conservation Science in Museum
• /
• 제25권
• /
• pp.1-8
• /
• 2021

This study investigated White Porcelain Water Dropper with Openwork Lotus Scroll Design and Eight Trigram Design in Cobalt-blue Underglaze (hereinafter, the "water dropper") in the collection of the National Museum of Korea using computed tomography (CT). A replica was produced to examine both the structure and its original production method. The CT scanning identified no joint lines or pores in the clay, which suggests that the body (the lower part of the water dropper) was shaped in a single piece using a mold and was then matched with a mold-formed lid (the upper part of the water dropper). The inner container of the body portion was roughly trimmed with a bamboo knife so that its upper surface could be securely attached to the bottom of the lid and prevent any leakage in the joined surface. It appears that the inner container for storing water was made first in a cylindrical shape that met the unit of quantity used at the time and could be easily formed by molding. It was transformed into a trapezoid shape during the process of combining it with the lid. A cylindrical inner container was reproduced using silicon 3D printing to compare its capacity with that of the original inner container. The comparison revealed that the reproduced container had a capacity of 152.5㎖, whereas the original container holds approximately 168.6㎖, a figure similar to three hop (around 174㎖) in Joseon-period units of quantity. Since the capacity of the cylindrical inner container corresponds to a known measure from the late Joseon dynasty, it is likely that the water dropper was originally produced to contain a cylindrical inner container.

• Economic and Environmental Geology
• /
• 제18권4호
• /
• pp.309-320
• /
• 1985

The crustal structure of the southern part of the Korean peninsula has been investigated based on the results of processing and anlaysis of gravity data. The processing techniques involve i) seperation of regional and residual anomalies by polynomial fittings, ii) power spectral analyses to determine the mean depth to the crustal base, iii) a filtering operation called "high-cut filtering and resampling," and iv) downward continuation to determine the undulation of the crustal base. The Bouguer anomalies show a lineation in the NE-SW direction which is the same as that of most mountains and tectonic lines of this area. The mean crustal depth is found to be 34km. The depth of the crustal base is varying in the estimated range of 26km to 36km with a thinner crust below the east coast than that of the west coast. The relief of the crustal base is appeared to be correlated with the regional surface topography. The linear regression relations computed between elevations and gravity anomalies indicate that the crust of this area seems to be not in perfect isostatic equilibrium but a little undercompensated state.

• Korean Journal of Food Science and Technology
• /
• 제6권2호
• /
• pp.79-85
• /
• 1974

To obtain further information concerning the nature myofibrillar proteins in a food system, an investigation has been conducted to compare the change in the biochemical property of the myofibril with the changes in the morphological structure of the myofibril. When myofibrils were prepared with 0.16 M KCl-0.04 M Tris-HCl, the band pattern was clear and distinct. There was a uniform thickening of A-band, a sharp appearence of Z-lines and a wide I-band. The band pattern of myofibrils was changed as the composition of extraction solution was changed. Also the ATPase activity of myofibril changed as the length of sarcomere changed. When myofibrils were treated with a low concentration of trypsin, myofibrils turned in the contracted state. With the progress of prolonged trypsin treatment, most of myofibrils exhibited a pattern of alternating light and dark bands, supercontracted pattern. Although myofibrils exhibited a supercontracted band pattern, the ATPase activity of myofibril continued to increase with the progress of trypsin treatment. An assumption was made that tropomyosin may be located in Z-line and that troponin-tropomyosin complex can inhibit the ATPase activity of myofibrils through the structural alternation of myofibril.

• Journal of the Korean Wood Science and Technology
• /
• 제41권6호
• /
• pp.515-527
• /
• 2013

Building energy simulations which are mainly used in Korea have evaluated the building energy performance with the different thermal conductivity of construction materials. In order to evaluate the energy consumption accurately, the difference in thermal conductivity of the wood used in stud for wooden structure was confirmed from the each simulation. In addition, the thermal transmission of building members and the thermal bridge at the conjunction of building members according to thermal conductivity from each simulation programs were researched. The thermal conductivity of pine that has the largest variation among the energy simulations was applied to the thermal properties of studs in wooden structure. The maximum error between the maximum and minimum thermal transmission of roof, wall, and floor slab was $0.023W/m^2{\cdot}K$. Plus, that thermal bridge at Rafter junction on the roof, roof-wall joint, and floor slab-wall joint was $0.025W/m{\cdot}K$. The heat transfer image for changes in temperature and the heat exchange were analyzed by HEAT2 program. The distorted temperature lines were found around the insufficient insulated connection parts. It was predicted that the temperature at the distorted parts in the analyzed image was lower than that of the other portion of the other structures.

• Archives of design research
• /
• 제11권
• /
• pp.22-29
• /
• 1995

I have to find standpoint of sight moulding of Chi I Sung Hwa(seven stars picture) analysis of graphic systems of a symbol sight native to our nation. And I will comprehend emotion of folkways by simple and graphic lines and colors in mathematical Grid of which ancestor had expressed in gauge moulding consciousness. This papers aim is to make a contribution to lead by on part of communication design. About structural analysis of pictorial graphic side. I) Mathematical thought of the Orient and space constitution are first basically the Orient expressed number notion of mathematics of unlimitedness and notion of zero so called space and empty second can analigize a diagonal expansion method by development of symmetry notion to basic the dual principle of the negative and positive by degrees development expressed space division method by direction notion. 2) About the proportion analysis it based the golden section globularity and in modern layout it takes vision center of position, after appointing the brow of sacred image of Chil Sung Hwa as center point of proportion and applied to the point proportion and so analigized the posibility of established. Rule in union of each elements and rule of forms about picture image. 3) Mathematical structure analysis to search a unified principle at the balanced arrangement and rule of forms it analigized the standard the rule of forms. it analigized the standard the rule of forms to body module of basic movement of protagonist and follower above basic forms of grid that is the basis of design system.

• Archives of design research
• /
• 제13권1호
• /
• pp.111-120
• /
• 2000

Certain complex forces are existing at the other side of a canvas. These are visual arrangements and within the arrangement, even the simple combination of dots and lines create more than visual patterns. No matter what form that visual art has taken, it is performed in a certain space and it is constucted with various visual elements. For effective communication, visual elements must form a stable sturcture by extablishing organic relationship among each other. These requires an understanding of the human visual characteristics and psychonology, because human sight senses the same biological and psychological visual elements differently in its force and weight, according to the position within a given space. Although the structure which controls such force and weight exists within a peice of work, it is a internal plan of the work that actually controls the communication through a man\ulcorner psychological reactions towards the horizontal and virtical structures within it. Moreover it is a visual statement that effectively expresses a theme or a message. This thesis has studied visual structures through the analysis of art pieces regarding of these kind of a visual picture plane, characteristics of a picture plane formed by a structure of force existing on the other side of the picture and the theory of visual balance. In addition, the aim of this study is to help designers who deals with visual image works to understand the visual structures and psychological recognitions and to apply these picture plane compositions at their real work by recognizing the psychological power within the construction elements.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• 제17권9호
• /
• pp.811-820
• /
• 2006

Ultra wideband CPW batons are proposed in this paper. The proposed talons are consisted of ultra wideband multi-stage Wilkinson dividers and 'X'-shaped $180^{\circ}$ out-of-phase generator. Bottom-bridges and via-holes are used to connect CPW ground lines instead of the conventional air-bridges which require troublesome manual working in fabrication with HMIC(Hybrid Microwave Integrated Circuits) substrates. The proposed CPW batons have ultra wideband of 3 or $10(=F_{figh}/F_{low})$ theoretically, the wideband characteristics and S-parameters of the basis Wilkinson divider are directly converted to those of the proposed batons. The proposed batons are so compact and small compared to the conventional Wilkinson batons because no additional area for out-of-phase section is required. So the size of the proposed batons is exactly the same as that of the basis Wilkinson dividers. As examples, 3-stage and 7-stage wideband Wilkinson dividers are converted to the proposed batons. Their measured operating bandwidth are $1\sim3GHz$ and $0.8\sim5GHz$, respectively, with excellent matching, isolation and power division performances. The measured magnitude and phase balance errors are ${\pm}0.5dB\;and\;0.45\;dB,\;and\;{\pm}5^{\circ}\;and\;{\pm}10^{\circ}C$ over $1\sim3GHz\;and\;0.8\sim5GHz$, respectively.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• 제19권4호
• /
• pp.477-483
• /
• 2008

The paper introduces mobile handset multi-band chip antenna to be used on meander line PIFA structure and parasite patch. The proposed antenna uses an FR-4 substrate. The top layer is consist of meander lines PIFA structure to implement GSM900 and is connected with each rad and meander line on the via-hole for maximize space efficiency. The middle layer is designed with the signal line and gap to implement a DCS and PCS bands, the bottom layer which is added to a parasite patch on the ground can be show an adjust of frequency and impedance character by the connection of the radiators of middle layer and coupling. The fabricated antenna with the dimension of $28{\times}6{\times}4\;mm^3$. The ground plane a dimension of $45{\times}90\;mm$, designed by a commercial software CST simulator. The experimental results show that the bandwidth for(VSWR<3) is 90($875{\sim}965$) MHz in GSM900 band operation and 380($1,670{\sim}2,050$) MHz in DCS, PCS band operation. The maximum gains of antenna are 0.25 dBi, 3.65 dBi and 3.3 dBi at resonance frequencies and it has omni-directional pattern practically.