• Communications for Statistical Applications and Methods
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• 제10권1호
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• pp.125-134
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• 2003

Standard estimation methods for linear mixed models are sensitive to influential observations. However, tools and concepts for linear mixed model diagnostics are rudimentary until now and research is heavily demanded in linear mixed models. In this paper, we consider two diagnostics to evaluate the effects of individual observations in the estimation of fixed effects for linear mixed models. Those are Cook's distance and COVRATIO. Results of our limited simulation study suggest that the Cook's distance is not good statistical quantity in linear mixed models. Also calibration point for COVRATIO seems to be quite conservative.

• Communications for Statistical Applications and Methods
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• 제15권6호
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• pp.969-976
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• 2008

Mixed linear models have been widely used in various correlated data including multivariate survival data. In this paper we extend hierarchical-likelihood(h-likelihood) approach for mixed linear models with right censored data to that for left censored data. We also allow a general random-effect structure and propose the estimation procedure. The proposed method is illustrated using a numerical data set and is also compared with marginal likelihood method.

• Communications for Statistical Applications and Methods
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• 제7권3호
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• pp.677-686
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• 2000

Outliers may occur with respect to any of the random components in mixed linear models. We develop a use of simple, inexpensive updating formulas to consider the effect of case-deletion for mixed linear models. The method described here requires inversions of an n x n matrix, where n is the number of nonempty cells. A numerical example illustrates the use of computational formulas.

• Journal of the Korean Statistical Society
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• 제28권2호
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• pp.211-223
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• 1999

We propose a simple estimation procedure in the mixed linear models with censored normal data, using both Buckly and James(1979) type pseudo random variables and Lee and Nelder's(1996) estimation procedure. The proposed method is illustrated with the matched pairs data in Pettitt(1986).

• 응용통계연구
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• 제28권2호
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• pp.353-360
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• 2015

공간적으로 관측되는 연속형 자료를 분석하는 모형으로 공간적 상관관계를 고려한 다양한 정규모형이 지난 수십 년간 제안되었다. 그 중에서 공간효과를 랜덤효과로 모형화하는 공간선형모형(Spatial Linear Mixed Model; SLMM)이 가장 널리 활용되는 모형 중 하나일 것이다. 연결함수(link function)을 사용하면 SLMM을 비정규 데이터도 적용할 수 있는 일반화된 공간선형모형(Spatial Generalized Linear Mixed Model; SGLMM)으로 자연스럽게 확장할 수 있다. 이 논문에서는 가장 널리 활용되는 SGLMM을 알아보고 실제 데이터 적용사례를 R 패키지를 활용하여 제시하고자 한다.

• Journal of the Korean Statistical Society
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• 제19권2호
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• pp.171-175
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• 1990

A diagnostic test for detecting nonconstant variance in mixed linear models based on the score statistic is derived through the technique of model expansion, and compared to the log likelihood ratio test.

• 응용통계연구
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• 제28권2호
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• pp.295-308
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• 2015

지난 수십 년 동안 유전형 기술(genotyping technology)의 발달로 개인별 유전자 정보를 얻기 위해 필요한 비용이 감소함에 따라, 다양한 인간 질병의 원인 유전자를 규명하기 위한 많은 유전역학 연구들이 진행되어 왔다. 예를 들어 전장유전체관련분석(genome-wide association studies)은 수백 개에 이르는 표현형(phenotypes)에 대하여 수천 개에 이르는 원인유전자를 규명하였다. 유전체 자료의 홍수로 인하여 대규모 유전체 자료를 분석할 수 있는 다양한 분석 알고리즘에 개발되었으며, 특별히 선형혼합모형은 유전율의 추정부터 관련분석(association studies)에 이르기까지 유전역학 연구에서 광범위하게 활용되고 방법론이었다. 본 논문에서는 유전역학 연구에 있어 빈번하게 활용되는 선형혼합모형의 활용 사례를 나열하고, 각 분석 모형 별 추정치들의 생물학적 의미를 논하고자 한다.

• Journal of the Korean Data and Information Science Society
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• 제28권4호
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• pp.927-936
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• 2017

To analyze longitudinal count data, Poisson linear mixed models are commonly used. In the models the random effects covariance matrix explains both within-subject variation and serial correlation of repeated count outcomes. When the random effects covariance matrix is assumed to be misspecified, the estimates of covariates effects can be biased. Therefore, we propose reasonable and flexible structures of the covariance matrix using autoregressive and moving average Cholesky decomposition (ARMACD). The ARMACD factors the covariance matrix into generalized autoregressive parameters (GARPs), generalized moving average parameters (GMAPs) and innovation variances (IVs). Positive IVs guarantee the positive-definiteness of the covariance matrix. In this paper, we use the ARMACD to model the random effects covariance matrix in Poisson loglinear mixed models. We analyze epileptic seizure data using our proposed model.

• Communications for Statistical Applications and Methods
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• 제22권5호
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• pp.507-518
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• 2015

It is not easy to select a linear mixed model since the main interest for model building could be different and the number of parameters in the model could not be clearly defined. In this paper, performance of conditional Akaike Information Criteria and its bias-corrected version are compared with marginal Bayesian and Akaike Information Criteria through a simulation study. The results from the simulation study indicate that bias-corrected conditional Akaike Information Criteria shows promising performance when candidate models exclude large models containing the true model, but bias-corrected one prefers over-parametrized models more intensively when a set of candidate models increases. Marginal Bayesian and Akaike Information Criteria also have some difficulty to select the true model when the design for random effects is nested.

• Journal of the Korean Data and Information Science Society
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• 제26권2호
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• pp.465-474
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• 2015

In this paper, we study the local influence analysis of LIU type estimator in the linear mixed models. Using the method proposed by Shi (1997), the local influence of LIU type estimator in three disturbance models are investigated respectively. Furthermore, we give the generalized Cook's distance to assess the influence, and illustrate the efficiency of the proposed method by example.