• Restorative Dentistry and Endodontics
• /
• 제49권3호
• /
• pp.27.1-27.13
• /
• 2024

Objectives: This study aimed to develop whitening mouth rinses formulated with industrial mushrooms and compare them with over-the-counter whitening mouth rinses. Materials and Methods: Formulations with black shimeji mushrooms, mushroom substrates, and mushroom stalks were developed. Bovine enamel/dentin samples were divided into 7 groups (n = 10): Colgate Luminous White, Listerine Whitening Extreme (LWE), Listerine Cool Mint (LC), mushroom extract rinse (MEC), mushroom substrate rinse (MSB), mushroom stalk rinse (MTC), and artificial saliva. Samples were stained with black tea for 6 days, and then were immersed in 100 mL of each mouth rinse twice daily for 14 days. Color parameters (CIELAB [ΔE^*], CIEDE2000 [ΔE₀₀], whiteness index for dentistry [ΔWI_D]) and microhardness (Knoop hardness number [KHN]) were analyzed at T₁ (initial), T₂ (24 hours), and T₃ (7 days). Mouth rinse pH was measured, and enamel was examined using a scanning electron microscope. Data were analyzed using generalized linear models, and KHN with the generalized linear mixed model for repeated measures (p ≤ 0.05). Results: ΔE^* was higher in LW and MSB groups. No significant differences were found for ΔE₀₀ (p = 0.0982) and ΔWI_D (p = 0.2536). Experimental mouth rinses did not promote enamel whitening based on ΔE₀₀ and ΔWI_D. LWE and LC reduced KHN and had a more acidic pH, while MEC had higher KHN at T2. MEC, MSB, and MTC had alkaline pH, not altering the tooth surface. Conclusions: Black shimeji mushrooms are promising for mouth rinse development due to their alkaline pH and non-altering effect on surface microhardness.

• 한국임상약학회지
• /
• 제28권1호
• /
• pp.24-29
• /
• 2018

Background: Cyclosporine is an immunosuppressive agent used to treat and prevent graft versus host reaction (GVHR)-a complication associated with stem cell transplantation. This study aimed to develop a population pharmacokinetic model of cyclosporine and investigate factors affecting cyclosporine clearance in pediatric hematopoietic stem cell transplant patients. Methods: A total of 650 cyclosporine concentrations recorded in 65 patients who underwent hematopoietic stem cell transplantation were used. Data including age, sex, weight, height, body surface area (BSA), type of disease, chemotherapy before stem cell transplantation, type of donor, serum creatinine levels, total bilirubin concentration, hematocrit value, and type of concomitant anti-fungal agents and methylprednisolone used were retrospectively collected. Data related to cyclosporine dosage, administration time, and blood concentration were also collected. All data were analyzed using the non-linear mixed effect model; a two-compartment model with first-order elimination was used. Results: The population pharmacokinetic model of cyclosporine using the NONMEM program was as follows: $CL(L/h)=5.9{\times}(BSA/1.2)^{0.9}$, V2 (L) = 54.5, Q (L/h) = 3.5, V3 (L) = 1080.0, $k_a(h^{-1})=0.000377$. BSA was selected as a covariate of cyclosporine clearance, which increased with an increase in BSA. Conclusion: A population pharmacokinetic model for Korean pediatric hematopoietic stem cell transplant patients was developed, and the important factor affecting cyclosporine clearance was found to be BSA. The model might contribute to the development of the most appropriate dosing regimen for cyclosporine. Further studies on population pharmacokinetics should be carried out, prospectively targeting pediatric patients.

• The Korean Journal of Physiology and Pharmacology
• /
• 제28권2호
• /
• pp.121-127
• /
• 2024

Vancomycin is a frequently used antibiotic in intensive care units, and the patient's renal clearance affects the pharmacokinetic characteristics of vancomycin. Several advantages have been reported for vancomycin continuous intravenous infusion, but studies on continuous dosing regimens based on patients' renal clearance are insufficient. The aim of this study was to develop a vancomycin serum concentration prediction model by factoring in a patient's renal clearance. Children admitted to our institution between July 1, 2021, and July 31, 2022 with records of continuous infusion of vancomycin were included in the study. Sex, age, height, weight, vancomycin dose by weight, interval from the start of vancomycin administration to the time of therapeutic drug monitoring sampling, and vancomycin serum concentrations were analyzed with the linear regression analysis of the mixed effect model. Univariable regression analysis was performed using the vancomycin serum concentration as a dependent variable. It showed that vancomycin dose (p < 0.001) and serum creatinine (p = 0.007) were factors that had the most impact on vancomycin serum concentration. Vancomycin serum concentration was affected by vancomycin dose (p < 0.001) and serum creatinine (p = 0.001) with statistical significance, and a multivariable regression model was obtained as follows: Vancomycin serum concentration (mg/l) = -1.296 + 0.281 × vancomycin dose (mg/kg) + 20.458 × serum creatinine (mg/dl) (adjusted coefficient of determination, R² = 0.66). This prediction model is expected to contribute to establishing an optimal continuous infusion regimen for vancomycin.

• 한국컴퓨터정보학회논문지
• /
• 제25권11호
• /
• pp.27-40
• /
• 2020

본 논문은 장단기기억신경망(LSTM)이 영어를 배우면서 학습한 암묵적 통사 관계인 필러-갭 의존 관계를 조사하여 영어 문장 학습량과 한국인 영어 학습자(L2ers)의 문장 처리 패턴 간의 상관관계를 규명한다. 이를 위해, 먼저 장단기기억신경망 언어모델(LSTM LM)을 구축하였다. 이 모델은 L2ers가 영어 학습 과정에서 잠재적으로 배울 수 있는 L2 코퍼스의 영어 문장들로 심층학습을 하였다. 다음으로, 이 언어 모델을 이용하여 필러-갭 의존 관계 구조를 위반한 영어 문장을 대상으로 의문사 상호작용 효과(wh-licensing interaction effect) 즉, 정보 이론의 정보량인 놀라움(surprisal)의 정도를 계산하여 문장 처리 양상을 조사하였다. 또한 L2ers 언어모델과 상응하는 원어민 언어모델을 비교 분석함으로써, 두 언어모델이 문장 처리에서 필러-갭 의존 관계에 내재된 추상적 구문 구조를 추적할 수 있음을 보여주었을 뿐만 아니라, 또한 선형 혼합효과 회귀모델을 사용하여 본 논문의 중심 연구 주제인 의존 관계 처리에 있어서 원어민 언어모델과 L2ers 언어모델간 통계적으로 유의미한 차이가 존재함을 규명하였다.

• 정신신체의학
• /
• 제31권2호
• /
• pp.142-148
• /
• 2023

연구목적 본 연구는 틱장애 소아청소년들을 대상으로 틱증상 심각도, 전조 충동, 강박증상, 주의력결핍과잉행동 증상을 종단적으로 평가하여 틱장애의 임상적 특성을 알아보기 위해 시행하였다. 방 법 본 연구는 10-18세 소아청소년 26명을 대상으로 틱증상, 전조충동, 강박증상, ADHD 증상에 관한 척도를 2차례 반복 측정 하였다. 반복 측정 상관 분석(repeated measures correlation analysis)을 통해 척도간 상관관계를 확인하였고 선형 혼합 모형(linear mixed model)을 이용한 회귀 분석을 통해 척도간 인과관계를 확인하였다. 결 과 틱장애 소아청소년들에서 전조충동은 틱증상 정도, 강박증상 정도, 주의력결핍과잉행동 증상 정도와 각각 유의한 양의 상관관계를 보였고 주의력결핍과잉행동 증상은 틱증상 심각도와 유의한 양의 상관관계를 나타냈다. 이러한 결과는 강박장애를 공존질환으로 진단 받지 않은 틱장애 소아청소년들에서도 같았다. 또한 전조충동은 틱증상의 심각도에 유의한 양의 영향을 미치는 것으로 나타났다. 결 론 이러한 결과는 틱장애 치료에 도움이 될 수 있으며 향후 발달 경로를 고려한 틱장애 연구에 활용될 수 있다.

• Advances in Computational Design
• /
• 제5권2호
• /
• pp.195-207
• /
• 2020

The present study focuses on the application of artificial neural network (ANN) and Multiple linear Regression (MLR) analysis for developing a model to predict the unconfined compressive strength (UCS) and split tensile strength (STS) of the fiber reinforced clay stabilized with grass ash, fly ash and lime. Unconfined compressive strength and Split tensile strength are the nonlinear functions and becomes difficult for developing a predicting model. Artificial neural networks are the efficient tools for predicting models possessing non linearity and are used in the present study along with regression analysis for predicting both UCS and STS. The data required for the model was obtained by systematic experiments performed on only Kaolin clay, clay mixed with varying percentages of fly ash, grass ash, polypropylene fibers and lime as between 10-20%, 1-4%, 0-1.5% and 0-8% respectively. Further, the optimum values of the various stabilizing materials were determined from the experiments. The effect of stabilization is observed by performing compaction tests, split tensile tests and unconfined compression tests. ANN models are trained using the inputs and targets obtained from the experiments. Performance of ANN and Regression analysis is checked with statistical error of correlation coefficient (R) and both the methods predict the UCS and STS values quite well; but it is observed that ANN can predict both the values of UCS as well as STS simultaneously whereas MLR predicts the values separately. It is also observed that only STS values can be predicted efficiently by MLR.

• 농업과학연구
• /
• 제38권4호
• /
• pp.673-680
• /
• 2011

The aim of this study was to identify the polymorphism on fatty acid binding protein (FABP4) gene promoter region and its association with carcass traits in Hanwoo. We performed PCR-direct sequencing of FABP4 promoter region to identify single nucleotide polymorphism (SNPs) using unrelated 24 Hanwoo bulls. Four SNPs (-298A>G, -472A>G, -887A>G, -862A>G) were detected in the promoter region and genotyped on 583 Hanwoo steers. A linear mixed model revealed an association of three SNPs (-298A>G, -472A>G and -862A>G) with carcass weight and marbling score in dominance model (P<0.05). The animals with AA genotypes for the three SNPs were heavier carcass weight (5 kg) than animals with GG genotypes in the statistical analysis. For the marbling score, the AA genotype was lower effect of marbling score (0.21) than GG genotypes. In conclusion, this study indicates an important role for three SNPs detected in promoter region of FABP4 in determining carcass weight and marbling score in Hanwoo.

• 한국간호교육학회지
• /
• 제21권3호
• /
• pp.350-360
• /
• 2015

Purpose: The purpose of this study was to evaluate the effectiveness and retention period of immediate remediation for infant cardiopulmonary resuscitation (CPR) in child care teachers. Methods: This study used a nonequivalent comparison pre- and post-test design to measure knowledge about and confidence in infant CPR and an interrupted time-series design to determine skill performance. The experimental group (n=25) received both immediate remediation and video learning for infant CPR, and the comparison group (n=28) received video learning only. Knowledge and confidence were measured before and after 4 weeks. Their skill performance was tested immediately, and 4 weeks, 8 weeks, 12 weeks, and 24 weeks after intervention. Data analysis consisted of ${\chi}^2$ tests, t-tests, paired t-tests, and a generalized linear mixed model. Results: There were significant increases in knowledge and confidence within the experimental group. Skill performance showed a significant difference according to the group factor (F=10.81, p=.002) and measurement time (F=146.80, p<.001). The experimental group maintained significantly higher skill performance than did the comparison group. Conclusion: These findings support the necessity of immediate remediation education for infant CPR to maintain skill performance. In addition, appropriate renewal time and the improvement of training programs for child care teachers are necessary.

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2008년도 추계학술대회 논문집
• /
• pp.310-315
• /
• 2008

Authors design a rotary-type small-scaled linear induction motor(LIM) and a performance test machine before manufacturing a real-scaled LIM for a railway transit. The designed LIM is a single-sided, short primary type and its primary has 4 poles. The rated power is 10(kW). In order to analyze characteristics of the LIM, authors use a mixed 2D-3D FEM analysis. 3-D FEM analysis is used for calculating a distribution of eddy-current on the semi-caped AL-sheet of the secondary reaction. Authors calculate a correction factor of conductivity and an equivalent conductivity on the secondary AL-sheet using a normalized eddy-current. The equivalent conductivity which is calculated in this way includes a transverse edge-effect of the LIM. Authors apply the equivalent conductivity on the secondary AL-sheet of 2D-FEM model and get performance characteristics of the LIM. Basic characteristics such as thrust and normal force, input current, efficiency and power factor of the LIM have been analyzed with the variation of frequency and speed. In order to apply an air-gap control system, the variation of the basic characteristics have been analyzed with the air-gap length variation of the LIM. Finally, authors introduce an operation mode using the air-gap control system and conduct a research on feasibility of the system.

• Korean Journal of Radiology
• /
• 제22권10호
• /
• pp.1708-1718
• /
• 2021

Objective: The purpose of this study was to evaluate the magnetic resonance (MR) characteristics and applicability of new, uniform, extremely small iron-based nanoparticles (ESIONs) with 3-4-nm iron cores using contrast-enhanced magnetic resonance angiography (MRA). Materials and Methods: Seven types of ESIONs were used in phantom and animal experiments with 1.5T, 3T, and 4.7T scanners. The MR characteristics of the ESIONs were evaluated via phantom experiments. With the ESIONs selected by the phantom experiments, animal experiments were performed on eight rabbits. In the animal experiments, the in vivo kinetics and enhancement effect of the ESIONs were evaluated using half-diluted and non-diluted ESIONs. The between-group differences were assessed using a linear mixed model. A commercially available gadolinium-based contrast agent (GBCA) was used as a control. Results: All ESIONs showed a good T1 shortening effect and were applicable for MRA at 1.5T and 3T. The relaxivity ratio of the ESIONs increased with increasing magnetic field strength. In the animal experiments, the ESIONs showed peak signal intensity on the first-pass images and persistent vascular enhancement until 90 minutes. On the 1-week follow-up images, the ESIONs were nearly washed out from the vascular structures and organs. The peak signal intensity on the first-pass images showed no significant difference between the non-diluted ESIONs with 3-mm iron cores and GBCA (p = 1.000). On the 10-minutes post-contrast images, the non-diluted ESIONs showed a significantly higher signal intensity than did the GBCA (p < 0.001). Conclusion: In the phantom experiments, the ESIONs with 3-4-nm iron oxide cores showed a good T1 shortening effect at 1.5T and 3T. In the animal experiments, the ESIONs with 3-nm iron cores showed comparable enhancement on the first-pass images and superior enhancement effect on the delayed images compared to the commercially available GBCA at 3T.