• Proceedings of the Korean Society for Applied Microbiology Conference
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• 한국미생물생명공학회 1978년도 추계학술대회
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• pp.206.4-206
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• 1978

By utilizillg whole cell enzyme of the Xantho-monas citri IFO 3835, cephalexin is synthesized directly from 7-amino-deacetoxy cephalosporanic acid (7-ADCA) and phenyl glycine methyl ester (PGM). To date, cephalexin has been manufactu-red by chemical process involving fairly large number of steps to protect the amino group of phenly glycine and carboxyl group of 7-ADCA. However, the enzymatic process involves only a single step with 85％ conversion in 90 minutes. The fermentation variables studied indicate that oxygen transfer is limiting step in the enzyme production. Optimum conditions for enzymatic reaction were 37 C, pH 6.0, and the optimum substrate molar ratio of PGM to 7-ADCA was 2. Other variables that are related to the biochemical properties of whole cell enzyme temperature stability, pH stability, kinetic constants, reusing effect, enzyme loading effect were also evaluated.

• Advances in materials Research
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• 제13권3호
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• pp.195-202
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• 2024

Aluminum alloy is a material that is frequently used in the aerospace and transportation industries due to its high mechanical and corrosion resistance qualities. Unfortunately, aluminum alloys are prone to corrosion, limiting their application in some harsh situations such as when submerged in aqueous environments. The purpose of this study is to investigate how anodizing can increase the corrosion resistance of 6061 Aluminum alloy. The anodizing process was carried out using two different parameters which are voltage (5V, 10V, 15V) and electrolyte sulfuric acid (H₂SO₄) concentration (0.3M, 0.5M) for 1 hour. The anodized samples were performed using several analyses such as X-ray diffraction (XRD) analysis, morphology analysis, and corrosion test. From this study, it is found that the difference in anodizing parameters affects the corrosion resistance of the samples. Sample anodized at 15V, 0.5M gives the best corrosion resistance.

• Proceedings of the KIEE Conference
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• 대한전기학회 1988년도 추계학술대회 논문집 학회본부
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• pp.210-213
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• 1988

A new and accurate expression to derive a window area is presented with a sequence for daylighting design using Daylight Factor Method process not in its classical point--by-point method but in lumen method as in artificial lighting design process to consider daylight in the early stage of a building design process. Accepting CIE Overcast Sky as the worst state with the lowest sky luminance, a user of a room can have more available daylight in his or her room. In the design process uniformity is checked to ensure reasonably even daylighting by comparing the depth of the room with the computed limiting depth. After these steps the shape and position of window is altered, of which the Sky Component of Daylight Factor under an Overcast Sky, SCo, is investigated and computed in Composite Simpson Multiple Integral so that a building designer or an analyst can choose the best shape and location that satisfies his/her taste and purpose of the room.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 한국소성가공학회 2000년도 춘계학술대회논문집
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• pp.123-128
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• 2000

Fundamental and informative data of axi-symmetric stretch-drawing of several sheetmetals with thicknesses of 0.7-1.0mm are presented both for single and double operations. Very small radius is applied to the die profile (or-shoulder) ion all operations. to induce wall-thinning by the effect of bending-under-tension from which the name 'stretch-drawing' comes. It is clearly demonstrated that deeper cups could be formed by single and double stretch-drawings from smaller circular blanks due to such wall-thinning action than in the usual deep-drawing of larger blanks, From this fact it is emphasized that the deep-drawability of a sheet metal is not evaluated simply by the conventional L.D.R (limiting drawing ratio) but the depth of the drawn cup should also be taken into account./ Many experimental data about various metals and thicknesses given in this paper offer a valuable information in this process for more general use which recommends to replace the conventional deep-drawing process by the stretch-drawing process both for single and double operations. In the single stretch-drawing it is also confirmed that a deeper cup can be produced by raising the blank-holding force at later stage of operation.

• Journal of Microbiology and Biotechnology
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• 제15권1호
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• pp.206-215
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• 2005

Polyhydroxyalkanoates (PHAs) are homo or hetero polyesters of (R)-hydroxyalkanoates accumulated in various microorganisms under growth-limiting condition in the presence of excess carbon source. They have been suggested as biodegradable substitutes for chemically synthesized polymers. Recombinant Escherichia coli is one of the promising host strains for the economical production of PHAs, and has been extensively investigated for the process development. The heterologous PHA biosynthetic pathways have been established through the metabolic engineering and inherent metabolic pathways of E. coli have been redirected to supply PHA precursors. Fermentation strategies for cultivating these recombinant E. coli strains have also been developed for the efficient production of PHAs. Nowadays, short-chain-length (SCL) PHAs are being re-invited due to its improved mechanical properties and possible applications in the biomedical area. In this article, recent advances in the development of metabolically engineered E. coli strains for the enhanced production of SCL-PHAs are reviewed. Also, medical applications of SCL-PHAs are discussed.

• The Journal of Korean Physical Therapy
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• 제12권3호
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• pp.497-507
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• 2000

This study was performed to understanding on guidelines for using therapeutic modalities according to injury phases of soft tissue. Clinical decisions on how and when therapeutic modalities may be used should be based on recognition of signs and symptoms. as well as some awareness of the time frames associated with the various phases of the Healing process. The physical therapist must have a sound understanding of that process in terms of the sequence of the various process of healing stage. The results of this study are as follows: 1. Once an acute injury has occured, the healing process consists of the imflammatory response phase, the fibroblastic-repair phase, and the maturation-remodeling phase and can impede by various pathologic factors. 2. Modality use in the initial acute injury phase and the inflammatory response phase should be directed toward limiting the amount of swelling and reducing pain. 3. Modality use in the Fibroblastic repair phase may be change from cold to heat. The purpose of heat is to increase circulation to the injured area to promote healing. 4. During the Maturation-Remodeling phase, some type of heating modalities, ultrasound, or short wave and microwave diathermy should be used to increase circulation to the deeper tissue. In this phases, physical therapists must control training and conditioning habits to allow the injury to heal sufficiently.

• Journal of the Korean Society of Systems Engineering
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• 제19권1호
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• pp.44-55
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• 2023

The defense M&S system, which has been classified as a weapon system between requirements determination and project implementation, is being developed by applying the weapon system development procedure of the Defense Acquisition Program Administration. The M&S system abstracts and models the real world to suit the intended use and proceeds with the process of developing it as a software-oriented system. Overseas, the conceptual model development stage is staged before entering the design stage after the requirements analysis. In addition, each step includes verification and validation processes. In Korea, while establishing and applying the weapon system development procedure based on the SE process, the M&S system is also applied in the same way as the general weapon system, limiting appropriate development outputs and verification and validation. In this study, the system development procedure of the M&S system is established and presented based on the relevant standards and SE process of developed countries.

• Journal of the Korean Data and Information Science Society
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• 제24권3호
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• pp.465-475
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• 2013

Higher quality level is generally perceived by customers as improved performance by assigning a correspondingly higher satisfaction score. Usually, the quality level is measured by process capability indices. The index is used to determine whether a production process is capable of producing items within a specified tolerance. Some useful process capability indices $C_p$, $C_{pk}$ and $C_{pm}$ have been widely used in six sigma industries to assess process performance. Most evaluations on process capability indices focus on point estimates, which may result in unreliable assessments of process performance. It is necessary to investigate their asymptotic correlationship among process capability indices $\hat{C}_p$, $\hat{C}_{pk}$ and $\hat{C}_{pm}$. In this paper, we study their asymptotic correlationship for some process capability indices $\hat{C}_p$, $\hat{C}_{pk}$ and $\hat{C}_{pm}$ under the normal process.

• Journal of Korean Society of Water and Wastewater
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• 제16권6호
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• pp.670-678
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• 2002

Since Korean government imposed a stricter regulation on effluent T-N and T-P concentrations from wastewater treatment plant, a new process has to be developed to meet these rules and this process should remove T-N and T-P, economically, from weak wastewater that is typical for Korea's combined sewer system sewage. In this study, a computer simulator, BioWin from EnviroSim, Inc. was used. Three processes - A2/O, Modified Johannesburg, UCT- had been simulated under same operational conditions and a new process - Parallel BNR Process - had been developed based on these simulation results. The Parallel BNR process consists of two rows of reactors: One row has anaerobic and aerobic reactors in series, and the other row has RAS anoxic1 and RAS anoxic2 reactors in series. In order to ensure anaerobic state in anaerobic tank, a part of influent is fed to RAS anoxic1 tank in second row. This process had been simulated under same conditions of other three processes and the simulation results were compared. The results showed that three existing processes could not perform biological phosphorus removal when the average influent was fed at any operation temperatures. However, the Parallel BNR process was found that biological phosphorus removal could be performed when both design and average influent were fed at any operation temperatures. This process showed the T-N concentration in effluent had a maximum value of 15mg/L when design influent was fed at $13^{\circ}C$ and a minimum value of 14mg/L when average influent was fed at $20^{\circ}C$. Also, T-P concentrations had a maximum value of 1.3mg/L when average influent was fed at $20^{\circ}C$ and a minimum value of 1.1mg/L when design influent was fed at $13^{\circ}C$. Based on these results, we found that this process can remove nitrogen and phosphorus biologically under any operational conditions.

• Polymer(Korea)
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• 제39권3호
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• pp.433-440
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• 2015

Aluminum trihydroxide (ATH) has been commonly employed as a flame retardant for ethylene vinyl acetate (EVA) copolymers. In the present work, ATH was obtained from a recycling process of multi-layer packaging film wastes. EVA/ATH composite samples were prepared using a two roll-mill and flame retardancy of EVA/ATH composites were examined using limiting oxygen index (LOI) and flame retardancy test (UL94). We observed excellent flame retardancy in case of adding 150 phr or more of recycled ATH to EVA. Particle size and specific surface area play crucial roles in LOI value and UL-94 classification of the EVA/ATH composites. Smaller particle size and higher specific surface area of ATH was found out to improve the flame retardancy. Regarding tensile properties, crosslinked EVA/ATH compounds which is practically used for electric cables had similar to or even better tensile property values than the ones without ATH.