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Histological Comparison of Vascular Grafts in a Pig to Goat Xenotransplantation Model (돼지-염소 이종이식모델에서 냉동 및 무세포화 혈관이식편의 조직학적 비교분석)

  • Yang Ji-Hyuk;Sung Ki-Ick;Kim Won-Geon
    • Journal of Chest Surgery
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    • v.39 no.6 s.263
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    • pp.427-433
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    • 2006
  • Background: Current vascular prostheses are considered still inadequate for reconstruction of small-diameter vessels. To evaluate the potential use of xenograft vessels as small diameter arterial grafts, we implanted porcine vessels in goats. The grafts were treated with two different processes, freezing and acellularization, before implantation, and gross inspection as well as microscopic examination followed after a predetermined period. Material and Method: Bilateral porcine carotid arteries were harvested and immediately stored at $-70^{\circ}C$ within tissue preservation solution. One of them was designated as frozen xenograft vessel. The other one was put on acellularization process using NaCl-SDS solution and stored frozen until further use. Grafts were implanted in the place of carotid arteries of the same goat. The grafts have remained implanted for 1, 3, and 6 months in three animals, respectively. Periodic ultrasonographic examinations were performed during the observation period. After explantation, the grafts were analyzed grossly and histologically under light microscope. Result: All animals survived the experimental procedure without problems. Ultrasonographic examinations showed excellent patency of all the grafts during the observation period. Gross examination revealed nonthrombotic, patent lumens with smooth surfaces. Microscopic examinations of the explanted grafts showed cellular reconstruction at the 6-month stage in both grafts. Although more inflammatory responses were observed in the early phase of frozen xenografts, there was no evidence of significant rejection. Conclusion: These findings suggest that porcine xenograft vessels, regardless of pre-implantation processes of acelluarization or freezing, can be acceptably implanted in goats, although short duration of observation in a small number of animals may limit this study.

Interpretation of the Umbrella Clause in Investment Treaties (국제투자조약상 포괄적 보호조항(Umbrella Clauses)의 해석에 관한 연구)

  • Jo, Hee-Moon
    • Journal of Arbitration Studies
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    • v.19 no.2
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    • pp.95-126
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    • 2009
  • One of the controversial issues in investor-state investment arbitration is the interpretation of "umbrella clause" that is found in most BIT and FTAs. This treaty clause requires on Contracting State of treaty to observe all investment obligations entered into with foreign investors from the other Contracting State. This clause did not receive in-depth attention until SGS v. Pakistan and SGS v. Philippines cases produced starkly different conclusions on the relations about treaty-based jurisdiction and contract-based jurisdiction. More recent decisions by other arbitral tribunals continue to show different approaches in their interpretation of umbrella clauses. Following the SGS v. Philippines decision, some recent decisions understand that all contracts are covered by umbrella clause, for example, in Siemens A.G. v. Argentina, LG&E Energy Corp. v. Argentina, Sempra Energy Int'l v. Argentina and Enron Corp. V. Argentina. However, other recent decisions have found a different approach that only certain kinds of public contracts are covered by umbrella clauses, for example, in El Paso Energy Int'l Co. v. Argentina, Pan American Energy LLC v. Argentina and CMS Gas Transmission Co. v. Argentina. With relation to the exhaustion of domestic remedies, most of tribunals have the position that the contractual remedy should not affect the jurisdiction of BIT tribunal. Even some tribunals considered that there is no need to exhaust contract remedies before bringing BIT arbitration, provoking suspicion of the validity of sanctity of contract in front of treaty obligation. The decision of the Annulment Committee In CMS case in 2007 was an extraordinarily surprising one and poured oil on the debate. The Committee composed of the three respected international lawyers, Gilbert Guillaume and Nabil Elaraby, both from the ICJ, and professor James Crawford, the Rapportuer of the International Law Commission on the Draft Articles on the Responsibility of States for Internationally Wrongful Acts, observed that the arbitral tribunal made critical errors of law, however, noting that it has limited power to review and overturn the award. The position of the Committee was a direct attack on ICSID system showing as an internal recognition of ICSID itself that the current system of investor-state arbitration is problematic. States are coming to limit the scope of umbrella clauses. For example, the 2004 U.S. Model BIT detailed definition of the type of contracts for which breach of contract claims may be submitted to arbitration, to increase certainty and predictability. Latin American countries, in particular, Argentina, are feeling collectively victims of these pro-investor interpretations of the ICSID tribunals. In fact, BIT between developed and developing countries are negotiated to protect foreign investment from developing countries. This general characteristic of BIT reflects naturally on the provisions making them extremely protective for foreign investors. Naturally, developing countries seek to interpret restrictively BIT provisions, whereas developed countries try to interpret more expansively. As most of cases arising out of alleged violation of BIT are administered in the ICSID, a forum under the auspices of the World Bank, these Latin American countries have been raising the legitimacy deficit of the ICSID. The Argentine cases have been provoking many legal issues of international law, predicting crisis almost coming in actual investor-state arbitration system. Some Latin American countries, such as Bolivia, Venezuela, Ecuador, Argentina, already showed their dissatisfaction with the ICSID system considering withdrawing from it to minimize the eventual investor-state dispute. Thus the disagreement over umbrella clauses in their interpretation is becoming interpreted as an historical reflection on the continued tension between developing and developed countries on foreign investment. There is an academic and political discussion on the possible return of the Calvo Doctrine in Latin America. The paper will comment on these problems related to the interpretation of umbrella clause. The paper analyses ICSID cases involving principally Latin American countries to identify the critical legal issues arising between developing and developed countries. And the paper discusses alternatives in improving actual investor-State investment arbitration; inter alia, the introduction of an appellate system and treaty interpretation rules.

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The Legal Response and Future Tasks regarding Oil-Spill Damage to Korea - Focusing on the Hebei Spirit oil-spill (한국의 해양유류오염피해에 대한 법적 대응과 과제 - HEBEI SPIRIT호 유류유출사고를 중심으로 -)

  • Han, Sang-Woon
    • Journal of Environmental Policy
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    • v.7 no.3
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    • pp.89-120
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    • 2008
  • With petroleum being a major source of energy in Korea, the quantity of petroleum transported via ocean routes is on its way up due to increased consumption. Due to the increase, more than 300 cases of pollution caused by petroleum occur annually. Moreover, the number of oil-spill accidents is also on the rise. Causes of such accidents, not including the disposal of waste oil on purpose, turn out to be human error during navigation or defects in the vessels, showing that most accidents are caused by humans. Therefore, to prevent future oil spills, it is imperative that navigation efficiency be enhanced by improving the quality of navigators and replacing old vessels with newer ones. Nevertheless, such improvements cannot occur overnight, so long- and mid-term efforts should be made to achieve it institutionally. As large-scale oil-spill accidents can happen at anytime along the coastal waters of Korea, it is necessary to set-up institutional devices which go beyond the compensation limit of 92FC. The current special law regarding this issue has its limits in that it prescribes compensation be supplemented solely by national taxes. Therefore, the setting-up of a new 'national fund' is recommended for consideration rather than to subscribe to the '2003 Convention for the Supplementary Fund'. It is strongly suggested that a National fund be created from fees collected from oil companies based on the risks involved in oil transportation and according to the profiteers pay principle. In addition, a public fund should be created to handle general environmental damage, such as the large-scale destruction of the ecosystem, which is distinct from the economic damage that harms the local people. The posterior responses to the large-scale oil spill have always been unsatisfactory because of the symbolic nature of the disasters included in such accidents. Oil-spills can be prevented in advance, because they are caused by human beings. But once they occur, they inflict long-term damage to both human life and the natural ecosystem. Therefore, the best response to future oil-spills is to work to prevent them.

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Characteristics of Ammonia in Alkaline Stabilization Facility of Sludge from Sewage Treatment Plant (하수처리오니 알칼리 안정화 처리시설에서의 암모니아 발생특성)

  • Kim, Yong-Jun;Chung, David;Jeong, Mi-Jeong;Yoo, Hye-Young;Yoon, Cheol-Woo;Shin, Sun-Kyoung
    • Journal of the Korea Organic Resources Recycling Association
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    • v.24 no.3
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    • pp.23-33
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    • 2016
  • The characteristics of ammonia generated from alkaline stabilization facilities was investigated which are for organic sewage sludge from wastewater treatment plants. The highest concentration of ammonia was found in mixing and curing process in alkaline stabilization facility and ammonia mainly showed a range of 87.78 ppm($66.62mg/m^3$) to 1,933 ppm($1,467.01mg/m^3$) by detection tube. This is presumed to occur because nitrogen oxides are converted into ammonia as the sewage sludge is mixed with lime. In some facilities, hydrogen sulfide and methyl mercaptan were detected in relatively high concentrations, but odor materials except ammonia were not detected in most of the facilities. The concentration of ammonia caused by process was generally high in the order of "mixing > curing > output > storage > drying > input." It was found that odor compounds are removed by wet absorption using sulfuric acid and sodium hypochlorite in the 5 alkaline stabilization facilities currently in operation. Each facility was designed to meet the concentration of after-treatment emission in 1 ppm($0.76mg/m^3$), 50 ppm($37.95mg/m^3$) or 100 ppm($75.89mg/m^3$), but no facility satisfied the design standard for their emssion limit. In case of ammonia, some workplaces in alkaline stabilization facilities exceeded the exposure limits established by the Ministry of Labor. It appears that proper ventilation should be provided for the safety of workers in future. No odor compound including ammonia was found by detection tubes in the border of the facilities, but trace amounts of odor compounds are expected to exist, given the current operational status of facilities.

A Study on Comics Outreach Programs for Contents marginalized Areas (콘텐츠 소외지역의 만화 아웃리치 프로그램 모델링 연구)

  • Lee, Seung-Jin
    • Cartoon and Animation Studies
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    • s.49
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    • pp.359-382
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    • 2017
  • Content is the complex of art and technology of trend, so it is important to experience different technologies for content education. Today, many non-profit organizations plan and operate numbers of programs for disabilities, low-income, and minority families to enhance the quality of life and the realization of social integration. These programs are limited to museums and galleries, not so pro-actively in progressing. Various contend education is necessary to the expansion of cultural exchange for the culturally alienated area. Naver is running an outreach program named . It is an experience-based outreach program where current cartoon / webtoon writers come directly to the school to inform students about the basic story of comics and comic techniques. However, the fact that the is not centered on the marginalized area but is centered on the Seoul Gyeonggi area, has the limitation that they can not benefit from a wide range of programs because they have a space limit of 'school', and, has a spatial limitation that the experience of the work is excluded. 'Outreach programs in marginalized areas' must be reorganized into a fluid dimension, not a fixed, single-system program. You should be able to experience and experience your work by directly using various professional equipment of comics based on your capacity and experience, local culture, religion, and society. These program participants will gain the effect of attractive and effective learning with empathy with their comic experience. Meanings of Comics content outreach program are following: First, the rich cultural archive can be used efficiently by providing various contents to existing outreach programs with the educational limitation of museums and galleries. Second, Comics contents can be enjoyed as a part of our life by understanding diversity and technology of contents. Third, because it is the program of expertise' participation, it can remodel, and restructure the severed experience in remote areas for the continuous growth and development, and furthermore, it can enhance the understanding of society.

Constitutional Issue Review of Compensation for Inevitable Medical Accidents During Delivery (불가항력 의료사고 보상사업에 대한 헌법적 쟁점 검토)

  • JUN, HYUN JUNG
    • The Korean Society of Law and Medicine
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    • v.21 no.1
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    • pp.153-185
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    • 2020
  • In principle, even if serious consequences such as death or serious injury of a patient occur as a result of a medical accident, if the medical malpractice of a health care worker is not recognized, the health care worker is not held liable for said consequences. However, with the opening of the Korea Medical Dispute Mediation and Arbitration Agency on April 7, 2012, a system was established to compensate health care personnel for their medical malpractices only in the case of "injuries caused by medical accidents in the course of childbirth" (hereinafter referred to as "program for compensation of medical accidents"). Article 46 paragraph 1 of the current Medical Dispute Mediation Act, which is the basis of the Force Majeure Medical Accident Compensation System, stipulates that "medical accidents under delivery" claims are to be determined by the Medical Accident Compensation Review Committee are subject to the compensation project. And the details of the compensation, ratio of sharing financial resources for compensation, scope of compensation, and the guidelines and procedure for the payment of compensations are prescribed by Presidential Decree. In other words, the Presidential Decree requires the state to pay 70 percent of the compensation funds, and 30 percent of the above funds among health care providers. The Constitutional Court has decided on the 2015Hun-Ga13 that the scope of the health care institution's founders and the share of the compensation funds cannot be directly determined by the law, and that the portion delegated by the Presidential decree does not violate the Principle of Legal Protection nor Comprehensive Nondelegation Doctrine. However, this can be seen as an exclusion of accountability for force-induced delivery accidents even if there is no negligence of the medical staff. If the nature of the system is a type of social security system with a social compensatory nature, it could consider eliminating the health care innovator's cost-sharing provisions, leaving the full cost to the state. However, it is also necessary to review institutional protocols that strengthen the efforts of medical institutions in areas such as analysis of the causes of medical accidents and measures to prevent their recurrence. In addition, I think that the conclusion of the Act is in line with the purpose of the Comprehensive Wage Support Regulations that at minimum the law sets an upper limit of the compensation funds that are to be paid by health and medical institutions. Moreover, it is reasonable for the Medical Accident Compensation Review Committee to specify gestational age and weight of births, which are the criteria for compensation, under the Enforcement Decree of the Medical Dispute Mediation Act, in relation to the criteria for payment of contributions by the Medical Accident Compensation Review Committee, and to set the detailed criteria.

Characteristic of Pesticide Residues in Some Leafy Vegetables at the Whole Market in Gyeonggi-do from 2009 to 2013 (경기지역 농산물도매시장 일부 엽채류의 월별 농약 잔류특성(2009~2013년))

  • Kwon, Sun-Mok;Kwon, Yong-Hae;Choi, Ok-Kyung;Park, Myong-Ki;Kim, Ki-Cheol;Kang, Suk-Ho;Kang, Heung-Gyu;Ha, Jin-Ok;Yu, Su-Hwan;Lee, Moo-Young;Jang, Jin Ho;Park, Kwang Hee;Kim, Jung-Beom
    • Journal of Food Hygiene and Safety
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    • v.30 no.2
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    • pp.196-201
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    • 2015
  • This study was conducted to monitor the current status of pesticide residues and to calculate the correlation between monthly price fluctuation and distribution of pesticide residues in leafy vegetables at the whole market in Gyeonggi-do from 2009 to 2013. From the result, the maximum residue limit (MRL) were frequently exceeded in 5 leafy vegetables which were 48 cases of crown daisy (5.8%), 28 cases of chard (5.1%), 28 cases of spinach (3.4%), 25 cases of perilla leaves (3.4%) and 24 cases of chamnamul (3.7%). The high rate of monthly pesticide residues exceeding MRL showed on crown daisy and chard observed in June and September, spinach in October to November and December to January, perilla leaves in July to August and January, and chamnamul in August to September. To calculate the correlation between monthly price fluctuation and distribution of pesticide residues, we performed the Pearson's correlation analysis. From the results, there were significant differences between monthly price and pesticide residues detected in chamnamul, spinach and perilla leaves (p < 0.05). There were also significant differences between monthly price and pesticide residues exceeding MRL in chamnamul and crown daisy (p < 0.05). Although the small number of leafy vegetables and short period were analyzed in this study, the consolidation monitor of pesticide residues according to the season and price will be needed to acquire the safety of agricultural products.

Optimization for Underwater Welding of Marine Steel Plates (선박용 강판의 수중 용접 최적화에 관한 연구)

  • 오세규
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.20 no.1
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    • pp.49-59
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    • 1984
  • Optimizing investigation of characteristics of underwater welding by a gravity type arc welding process was experimentally carried out by using six types of domestic coated welding electrodes for welding of domestic marine structural steel plates (KR Grade A-1, SWS41A, SWS41B,) in order to develop the underwater welding techniques in practical use. Main results obtained are summarized as follows: 1. The absorption speed of the coating of domestic coated lime titania type welding-electrode became constant at about 60 minutes in water and it was about 0.18%/min during initial 8 minutes of absorption time. 2. Thus, the immediate welding electrode could be used in underwater welding for such a short time in comparison with the joint strength of in-atmosphere-and on-water-welding by dry-, wet-or immediate-welding-electrode. 3. By bead appearance and X-ray inspection, ilmenite, limetitania and high titanium oxide types of electrodes were found better for underwater-welding of 10 mm KR Grade A-1 steel plates, while proper welding angle, current and electrode diameter were 6$0^{\circ}C$, above 160A and 4mm respectively under 28cm/min of welding speed. 4. The weld metal tensile strength or proof stress of underwater-welded-joints has a quadratic relationship with the heat input, and the optimal heat input zone is about 13 to 15KJ/cm for 10mm SWS41A steel plates, resulting from consideration upon both joint efficiency of above-100% and recovery of impact strength and strain. Meanwhile, the optimal heat input zone resulting from tension-tension fatigue limit above the base metal's of SWS41A plates is 16 to 19KJ/cm. Reliability of all the empirical equations reveals 95% confidence level. 6. The microstructure of the underwater welds of SES41A welded in such a zone has no weld defects such as hydrogen brittleness with supreme high hardness, since the HAZ-bond boundary area adjacent to both surface and base metal has only Hv400 max with the microstructure of fine martensite, bainite, pearlite and small amount of ferrite.

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Studies on Stability for the Quality of Ginseng Products -3. Determination of Sorption Properties and Optimum Moisture Contents in Extract, Extract Powder and Extract Tea of Red Ginseng- (인삼제품(人蔘製品)의 품질안정성(品質安定性)에 관한 연구(硏究) -3. 홍삼정(紅蔘精), 정분(精粉) 및 정차(精茶)의 흡습특성(吸濕特性)과 적정수분함량(適正水分含量) 기준설정(基準設定)-)

  • Choi, Jin-Ho;Byun, Dae-Seok;Park, Kil-Dang;Kim, Mu-Nam
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.13 no.2
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    • pp.215-221
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    • 1984
  • To investigate stability for the quality of selected ginseng products, their sorption properties were clarified in red ginseng extract(RGEP), and red ginseng extract powder(RGEP), and red ginseng extract tea(RGET). Simultaneously, the BET monolayer value of each product was determined in order to inquire out the possibility of establishment as a criterion for the optimum moisture content of the ginseng products. Based on the BET monolayer moisture level of spray dried RGEP which ranged from 4.08 to 4.65%, it would be desirable to establish the optimum moisture content of the products at 4.4${\pm}$0.3%. This is 1.3 to 1.9% lower than the criter on, "less than 6.0%". The optimum moisture level for RGET of which monolayer value ranged 0.93 to 1.37% would be 1.2${\pm}$0.17%. In this case, the maximum permissible limit of moisture content could presumably be raised up to 1.37% in place of current criterion, "less than l.2%". From the results of a study on the growth of molds, the optimum moisture content for RGE assumed to be extended up to 40.0${\pm}$1.07 despite 36.0${\pm}$1.0% of the present criterion. On the other hand, a storage study under the maltreated condition, $48{\pm}2^{\circ}C$ 75%RH, was also carried out in order to make it clear whether the BET monolayer values were able to be used as indices for optimum moisture level of the products. In all samples tested adsorption occurred at even higher levels of moisture than the monolayer values. However, since there are many other possible factors affecting the quality of products the optimum moisture content is preferable to be reduced to the monolayer value. As a result, it was proved that the optimum level of moisture for both RGEP and RGET could be established by the monolayer values.

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A study on sprouting of a young merchantable pitch pine stand (장령기(壯令期)에 가까운 리기다소나무 임분(林分)의 맹아(萌芽) 갱신(更新)에 대(對)한 연구(硏究))

  • Park, Tai Sik
    • Journal of Korean Society of Forest Science
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    • v.1 no.1
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    • pp.22-29
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    • 1962
  • (1) The objects of this study are to observe the possibility of regenerating a young merchantable pitch pine stand by sprouts and to compare the growth trend of sprouts with that of seedlings of same age grown under the almost same circumstances. (2) A plot of 20 year old pitch pine plantation, i.e. 200 trees on 0.1 ha of average D.B.H. 14 cm was clearcut at 20 cm above ground in April, 1945. By the late spring of that year sixty per cent of the cut stumps had sprouted. (3) Fourty to eighty sprouts were found on each stump (maximum:412 sprouts) at the first, but many of them had gradually died out leaving only four to five sprouts per stump by the time of three years after cutting. At that time only one vigorous sprout was left per stump by eliminating the weaker ones. (4) The sprouts, as they grew, started to cover the old stumps with new tissues developed from lower part of sprouts;consequently forming new root systems from the base of new tissues, and they appeared to be seedlings. When the age of sprouts was thirteen years old, the old stumps were completely decayed away and the reproduced stand from sprouts was averaged at 9.7 cm in D.B.H. and at 5.5m in height. (5) When the age of sprouts was thirteen years old, the sprouts exceeded the seedlings in both of total present growth and mean annual increment in height, volume, D.B.H. and basal area, but the seedlings began to exceed the sprouts in current annual increment of height, volume, D.B.H. and basal area at about ten years of age. The rates of increment of the seedling in height, volume, ect. were larger than those of sprouts except when they were one to four years old. From above facts, the following may be concluded: (1) In regenerating a pitch pine stand by sprouts, the lower the stump height, the better the result. (2) If no light limit exists, regenerating a pitch pine stand by sprouts is well possible even at the age of 20 year. (3) Pitch pine reproduction started from sprouts exceeds the seedlings of same age in growth under the almost same circumstances until they get ten years of age.