• Title/Summary/Keyword: library discovery

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A Study of a Semantic Web Driven Architecture in Information Retrieval: Developing an Exploratory Discovery Model Using Ontology and Social Tagging (정보검색의 시맨틱웹 지향 설계에 관한 연구 - 온톨로지와 소셜태깅을 활용한 탐험적 발견행위 모델개발을 중심으로 -)

  • Cho, Myung-Dae
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.21 no.3
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    • pp.151-163
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    • 2010
  • It is necessary, due to changes in the information environment, to investigate problems in existing information retrieval systems. Ontologies and social tagging, which are a relatively new means of information organization, enable exploratory discovery of information. These two connect a thought of a user with the thoughts of numerous other people on the Internet. With these connection chains through the interactions, users are foraging information actively and exploratively. Thus, the purpose of this study is, through qualitative research methods, to identify numerous discovery facilitators provided by ontologies and social tagging, and to create an exploratory discovery model based on them. The results show that there are three uppermost categories in which 5, 4 and 4 subcategories are enumerated respectively. The first category, 'Browsing and Monitoring,' has 5 sub categories: Noticing the Needs, Being Aware, Perceiving, Stopping, and Examining a Resource. The second category, Actively Participating, has 4 categories: Constructing Meaning, Social Bookmarking and Tagging, Sharing on Social Networking, Specifying the Original Needs. The third category, Actively Extends Thinking, also has 4 categories: Social Learning, Emerging Fortuitous Discovery, Creative Thinking, Enhancing Problem Solving Abilities. This model could contribute to the design of information systems, which enhance the ability of exploratory discovery.

The Identification of Binding Mode for Arabidopsis thaliana 7-Keto-8-aminopelargonic Acid Synthase (AtKAPAS) Inhibitors

  • Cho, Jae-Eun;Kang, Sun-Young;Choi, Jung-Sup;Ko, Young-Kwan;Hwang, In-Taek;Kang, Nam-Sook
    • Bulletin of the Korean Chemical Society
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    • v.33 no.5
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    • pp.1597-1602
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    • 2012
  • In this study, we determined the 3D-structure of Arabidopsis thaliana KAPAS by homology modeling. We then investigated the binding mode of compounds obtained from in-house library using computational docking methods. From the flexible docking study, we achieved high dock scores for the active compounds denoted in this study as compound $\mathbf{3}$ and compound $\mathbf{4}$. Thus, we highlight the flexibility of specific residues, Lys 312 and Phe 172, when used in active sites.

Discovery of Novel Transcription Factor Inhibitors Using a Pyrazole-based Small Molecule Library

  • Ha, Hyung-Ho;Kim, B.Moon
    • Bulletin of the Korean Chemical Society
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    • v.29 no.2
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    • pp.323-327
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    • 2008
  • A focused library of pyrazole-based compounds was constructed towards novel transcription factor inhibitors. Complementary hydrogen bonding interaction with b-sheet peptide structures was the basis for the design of 5-amino-3-pyrazole carboxamide scaffold. From the preliminary inhibition assay against several transcription factors, compounds 7e and 8g were identified as novel lead compounds against HIF-1a and NF-AT transcription factors, respectively.

Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries

  • Kim, Ji-Hye;Gong, Young-Dae;Lee, Gee-Hyung;Seo, Jin-Soo
    • Bulletin of the Korean Chemical Society
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    • v.33 no.1
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    • pp.128-136
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    • 2012
  • We report the solid-phase library construction of 222 number of a novel N-[alkyl sulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B derivatives. The polymer-bound N-[alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 9 and amine 10 derivatives were obtained by first diversity generation with various acid chlorides and alkyl halides. Further reactions on the resins 9 and 10 with substituted sulfonyl chlorides produced the desired N-[alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B analogues.

The Modeling of a Systematic Collection Development and Retrieval to Foreign Government Information Resources on the Internet (외국정부정보에 대한 정보원개발과 검색모형 연구 - 메타사이트와 메타DB개발에 대하여 -)

  • Ahn, In-Ja
    • Journal of the Korean Society for Library and Information Science
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    • v.34 no.2
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    • pp.211-232
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    • 2000
  • The acquisition of foreign government documents by exchange or gift is problematic in the electronic government era because the pattern of distributing system is changed. The alternatives for the collection development are developing the meta-site and establishing the subject gateways for the foreign government information as the resource discovery tools. The anchor and link functions of the AltaVista are used to evaluate a meta-site. The Scout Project Isaac is suggested as the model of interoperating resource discovery services for the geographically distributed metadata databases.

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An Analysis on the Functions of the Next Generation Library Catalog: With a Focus on SearchWorks (차세대 도서관 목록의 제반 기능에 관한 분석 - SearchWorks를 중심으로 -)

  • Yoon, Cheong-Ok
    • Journal of the Korean Society for Library and Information Science
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    • v.47 no.4
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    • pp.5-23
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    • 2013
  • The purpose of this study is to examine the functions and features of SearchWorks developed as the Next Generation Library Catalog by Stanford University Libraries. It was designed to fully represent the needs and search behaviors of users, with Blacklight, an open source software. Its main features are not different from those standard functions supplied by other commercial packages of Next Generation Library Catalogs, and its continuing improvement and changes, including the addition and expansion of more useful functions and the removal of unnecessary ones, have been observed since the introduction of a beta version in 2010.

A Case Study on the Librarian's Perception of Information Commons (정보광장에 대한 사서의 인식 사례연구)

  • Youn, Eunha;Chang, Yunkeum;Jeon, Kyungsun
    • Journal of the Korean Society for information Management
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    • v.31 no.2
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    • pp.189-209
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    • 2014
  • This study examined librarians' perceptions of Information Commons(I.C.), user's information seeking behaviors, and new role of library in the digital ages. Interviews with 28 librarians found that the perceptions of the librarians were widely differed depending on their understandings of the nature of the space. The interview results were divided into three different categories of librarians: the librarians; 1) understanding library as a place only with academic functions, 2) library as academic place along with multi-cultural functions, and 3) library as open learning space with focus on creativity and discovery of users. The findings also indicated that all these perceptions are closely related to understanding of the role of library and its future development.