• 한국문헌정보학회지
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• 제43권4호
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• pp.139-161
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• 2009

이 연구는 도서관의 영아 대상 서비스 실태를 분석하고, 특히 북스타트가 영아 대상 서비스 확대에 미치는 영향을 분석하였다. 이 연구에서는 도서관 회원 등록기준을 분석하였으며, 도서관 어린이실 사서를 대상으로 질문지 조사(76명)와 면접조사(14명)를 실시하였다. 연구결과, 첫째, 어린이 공공도서관의 회원 등록은 출생 직후부터 초등학생까지를 기준으로 제시하는 경우가 대부분이지만, 영아를 포함하지 않는 도서관이 있었다. 도서관에서 만36개월 미만 영아들을 위한 서비스를 시행하는 경우가 54.8%로 나타났다. 둘째, 사서들은 도서관 첫 이용 시기로 영아기(44.0%)보다 유아기(52.0%)를 더 적합한 것으로 인식하고 있다. 셋째, 도서관 사서들은 북스타트의 취지에 적극 동의하고 있었으며(100%), 북스타트가 시행되어야 할 가장 적합한 장소로 도서관을 꼽은 비율이 82.4%이다. 넷째, 북스타트 도입 이후 영아 서비스 확대, 지역사회 및 아기 양육자 인식 변화, 사회적 공동 육아 실현, 이용 횟수 증가, 사서의 독서지도 및 프로그램 기획 역할 강화, 영 유아 조기 독서습관 형성에 기여, 도서 대출량 증가, 가족 이용자의 증가 등 도서관의 영아 대상 서비스 내용에서 변화가 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10421-10425
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• 2015

Background: While the incidence of non-Hodgkins lymphoma (NHL) has been rising worldwide, the reasons remain undefined. Recent research has focused on effect of red andf processed meat intake as a risk factor, but with inconclusive results. We therefore conducted a meta-analysis of data published to date, to ascertain the overall association between intake and NHL. Materials and Methods: A published literature search was performed through Pubmed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using Chi-square and I2 statistics. Dissemination bias was evaluated by funnel plot analysis.We performed a formal meta-analysis using summary measures from these studies. Results: In total, 11 published studies were included in the final analysis. The combined analysis revealed that there was significant association between the red meat and NHL risk (OR=1.10, 95%CI: 1.02 to 1.19, p=0.01). Additionally, there was showed significance association between processed red meat and NHL risk (OR=1.17, 95%CI: 1.06 to 1.29, p=0.001). In subgroup analysis, a statistical significant association was noted between diffuse large B-cell lymphoma (DLBCL) (OR=1.20, 95%CI: 1.04 to 2.37, P=0.01) and red meat intake. Conclusions: In this meta-Analysis, there was evidence for association between consumption of red meat, or processed meat and risk of NHL, particularly with the DLBCL subtype in the red meat case.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3823-3827
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• 2016

Background: To investigate the association circumcision with prostate cancer. Materials and Methods: We searched PubMed, EMBASE, the Cochrane Library, and Chinese biomedicine literature database up to August 2015. All case-control studies were identified in which investigated the association circumcision with prostate cancer. Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3 and STATA version 11.0. Results: Six case-control studies met the inclusion criteria. The pooled meta-analysis showed that there was a lower incidence of circumcision in prostate cancer patients compared with control (OR=0.90, 95% confidence interval [CI] 0.82-0.98, P=0.01). The results of meta-analysis also showed that no significant difference was found between circumcision and less aggressive prostate cancer (OR=0.93, 95% CI 0.83-1.04, P=0.19); however, there was a lower incidence of circumcision in more aggressive prostate cancer compared with control (OR =0.84, 95% CI 0.72-0.97, P=0.02). The Egger's results did not show any evidence of publication bias(P=0.798). Conclusions: In summary, within the limits of available data, male with circumcision appears to have a lower incidence of prostate cancer. In the future, high-quality multicenter studies are needed to thoroughly verify the outcome.

• 대한암한의학회지
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• 제25권2호
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• pp.23-36
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• 2020

Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

• Clinical Nutrition Research
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• 제11권3호
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• pp.228-239
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• 2022

Studies examining the effect of artichoke on liver enzymes have reported inconsistent results. This systematic review and meta-analysis aimed to assess the effects of artichoke administration on the liver enzymes. PubMed, Embase, the Cochrane Library, and Scopus databases were searched for articles published up to January 2022. Standardized mean difference (Hedges' g) were analyzed using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were assessed for the liver enzymes. Pooled analysis of seven randomized controlled trials (RCTs) suggested that the artichoke administration has an effect on both alanine aminotransferase (ALT) (Hedges' g, -1.08; 95% confidence interval [CI], -1.76 to -0.40; p = 0.002), and aspartate aminotransferase (AST) (Hedges' g, -1.02; 95% CI, -1.76 to -0.28; p = 0.007). Greater effects on ALT were detected in trials that lasted ≤8 weeks. Also, greater effects on AST were detected in trials using > 500 mg artichoke. Overall, this meta-analysis demonstrated artichoke supplementation decreased ALT and AST.

• 치위생과학회지
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• 제17권2호
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• pp.160-167
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• 2017

본 연구는 치주질환과 신장질환의 연관성을 알아보기 위한 체계적 고찰이다. Embase, PubMed, The Cochrane Library 데이터베이스에서 2016년 4월 17일 검색을 완료하였다. 문헌의 선택은 코호트 연구 설계를 기준으로 하였으며, 환자군은 치주질환 또는 중증의 치주질환이 있는 대상자로 하였다. 최종 결과는 만성신장질환의 발생이나 신장기능의 저하로 eGFR을 제시한 연구로 하였다. 최종 선정된 문헌의 양적합성을 위하여 Review Manager (RevMan) 통계 분석 소프트웨어를 이용하였다. 고정효과모형 멘텔-헨젤 방법(M-H)을 이용하여 메타분석을 시행하여 치주질환과 만성신장질환의 연관성을 추정하였다. 검색 전략을 이용하여 총 3,018개의 문헌이 검색되었고, 그 중 4개의 문헌이 최종 분석에 포함되어 메타 분석한 결과 치주질환이 만성신장질환 발생위험과 유의한 연관성이 있음이 나타났다(OR, 1.65; 95% CI, 1.44~1.90; p<0.001). 만성신장질환 발생 및 신장기능저하를 예방하기 위해서는 개인의 삶의 질 저하와 의료비용부담을 줄이기 위해 기존에 알려진 전통적 위험인자 외에 만성신장질환에 영향을 미치는 치주질환의 예방 및 관리의 필요성이 크다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2001년도 추계학술대회
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• pp.16-25
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• 2001

A genomic library of biphenyl-degrading strain Comamonas sp. SMN4 was constructed by using the cosmid vector pWE15 and introduced into Escherichia coli. Of 1,000 recombinant clones tested, two clones that expressed 2,3-dihydroxybiphenyl 1,2-dioxygenase activity were found (named pNB 1 and pNB2). From pNB1 clone, subclone pNA210, demonstrated 2,3-dihydroxybiphenyl 1,2-dioxygenase activity, is isolated. 2,3-Dihydroxybiphenyl 1,2-dioxygenase (23DBDO, BphC) is an extradiol-type dioxygenase that involved in third step of biphenyl degradation pathway. The nucleotide sequence of the Comamonas sp. SMN4 gene bphC, which encodes 23DBDO, was cloned into a plasmid pQE30. The His-tagged 23DBDO produced by a recombinant Escherichia coli, SG 13009 (pREP4)(pNPC), and purified with a Ni-nitrilotriacetic acid resin affinity column using the His-bind Qiagen system. The His-tagged 23DBDO construction was active. SDS-PAGE analysis of the purified active 23DBDO gave a single band of 32 kDa; this is in agreement with the size of the bphC coding region. The 23DBDO exhibited maximum activity at pH 9.0. The CD data for the pHs, showed that this enzyme had a typical a-helical folding structures at neutral pHs ranged from pH 4.5 to pH 9.0. This structure maintained up to pH 10.5. However, this high stable folding strucure was converted to unfolded structure in acidic region (pH 2.5) or in high pH (pH 12.0). The result of CD spectra observed with pH effects on 23DBDO activity, suggested that charge transition by pH change have affected change of conformational structure for 23DBDO catalytic reaction. The $K_m$ for 2,3-dihydroxybiphenyl, 3-metylcatechol, 4-methylcatechol and catechol was 11.7 $\mu$M, 24 $\mu$M, 50 mM and 625 $\mu$M.

• 정보보호학회논문지
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• 제17권6호
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• pp.29-39
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• 2007

본 논문에서는 래딕스-4 몽고메리 곱셈기 기반의 고속 RSA 연산기를 제안하고 그 구현 결과를 제시한다. 캐리저장 가산기 기반의 래딕스-4 몽고메리 곱셈기를 제안하고, 중국인의 나머지 정리를 적용할 수 있도록 그 구조를 확장하였다. 이를 바탕으로 설계한 1024-비트 RSA 연산기는 1024-비트 모듈러 지수승을 0.84M 클락 사이클, 512-비트 지수승은 0.25M 클락 사이클 동안 각각 계산할 수 있으며, 0.18um 공정을 이용하여 구현한 결과, 최대 300MHz 클락 속도를 가지므로 1024-비트 지수승은 365Kbps, 512-비트 지수승은 1,233Kbps의 성능을 각각 가진다. 또한 고속 RSA 암호 시스템의 구현을 위해, 몽고메리 매핑 계수 계산 및 중국인 나머지 정리의 전처리 과정에 적용할 수 있도록 모듈러 감산 기능을 하드웨어로 구현하였다.

• 한국문헌정보학회지
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• 제25권
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• pp.389-413
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• 1993

This study was inspired by the growing importance of information as a resource for improving the quality of life, the lack of systematic research about the information environment of Koreans in the United States and the lack of understanding of the relationships between individual characteristics and information seeking behavior. During 1990 and 1991, 204 Koreans, 18 years old and more, residing in the City of Los Angeles, were interviewed. Generally the information seeking behavior of Koreans appeared to be similar to that of the socioeconomically advantaged segment of the general public. They are relatively well aware of their information needs. capable of articulating them, and willing to pursue information to meet their needs. Major findings include: (1) the dominance of educational information needs: (2) positive feelings of hope, curiosity. and interest associated with information needs: (3) the tendency to pursue information with the expectation of potential rather than immediate rewards: (4) the expertise of information sources and their ability to provide information directly relevant to a need as criteria for selecting an information source: (5) the generally heavy reliance on informal interpersonal information sources and the high ranking of professionals as the starting point for information seeking and in judgements of usefulness: and (6) the dominant use of Korean ethnic information sources. Statistically significant correlations found at the 0.05 level relate (1) level of education, age, and gender with type of information need, the feelings associated with an information need, motivations to seek information, and the use of information sources, (2) proficiency in English and length of residence in the United States with the extent to which ethnic information sources are used, and (3) pattern of daily use of media with the use of media in seeking information.

• 한국문헌정보학회지
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• 제35권3호
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• pp.93-115
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• 2001

국가 차원의 정보화 사업이 국내 정부부처를 중심으로 진행되고 있는 현재. 본 연구는 국내 40개 행정부처의 대 국민 서비스를 목적으로 제공되는 웹 정보서비스의 실태를 조사하고 서비스 품질을 평가하여, 정부기관의 정보서비스 개선을 위한 방향을 제시하였다. 연구팀은 6개월 간 해당 부처의 홈페이지와 민원정보와 R & D 정보의 실험검색들을 실시하였으며 서비스 평가는 Web정보 서비스 품질 평가기준에 따라 측정되었다. 1${\sim}$7점 척도에서정보서비스 품질의 평균은 3.6(최고 5.3 ${\sim}$ 최하 2.2)이었고, 검색성은 3.7, 용이성은 3.9, 이용자지원성은 3.1 등 모두 기준 척도의 중간치 (4.0)를 밑도는 결과를 보였다. 정부정보 서비스품질에서 가장 취약한 부분이 이용자 지원성 측면이었으며 대 국민 정보 서비스 전반에 걸쳐 각 부처별 정보서비스 품질에 대한 개선 노력이 절실함을 보이는 결과를 보였다.