• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.696-700
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• 2009

Purpose : We screened more than 350 compounds with an endoperoxide ring structure in search of an anti-leukemic drug and found that compound 127 (c-127) could induce significant cytotoxicity in HL-60 cells. In this study, we investigated the molecular mechanisms of compound 127-induced antitumor activity on HL-60 cells. Methods : HL-60 cells were cultured in Rosewell Park Memorial Institute 1640 and cell viability was measured by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], a tetrazole assay. Apoptosis was assessed by a DNA fragmentation test. Apoptotic machineries were determined by Western blot analysis. Results : C-127 could induce a cytotoxic effect at 24 h and apoptosis at 6 h, which was demonstrated with MTT assay and DNA fragmentation test, respectively. The apoptotic effect of this drug was caused by the activation of the intracellular caspase-8,3 activation, the cleavage of pro-apoptotic Bid, and the increase of c-Jun expression accompanied with JNK (Jun N-terminal kinases) phosphorylation. On the contrary, it increased the expression of anti-apoptotic Bcl-2 levels, leading to the induction of the induction of anti-apoptotic effect. Taken together, the present study demonstrated that c-127 was a potent inducer of cytotoxicity on HL-60 cells through apoptotic mechanisms, which included the activation of caspase family, the regulation of Bcl-2 family, and the activation of JNK signaling pathway. Conclusion : Our results suggest that c-127 has a strong antitumor activity through the regulation of various apoptotic machineries on HL-60 cells. The compound may be utilized as an effective and potentially therapeutic drug in leukemia.

• Journal of Korea Water Resources Association
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• v.42 no.4
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• pp.319-329
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• 2009

Sediment release openings or pipes are installed in the flood control dam constructed to reduce flood damages, which are to allow water and sediments pass through the dam and to prevent flow blockage and sedimentation in the upstream area of the dam. The Hantan River Flood Control Dam (HRFCD) has been projected for flood damage reduction and sediment release openings and ecological passages are considered for the dam design. In this study, sediment deposition due to the construction of HRFCD was analyzed using the HEC-6 model and compared with the state before the dam construction with respect to the conditions of the annual mean daily discharge and annual discharge hydrograph. According to the numerical results, although downstream water levels were changed by the dam structure, the effects of bed changes were not propagated from the dam over 2 km upstream. Also, 2D numerical models of RMA2 and SED2D were used to predict bed changes in the upstream area with and without sediment release openings. Consequently, it is presented that sediment release openings decreased maximum deposition height in the upstream channel of the dam.

• Journal of Korean Home Economics Education Association
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• v.15 no.4
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• pp.159-174
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• 2003

The purposes of this study were to determine the relationship between school education for life-long education and home economics education. to analyze the present state of the life-long education programs through the school in terms of the home economics education, and to understand the role and obtainable qualification of the home economics teachers as the life-long education leader. The results of this study was intended to provide as fundamental materials for direction and plans for life-long education programs in terms of home economics educations. This study was conducted through the analysis of the literature on life long education and the working reports for-16 model schools nationwide for life long education. The results are as follows : 1. The objectives and contents for programs should be developed systematically on the relationship with society. 2. The structure of programs should be developed by characters of organizations, school levels, and regions. 3. Programs should be classified by the purposes and constructed systematically. 4. The subject of programs should be all the members of a family, not only house wives or female adults. 5. The compensation system should be followed for the home economics teachers participating on the program of life long education. 6. Various opportunities for education should be provided to the home economics teachers who want to obtain the qualification as a family-life educator.

• Journal of Life Science
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• v.21 no.5
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• pp.631-646
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• 2011

Mesenchymal stem cells (MSC) are multipotent and can be isolated from diverse human tissues including bone marrow, fat, placenta, dental pulp, synovium, tonsil, and the thymus. They function as regulators of tissue homeostasis. Because of their various advantages such as plasticity, easy isolation and manipulation, chemotaxis to cancer, and immune regulatory function, MSCs have been considered to be a potent cell source for regenerative medicine, cancer treatment and other cell based therapy such as GVHD. However, relating to its supportive feature for surrounding cell and tissue, it has been frequently reported that MSCs accelerate tumor growth by modulating cancer microenvironment through promoting angiogenesis, secreting growth factors, and suppressing anti-tumorigenic immune reaction. Thus, clinical application of MSCs has been limited. To understand the underlying mechanism which modulates MSCs to function as tumor supportive cells, we co-cultured human adipose tissue derived mesenchymal stem cells (ASC) with cancer cell lines H460 and U87MG. Then, expression data of ASCs co-cultured with cancer cells and cultured alone were obtained via microarray. Comparative expression analysis was carried out using DAVID (Database for Annotation, Visualization and Integrated Discovery) and PANTHER (Protein ANalysis THrough Evolutionary Relationships) in divers aspects including biological process, molecular function, cellular component, protein class, disease, tissue expression, and signal pathway. We found that cancer cells alter the expression profile of MSCs to cancer associated fibroblast like cells by modulating its energy metabolism, stemness, cell structure components, and paracrine effect in a variety of levels. These findings will improve the clinical efficacy and safety of MSCs based cell therapy.

• Journal of the Korean Society of Earth Science Education
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• v.16 no.1
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• pp.72-86
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• 2023

The purpose of this study is to examine what epistemological beliefs pre-service teachers have about science depending on the situation, and to explore in-depth changes in epistemological beliefs through disciplinary reading. For this purpose, 77 essays written by pre-service elementary school teachers after reading Feynman's 'the meaning of it all' were analyzed using an inductive analysis method. As a result of the study, the epistemological beliefs of pre-service teachers were divided into two situations: 'science in subject learning' and 'science in daily life', and the epistemological beliefs formed in the 'science handled by scientists' situation were analyzed after reading the book. Each situation was divided into sub-categories of 'Impression of Knowledge', 'Source of Knowledge', 'Justification of Knowledge', 'Variability of Knowledge', 'Structure of Knowledge', and 'Value of Knowledge Acquisition' to reveal differences in sophisticated beliefs and naive belief levels. As a result, it was derived that Feynman's science lecture influenced pre-service teachers in terms of establishing new perspectives and recontextualizing existing epistemological beliefs. This study is meaningful in that pre-service teachers' scientific epistemological beliefs may vary depending on the situation, and that the scope and depth of epistemological beliefs may be expanded to include scientists' beliefs in science through disciplinary reading.

• Korean Journal of Health Psychology
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• v.19 no.3
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• pp.711-727
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• 2014

The purpose of this study was to develop and standardize the Korean version of the Parent Mealtime Action Scale(K-PMAS). The parents of typically developing preschool and elementary school children (N=887) ranging in age from 1 to 11 years as well as parents of children with developmental disorders (N=116) completed the PMAS. A subset of the participants were retested for reliability and also completed the Children's Eating Behavior Inventory- Korean Version (K-CEBI), which was used for assessing validity. The confirmatory factor analysis revealed that the theoretically-based 8-factor structure of PMAS fit the data well. The PMAS scores suggested acceptable levels of internal consistency and test-retest reliability. Validity was also supported by significant correlations between the K-CEBI scores and the differences in K-PMAS scores between the parents of children with developmental disorders and those of typically developing children. The results of one-way ANOVA showed no significant differences in K-PMAS scores between the genders. However, there were significant differences across ages. The means and standard deviations of the PMAS scale scores are provided. Clinical and research implications as well as limitations are discussed.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.325-336
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• 2019

The purpose of this study is to analyze the structural relationship between internal capabilities and job satisfaction using the 7S model and propose measures to improve management performance through internal factors. For this study, seven research hypotheses were set up, and the survey conducted among members of all professions working in general hospitals in small and medium-sized cities in the provinces. From September 20 to October 20, 2016, 385 people were surveyed, and 327 pieces of data (84.9%) used for the study. Multiple regression analyses were performed to verify the effects of internal capabilities on job satisfaction. The analysis results showed that the explanatory power of the research model was suitable by showing 69.1%, and among the 7S factors, the leadership style (β=.392^**), the organizational structure (β=.129^*), the membership (β=.232^**), and the management technique (β=.204^*) showed a positive influence on job satisfaction. That has been confirmed to affect job satisfaction as the standardized factor values increase. Relationships between strategies, systems, and shared values on job satisfaction could not be identified. Significantly observed in the relationship between some internal capacity factors and job satisfaction is that internal capacity can be used as an alternative to an organization's performance improvement measures. Internal capacity can be affected by various environmental variables, such as establishment classification, size, and location. Further implications will also be provided for measuring future internal satisfaction levels separately from internal and external factors.

• Education of Primary School Mathematics
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• v.20 no.3
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• pp.205-224
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• 2017

A model method has been known as the main characteristic of Singaporean elementary mathematics textbooks. However, little research has been conducted on how the model method is employed in the textbooks. In this study, we extracted contents related to the model method in the Singaporean elementary mathematics curriculum and then analyzed the characteristics of the model method applied to the textbooks. Specifically, this study investigated the units and lessons where the model method was employed, and explored how it was addressed for what purpose according to the numbers and operations. The results of this study showed that the model method was applied to the units and lessons related to operations and word problems, starting from whole numbers through fractions to decimals. The model method was systematically applied to addition, subtraction, multiplication, and division tailored by the grade levels. It was also explicitly applied to all stages of the problem solving process. Based on these results, this study described the implications of using a main model in the textbooks to demonstrate the structure of the given problem consistently and systematically.

• Journal of Embryo Transfer
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• v.19 no.3
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• pp.291-299
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• 2004

Characterization of quantitative trait loci (QTL) was investigated in the experimental cross population between Berkshire and Yorkshire breed. A total of 512 F$_2$ offspring from 65 matting of F$_1$ parents were phenotyped the carcass traits included average daily gain (ADG), average backfat thickness (ABF), tenth rip backfat thickness (TRF), loin eye area (LEA), and last rip backfat thickness (LRF). All animals were genotyped for 125 markers across the genome. Marker linkage maps were derived and used in QTL analysis based on line cross least squares regression interval mapping. A decision tree to identify QTL with imprinting effects was developed based on tests against the Mendelian mode of QTL expression. To set the evidence of QTL presence, empirical significance thresholds were derived at chromosome-wise and genome-wise levels using specialized permutation strategies. Significance thresholds derived by the permutation test were validated in the data set based on simulation of a pedigree and data structure similar to the Berkshire-Yorkshire population. Genome scan revealed significant evidences for 13 imprinted QTLs affecting growth and body compositions of which nine were identified to be QTL with paternally expressed inheritance mode. Four of QTLs in the loin eye area (LEA), and tenth rip backfat thickness (TRF), a maternally expressed QTL were found on chromosome 10 and 12. These results support the useful statistical models to analyse the imprinting far the QTLs related carcass trait.

• The Mathematical Education
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• v.60 no.2
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• pp.173-190
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• 2021

Education for Sustainable Development is an imperative mean to achieve the sustainable development which is the key idea that meets the needs of both present and succeeding generations by reconciling environmental protection, social development and economic growth. This study addressed the following question. First, what is the overall structure of the ESD contents presented in the textbooks? Second, How are the sub-contents of ESD distributed in the textbooks? Lastly, How are the ESD contents connected to mathematics in the textbooks? For this purpose, the contents in the elemtentary mathematics textbooks from 1^st to 6^th grades were analyzed at both macro and micro levels through quantitative and qualitative research methods. As results, contents related to environmental, social, and economic dimensions were presented from the first grade. The contents were involved the mathematics content domains of Numbers and Operations, Data and Possibilities, and Patterns. However, the contents were presented intensively in middle and high grades, and environmental topics accounted for a high proportion. Among the activities related to ESD, many were focused on solving problems mathematically while some were presented to solve problems as well as to consider sustainability through the activities. Based on the results, the study aims to provide implications for the direction of mathematics education for sustainable development in elementary school.