• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.44-50
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• 2020

Background: Drug-drug interactions (DDIs) in patients using oral anticancer treatment are more common than in those using injectable anticancer agents. In addition, DDIs related to anticancer treatment are known to cause clinically significant outcomes, such as treatment failure and severe toxicity. To prevent these negative outcomes, significant DDIs are monitored and managed using the information provided in drug databases. We aimed to evaluate the consistency of information on clinically significant DDIs for tyrosine kinase inhibitors (TKIs) between representative drug databases. Methods: We selected clinically significant DDIs involving medications that are co-prescribed with TKIs and met the following criteria: the severity level of DDIs was equal or greater than "D" in Lexicomp^® or "major" in Micromedex^®. We then analyzed the consistency of the severity classification and evidence level between the drug databases. Spearman's correlation coefficient was used to identify the relationship between DDI information in the drug databases. Results: In total, 627 DDI pairs were identified as clinically significant; information on these was provided by Lexicomp^® and Micromedex^® for 571 and 438 pairs, respectively, and both drug databases provided information on 382 DDI pairs. There was no correlation between the severity and evidence level of DDIs provided in the two databases; Spearman's correlation coefficient for Lexicomp^® and Micromedex^® was -0.009 (p=0.861) and -0.064 (p=0.209), respectively. Conclusion: To judge the significance of DDIs, healthcare providers should consider that the information on DDIs may be different between drug information databases; hence, clinical factors must be considered concurrently.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.37 no.4 s.112
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• pp.18-25
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• 2005

The mechanical strength is the prime requisite for linerboard and corrugating mediums. Repeatedly recycled OCC fibers show less suitable property for papermaking mostly due to hornification and reduced fiber length. To overcome these problems many researches including fractionation, enzymatic treatment, and chemical or mechanical treatments of fibers have been carried out. In this study, the effect of mechanical treatment by high consistency pulping on the characteristics of recycled fibers as well as mechanical properties of sheets were investigated. Results on the strength properties of handsheets made of recycled fibers that were treated to same freeness level by beating and high consistency pulping, respectively, showed that beating treatment was more efficient in improving strength. Drainage and recycling potential of the fibers treated by high consistency pulping, however, were expected to be superior to beating because fines content and fiber length didn't change significantly.

• Korean Journal of Child Studies
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• v.13 no.2
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• pp.203-216
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• 1992

The purpose of this study was to investigate the utility of the Luria-Nebraska Battery-Children's Revision (LNNB-CR) in the clinical situation in Korea: LNNB-CR was applied clinically in order to examine how well it differentiates brain damaged children from normals. Subjects were 30 children with the average age of 10 years. Among them 15 were diagnosed as the 'brain damaged' group, and the remaining 15 were normal. All subjects of the two groups were tested on all items in accordance with LNNB-CR manual. Data were analyzed by percentage, correlation coefficient, and t-test. The results were (1) the degree of consistency between testers averaged 97.2％ which confirmed the stability of the scoring system. (2) Split-half reliability was ranged from .75 on the Tactile Scale (C3) to .95 on the Memory Scale (C10). Thus, consistency of items within the scales appeared high. (3) Internal consistency reliability ranged from .74 on the Visual Scale (C4) to .98 on the Reading Scale (C9). Thus, the homogenity of items within the scales appeared high. (4) In the diagnostic discriminative power test between the two groups, both individual scales and total scores showed significant differences at the level of p<.001. (5) The discriminative power test between two groups on all items showed significant differences at the level of p<.05 or better in 126(85％) out of 149 items. These results are supportive of the diagnostic utility of the application of LNNB-CR to the clinical situation in Korea. However, extensive additional research is needed in order to prove its worth.

• Safety and Health at Work
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• v.13 no.4
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• pp.500-506
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• 2022

This study evaluated the consistency between two quantitative fit test devices with different methods of ambient aerosol counting. Three types of respirators (N95, half mask, and full facepiece) were worn by 50 participants (male, n = 25; female, n = 25), PortaCount (Pro+ 8038) and MT (05U) were connected to one probe to one mask, and fit factors (FFs) were measured simultaneously with the original and modified protocols. As a result of comparing MT FFs with PortaCount FFs as references and by applying for the pass/fail criteria (FF = 100), the consistency between the two devices for half masks and full facepieces was very high. N95 was somewhat weaker than the two type of respirators in the consistency; however, the correlation between the two devices was very strong (p < 0.0001). The results showed that an FF of 100 as measured by PortaCount was likely to be measured as 75 by the MT. Therefore, when performing the fit test for N95 using the MT and pass level of FF 100, a certain level of adjustment is necessary, whether end-user or putting a scaling factor by manufacturer.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.3
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• pp.352-358
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• 2009

The physicochemical properties of dextran culture fermented by Leuconostoc citreum S5 were evaluated by the addition of various polysaccharides and heat-treatment. The consistency of dextran culture increased with the addition of carrot juice residue (CJR) in submerged culture, resulting in the highest consistency of 150 $Pa{\cdot}s^n$ and viable cell counts of $2.36{\times}10^9$ CFU/mL at 20% level of CJR. The dextran culture showed the pseudoplastic behavior and its consistency was greatly increased with the addition of various polysaccharides at 2% level. Addition of glucomannan indicated the highest consistency of 1275 $Pa{\cdot}s^n$ and their heat-treatment resulted in the increase of consistency except for glucomannan. After heat-treatment, the fermented dextran culture containing CJR fortified with gellan gum and carrageenan showed great change in rheology, indicating the highest consistency and hardness value resulted in the great increase of elastic and viscous moduli. The dynamic viscoelastic properties of dextran culture were greatly increased by the heat-treatment after fortification of various polysaccharides. Thus, the consistency and viable cell counts of dextran culture were increased with the addition of CJR. The rheological properties of dextran culture were manipulated by the fortification of various polysaccharides and heat-treatment.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.32 no.3
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• pp.1-9
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• 2000

The MDDA (Modified Dynamic Drainage Analyzer) was developed to evaluate the drainage characteristics on paper machine. The initial forming vacuum velocity was decreased with the increase of stock consistency and there were no significant effects of the applied vac-uum. On the other hand the initial forming drainage velocity was rapidly decreased with the increase of stock consistency above the 0.35 bar of applied vacuum. The final drainage time and wet web permeability showed similar trends under 0.075% consistency but increased rapidly at the higher consistencies. SFR(Specific Filtration Resistance) and drainage obtained for different vacuum level applied and deposited weights measured by using MDDA showed the linear relationship.

• The Transactions of the Korea Information Processing Society
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• v.7 no.3
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• pp.799-807
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• 2000

In this paper, object replication Client/server under distributed computing system is design and implementation. Today many end-users have a computer communication by using internet in the distributed system of client/server. If many users request services to a specific remote server, the server should have got a overhead for hat service processing, delayed the speed for replay, and bring a bottleneck in communication network. Therefore object replication method was proposed to solve this problems. The growth of internet works and distributed applications has increased the need for large scale replicated systems. However, existing replication protocols do not address scale and autonomy issues adequately. Further, current application protocol require consistency of different levels, and therefore should be the selection function of consistency in them, in order to have particular semantics of each level. In this paper, server overhead and bottleneck happening in remote procedure call be using server object replication. Therefore access transparency can be improved by sharing object duplicately. So it will Keep up with the consistency within the replicated objects.

• Proceedings of the IEEK Conference
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• 2003.07d
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• pp.1327-1330
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• 2003

The internet SCSI(iSCSI) disk has been studied as a storage system which can be directly connected to TCP/IP network. We designed and implemented a shared disk following the iSCSI protocol and providing cache consistency. It is named as intelligent iSCSI(i$^2$SCSI) disk. The i$^2$SCSI disk provides cache consistency of all blocks that belong to the disk using a conventional lease method and it uses 'contiguous blocks-level locking' The prototype of the i$^2$SCSI disk emulator and its client is designed and implemented in Linux 2.4.

• International Journal of Highway Engineering
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• v.17 no.3
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• pp.27-33
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• 2015

PURPOSES : To ensure appropriate RCC properties with sufficient strength development and workability, it is necessary to secure a proper level of consistency. It is also necessary to secure maximum dry density, which is an important factor for increasing the interaction of aggregate interlocking, leading to an augmentation of RCC strength. On the other hand, the dry density of RCC can be changed owing to the compaction conditions, water content, and particle size distribution. A Proctor test and a modified Proctor test were used for determining the optimum water content needed to achieve maximum dry density with different amounts of compaction energy. A Vebe test, on the other hand, was used for checking the level of consistency, which is important for producing a workable mixture. METHODS : To confirm the degree of compaction at various particle sizes, RCC mixtures with different sand/aggregate ratios were evaluated. The Proctor test and modified Proctor test were applied to these mixtures to check the effect of the aggregate gradation and compaction energy on the maximum dry density and optimum water content. During each test, three specimens were produced for all types of water content under each aggregate gradation. A compaction curve and the optimum water content and maximum dry density for each aggregate gradation were then obtained for both tests. The range of water content for the appropriate consistency of each aggregate gradation was determined through a Vebe test. The optimum water content was then evaluated based on this range. RESULTS : The compaction test results show that the modified Proctor test provides a higher maximum dry density and lower optimum water content compared with the standard Proctor test. For the modified Proctor test, two cases of aggregate gradation (s/a = 30% and 70%) had the optimum water contents outside of the appropriate water content range. For the standard Proctor test, on the other hand, none of aggregate gradations provided the optimum water content within the desired range. CONCLUSIONS : The modified Proctor test should be used for an RCC mixture design because it can provide adequacy between maximum dry density and consistency. Moreover, the compaction roller has become highly developed for higher compaction energy.

• The KIPS Transactions:PartD
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• v.8D no.5
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• pp.593-604
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• 2001

A database sharing system (DSS) refers to a system for high performance transaction processing. In the DSS, the processing nodes are coupled via a high speed network and share a common database at the disk level. Each node has a local memory and a separate copy of operating system. To reduce the number of disk accesses, the node caches data pages and index pages in its memory buffer. In general, B-tree index pages are accessed more often and thus cached at more processing nodes, than their corresponding data pages. There are also complicated operations in the B-tree such as Fetch, Fetch Next, Insertion and Deletion. Therefore, an efficient cache consistency scheme supporting high level concurrency is required. In this paper, we propose cache consistency schemes using identifiers of index pages and page_LSN of leaf page. The propose schemes can improve the system throughput by reducing the required message traffic between nodes and index re-traversal.