• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.6
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• pp.481-489
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• 2010

Introduction: TLR-5, a member of the toll-like receptor (TLR) family, is a element of the type I transmembrane receptors, which are characterized by an intracellular signaling domain homolog to the interleukin-1 receptor. These receptors recognize microbial components, particularly bacterial flagellin. All-trans retinoic acid (atRA, tretinoin), a natural metabolite of vitamin A, acts as a growth and differentiation factor in many tissues, and is also needed for immune functions. In this study, THP-1 human macrophage-monocytes were used to examine the mechanisms by which atRA regulated the expression of TLR-5. Because the molecular mechanism underlying this regulation at the transcriptional level is also unclear, this study examined which putative transcription factors are responsible for TLR-5 expression by atRA in immune cells. Materials and Methods: This study examined whether atRA induces the expression of TLR-5 in THP-1 cells using reverse transcription-polymerase chain reaction (RT-PCR), and which transcription factors are involved in regulating the TLR-5 promoter in RAW264.7 cells using a reporter assay system. Western blot analysis was used to determine which signal pathway is involved in the expression of TLR-5 in atRA-treated THP-1 cells. Results: atRA at a concentration of 10 nM greatly induced the expression of TLR-5 in THP-1 cells. Human TLR-5 promoter contains three Sp-1/GC binding sites around -50 bp and two NF-kB binding sites at -380 bp and -160 bp from the transcriptional start site of the TLR-5 gene. Sp-1/GC is primarily responsible for the constitutive TLR-5 expression, and may also contribute to NF-kB at -160 bp to induce TLR-5 after atRA stimulation in THP-1 cells. The role of NF-kB in TLR-5 expression was further confirmed by inhibitor pyrrolidine dithiocarbamate (PDTC) experiments, which greatly reduced the TLR-5 transcription by 70-80%. Conclusion: atRA induces the expression of the human TLR-5 gene and NF-kB is a critical transcription factor for the atRA-induced expression of TLR-5. Accordingly, it is conceivable that retinoids are required for adequate innate and adaptive immune responses to agents of infectious diseases. atRA and various synthetic retinoids have been used therapeutically in human diseases, such as leukemia and other cancers due to the antiproliferative and apoptosis inducing effects of retinoids. Therefore, understanding the molecular regulatory mechanism of TLR-5 may assist in the design of alternative strategies for the treatment of infectious diseases, leukemia and cancers.

• Journal of The Korean Association For Science Education
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• v.17 no.3
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• pp.289-299
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• 1997

This study has been undertaken in the light of constructivist view of teacher education. Participant observation, unstructured interview and questionnaire were used to explore the process and the role of practicum in science teacher education. The subjects were 19 student teachers majoring in physics education; 8 had participated at boys junior high school, 11 at senior high school. The student teachers had very critical and negative perception on their school days' science lessons. They had expected to do 'better' in their practicum but there were only 3 to 5 opportunities of teaching under the umbrella of textbook. Explanation in the classroom and solving exercise problem were the main features of student teachers' lessons. Much of the lessons were similar when it is to same topic and the main reference for their lesson preparation was the textbook. The student teachers felt the design of teaching approach as the most difficult thing during their lesson preparation. They realized that teaching is harder than they thought and they should consider students' level and responses. Though they had become to have more positive perception on teaching job through their field experiences, their decision on job preference did not change. More than half did not want to be a teacher. The student teachers recognised the courses related with science education as the most useful to their teaching in practice among the program of college of education which they had taken. The experience of writing one lesson plan or teaching in front of their peers, designing a new demonstration equipment were recognised as valuable and helpful element of the courses. They proposed to reduce the amount of general education courses and to emphasize the courses relevant with science education and practicum. The limited opportunity of teaching in practicum was pointed out as problematic. Though the practicum was recognized as a 'good' experience to student teachers, it was confined by textbook and limited teaching opportunity. In conclusion, the practicum was not organized and implemented as a meaningful experience of science teaching and learning. There should be more structured studies on what kind of perceptions and experiences the student teachers had brought to the science teacher education program, how they interact with the elements of the program and how they affect to their science teaching. The structure and content of practicum also should be studied and developed so as to make practicum as a meaningful experience of science teaching and learning.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.9 s.112
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• pp.900-912
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• 2006

A GPS receiving antenna installed in the missile's warhead is designed and fabricated at a center frequency 1.575 GHz. The circular shaped antenna is installed in the middle of the warhead where the antenna's patch and the ground plane are connected with a hollow cylindrical shaped short pin. Using the dual feeding and phase difference method, an omni-directional radiation pattern which direction is normal to the missile's axis(H-plane) is obtained. The optimized diameters of the circular patch and the cylindrical ring typed shorting pin of the GPS receiving antenna which use the FR4.material(dielectric constant $\varepsilon_r=4.6$) are 59.5 mm and 14 mm, respectively. The cylindrical body with diameter 100 mm and height 500 mm is attached to the lower part of the warhead in order to complete the missile figure. The radiation patterns are measured by changing the angle and phase between the dual feeding points. When the phase difference of dual feeding is $100^{\circ}$ and the angle between the dual feeding points is $100^{\circ}$, the nearly omni-directional radiation pattern in the H-plane is obtained. In this case, the antenna gain is -5.55 dBd and the relative level difference between the maximum and the minimum radiation intensity is 3.98 dB.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.3
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• pp.180-201
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• 2020

It has been widely known that the effect of diffracted waves at the tip of composite breakwater with finite length causes the change of standing wave height along the length of breakwater, the spatial change of wave pressure on caisson, and the occurrence of meandering damage on the different sliding distance in sequence. It is hard to deal with the spatial change of wave force on trunk of breakwater through the two-dimensional experiment and/or numerical analysis. In this study, two and three-dimensional numerical techniques with olaFlow model are used to approach the spatial change of wave force including the impulsive breaking wave pressure applied to trunk of breakwater, the effect of rear region, and the occurrence of diffracted waves at the tip of caisson located on the high crested rubble mound. In addition, it is thoroughly studied the mean wave height, mean horizontal velocity, and mean turbulent kinetic energy through the numerical analysis. In conclusion, it is confirmed that the larger wave pressure occurs at the front wall of caisson around the still water level than the original design conditions when it generates the shock-crushing wave pressure checked by not two-dimensional analysis, but three-dimensional analysis through the change of wave pressure applied to the caisson along the length of breakwater.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.3
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• pp.277-284
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• 2012

In this study, a heat-transfer performance analysis is carried out for a multi-channel volumetric air receiver for a solar power tower. On the basis of a series of reviews regarding the relevant literature, a calculation process is proposed for the prediction of the wall- and air- temperature distributions of a single channel at given geometric and input conditions. Furthermore, a unique mathematical model of the receiver effectiveness is presented through analysis of the temperature profile. The receiver is made of silicon carbide. A total of 225 square straight channels per module are molded to induce the air flow, and each channel has the dimensions of $2mm(W){\times}2mm(H){\times}0.2mm(t){\times}320mm(L)$. The heat-transfer rate, temperature distribution and effectiveness are presented according to the variation of the channel and module number under uniform irradiation and mass flow rate. The available air outlet temperature applied to the solar power tower should be over $700^{\circ}C$. This numerical model was actually used in the design of a 200 kW-level commercial solar air receiver, and the required number of modules satisfying the thermal performance could be obtained for the specified geometric and input conditions.

• Ecology and Resilient Infrastructure
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• v.4 no.2
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• pp.97-104
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• 2017

For the restoration of lateral connectivity between channel and floodplain, it is important to find the former floodplain and to characterize its land use in streams which were channelized by the levee construction for the flood protection. The aim of this study is to map the former floodplains and to assess its land use pattern in the Cheongmi-cheon Stream, Korea. The former floodplains were explored by being overlapped on a digital elevation model (DEM), digital topographic map and design flood level using a geographical information system (GIS) in the Cheongmi-cheon Stream basin. The land use of the identified former floodplains was classified by land-use map. The total number of the former floodplains was 104 and their total area was $11.9km^2$ in the Cheongmi-cheon Stream. The land use pattern of the former floodplains was mostly farmland (87.1%). The former floodplains were usually surrounded by mountain forest in the downstream of the Cheongmi-cheon Stream. These former floodplains are probably suitable for restoration of lateral connectivity because of lower ratio of urban area but higher ratio of farmland. The results of delineation and land use analysis of the former floodplain can be used as a baseline data for planning stream restoration in the Cheongmi-cheon Stream.

• Journal of the Society of Disaster Information
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• v.14 no.2
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• pp.107-114
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• 2018

Purpose : This study is to develop walls using wall recording technology applied on roofs to prevent fire spread in traditional markets. Method : The spray head installed on the developed wall was designed so that the fire does not spread to adjacent buildings after being used for plants. In addition, a spray head was attached to the upper section and some sections for the growth of plants planted on the wall to prevent the spread of fire. Results : These technologies suggested the development of walls that can be installed at the upper level of buildings, such as traditional markets, and separate isolation facilities were not necessary because they are integrated with structures and sprinklers. In addition, sprinklers can perform both the plant spray and fire spread prevention functions. It is believed that this is the only alternative technology proposed in Korea to prevent the spread of fire. Conclusion : In this study, the wall design, designed directly to derive the quantitative performance of the fire spread reduction effect, demonstrated the fire suppression method of the wall system, the durability of the wall itself, and the flame retardability performance.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.4
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• pp.284-291
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• 2017

There is no doubt that advances in UAV technology have improved military performance. However, these advances require humans to adapt to new and complex operational systems. UAV has been rapidly expanding to a variety of fields such as reconnaissance, transportation, communication and aerial photographing recently. Also, with the development of UAV automation technology, one operator is able to supervisory-control multiple-UAVs. However, as the number of assigned UAV increases, the amount of information increases and this results in the workload of the operator increasing and deterioration in controlling performance. Accordingly, there is a need for a model to determine the level of overload an operator may encounter with regard to multiple-UAV but nationally this kind of research is currently lacking. Therefore, this paper provides an experimental platform for evaluating workload index effectiveness integrating multiple-UAV operational environments, GCS, and eye-tracking system followed by a limited survey of domestic and international studies of multi-UAV overload studies.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.5
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• pp.383-390
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• 2020

Wedge locks have been widely used for spaceborne electronics for mounting or removal of a printed circuit board (PCB) during integration, test and maintenance process. However, it can basically provide a mechanical constraint on the edge of the board. Thus, securing a fatigue life of solder joint for electronic package by limiting board deflection becomes difficult as the board size increases. Previously, additional stiffeners have been applied to reduce the board deflection, but the mass and volume increases of electronics are unavoidable. To overcome the aforementioned limitation, we proposed an application of multi-layered PCB sheet with viscoelastic adhesive tapes to implement high-damping capability on the board. Thus, it is more advantageous in securing the fatigue life of package under launch environment compared with the previous approach. The basic characteristics of the PCB with the multi-layered sheet was investigated through free-vibration tests at various temperatures. The effectiveness of the proposed design was validated through launch vibration test at qualification level and fatigue life prediction of electronic package based on the test results.

• The Korean Journal of Food And Nutrition
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• v.22 no.4
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• pp.497-507
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• 2009

The principal objective of this study was to assess the situation of foodservice facilities, utilities, and physical environment in the Chonbuk area. Self-administered questionnaires were collected from 252 nutrition teachers and school dietitians. Statistical data analysis was completed using the SPSS v. 11.5 program. The results were summarized as follows: Approximately 99.2% of the subjects were women 76.6% were married, over 87% were between the ages of 30 and 40(p<0.01) and 56.8% had more than 11 years of experience(p<0.001). Among the 252 school foodservice systems evaluated, 51.6% of the schools were located in urban areas and 48.0% were in rural areas(p<0.01). Approximately 68.0% of the schools prepared meals in the conventional way, and 32.3% prepared them in the commissary way(p<0.001). The number of employees at each institution was separated into the following categories: 1 to 3(37.7%), 4 to 6(27.8%), and 7 to 9(25.4%, p<0.01). Approximately 54.0% of schools had been running a school meal service for longer than 11 years(p<0.001). However, 67.5% of those facilities had not been remodeled since the initial implementation of foodservices. Approximately 94.0% of the school foodservice facilities were located on the first floor. 72.2% among them were constructed of reinforced concrete and 16.7% were prefabricated(p<0.001). As the result of our evaluation of related physical evidence and the atmosphere of the space, the average importance grade was $4.41{\pm}0.46$, and the average performance grade was $2.78{\pm}0.67$. Most nutrition teachers and school dietitians in elementary, middle, & high schools responded that the related physical evidence and the atmosphere of the space in school foodservice facilities were important, but the satisfaction level among the nutrition teachers and school dietitians was quite low. Therefore, it's important and necessary to analyze the opinions of the stakeholders in the foodservice industry prior to the remodeling of school foodservice facilities and utilities.