• BMB Reports
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• v.37 no.2
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.1
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• pp.106-115
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• 2007

In this study, first, child headform model was built up, satisfying requirement in the headform validation test. Also, for decreasing both acceleration peak and deformation, a new hood with dome shaped forming in inner panel was investigated. Next, headform impact, complying with draft of EEVC W/G 17, on the central portion of the newly proposed hood were simulated for a steel hood and three aluminum hoods with different thickness for examining the material and thickness effect on HIC value and inner panel deformation. The analysis results explained that aluminum hoods with dome shaped forming in inner panel were highly promising not only for meeting headform safety regulations but also for leading to weight savings. Finally, hood edge design technology in order to reduce pedestrian injury due to the high stiffness of beam type edge and the rigid support, was discussed. Various types of the foam filled edge were designed and their headform safety performance were evaluated. The edge structure with foam filled in upper one third of section exhibited excellent results.

• Archives of Craniofacial Surgery
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• v.20 no.3
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• pp.164-169
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• 2019

Background: The conventional surgical method for reconstructing orbital floor fractures involves restoration of orbital continuity by covering an onlay with a thin material under the periorbital region. However, in large orbital floor fractures, the implant after inserting is often dislocated, leading to malposition. This study aimed to propose a novel implanting method and compare it with existing methods. Methods: Among patients who underwent surgery for large orbital floor fractures, 24 who underwent the conventional onlay implanting method were compared with 21 who underwent the novel ${\gamma}$ implanting method that two implant sheets were stacked and bent to resemble the shape of the Greek alphabet ${\gamma}$. When inserting a ${\gamma}$-shaped implant, the posterior ledge of the orbital floor was placed between the two sheets and the bottom sheet was impacted onto the posterior wall of the maxilla to play a fixative role while the top sheet was placed above the residual orbital floor to support orbital contents. Wilcoxon signed-rank test and Mann-Whitney U test were used for data analyses. Results: Compared to the conventional onlay method, the gamma method resulted in better restoration of orbital contents, better improvement of enophthalmos, and fewer revision surgeries. Conclusion: Achieving good surgical outcomes for extended orbital floor fractures is known to be difficult. However, better surgical outcomes could be obtained by using the novel implantation method of impacting a ${\gamma}$-shaped porous polyethylene posteriorly.

• Land and Housing Review
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• v.8 no.2
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• pp.59-71
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• 2017

With the passing of Special Act on Promotion and Support for Urban Regeneration (will be hereafter referred to as the Urban Regeneration Special Act) in December 2013, urban regeneration projects have begun in full scale. 13 regions including Jongno District, Seoul were selected as the urban regeneration leading area in 2014 and 33 regions as urban regeneration general regions in 2015 to push ahead a nationwide urban regeneration front supported by government funds. However, it is not clear if these urban regeneration projects will be revitalized by the sole means of government's financial support. Above all, cooperation among all interested parties including the central government that is propelling urban regeneration, local governments, state corporations, private entities, and citizens is urgent. In an urban regeneration project, delegation between state and private entities is absolutely crucial. The central government and the pertinent local government must provide their support by forming new policies and repairing old institutions that are right for urban regeneration, securing the necessary subsidy, and outsourcing government-owned land development. A state corporation must play its part in every aspect that requires public character such as an overall project management of an urban regeneration project, cooperation with the local government, and infrastructure installation. The private stakeholder must share his private capital and know-hows as a construction investor and a development businessman to make possible a successful urban regeneration project. In order for these public and private entities to cooperate with one another, it is necessary to reestablish the role of a public developer and contemplate running an urban regeneration project that permeates public character through a public developer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6019-6023
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• 2013

Lung cancer, one of the leading causes of cancer-related deaths, usually appears as solitary pulmonary nodules (SPNs) which are hard to diagnose using the naked eye. In this paper, curvelet-based textural features and clinical parameters are used with three prediction models [a multilevel model, a least absolute shrinkage and selection operator (LASSO) regression method, and a support vector machine (SVM)] to improve the diagnosis of benign and malignant SPNs. Dimensionality reduction of the original curvelet-based textural features was achieved using principal component analysis. In addition, non-conditional logistical regression was used to find clinical predictors among demographic parameters and morphological features. The results showed that, combined with 11 clinical predictors, the accuracy rates using 12 principal components were higher than those using the original curvelet-based textural features. To evaluate the models, 10-fold cross validation and back substitution were applied. The results obtained, respectively, were 0.8549 and 0.9221 for the LASSO method, 0.9443 and 0.9831 for SVM, and 0.8722 and 0.9722 for the multilevel model. All in all, it was found that using curvelet-based textural features after dimensionality reduction and using clinical predictors, the highest accuracy rate was achieved with SVM. The method may be used as an auxiliary tool to differentiate between benign and malignant SPNs in CT images.

• Tribology and Lubricants
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• v.35 no.5
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• pp.300-309
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• 2019

Gas foil thrust bearings (GFTBs) support axial loads in oil-free, high speed rotating machinery using air or gas as a lubricant. Due to the inherent low viscosity of the lubricant, GFTBs often have super-laminar flows in the film region at operating conditions with high Reynolds numbers. This paper develops a mathematical model of a GFTB with turbulent flows and validates the model predictions against those from the literature. The pressure distribution, film thickness distribution, load carrying capacity, and power loss are predicted for both laminar and turbulent flow models and compared with each other. Predictions for an air lubricant show that the GFTB has high Reynolds numbers at the leading edge where the film thickness is large and relatively low Reynolds numbers at the trailing edge. The predicted load capacity and power loss for the turbulent flow model show little difference from those for the laminar flow model even at the highest speed of 100 krpm, because the Reynolds numbers are smaller than the critical Reynolds number. On the other hand, refrigerant (R-134a) lubricant, which has a higher density than air, had significant differences due to high Reynolds numbers in the film region, in particular, near the leading and outer edges. The predicted load capacity and power loss for the turbulent flow model are 2.1 and 2.3 times larger, respectively, than those for the laminar flow model, thus implying that the turbulent flow greatly affects the performance of the GFTB.

• Journal of Gifted/Talented Education
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• v.25 no.6
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• pp.971-987
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• 2015

This paper aims at analyzing SW club acitivities on the science core high school using information disclosure. Targeting 103 schools across the nation science core high schools, the factors influencing the SW Club was analyzed. And science core high school education plans, business plans and management reports were analyzed in SW club activities. It was the most influencing on the SW club in Creative-Experiential activities organization of computer courses. So computer curriculum reform is urgently needed. SW extra subject activities and funding was having a positive effect. Tuition reimbursement rates was having a negative effect. But academic achievement did not significantly affect. Therefore as many students as possible should be able to assist the SW extra subject activities. And it is required Programs and budget support that reflect the characteristics of local and school. Also, as science core high schools have STEAM education, science, mathematics and technology home economics teachers etc were leading the SW club activities by fusing the their curriculum and SW education. As these activities are consistent with the purpose of SW education, research should be more active autonomic consisting of various teachers.

• Geomechanics and Engineering
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• v.29 no.5
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• pp.509-522
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• 2022

Tail-grouting is an effective measure in shield engineering for filling the gap at the shield tail to reduce ground deformation. However, the gap-filling ratio affects the value of the gap parameters, leading to different surface settlements. It is impossible to adjust the fill ratio indiscriminately to study its effect, because the allowable adjustment range of the grouting quantity is limited to ensure construction site safety. In this study, taking the shield tunnel section between Chaoyanggang Station and Shilihe Station of Beijing Metro Line 17 as an example, the correlation between the tail-grouting parameter and the surface settlement is investigated and the optimal grouting quantity is evaluated. This site is suitable for conducting field tests to reduce the tail-grouting quantity of shield tunneling over a large range. In addition, the shield tunneling under different grouting parameters was simulated. Furthermore, we analyzed the evolution law of the surface settlement under different grouting parameters and obtained the difference in the settlement parameters for each construction stage. The results obtained indicate that the characteristics of the grout affect the development of the surface settlement. Therefore, reducing the setting time or increasing the initial strength of the grout could effectively suppress the development of surface subsidence. As the fill ratio decreases, the loose zone of the soil above the tunnel expands, and the soil deformation is easily transmitted to the surface. Meanwhile, owing to insufficient grout support, the lateral pressure on the tunnel segments is significantly reduced, and the segment moves considerably after being removed from the shield tail.

• Asia Marketing Journal
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• v.14 no.3
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• pp.7-26
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• 2012

The success story of E-mart fascinated many academics and practitioners alike. Though E-mart began as a nameless discount store in Chang-dong, Seoul in 1993, it has transformed itself into a leading distribution company and one of the most powerful brands in Korea. Surprisingly, it achieved the great success against the two crises it met: the national economic crisis and the invasion of the global giant Walmart. The main objective of this case study is to formally examine how E-mart overcame the two crises. More specifically, this case study highlights the ways with which E-mart turned those difficulties into opportunities for growth. In our examination of the E-mart case, we could clearly see E-mart's competence and spirit that allowed it to turn crises into advantageous opportunities. E-mart attracted the customers who wanted value-oriented consumption by its positioning as the "Lowest price discount store", when consumer sentiment was frozen under the economic crisis. Furthermore, when a large-scale foreign discount store like Walmart entered the Korea market, E-mart built its core competencies as the 'Korean style discount store'. These ingenious positioning and efforts resulted in E-mart taking over their archrival, Walmart, and forced the global Goliath to exit the Korean market. The case of E-mart's effective crisis management teaches many important lessons and a few core lessons that apply to many companies. One such lesson is the importance of positioning which enabled E-mart to turn crises into opportunities. Granted, the strategy of positioning as the 'Korean style discount store', or 'Lowest price discount store' was possible due to overall support with cost reduction, development and management of their own system, an apprentice educate system, etc. based on an excellent selection of location of the store and efficient distribution systems. Still, the positioning strategy of E-mart was truly ground breaking in distancing itself from its competitors. The lessons from E-mart will help those companies currently in a stagnant situation or a crisis to turn their obstacles into great success.

• 한국벤처창업학회:학술대회논문집
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• 2007.11a
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• pp.143-174
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• 2007

The objective of Starts-up education rears leading company that minimize a risk & connect them with successful idea. Internet Starts-up education is serviced in public & civil parts, it is insufficient to reach successful Starts-up support. This study is targeting on review the present condition of the Internet Starts-up education, research which it sees Internet Starts-up education actual condition investigation through investigation student of education satisfactorily and education contents and the plan to grope an Starts-up education progress coat problem and developmental plan it did. The current events point which has become research result escape first, age of the students of education, followed in educational background and, education motive and education experience presence education satisfactory boat song it appeared in these demand different, base grudge the form which is various it fixed and the education was demanded. Second, currently the department of pedagogy joining in establishment leader against the technical element which is advanced swip, the education reinforcement against an enterprise accomplishment ability back human factor, an enterprise propulsion environment and an enterprise item back enterprise environment element was demanded. Time after support and consulting, completion lifestyle community construction, completion lifestyle for item connection support and the trade name net after third, establishing an enterprise we the king, after toe ring back educating which carries on shoulder the importance of the civil official was embossed. The study which it sees led and like this investigation analysis the education progress for the successful support of the Internet Starts-up and time after connection setup construction it led and the plan which it will put out advancement of Starts-up education and it groped.