• The Korean Journal of Food & Health Convergence
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• v.5 no.4
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• pp.13-17
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• 2019

Amiodarone hydrochloride is an antiarrhythmic agent which has low aqueous solubility and presents bioavailability problem. These properties are a challenge for the pharmaceutical industry. Inclusion of lipophilic compound in the hydrophobic core of micelles, i.e. self-assembled structures based on surfactants in aqueous solution, is one way of increasing the solubility. Intravenous formulation of amiodarone hydrochloride with polysorbate 80 as a detergent and benzyl alcohol as a co-solvent is used in medical practice. This paper aimed to study the effect of polysorbate 80 and benzyl alcohol on the water solubility of amiodarone hydrochloride. Formation of mixed micelles consisting of nonionic surfactant polysorbate 80 and cationic amiodarone with chloride counterion was investigated by fluorescence spectroscopy. Benzyl alcohol was found to decrease the stability of the mixed micelles and lead to crystallization of amiodarone hydrochloride. The greatest amounts of crystals formed at 4℃ for 30 days in the model drug solutions with polysorbate 80 concentrations of 100.1 mg/mL and 97.9 mg/mL. A change of the polysorbate 80 concentration and avoidance the use of benzyl alcohol are recommended to improve the stability of the parenteral dosage form. These results can open new perspectives in the optimization of amiodarone intravenous formulations.

• Earthquakes and Structures
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• v.9 no.6
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• pp.1337-1353
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• 2015

Seismic upgrading of existing structures is a technical and social issue aimed at risk reduction. Sustainable design is one of the most important challenges in any structural project. Nowadays, many retrofit strategies are feasible and several traditional and innovative options are available to engineers. Basically, the design strategy can lead to increase structural ductility, strength, or both of them, but also stiffness regulation and supplemental damping are possible strategies to reduce seismic vulnerability. Each design solution has different technical and economical performances. In this paper, four different design solutions are presented for the retrofit of an existing RC frame with poor concrete quality and inadequate reinforcement detailing. The considered solutions are based on FRP wrapping of the existing structural elements or alternatively on new RC shear walls introduction. This paper shows the comparison among the considered design strategies in order to select the suitable solution, which reaches the compromise between the obtained safety level and costs during the life-cycle of the building. Each solution is worked out by considering three different levels of seismic demand. The structural capacity of the considered retrofit solutions is assessed with nonlinear static analysis and the seismic performance is evaluated with the capacity spectrum method.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.30 no.3
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• pp.89-93
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• 2007

In this study, we consider an assembly line operated under a base-stock policy. A product consists of two parts, and a finished product transfers to a warehouse in which demands are satisfied. Assume that demands arrive according to a Poisson process and processing times at each production line are exponentially distributed. Whenever a demand arrives, it is satisfied immediately from an inventory in the warehouse if available; otherwise, it is backlogged and satisfied later by the next product exiting from production lines. In either case, an arriving demand automatically triggers the production of a part at both production lines. These two parts will be assembled into a product that eventually transfers to the warehouse. We obtain a closed form formula of approximation for delay time or lead time distribution of a demand when a base- stock level is s. Moreover, it can be applied to the optimal base-stock level which minimizes the total inventory cost. Numerical examples are presented to show our optimal base-stock level's quality.

• International Journal of Naval Architecture and Ocean Engineering
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• v.5 no.3
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• pp.468-477
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• 2013

An automatic pipe routing system is proposed and implemented. Generally, the pipe routing design as a part of the shipbuilding process requires a considerable number of man hours due to the complexity which comes from physical and operational constraints and the crucial influence on outfitting construction productivity. Therefore, the automation of pipe routing design operations and processes has always been one of the most important goals for improvements in shipbuilding design. The proposed system is applied to a pipe routing design in the engine room space of a commercial ship. The effectiveness of this system is verified as a reasonable form of support for pipe routing design jobs. The automatic routing result of this system can serve as a good basis model in the initial stages of pipe routing design, allowing the designer to reduce their design lead time significantly. As a result, the design productivity overall can be improved with this automatic pipe routing system.

• International Journal of High-Rise Buildings
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• v.9 no.3
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• pp.245-253
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• 2020

With the ever-increasing height of timber buildings, the complexity of timber as a structural material gives rise to behaviors not previously studied by engineers. An urgent call is needed regarding their performance in damage scenarios: activating alternative load paths in tall timber buildings is not the same as in tall buildings made with steel and concrete. In this paper we propose a robustness framework covering all building materials, whose application in timber may lead to new conceptual designs for the next generation of tall timber buildings. Qualitatively, the importance of building scale and the distinction between localized and systematic exposures are discussed, and how existing supertall structures can be an example for future generations of tall timber buildings. Quantitatively, the robustness index is introduced alongside a method to calculate the performance of a given building regarding robustness, in order to find the most cost-effective structural solutions for improved robustness. A three-level application recommendation is made, depending on the importance of the building in question. Primarily, the paper highlights the importance of conceptual design to achieve structural robustness and encourages the practicing engineering community to use the proposed framework to quantitatively come up with the new generation of tall timber buildings.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.363-371
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• 2008

As a computational method for the discovery of the effective agonists for PPARd, we address the usefulness of molecular dynamics free energy (MDFE) simulation with explicit solvent in terms of the accuracy and the computing cost. For this purpose, we establish an efficient computational protocol of thermodynamic integration (TI) that is superior to free energy perturbation (FEP) method in parallel computing environment. Using this protocol, the relative binding affinities of GW501516 and its derivatives for PPARd are calculated. The accuracy of our protocol was evaluated in two steps. First, we devise a thermodynamic cycle to calculate the absolute and relative hydration free energies of test molecules. This allows a self-consistent check for the accuracy of the calculation protocol. Second, the calculated relative binding affinities of the selected ligands are compared with experimental IC50 values. The average deviation of the calculated binding free energies from the experimental results amounts at the most to 1 kcal/mol. The computational efficiency of current protocol is also assessed by comparing its execution times with those of the sequential version of the TI protocol. The results show that the calculation can be accelerated by 4 times when compared to the sequential run. Based on the calculations with the parallel computational protocol, a new potential agonist of GW501516 derivative is proposed.

• Journal of Korean Society of Water and Wastewater
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• v.18 no.2
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• pp.222-227
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• 2004

Flotation processes involve the use of very small bubbles (micro-bubbles) to separate particles from water. The process has become a good alternative to sedimentation, especially where the particles are small or of low density. Although the flotation process commences with a collision between particles and bubbles, most research has been focused only on the characteristics of the particles. In this paper, recent theoretical and experimental research on the characteristics of bubbles is summarized. The effect on the collision efficiency of the size and charge of bubbles is calculated through trajectory analysis. The size and charge of bubbles are measured under different conditions and the ramifications of the results are discussed. The results may lead to a better understanding and optimization of the existing process. In particular, we discuss an idea that a new advanced flotation process might be possible by the modification of the characteristics of the bubble alone or of both bubble and particle.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.2
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• pp.178-182
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• 2011

Generally in order to reduce the steel weight of stiffened plate, stiffener spaces tend to be narrow and the plate gets thin. However, it will involve more fabrication cost because it can lead to the increase of welding length and the number of structural members. In the yard, the design which is able to reduce the total fabrication cost is needed, although it requires more steel weight. The purpose of this study is to find optimum stiffener spaces to minimize the fabrication cost for the cargo tank of LPG Carriers. Global optimization methods such as ES(Evolution Strategy) and GA(Genetic Algorithm) are introduced to find a global optimum solution and the sum of steel material cost and labor cost is selected as main objective function. Convergence degree of both methods in according to the size of searching population is examined and an efficient size is investigated. In order to verify the necessity of the optimum design based on the cost, minimum weight design and minimum cost design are carried out.

• 한국연소학회:학술대회논문집
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• 1998.10a
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• pp.9-21
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• 1998

The optimization of frontal device including fuel nozzle and swirler is required to secure the mixing of fuel and air, and the combustion stability in the gas turbine combustor design for the reduction of pollutant emissions and the increase of combustion efficiency. The effects of injection nozzle and swirler on the flow field, spray characteristics and consequently the combustion stability, were experimentally investigated by measuring the velocity field, droplet sizes of fuel spray, lean combustion limit and the temperature field in the main combustion region. The effect of fuel injection nozzle was tested by adopting three different nozzles; a dual orifice fuel nozzle, a hollow cone nozzle and a solid cone nozzle. These tests were combined with the three different swirler geometries; a dual-stage swirler with 40$^{\circ}$ /-4 5$^{\circ}$ vanes and two single-stage swirlers with 40$^{\circ}$ vane angle having 12 and 16vanes, respectively. Flow fields and spray characteristics were measured with APV(Adaptive Phase Doppler Velocimetry) under atmospheric condition using kerosine fuel. Temperatures were measured by Pt-PtI3%Rh, R-type thermocouple which was 0.2mm thick. It was found that the dual swirler resulted in the biggest recirculation zone with the highest reverse flow velocity at the central region, which lead the most stable combustion. The various combustion characteristics were observed as a function of the combination between the injector and swirler, that gave a tip for the better design of gas turbine combustor.

• International Journal of Railway
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• v.4 no.4
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• pp.97-102
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• 2011

In an EMS (Electromagnetic suspension)-type Maglev (Magnetically-levitated) vehicle, the flexibility of the bogie frame may affect the acceleration of the electromagnet that is input into the control system, which could lead to instability in some cases. For this reason, it is desirable to consider bogie frame flexibility in air gap simulations, for the optimization of bogie structure. The objective of this paper is to develop a flexible multibody dynamic model of 1/2 of an EMS-type Maglev vehicle that is under testing, and to compare the air gap responses obtained from the rigid and the flexible body model. The feedback control system and electromagnet models that are unique to the EMS-type maglev vehicle must be included in the model. With this model, dynamics simulations are carried out to predict the air gap responses from the two models, of the rigid and flexible model, and the air gaps are compared. Such a comparative study could be useful in the prediction of the air gap in the design stage, and in designing an air gap control system.