• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2004.11a
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• pp.185-197
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• 2004

Type 2 diabetes is characterized by hyperglycemia and hyperinsulinemia, features of insulin resistance. In vivo treatment of ob/ob mice with hydrolyzed fibroin reverses these pathological attributes (6). To explore the mechanism underlying this effect, we have used the 3T3-Ll adipocytes as a cell type which would represent the periphery, in vivo. Exposure of 3T3-Ll adipocytes to chronic insulin leads to the a 50% loss of insulin-stimulated glucose uptake. Chronic exposure to fibroin blocked, in part, the response to chronic insulin but also increased the sensitivity of control cells to the acute action of insulin. The later effect was most robust at physiological concentrations of insulin. Fibroin did not prevent the insulin-induced down-regulation of the insulin receptor or the tyrosine kinase activity associated with the receptor. Further, fibroin had no affect on the loss in activity of the insulin-sensitive down-stream kinase, Akt. Interestingly, fibroin accelerated glucose metabolism and glycogen turnover independent of insulin action. In addition, fibroin up-regulated GLUT1 which increased its expression at the cell surface and caused the redistribution of GLUT4 to the plasma membrane. Together, these later effects would lead to an improvement in hyperglycemia in vivo which would in turn reduce the need for insulin.

• Archives of Plastic Surgery
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• v.34 no.6
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• pp.719-723
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• 2007

Purpose: Blowout fracture can lead to functional impairments and esthetic deformities such as impairment of ocular movement, diplopia, visual loss and enophthalmos. The object of this study is to present a classification and its analysis according to the computed tomographic scan in blowout fractures. We classified blow out fractures into three types according to the anatomical location of fracture, the size of the bone defect and the degree of periosteal injury by using the computed tomography scan. Each progress and complications were analyzed more than mean 1 year. Methods: Among the 155 cases during 4 years, there were 11 cases of medial orbital wall fracture, 97 cases of inferior orbital wall fracture, 47 cases of combined type. The mean age of patients was 31.2 years, ranged from 8 to 84 years. Results: According to our classification, surgical treatments through the nasoendoscopic approach, the subciliary approach, the transconjunctival approach or their combinations were performed in 116 patients, and conservative treatments were done in 46 patients. Presurgical clinical findings of diplopia, impairment of ocular movement, enophthalmos of more than 2 mm were present in 62 patients. After surgical treatment, clinical findings were remained in 7 patients. Conclusion: We think that our classification according to computed tomographic scan is helpful for the indication and it may decrease the complications such as impairment of ocular movement, diplopia, visual loss and enophthalmos.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.11
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• pp.1323-1329
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• 2011

The purpose of study was to analyze how the visual information affects balance control of individuals during single leg stance. A total of 27 young normal people (20 males and 7 females, age: $13.7{\pm}2.6$, height: $162.3{\pm}13.2$ cm, weight: $53.9{\pm}13.9$ kg) was voluntarily involved in the experiment. The subjects were requested to maintain balance for 20 seconds with eyes both open and closed on a force plate and then foot ground reaction data were collected for that duration. Results showed that mean velocity of COP in closed eyes condition was larger 1.84 times than that of the open-eyes condition and range of vertical angle was increased approximately one degree in the closed eyes condition. To accomplish a balance, the frequency power in mediolateral and anteroposterior components of the foot-ground reaction force was increased by 1.3~1.4 times. Consequently, visual absence during single leg stance can result in critical loss of balance and lead to instability of body control.

• KIEAE Journal
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• v.5 no.2
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• pp.19-26
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• 2005

Every site has a different given geometrical and climatic condition, which influenced not only the lifestyle of the humanbeings but also the regional architecture. For example, on a cold region, the reduction of the energy loss is necessary, like an igloo, which has a littlest energy loss at hemisphere. Or on a warm region, the house must be protected thermally from the overheating at the sunshining. like a huge shading. An architectural interpretation in the (extreme) moderate climate, like Korea, has always tried to satisfy the both opposite demands simultaneously. A facade, which divides out- and inside, has an ideal position to lead the regulated regional climatic conditions into the room. The Double Facade System(DFS) is well known as an innovative solution in the european countries, like Germany. It provides an reasonable alternative, which can achieve these goals at the same time. A Double Facade System provides an effective sunshade, which means a cooling energy reduction at the warm season. In addition, it enables a natural ventilation at the cold season with the preheating at the system as well as spring and autumn. An ordinary Single Facade System with a inside or outside sun blind provides a solution just for a specified season, like a summer or winter. But the Double Facade System can deal with the various climatic conditions in the moderate climate.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.276-279
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• 2008

In order to measure sound transmission loss (STL) of a shipboard window of small size, a special partition is built into the test opening between two reverberation rooms and the specimen is placed in that partition. For high sound insulation, the filler wall often has multi-layered structure such as double-brick wall or buckhead structure with thick steel plate, absorptive material, and sandwich panels. This paper discusses the installation method of a multi-layered filler wall that consist of gypsum boards, lead plates, and glass wool. The experimental results of various wall structures are introduced. The comparison between the results show that the sound bridge effect plays a significant role in lowering the maximum STL of the filler wall. It is also found that the higher the sound insulation performance of the filler wall is, the more important the franking transmission through other side wall of the test facility is.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.12
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• pp.94-105
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• 2003

OBS(Optical Burst Switching) networks which decouple the burst from its header has characteristic one-way reservation. Therefore, the fault of a fiber link may lead to the magnitude of burst loss. Since sending a header packet and using an offset time before the transmission of the corresponding burst. In this paper, we analysis a offset time based on the burst loss rate resulting from only link failure and by applying the restoration schemes in an optical burst switching networks. The simulation results in terms of the effect of a offset time is evaluated in our network model to verify that comparing the numerical analysis with simulation result. Finally, and through these results, We propose the new restoration scheme based on offset time considered Quality of Service.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.55 no.9
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• pp.429-433
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• 2006

PZT(80/0) powder was prepared by a sol-gel method and PZT thick films were fabricated by the screen-printing method on the alumina substrates. The coating and drying procedure was repeated 4 times. And then the PZT(20/80) precusor solution was spin-coated on the PZT thick films. A concentration of a coating solution was 0.5mol/L and the number of coating was varied from 0 to 6. The porosity decreased and the grain size increased with increasing the number of coatings. The thickness of the PZT-6(6: number of coatings) films was about $60{\mu}m$. The relative dielectric constant increased and the dielectric loss decreased with increasing the number of PZT(20/80) sol coatings. The relative dielectric constant and dielectric loss of the PZT-6 thick film were 275 and 3.5%, respectively. The remanent polarization, coercive field and breakdown strength of the PZT-6 film were $19.8{\mu}C/cm^2$, 13.7kV/cm and 130kV/cm, respectively.

• Molecules and Cells
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• v.38 no.3
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• pp.251-258
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• 2015

Germline mutations in the breast cancer type 2 susceptibility gene (BRCA2) are linked to familial breast cancer and the progressive bone marrow failure syndrome Fanconi anaemia. Established Brca2 mouse knockout models show embryonic lethality, but those with a truncating mutation at the C-terminus survive to birth and develop thymic lymphoma at an early age. To overcome early lethality and investigate the function of BRCA2, we used T cell-specific conditional Brca2 knockout mice, which were previously shown to develop thymic lymphoma at a low penetrance. In the current study we showed that the number of peripheral T cells, particularly na$\ddot{i}$ve pools, drastically declined with age. This decline was primarily ascribed to improper peripheral maintenance. Furthermore, heterozygous mice with one wild-type Brca2 allele manifested reduced T cell numbers, suggesting that Brca2 haploinsufficiency might also result in T cell loss. Our study reveals molecular events occurring in Brca2-deficient T cells and suggests that both heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.11
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• pp.1523-1526
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• 2002

Genetic parameters of carcass weight (CWT), dressing percent (DP), cook loss (CL), eye muscle area (EMA), back fat thickness (BFT), and meat tenderness in terms of mastication (MAS), shear force (SFR) and penetration (PEN) in Korean native cattle were estimated in this study. Effects of sire, location and their interaction on these traits were also evaluated. Sire effects were found to be significant on all the traits studied except for PEN. The CWT and DP were also significantly affected both by location (p<0.01) and by interaction effect between sire${\times}$location (p<0.05). The EMA was significantly (p<0.05) affected by location but not by interaction effect between sire${\times}$location. All the traits were positively correlated ($r_g$ and $r_p$) with each other except between CL and meat tenderness (negatively correlated). Moderate to high genetic correlations between CWT and other important traits were obtained; indicating that selection for CWT would lead to improve carcass quality. Heritability estimates were 0.64, 0.52, 0.37, 0.25, 0.19 and 0.18 for MAS, SFR, CWT, PEN, DP and EMA, respectively.

• Science of Emotion and Sensibility
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• v.16 no.1
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• pp.11-28
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• 2013

This article aims to explore the interactive roles of types of primed identity (local versus global identity) and types of ad framing on brand evaluations. The authors designed 2 experiments in which each experiment followed a $2{\times}2$ between-subject design. The empirical results showed that a gain-framed ad induced more positive emotional responses than a loss-framed ad, and the positive affective responses lead to more favorable brand evaluation. Furthermore, the results showed that there were interactive effects of primed identity and types of advertisement frame on brand evaluation. In the additional analysis, the results showed that when people with local identity were exposed to the gain-framed ad, they would engage in a higher level of integration processing than those in the control group, which in turn induced more favorable evaluation to the local brand. That is, the integration processing mode played a mediating role between the interaction (local id priming ${\times}$ ad frame) and the local brand evaluation. However, in the case of global brand evaluation, the integration processing mode did not play such a mediating role.