• Title/Summary/Keyword: latent period

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Antinociceptive, antidiarrhoeal and cytotoxic activity of Aegiceras corniculatum

  • Ahmed, F;Mamun, AH AI;Shahid, IZ;Rahman, AA;Sadhu, SK
    • Advances in Traditional Medicine
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    • v.7 no.2
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    • pp.191-196
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    • 2007
  • The ethanol extract of leaves of the mangrove Aegiceras corniculatum Blanco (Myrsinaceae) was screened for its antinociceptive, antidiarrhoeal and cytotoxic activities. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001), which was comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrhoeal effects on castor oil induced diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the oral dose of 500 mg/kg body weight (P<0.05; P<0.01) comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. Moreover, when tested for toxicity using brine shrimp, the extract showed potent activity against the brine shrimp Artemia salina ($LC_{50}$ 10 mg/ml). The overall results tend to suggest the antinociceptive, antidiarrhoeal and cytotoxic activities of the extract.

Analysis of Lethality in Echinococcal Disease

  • Khachatryan, Anna S.
    • Parasites, Hosts and Diseases
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    • v.55 no.5
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    • pp.549-553
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    • 2017
  • The information on mortality from echinococcosis is important not only for a better understanding of the severity of the disease, but also for evaluating the effectiveness of public health interventions. The aim of this research was to study the causes of mortality from echinococcosis. We have collected and analyzed the materials of 1,470 patients in 10 age - groups in the Republic of Armenia (from 2000 to 2016). To find out the causes of mortality from echinococcosis, we have analyzed the medical histories and protocols of postmortem examinations of 19 deaths from echinococcosis and 17 deaths due to other indirect causes not associated with the parasite. The average annual death rate from echinococcosis is 0.007 per 10,000 population, and the mortality is 1.29 (per 100 patients). The highest mortality occurs in people aged 70-79. Mortality from echinococcosis is also recorded among the unoperated children. The rupture of the parasitic cyst and hepatic insufficiency are major among the direct causes of mortality. Sometimes the hydatid cysts unrecognized during the life were first diagnosed at autopsy. Insufficient qualification of doctors in the field of helminthology, as well as the latent course of the disease or manifestation of minor symptoms in echinococcosis over a long period often led to medical errors. Further decline in mortality can be achieved by early diagnosis, timely hospitalization and treatment before the development of severe complications worsening the prognosis and outcomes of surgical intervention.

Research Trend Analysis for Smart Grids Using Dynamic Topic Modeling (동적 토픽분석을 활용한 스마트그리드 연구동향 분석)

  • Na, Sang-Tae;Ahn, Joo-Eon;Jung, Min-Ho;Kim, Ja-Hee
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.66 no.4
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    • pp.613-620
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    • 2017
  • The power grid has been changed to a smart grid system to satisfy the growing need for power grid complexity, demand, reliability, security, and efficiency with a combination of existing power and ICT technology. This study analyzes the research trends in smart grid technology in the period since the introduction of the smart grid system and compares it with industrial trends to grasp the progress and characteristics of Smart Grid technology and look for ways to innovate the technology. To do this, we analyze the research trends using dynamic topic modeling, which is capable of time-series research topic analysis. Next, we compare the results of research trends with industrial trends analyzed by Gartner's experts to demonstrate that smart grid research is evolving to the level of industrialization. The results of this study are quantitative analysis through data mining, and it is expected that it will be used in many fields such as companies that want to participate in industry and government agencies that need to establish policies by showing more objective analysis results.

Survey of Garlic Virus Disease and phylogenetic Characterization of Garlic Viruses of the Genus Allexivirus Isolated in Korea

  • Koo, Bong-Jin;Kang, Sang-Cu;Chang, Moo-Ung
    • The Plant Pathology Journal
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    • v.18 no.5
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    • pp.237-243
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    • 2002
  • A survey of virus infection in garlic plants cultivated in Korea was conducted for three years. Most virus-infected garlic plants (Allium sativum) showed typical symptoms on the leaves such as yellow mosaic, stripes, and distortion. Through immunosorbent electron micro-scopy and RT-PCR analysis, the complex mixtures of viruses including garlic viruses of the genus Allerivirus, gaylic strain of Leek yellow stripe virus of the genus Potyvirus, and Garlic latent virus of the genus Carlavirus were identified in the virus-infected garlic plants. Among these viruses, Allexivirus was the most frequently detect-ed in the regions surveyed. Using sets of differential primers for Allexivirus genomes, two members of the genus were amplified and sequenced from the purified viruses. The deduced amino acid sequences for the coat proteins and the nucleic acid binding proteins of two viruses showed high homologies to Garlic virus A (CarV-A) and Garlic virus D (GarV-D) of Allekivirus. This is the first report of GarV-A and GarV-D in Korea. This suggests that Allexivirus in gavlic plants in Korea was mixed and varied. Phylogenetic analyses showed that the genus Allexivirus was diversi(ied by the processes of accumulation and evolution of viruses in garlic plants due to the long period of repeated vegetative propagation.

Isolation and Physiological Characterization of a New Algicidal Virus Infecting the Harmful Dinoflagellate Heterocapsa pygmaea

  • Kim, JinJoo;Kim, Chang-Hoon;Takano, Yoshihito;Jang, In-Kwon;Kim, Si Wouk;Choi, Tae-Jin
    • The Plant Pathology Journal
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    • v.28 no.4
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    • pp.433-438
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    • 2012
  • Dinoflagellates are considered one of the most abundant and diverse groups of marine microplankton and viruses are recognized as one of the significant factors affecting the plankton dynamics. Here, we report basic characteristics of a new dinoflagellate-infecting virus, Heterocapsa pygmaea DNA virus (HpygDNAV) which infects a toxic dinoflagellate, H. pygmaea. HpygDNAV is a polyhedral large virus (ca. 160-170 nm in diameter) propagating in its host's cytoplasm. Because of the virion size, appearance in thin sections, and propagation characteristics, HpygDNAV is assumed to harbor a large double-stranded DNA genome; i.e., HpygDNAV is most likely a nucleocytoplasmic large DNA virus (NCLDV) belonging to the family Phycodnaviridae. Its infectivity is strain-specific, rather than species-specific, as is the case for other algal viruses. The burst size and latent period are estimated to be roughly 100-250 infectious units $cell^{-1}$ and < 96 h, respectively.

Prevalence of the Vibration Syndrome among Rock-drillers in the Anthracite Mining Area (일부지역 탄광 착암 근로자의 진동증후군 유병율)

  • Roh, Jae-Hoon
    • Journal of Preventive Medicine and Public Health
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    • v.14 no.1
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    • pp.75-80
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    • 1981
  • Due to rapid industrialization and economic development, the occupational diseases have appeared as one of the social problems in Korea. Up until now little has been known about the prevalence rate, predisposing factors and symptomatology of the occupational disease due to localized vibration in Korea. The researcher intends to investigate the prevalence rate and affecting factors of the occupational disease due to localized vibration among rock-drillers in the anthracite mines. A total of 135 rock-drillers were interviewed and examined from May 15th to 31th, 1980. The results were revealed as follows; 1. The prevalence rate of the vibration syndrome among rock-drillers was 12.6%. 2. The latent period of the vibration syndrome was 6.8 years. 3. The prevalence rate of the vibration syndrome was not significantly different between smokers and non-smokers. 4. With the increase of total vibration exposure time, the prevalence rate of the vibration syndrome increased also. 5. The average vibration sensation threshold was high (6.4dB) in stage 1 of the vibration syndrome and low (-0.6dB) in stage 0. 6. The average pain sensation threshold was high (4.4g) in stage 1 of the vibration syndrome and low (2.5g) in stage 0.

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Forecasting probabilities of earthquake in Korea based on seismological data (지진 관측자료를 기반으로 한 한반도 지진 발생 확률 예측)

  • Choi, Seowon;Jang, Woncheol
    • The Korean Journal of Applied Statistics
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    • v.30 no.5
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    • pp.759-774
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    • 2017
  • Earthquake concerns have grown after a remarkable earthquake incident on September 12th, 2016 in Gyeongju, Korea. Earthquake forecasting is gaining in importance in order to guarantee infrastructure safety and develop protection policies. In this paper, we adopt a power-law distribution model to fit past earthquake occurrences in Korea with various historical and modern seismological records. We estimated power-law distribution parameters using empirical distributions and calculated the future probabilities for large earthquake events based on our model. We provide the probability that a future event has a larger magnitude than given levels, and the probability that a future event over certain levels will occur in a given period of time. This model contributes to the assessment of latent seismological risk in Korea by estimating future earthquake probabilities.

Experimental Study of the Effect on Cabin Thermal Comfort for Cold Storage Systems in Vehicles (축냉 시스템이 차 실내 열 쾌적성에 미치는 영향에 관한 실험적 연구)

  • Lee, Daewoong
    • Transactions of the Korean Society of Automotive Engineers
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    • v.23 no.4
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    • pp.428-435
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    • 2015
  • This paper presents the experimental study of cabin thermal comfort using a cold storage heat exchanger in a vehicle air-conditioning system. Recent vehicle-applied ISG functions for fuel economy and emission, but when vehicles stop, compressors in the air-conditioning system stop, and the cabin temperature sharply increases, making passengers feel thermal discomfort. This study conducts thermal comfort evaluation in the vehicle, which is applied to a cold storage system for the climate control wind tunnel test and the vehicle fleet road test with various airflow volume rates and ambient temperatures blowing to the cold storage heat exchanger. The experimental results, in the cold storage system, air discharge temperature is $3.1-4.2^{\circ}C$ lower than current air-conditioning system when the compressor stops and provides cold air for at least 38 extra seconds. In addition, the blowing airflow volume to the cold storage heat exchanger with various ambient temperature was examined for the control logic of the cold storage system, and in the results, the airflow volume rate is dominant over the outside temperature. For this study, a cold storage system is economically useful to keep the cabin at a thermally comfortable level during the short period when the engine stops in ISG vehicles.

Effects of Aromatherapy on Labor Pain & Perception of Childbirth Experience (아로마테라피가 분만동통 및 분만경험지각에 미치는 효과)

  • Hur, Myung-Haeng;Oh, Hee-Young;Park, Young-Sook
    • Women's Health Nursing
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    • v.11 no.2
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    • pp.135-141
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    • 2005
  • Purpose: The purposes of this study were to verify the effects of aromatherapy on labor pain and perception of the childbirth experience. Methods: This study was a nonequivalent control group pretest-posttest design. The subjects of this experiment consisted of forty eight primiparas without problems during the gestation period. Twenty four primiparas in the experimental group were given general obstetric nursing care with aromatherapy every two hours. Twenty four primiparas in the control group were given general obstetric nursing care only. Data was collected for labor pain measured by a labor pain expression scale, uterine contraction activity measured by Montevideo units in the latent phase, active phase, and transition phase and the perception of childbirth experience 24hours after birth. Data was analyzed by t-test, and repeated measures of ANOVA with an SPSS program. Results: No significant group effects were found, but significant time effects were found for labor pain, and uterine contraction activity. There was no significant difference in postpartum mothers' perception about childbirth. Conclusion: In this study, effects of aromtherapy decreasing labor pain expression, and increasing the perception of childbirth was not found.

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The Effects of Parenting Practice on the Trajectories of Change in the School Adjustment of Upper Elementary Students (부모의 양육방식이 초등학교 고학년의 학교생활 적응의 변화 궤적에 미치는 영향)

  • Lee, Jungmin;Kang, Sujeong;Lee, Kangyi;Yi, Soonhyeong
    • Korean Journal of Child Studies
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    • v.36 no.4
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    • pp.91-110
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    • 2015
  • In upper elementary period school adjustment and the effect of parenting face a new set of dynamics. We assumed that parental supervision, affection, incoherence, over-expectation, over-interruption and logical explanation would have an effect on individual trajectories in the development of school adjustment. Additionally, we hypothesized that this model would be different among boys and girls. In this study we analyzed three waves of data collected from 2,378 children nationwide in South Korea. This data was gathered from the Panel Study of Korean Youth and Adolescents conducted by the National Youth Policy Institute(NYPI). Growth-curve longitudinal analysis was conducted and the results indicate that levels of school adjustment had decreased through the $4^{th}$ to $6^{th}$ grade. Parents' supervision, affection and logical explanation significantly predict children's initial school adjustment as well as their rate of decrease in their levels of school adjustment. Parents' supervision had a positive effect on girls' school adjustment. Parents' over-expectation had negative effect on boys' school adjustment levels. Policy implications and future directions for research were also discussed.