• Biomolecules & Therapeutics
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• 제7권3호
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• pp.242-248
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• 1999

Diazepam, a benzodiazepine (BDZ) agonist, produces sedation and flumazenil, a BDZ antagonist, blocks these actions. The aim of this study was to examine the effects of BDZs on cortical electroencephalogram (EEG) in rats. The recording electrodes were implanted over the frontal and parietal cortices bilaterally, and the reference and ground electrodes over cerebellum under ketamine anesthesia. To assess the effects of diazepam and flumazenil, rats were injected with diazepam (1 mgHg, i.p.) and/or flumazenil ( 1 mg/kg, i.p.), and the EEG was recorded before and after drugs. Normal awake had theta peak in the spectrum and low amplitude waves, while normal sleep showed large amplitude of slow waves. The powers of delta, theta and alpha bands were increased during sleep compared with during awake. Diazepam reduced the mobility of the rat and induced sleep with intermittent fast spindles and large amplitude of slow activity, and it produced broad peak over betaL band and increased the power of gamma band, which were different from EEG patterns in normal sleep. Saline injection awakened rats and abolished fast spindles for a short period about 2-5 min from EEG pattern during diazepam-induced sleep. Flumazenil blocked both diazepam-induced sleep and decreased the slow activities of delta, theta, alpha and betaL, but not of gamma activity for about 10 min or more. This study may indicate that decrease in power of betaL and betaH bands can be used as the measure of central action of benzodiazepines, and that the EEG parameters of benzodiazepines have to be measured without control over the behavioral state by experimenter.

• Korea-Australia Rheology Journal
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• 제18권2호
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• pp.67-81
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• 2006

Using a strain-controlled rheometer, the dynamic viscoelastic properties of aqueous xanthan gum solutions with different concentrations were measured over a wide range of strain amplitudes and then the linear viscoelastic behavior in small amplitude oscillatory shear flow fields was investigated over a broad range of angular frequencies. In this article, both the strain amplitude and concentration dependencies of dynamic viscoelastic behavior were reported at full length from the experimental data obtained from strain-sweep tests. In addition, the linear viscoelastic behavior was explained in detail and the effects of angular frequency and concentration on this behavior were discussed using the well-known power-law type equations. Finally, a fractional derivative model originally developed by Ma and Barbosa-Canovas (1996) was employed to make a quantitative description of a linear viscoelastic behavior and then the applicability of this model was examined with a brief comment on its limitations. Main findings obtained from this study can be summarized as follows: (1) At strain amplitude range larger than 10%, the storage modulus shows a nonlinear strain-thinning behavior, indicating a decrease in storage modulus as an increase in strain amplitude. (2) At strain amplitude range larger than 80%, the loss modulus exhibits an exceptional nonlinear strain-overshoot behavior, indicating that the loss modulus is first increased up to a certain strain amplitude(${\gamma}_0{\approx}150%$) beyond which followed by a decrease in loss modulus with an increase in strain amplitude. (3) At sufficiently large strain amplitude range (${\gamma}_0>200%$), a viscous behavior becomes superior to an elastic behavior. (4) An ability to flow without fracture at large strain amplitudes is one of the most important differences between typical strong gel systems and concentrated xanthan gum solutions. (5) The linear viscoelastic behavior of concentrated xanthan gum solutions is dominated by an elastic nature rather than a viscous nature and a gel-like structure is present in these systems. (6) As the polymer concentration is increased, xanthan gum solutions become more elastic and can be characterized by a slower relaxation mechanism. (7) Concentrated xanthan gum solutions do not form a chemically cross-linked stable (strong) gel but exhibit a weak gel-like behavior. (8) A fractional derivative model may be an attractive means for predicting a linear viscoelastic behavior of concentrated xanthan gum solutions but classified as a semi-empirical relationship because there exists no real physical meaning for the model parameters.

• 대한의생명과학회지
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• 제18권3호
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• pp.218-226
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• 2012

Dopamine is an enteric neurotransmitter that regulates gastrointestinal motility. This study was done to investigate whether dopamine modulates spontaneous pacemaker activity in cultured interstitial cells of Cajal (ICCs) from mouse using whole cell patch clamp technique, RT-PCR and live $Ca^{2+}$ imaging analysis. ICCs generate pacemaker inward currents at a holding potential of -70 mV and generate pacemaker potentials in current-clamp mode. Dopamine did not change the frequency and amplitude of pacemaker activity in small intestinal ICCs. On the contrary dopamine reduced the frequency and amplitude of pacemaker activity in large intestinal ICCs. RT-PCR analysis revealed that Dopamine2 and 4-receptors are expressed in c-Kit positive ICCs. Dopamine2 and 4 receptor agonists inhibited pacemaker activity in large intestinal ICCs mimicked those of dopamine. Domperidone, dopamine2 receptor antagonist, increased the frequency of pacemaker activity of large intestinal ICCs. In $Ca^{2+}$-imaging, dopamine inhibited spontaneous intracellular $Ca^{2+}$ oscillations of ICCs. These results suggest that dopamine can regulate gastrointestinal motility through modulating pacemaker activity of large intestinal ICCs and dopamine effects on ICCs are mediated by dopamine2 receptor and intracellular $Ca^{2+}$ modulation.

• 전자공학회논문지
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• 제52권2호
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• pp.119-124
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• 2015

본 논문은 광원 라인폭이 spectral amplitude coding (SAC) OCDMA 시스템에 미치는 영향을 구하였다. q와 m값에 따라 다양한 코드를 구현할 수 있으므로 symmetric balance incomplete block design(BIBD) 코드를 분석에 사용하였다. 그 결과 입력파워가 큰 경우 ($P_{sr}=-10dBm$) 이상적인 BIBD 코드가 비이상적인 BIBD 코드보다 더 좁은 광원 라인폭이 요구되었다. 그러나 입력파워가 작은 경우 ($P_{sr}=-25dBm$)에는 그 반대로 비이상적인 BIBD 코드가 이상적인 BIBD 코드보다 더 좁은 광원 라인폭이 필요했다.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 춘계학술대회 초록집
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• pp.180.1-180.1
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• 2010

Wind turbine noise is generally lower than that from other environmental noise sources such as road and railway noise. Nevertheless, some residents living more than 1km away from wind turbines have claimed that they suffer sleep disturbance due to wind turbine noise. Several researchers have maintained that residents near a wind farm may perceive large amplitude modulation of wind turbine noise at night, and this amplitude modulation is the main cause of the noise annoyance. However, to date only few studies exist on the prediction of the amplitude modulation of wind turbine noise. Thus, this study predicts amplitude modulated noise generated from a generic 2.5MW wind turbine. Semi-empirical noise models are employed to predict the modulation depth and the overall sound pressure level of the wind turbine noise. The result shows that the amplitude modulation is observed regardless of atmospheric stability, but the modulation depth in a stable atmosphere is 1~3dB higher than that in an unstable atmosphere near the plane of rotation where the blades move downward. Moreover, using the result of the noise prediction, this study estimates the maximum perceptible distance of the wind turbine noise cause by amplitude modulation. The result indicates that the wind turbine noise can be perceived at a distance of up to 1600m in the range of about 30~60 degree from the on axis in a extremely low background noise environment.

• 음성과학
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• 제5권1호
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• pp.81-88
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• 1999

This paper provides a method for speech detection. After first order FIR filtering on the speech signals, we applied the conventional method of endpoint detection which utilizes the energy as the criterion in separating signals from background noise. By FIR filtering, only the Fourier components with large values of [amplitude x frequency] become significant in energy profile. By applying this procedure to the 445-words database constructed from ETRI, we confirmed that the low-amplitude noise and/or the low-frequency noise are separated clearly from the speech signals, thereby enhancing the feasibility of ideal endpoint detections.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1990년도 봄 학술발표회 논문집
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• pp.12-17
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• 1990

Stepped bean with immovable ends for large amplitude of vibration including effects of longitudinal displacement, shear deformation and rotary inertia is investigated for free and forced vibration using finite element method. Modified harmonic force matrix is introduced for analysis of vibration with finite amplitude of the stepped beam under uniform hamonic loading and beam with nonuniform harmonic loading. Numerical examples of stepped beam with various support conditions are analysed for deflections and natural frequencies. Results show that the proposed method is valid and efficient.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1997년도 추계학술대회논문집; 한국과학기술회관; 6 Nov. 1997
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• pp.339-344
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• 1997

Samsung Ltd. has developed a new-type cab mount for specific use on construct ion machinery subjected to strong vibration and multi-directional impact force. These all make it possible to achieve an excellent damping effect over a wide frequency range against large amplitude vibration as well as excellent insulation against small-amplitude vibration. This new mount make lower vibration and noise levels while increasing riding comfort at the same time. Characteristics of Cab mount were optimized through computer simulation, advanced bench testing, ODS testing, and a real equipment offroad testing.

• 대한수의학회지
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• 제27권1호
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• pp.19-25
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• 1987

To validate the comparision of proximal and distal large intestinal motility, the amplitude and frequency of spontaneous motility, the effect of acetylcholine, the effect of atropine on the response of acetylcholine, the effect of histamine and the effect of pyrilamine and cimetidine on the response of histamine were investigated in rabbit. The results were summarized as follows: 1. The amplitude of spontaneous motility was more powerful on the proximal large intestine than that of the distal large intestine, but the frequency of spontaneous motility was similar on the both proximal and distal large intestine in rabbit. 2. Acetylcholine caused the contraction of proximal and distal large intestine, and the contractile response were increased between the concentration of acetylcholne $10^{-9}$ and $5{\times}10^{-6}M$ and $10^{-7}$ and $10^{-4}M$ on the proximal and distal large intestine, respectively, with dose-dependent manner in rabbit. 3. The contractile response induced by acetylcholine was completely blocked by the post-treatment with cholinergic receptor blocker, atropine $10^{-6}M$. 4. Histamine caused the contraction of proximal and distal large intestine and the contractile response were increased between the concentration of histamine $10^{-9}$ and $5{\times}10^{-5}M$ and $10^{-5}$ and $10^{-3}M$ on the proximal and distal large intestine, respectively, with dose-depend ent manner in rabbit. 5. The contractile response induced by histamine was completely blocked by the pretreatment with $H_1$-receptor blocker, pyrilamine $10^{-6}M$, but not blocked by the pretreatment with $H_2$-receptor blocker, cimetidine $10^{-6}M$.

• Korea-Australia Rheology Journal
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• 제18권2호
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• pp.91-98
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• 2006

We compare FT (Fourier Transform) and SD (Stress Decomposition), the interpretation methods for LAOS (Large Amplitude Oscillatory Shear). Although the two methods are equivalent in mathematics. they are significantly different in numerical procedures. Precision of FT greatly depends on sampling rate and length of data because FT of experimental data is the discrete version of Fourier integral theorem. FT inevitably involves unnecessary frequencies which must not appear in LAOS. On the other hand, SD is free from the problems from which FT suffers, because SD involves only odd harmonics of primary frequency. SD is based on two axioms on shear stress: [1] shear stress is a sufficiently smooth function of strain and its time derivatives; [2] shear stress satisfies macroscopic time-reversal symmetry. In this paper, we compared numerical aspects of the two interpretation methods for LAOS.