• 한국산업보건학회지
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• 제23권3호
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• pp.307-314
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• 2013

Objectives: The aim of this study was to determine the prevalence of symptoms relating to musculoskeletal disorders (MSDs) and investigate the risk factors among researchers at university laboratories. Methods: 209 researchers were included in this study, drawn from 27 laboratories at three universities in Korea. Checklists for MSD symptoms and risk factor assessment were utilized. Results: The symptoms checklist showed reliable results with Cohen's Kappa 0.33-0.56, percent agreement 81.0-96.8%, and correlation coefficient 0.41-0.63. The overall prevalence of MSD symptoms was 68.9%, while the prevalence in specific parts of body were as follows: shoulders (47.6%), lower back (46.9%), neck (46.9%), knees (25.4%), wrists (20.1%), elbows (13.6%). The symptom prevalence among women was higher than among men (OR 2.67, 95% CI 1.37-5.18). Daily exposure time was observed to be a significant risk factor for developing MSD symptoms (OR 2.14-6.07). Conclusions: This study suggested that repetitive pipetting and static work posture are the most significant risk factors for MSD symptoms among laboratory researchers.

• Restorative Dentistry and Endodontics
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• 제49권1호
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• pp.4.1-4.9
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• 2024

Objectives: This study aims to correlate caries-causing microorganism load, lactic acid estimation, and blood groups to high caries risk in diabetic and non-diabetic individuals and low caries risk in healthy individuals. Materials and Methods: This study includes 30 participants divided into 3 groups: Group A, High-risk caries diabetic individuals; Group B, High-risk caries non-diabetic individuals; and Group C, Low-risk caries individuals. The medical condition, oral hygiene, and caries risk assessment (American Dental Association classification and International Caries Detection and Assessment System scoring) were documented. Each individual's 3 mL of saliva was analyzed for microbial load and lactic acid as follows: Part I: 2 mL for microbial quantity estimation using nutrient agar and blood agar medium, biochemical investigation, and carbohydrate fermentation tests; Part II: 0.5 mL for lactic acid estimation using spectrophotometric analysis. Among the selected individuals, blood group correlation was assessed. The χ² test, Kruskal-Wallis test, and post hoc analysis were done using Dunn's test (p < 0.05). Results: Group A had the highest microbial load and lactic acid concentration, followed by Groups B and C. The predominant bacteria were Lactobacilli (63.00 ± 15.49) and Streptococcus mutans (76.00 ± 13.90) in saliva. Blood Group B is prevalent in diabetic and non-diabetic high-risk caries patients but statistically insignificant. Conclusions: Diabetic individuals are more susceptible to dental caries due to high microbial loads and increased lactic acid production. These factors also lower the executing tendency of neutrophils, which accelerates microbial accumulation and increases the risk of caries in diabetic individuals.

• Journal of Genetic Medicine
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• 제18권1호
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• pp.38-43
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• 2021

Purpose: Demand for genetic counseling on cancer predisposition syndrome is increasing. We evaluated the psychological effect on counselees after genetic counseling at a clinic in a single center. Materials and Methods: We surveyed a total of 72 enrolled participants who visited a genetic counseling clinic at the Samsung Medical Center (SMC). The initial survey was conducted before the first genetic counseling session, and the second survey was conducted after the second genetic counseling session. A total of 43 participants completed both the initial and second surveys. Results: The initial survey of 72 participants indicated higher feelings of guilt in the group with religion, higher depression and anxiety in the group with a diagnosis of self, and higher anxiety in the group on self-referral to the genetic counseling clinic. In the completed survey of 43 participants, overall decreased depression was observed after the second genetic counseling session (P=0.013). Risk perception and anxiety decreased in the group diagnosed with benign variant/variant of uncertain significance (BV/VUS, 25/3) and increased in the group diagnosed with pathogenic variant (PV, 15). Risk perception and anxiety differed between the BV/VUS and PV groups (P<0.001 and P=0.03, respectively). Conclusion: The genetic counseling clinic at the SMC was effective in ameliorating the depression score. Assessment of survey results revealed different depression scores, feelings of guilt and anxiety, and different effects of the genetic counseling clinic, depending on the subgroups. Understanding the needs and psychological characteristics of different groups is necessary for improving genetic counseling services.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.348-348
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• 2005

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(1)
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• pp.899-905
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• 1998

The analysis priority makings the recommendation to reduce the total core damage frequency (CDF) of Wolsong nuclear Power Plant nits 2/3/4 was Performed in this paper. In order to derive the recommendation, the sensitivity analysis of CDF on which major contributors effect m performed based on the accident quantification results during Level 1 Probabilistic safety assessment (PSA). Priorities were ranked in tile way that compares the CDF reduction rate with efforts required to implement those recommendations using risk matrix

• Wind and Structures
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• 제26권1호
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• pp.45-56
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• 2018

Wind damage of urban trees arises to be a serious issue especially in the typhoon-prone areas. As a family of tree species widely-planted in Southeast China, the structural behaviors of Plane tree is investigated. In order to accommodate the complexities of tree morphology, a fractal theory based finite element modeling method is proposed. On-site measurement of Plane trees is performed for physical definition of structural parameters. It is revealed that modal frequencies of Plane trees distribute in a manner of grouped dense-frequencies; bending is the main mode of structural failure. In conjunction with the probability density evolution method, the fragility assessment of urban trees subjected to wind excitations is then proceeded. Numerical results indicate that small-size segments such as secondary branches feature a relatively higher failure risk in a low wind level, and a relatively lower failure risk in a high wind level owing to windward shrinks. Besides, the trunk of Plane tree is the segment most likely to be damaged than other segments in case of high winds. The failure position tends to occur at the connection between trunk and primary branches, where the logical protections and reinforcement measures can be implemented for mitigating the wind damage.

• 한국산업보건학회지
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• 제22권2호
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• pp.164-173
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• 2012

Objectives: Epichlorohydrin is a material that has been predicted to have high volatility and strong toxicity and is used normally in working area. Therefore, the hazardous and dangerous level and the foreign management system about epichlorohydrin should be invested at home and abroad and through hazard assessment for occupational environment measurement and exposure status of industrial workers in domestic working area. Methods: To assess risk and to suggest Development and Adoption to prevent health damage of workers owing to the epichlorohydrin exposure, the hazardousness and dangerousness of epichlorohydrin and its practical examples and regulation level for domestic and abroad health impairment are researched on the base of various references. Results: The epichlorohydrin caused skin and mucus membrane irritation, respiratory paralysis, kidney and live damage under the influence of acute toxicity and in animal study, it was confirmed as a doubtful carcinogenic substance to trigger reducement of sperm number and reproduction ability, abnormal spermatogenesis, mutagen, increase of forestomach epithelium and occurrence of papilloma and so on, as well as it induced stimulus asthma and allergic contact dermatitis for exposure workers. Conclusions: Epichlorohydrin was found to occur allergic contact dermatitis, carcinogenesis doubt and reproduction toxicity and was verified as a material which would be established reinforcement of management level to care health of handlers, such as denotement dangerousness of skin absorption.

• Geomechanics and Engineering
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• 제36권5호
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• pp.455-464
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• 2024

Seismic movements have varying effects on structures based on characteristics of local site. During an earthquake, weak soils are susceptible to damage due to amplified wave amplitudes. Soil-structure interaction issue has garnered increased attention in Türkiye, after devastating earthquakes in Kocaeli Gölcük (1999), Izmir (2020), Kahramanmaraş Pazarcık and Elbistan (2023). Consequently, liquefaction potential has been investigated in detail for different regions of Türkiye, mainly with available field test results. Çankırı, a city located close to North Anatolian Fault, is mainly built on alluvium, which is prone to liquefaction. However, no study on liquefaction hazard has been conducted thus far. In this study, groundwater level map, SPT map, and liquefaction risk map have been generated using Geographical Information System (GIS) for the Buğday Pazarı District of Çankırı province. Site investigations studies previously performed for 47 parcels (76 boreholes) were used within the scope of this study. The liquefaction assessment was conducted using Seed and Idriss's (1971) simplified method and the visualization of areas susceptible to liquefaction risk has been accomplished. The results of this study have been compared with the City Council's precautionary map which is currently in use. As a result of this study, it is recommended that minimum depth of boreholes in the region should be at least 30m and adequate number of laboratory tests particularly in liquefiable areas should be performed. Another important recommendation for the region is that detailed investigation should be performed by local authorities since findings of this study differ from currently used precautionary map.

• 한국군사과학기술학회지
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• 제18권3호
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• pp.335-342
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• 2015

Laboratory facilities for biology are designed as biosafety level 1, biosafety level 2, biosafety level 3, and biosafety level 4. Biosafety level designations are based on a composite of the design features, construction, containment facilities, equipment, practice and operation procedures required for working with agents from the various risk groups. Generally, biosafety level 3 means the facility that is appropriate for the experiments using pathogens which can cause serious diseases by aerosol transmission. The biosafety level assigned for the specific work to be done is driven by professional judgement based on a risk assessment, rather than by automatic assignment according to the particular risk group designation of the pathogenic agents to be used. In this paper, we introduced the biosafety level 3 facility operated in ADD(Agency for defense development). It contains the overview of facility, microbiological experiment, animal experiment, decontamination and waste disposal. Biosafety level 3 laboratory in ADD has served the vital role in the research of biological agents and antidote development.

• 대한의생명과학회지
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• 제22권4호
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• pp.140-149
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• 2016

All pesticides must be assessed strictly whether safe or not when agricultural operators are exposed to the pesticides in farmland. A pesticide is commonly regarded as safe when estimated dermal absorption amount is lower than the acceptable operator's exposure level (AOEL). In this study, dermal absorption rate of chlorpyrifos, a widely used organophosphate insecticide, was investigated using rat dermal tissue model. Chlorpyrifos wettable powder solved in water (250, 500 and 2,500 ppm) was applied to freshly excised rat dermal slices ($341{\sim}413{\mu}m$ thickness) on static Franz diffusion cells at $32^{\circ}C$ for 6 hours. After exposure period of 6 hours, and then washing-at residual amount of chlorpyrifos was analyzed in dermal tissues, tape strips, washing solution, washing swabs of receptor bottles and receptor fluids at 1, 2, 4, 8 and 24 hours. Chlorpyrifos was only detected in dermal tissue but not found in receptor fluid at each concentration and time point, and the absorption rate of 250, 500 and 2,500 ppm was 2.36%, 1.96% and 1.69%, respectively. The estimated exposure level of chlorpyrifos was calculated as 0.012 mg/kg bw/day. The health risk for farmers in this condition is a level of concern because the estimated exposure level is 12 times higher than AOEL 0.001 mg/kg bw/day. However, actual health risk will be alleviated than estimated because absorbed chlorpyrifos is not permeated into internal body system and only retained in skin layer.