• Toxicological Research
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• 제21권2호
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• pp.87-98
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• 2005

Human exposure to nano-sized particles (NSP) has increased over the last century with anthropogenic sources, and the rapid development of nanotechnology becomes an another source of such exposure. Information regarding the safety of nanotechnology and its product, nanoparticles, is urgently needed when assuming exposure through inhalation, oral intake, and penetration across skin is ever increasing as growing nanotechnology rapidly. The recent advancement of biokinetic studies with NSP and newer epidemiologic and toxicologic studies with ultrafine particles can be the basis for the nanotoxicology. Some concepts of nanotoxicology can be known from the results of these results. Specific small size of NSP, when inhaled, facilitates deposition by difusional mechanism in all regions of the respiratory tract and uptake into cells, ranscytosis across epithelial and endothelial cells into the blood and lymph circulation to reach target sites. Translocation along axons and dendrites of neuron makes an access to CNS and ganglia. These biokinetics are dependent on NSP surface chemistry. Risk assessments of NSP include appropriate and relevant doses/concentration selections, the increase effects in the organism and the benefits of possible desirable effects. An interdisciplinary team approach is desirable for nanotoxicology research and an appropriate risk assessment.

• 설비공학논문집
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• 제25권10호
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• pp.534-539
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• 2013

In general, entire supply air of the BSL3 laboratory should be vented to the outside for its biosafety and the air conditioning system should always be operating to maintain a room pressure difference. In this regard, annual energy consumption is approximately five or ten times greater than the magnitude of the office building. In addition, to adjust room pressure difference to the set value efficiently, the supply and exhaust duct system are installed in each room of the BSL3 lab. Thus, initial construction cost is extremely high. In this study, multizone simulation is performed to estimate maintaining the appropriate room pressure difference in the case of changing model A (each room supply and exhaust system) to model B (each zone supply and exhaust system) for verification of the BSL3 lab biosafety. Also, in the case of these two models, the multizone simulation for three kinds of biohazard scenario is performed as part of risk assessment. The analysis of initial construction cost of two models is conducted for comparison. According to the studies, initial construction cost of model B is less than about 22% of existing model A. Moreover, biosafety of the BSL3 lab is still maintaining in the case of the two models.

• 한국전문물리치료학회지
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• 제28권3호
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• pp.161-167
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• 2021

Understanding sciences behind fall-related hip fractures in older adults is important to develop effective interventions for prevention. The aim of this review is to provide biomechanical understanding and prevention strategies of falls and related hip fractures in older adults, in order to guide future research directions from biomechanical perspectives. While most hip fractures are due to a fall, a few of falls are injurious causing hip fractures, and most falls are non-injurious. Fall mechanics are important in determining injurious versus non-injurious falls. Many different biomechanical factors contribute to the risk of hip fracture, and effects of each individual factors are known well. However, combining effects, and correlation and causation among the factors are poorly understood. While fall prevention interventions include exercise, vision correction, vitamin D intake and environment modification, injury prevention strategies include use of hip protectors, compliant flooring and safe landing strategies, vitamin D intake and exercise. While fall risk assessments have well been established, limited efforts have been made for injury risk assessments. Better understanding is necessary on the correlation and causation among factors affecting the risk of falls and related hip fractures in older adults. Development of the hip fracture risk assessment technique is required to establish more efficient intervention models for fall-related hip fractures in older adults.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.267.1-267.1
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• 2002

The potential allergenicity of the transgene products in genetically modified organisms (GMOs). has been an important issue. As a part of the risk assessment of GMOs. we investigated the physicochemical stability and the immunogenicity of food allergens to determine their allergenicity. We have systematically evaluated the stability of food allergens in the gastrointestinal tract by using simple models of gastric (Stimulated gastric fluid) and intestinal (Stimulated intestinal fluid) digestion. (omitted)

• 대한안전경영과학회지
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• 제14권3호
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• pp.11-19
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• 2012

Especially because of the distinctiveness that new experiments and research provoke coexistence of various risk factors, the researchers in university laboratory are being exposed to incidents that are difficult to predict. Due to the fact that the numbers of accidents that occur at the university laboratory are increasing, the necessity for laboratory safety management is on the rise. Most laboratory accidents are caused by the ability that can detect risk factors such as unsafe behavior or unsafe condition but is not working perfectly. In order to prevent researchers in advance from unsafe behavior or unsafe condition, effective safety education, systematic safety management, safe research environment, continuous safety check and proper measures after accident are the most important factors. In this study, survey was conducted in university laboratory to identify the factors that affect on safety management and to measure the safety management level. As a result, effective measures are proposed for the improvement of the safety management level.

• 한국화재소방학회논문지
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• 제29권5호
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• pp.88-95
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• 2015

본 논문에서는 일상생활에서 화재에 대한 주민들의 경각심을 고취시킬 수 있도록 기상조건에 따른 화재위험을 평가할 수 있는 날씨 관련 서비스를 제안한다. 제안된 서비스는 기상예보에 따른 화재위험평가등급과 특정 기상조건에서 화재요인에 따른 화재위험도를 제공한다. 제안한 서비스에서는 데이터마이닝 기법인 의사결정트리를 이용하여 화재조사데이터와 관측된 기상데이터로부터 화재위험평가등급을 산출할 수 있는 화재 위험도 매트릭스를 생성한다. 주민들은 제안한 서비스를 통해 특정 기상조건에서 화재요인에 따라 화재위험도를 직접 평가할 수 있고, 화재위험도를 저감시킬 수 있는 예방책을 사용자가 선택할 수 있다. 제안한 서비스를 시스템화하여 서비스의 현실성을 확인하였다. 시스템은 온라인상에서 기상청의 기상예보가 갱신될 때마다 시도별로 기상예보에 따른 화재위험평가등급을 표시하고, 각 시도별로 해당 기상조건에서 화재요인에 따라 화재위험도를 평가할 수 있다.

• 한국품질경영학회:학술대회논문집
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• 한국품질경영학회 2004년도 품질경영모델을 통한 가치 창출
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• pp.266-271
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• 2004

Recently, consumers require products with high-reliability and high-safety. Risk management system and product safety become more important issue In view of product liability. This paper aims to propose a risk assessment system which can be applied to product with high-reliability and high-safety, and also show an empirical application of the proposed risk assessment system for the development of motorcycle helmets.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2006년도 춘계학술대회
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• pp.93-102
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• 2006

• Molecular & Cellular Toxicology
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• 제3권sup4호
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• pp.34.3-34.3
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• 2007

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.180-180
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• 2002

The potential allergenicity of the transgene products in genetically modified organisms (GMOs), has been an important issue. As a part of the risk assessment of GMOs, we investigated the physicochemical stability and the immunogenicity of food allergens to determine their allergenicity.(omitted)