• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4377-4384
• /
• 2014

According to the World Health Organization (WHO), 1.37 million people died of lung cancer all around the world in 2008, occupying the first place in all cancer-related deaths. However, this number might be decreased if patients were detected earlier and treated appropriately. Unfortunately, traditional imaging techniques are not sufficiently satisfactory for early detection of lung cancer because of limitations. As one alternative, breath volatile organic compounds (VOCs) may reflect the biochemical status of the body and provide clues to some diseases including lung cancer at early stage. Early detection of lung cancer based on breath analysis is becoming more and more valued because it is non-invasive, sensitive, inexpensive and simple. In this review article, we analyze the limitations of traditional imaging techniques in the early detection of lung cancer, illustrate possible mechanisms of the production of VOCs in cancerous cells, present evidence that supports the detection of such disease using breath analysis, and summarize the advances in the study of E-noses based on gas sensitive sensors. In conclusion, the analysis of breath VOCs is a better choice for the early detection of lung cancer compared to imaging techniques. We recommend a more comprehensive technique that integrates the analysis of VOCs and non-VOCs in breath. In addition, VOCs in urine may also be a trend in research on the early detection of lung cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9077-9083
• /
• 2014

Background: This study aimed to summarize the potential diagnostic value of serum DKK1 levels in cancer detection. Materials and Methods: Serum DKK1 was measured using enzyme-linked immunosorbent assay in a case-control study. Then we performed a meta-analysis and the pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic (sROC) curves were used to evaluate the overall test performance. Results: Serum DKK1 levels were found to be significantly upregulated in gastric cancer as compared to controls. ROC curve analysis revealed an AUC of 0.636, indicating the test has the potential to diagnose cancer with poor accuracy. The summary estimates of the pooled sensitivity, specificity and diagnostic odds ratio in meta-analysis were 0.55 with a 95% confidence interval (CI) (0.53-0.57), 0.86 (95%CI, 0.84-0.88) and 12.25 (95%CI, 5.31-28.28), respectively. The area under the sROC was 0.85. Subgroup analysis revealed that the diagnostic accuracy of serum DKK1 in lung cancer (sensitivity: 0.69 with 95%CI, 0.66-0.74; specificity: 0.95 with 95%CI, 0.92-0.97; diagnostic odds ratio: 44.93 with 95%CI, 26.19-77.08) was significantly higher than for any other cancer. Conclusions: Serum DKK1 might be useful as a noninvasive method for confirmation of cancer diagnosis, particularly in the case of lung cancer.

• ETRI Journal
• /
• 제27권5호
• /
• pp.497-503
• /
• 2005

In this paper, we present a performance analysis for an MPEG-4 video codec based on the on-chip network communication architecture. The existing on-chip buses of system-on-a-chip (SoC) have some limitation on data traffic bandwidth since a large number of silicon IPs share the bus. An on-chip network is introduced to solve the problem of on-chip buses, in which the concept of a computer network is applied to the communication architecture of SoC. We compared the performance of the MPEG-4 video codec based on the on-chip network and Advanced Micro-controller Bus Architecture (AMBA) on-chip bus. Experimental results show that the performance of the MPEG-4 video codec based on the on-chip network is improved over 50% compared to the design based on a multi-layer AMBA bus.

• Structural Engineering and Mechanics
• /
• 제69권6호
• /
• pp.637-649
• /
• 2019

In the current research paper, a quasi-3D beam theory is developed for free vibration analysis of functionally graded microbeams. The volume fractions of metal and ceramic are assumed to be distributed through a beam thickness by three functions, power function, symmetric power function and sigmoid law distribution. The modified coupled stress theory is used to incorporate size dependency of micobeam. The equation of motion is derived by using Hamilton's principle, however, Navier type solution method is used to obtain frequencies. Numerical results show the effects of the function distribution, power index and material scale parameter on fundamental frequencies of microbeams. This model provides designers with guidance to select the proper distributions and functions.

• 한국생물공학회:학술대회논문집
• /
• 한국생물공학회 2003년도 생물공학의 동향(XIII)
• /
• pp.391-391
• /
• 2003

• 한국통신학회:학술대회논문집
• /
• 한국통신학회 2006년도 하계종합학술발표회 논문 초록집
• /
• pp.729-729
• /
• 2006

• 한국광과학회:학술대회논문집
• /
• 한국광과학회 2003년도 학술대회지
• /
• pp.104-110
• /
• 2003

• 한국자기학회:학술대회 개요집
• /
• 한국자기학회 2003년도 somma/kms meeting
• /
• pp.59-59
• /
• 2003

• 한국방사성폐기물학회:학술대회논문집
• /
• 한국방사성폐기물학회 2010년도 추계 학술논문요약집
• /
• pp.425-426
• /
• 2010

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 춘계총회 및 학술대회
• /
• pp.133.1-133.1
• /
• 2000