• Title/Summary/Keyword: laboratory's safety

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A case of Advanced Gastric cancer patient treated by Korean Medicine monotherapy

  • Kim, Sulki;Son, Changgue;Choi, Inwoo;Park, Sojung
    • The Journal of Korean Medicine
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    • v.40 no.4
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    • pp.91-100
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    • 2019
  • Objectives: The present study reports case of an advanced gastric cancer patient who did not receive resection and was treated with Korean Medicine (KM) monotherapy. Methods: A 59-year-old female patient diagnosed with advanced gastric cancer visited the Dunsan Korean medicine Hospital of Daejeon University on April 15, 2018 for the Korean medicine treatment. The patient was treated with KM for approximately 1 year, from May, 2018 to May, 2019. Computed tomography (CT) was used to follow-up of the tumor site. Laboratory analysis and National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), version 5.0 were used to evaluate the safety of our treatment. Results: The patient's quality of life (QOL) and related symptoms improved during the treatment. Conclusion: This study suggests that KM may help to improve QOL of advanced gastric cancer patients. This is a valuable report that shows the natural history of Korean gastric cancer invasion to deeper layers over time.

ISI NDE Total Support System for Korean Nuclear Power Plants (원전 가동중검사 종합지원체계)

  • Jeong, Yi-Hwan Peter
    • Journal of the Korean Society for Nondestructive Testing
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    • v.18 no.4
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    • pp.321-329
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    • 1998
  • Structural integrity of nuclear components is important for a safe operation of nuclear power plants. Therefore, nuclear power plants require to perform reliable, periodic inservice inspections. Korea Electric Power Company(KEPCO) operates the entire Korean nuclear power plants. Since nuclear power plant safety and the associated inservice inspection(ISI) are under the plant owner's responsibility, Korea Electric Power Research Institute(KEPRI), the R&D division of KEPCO, has established the ISI NDE Total Support system(TSS) for an efficient performance of ISI tasks, and initiated both key ISI NDE technology development program and traing & qualification system development program for an independent ISI operation. This paper describes details of these programs.

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Structural robustness: A revisit

  • Andre, Joao
    • Structural Engineering and Mechanics
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    • v.76 no.2
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    • pp.193-205
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    • 2020
  • The growing need for assuring efficient and sustainable investments in civil engineering structures has determined a renovated interest in the rational design of such structures from designers, clients and authorities. As a result, risk-informed decision-making methodologies are increasingly being used as a direct decision tool or as an upper-level layer from which performance-based approaches are then calibrated against. One of the most important and challenging aspects of today's structural design is to adequately handle the system-level effects, the known unknowns and the unknown unknowns. These aspects revolve around assessing and evaluating relevant damage scenarios, namely those involving unacceptable/intolerable damage levels. Hence, the importance of risk analysis of disproportionate collapse, and along with it of robustness. However, the way robustness has been used in modern design codes varies substantially, from simple provisions of prescriptive rules to complex risk analysis of the disproportionate collapse. As a result, implementing design for robustness is still very much a grey area and more so when it comes to defining means to quantify robustness. This paper revisits the most common robustness frameworks, highlighting their merits and limitations, and identifies one among them which is very promising as a way forward to solve the still open challenges.

Seepage Characteristics of Embankment as with/without Gravel Layer under the Earth Fill (성토층 하부의 자갈층 유·무에 따른 침투특성 변화)

  • Lee Haeng Woo;Chang Pyoung Wuck;Chang Woong Hee;Kim See-Woon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.47 no.4
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    • pp.53-61
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    • 2005
  • A series of laboratory tests was carried out fur analyzing of seepage characteristics of two-layers embankment model which consists of gravel and earth fill layers. Gravel layers were built under the earth fill for a half and one-third width of earth fill of the model. Permeability of earth fill was ranged between $5.00\times10^{-5}\~3.00\times10^{-4}\;m/s$.. The tests were performed with hydraulic gradients(i), $0.10\~0.55$. From the test results, hydraulic head of earth fill with gravel layer was 1.6 times higher than that of earth fill without gravel layer. Seepage rate was increased up to $4\~22$ times and safety factor for piping was decreased to $13\~43\;\%$ comparing the earth fill with gravel layer to that without gravel layer. The gravel layer under the earth fill could, in general, give some serious seepage problems to seadike embankment.

Deep Borehole Disposal of Nuclear Wastes: Opportunities and Challenges

  • Schwartz, Franklin W.;Kim, Yongje;Chae, Byung-Gon
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.15 no.4
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    • pp.301-312
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    • 2017
  • The concept of deep borehole disposal (DBD) for high-level nuclear wastes has been around for about 40 years. Now, the Department of Energy (DOE) in the United States (U.S.) is re-examining this concept through recent studies at Sandia National Laboratory and a field test. With DBD, nuclear waste will be emplaced in boreholes at depths of 3 to 5 km in crystalline basement rocks. Thinking is that these settings will provide nearly intact rock and fluid density stratification, which together should act as a robust geologic barrier, requiring only minimal performance from the engineered components. The Nuclear Waste Technical Review Board (NWTRB) has raised concerns that the deep subsurface is more complicated, leading to science, engineering, and safety issues. However, given time and resources, DBD will evolve substantially in the ability to drill deep holes and make measurements there. A leap forward in technology for drilling could lead to other exciting geological applications. Possible innovations might include deep robotic mining, deep energy production, or crustal sequestration of $CO_2$, and new ideas for nuclear waste disposal. Novel technologies could be explored by Korean geologists through simple proof-of-concept experiments and technology demonstrations.

Mathematical Model Simulations Assessing the Effects of Temperature on Residual Chlorine Concentrations in Water Storage Tanks (온도 변화에 따른 수돗물 저장 저수조 내 잔류염소에 관한 수학적 모형 시뮬레이션)

  • Noh, Yoorae;Park, Joonhong
    • Journal of Korean Society on Water Environment
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    • v.33 no.2
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    • pp.187-196
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    • 2017
  • To ensure hygienic safety of drinking water in a water storage tank, the concentrations of residual chlorine should be above a certain regulation level. In this study, we conducted model simulations to investigate the effects of temperature on residual chlorine in water storage tank conditions typically used in Seoul. For this, values of model parameters (decomposition rate constant, sorption coefficient, and evaporation mass transfer coefficient) were experimentally determined from laboratory experiments. The model simulations under continuous flow conditions showed that the residual chlorine concentrations were satisfied the water quality standard level (0.1 mg/L) at all the temperature conditions ($5^{\circ}C$, $10^{\circ}C$, $15^{\circ}C$, $20^{\circ}C$ and $25^{\circ}C$). Meanwhile, when the tanks had a no flow condition (i.e., no tap-water influent due to a sudden shut-down), the concentrations became lower than the regulatory level after certain periods. The findings from this modeling works simulating Seoul's water storage tanks suggested disappearance rate of residual chlorine could be reduced through the tanks design optimization with maintenance of low water temperature, minimization of air flow and volume, suppression of dispersion and the use of wall materials with low sorption ability.

DTCF: A Distributed Trust Computing Framework for Vehicular Ad hoc Networks

  • Gazdar, Tahani;Belghith, Abdelfettah;AlMogren, Ahmad S.
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.3
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    • pp.1533-1556
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    • 2017
  • The concept of trust in vehicular ad hoc networks (VANETs) is usually utilized to assess the trustworthiness of the received data as well as that of the sending entities. The quality of safety applications in VANETs largely depends on the trustworthiness of exchanged data. In this paper, we propose a self-organized distributed trust computing framework (DTCF) for VANETs to compute the trustworthiness of each vehicle, in order to filter out malicious nodes and recognize fully trusted nodes. The proposed framework is solely based on the investigation of the direct experience among vehicles without using any recommendation system. A tier-based dissemination technique for data messages is used to filter out non authentic messages and corresponding events before even going farther away from the source of the event. Extensive simulations are conducted using Omnet++/Sumo in order to investigate the efficiency of our framework and the consistency of the computed trust metrics in both urban and highway environments. Despite the high dynamics in such networks, our proposed DTCF is capable of detecting more than 85% of fully trusted vehicles, and filtering out virtually all malicious entities. The resulting average delay to detect malicious vehicles and fraudulent data is showed to be less than 1 second, and the computed trust metrics are shown to be highly consistent throughout the network.

A Genotoxicological Safety Evaluation of Crude Antifungal Compounds Produced by Lactobacillus Plantarum AF1 and Lactobacillus Plantarum HD1 (Lactobacillus plantarum AF1와 Lactobacillus plantarum HD1이 생성한 조항균 물질의 유전학적 독성평가)

  • Chang, Hae-Choon;Koh, Sang-Bum;Lee, Jae-Joon
    • The Korean Journal of Community Living Science
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    • v.26 no.4
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    • pp.633-645
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    • 2015
  • This study investigates the genotoxicity of crude antifungal compounds produced by Lactobacillus plantarum AF1 (L.plantarum AF1) and Lactobacillus plantarum HD1 (L. plantarum HD1) isolated from kimchi. The genetic toxicity of crude antifungal compounds was evaluated in bacterial reverse mutation in Salmonella and Escherichia spp., chromosome aberrations in Chinese hamster lung cells, and micronucleous formations in mice. In bacterial reversion assays with Salmonella Typhimurium TA98, TA100, TA1535, TA1537, and WP2uvrA, crude antifungal compounds did not increase the number of revertant colonies in both the absence and presence of the 59 metabolic activation system. In the chromosome aberration test with Chinese hamster lung cells, crude antifungal compounds showed no increase in the frequency of chromosome aberrations in the short-period test with/without the S9 mix or in the continuos test. In the in vivo mouse micronucleus assay, crude antifungal compounds showed no increase in the frequency of polychromatic erythrocytes with micronuclei. The results show that crude antifungal compounds produced by L. plantarum AF1 and L. plantarum HD1 did not induce any genotoxicity.

The Calculation and Measurement of Flash Point for Water+1-Propanol and Water+2-Propanol Using Closed Cup Aparatus (밀폐식 장치를 사용한 Water+1-Propanol 과 Water+2-Propanol의 인화점 측정과 계산)

  • Ha, Dong-Myeong;Lee, Sungjin
    • Journal of Energy Engineering
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    • v.25 no.4
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    • pp.190-197
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    • 2016
  • Flash point is the one of the important properties for the safe handling of inflammable liquid solution. In this paper, flash points of binary liquid solutions, water+1-propanol and water+2-propanol, were been measured by using Seta flash closed cup aparatus. Flash point was estimated using regression analysis method. Flash points were also estimated by the method based on Raoul's law and the method optimizing the binary parameters of van Laar equation. Experimental results were compared with the calculated results. The regression analysis method is able to estimate the flash point fairly well for water+1-propanol and water+2-propanol mixture.

Multispectral Wavelength Selection to Detect 'Fuji' Apple Surface Defects with Pixel-sampling Analysis

  • Park, Soo Hyun;Lee, Hoyoung;Noh, Sang Ha
    • Journal of Biosystems Engineering
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    • v.39 no.3
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    • pp.166-173
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    • 2014
  • Purpose: In this study, we focused on the image processing method to determine the external quality of Fuji apples by identifying surface defects such as scabs and bruises. Method: A CCD camera was used to capture filter images with 24 different wavelengths ranging between 530 nm and 1050 nm. Image subtraction and division operations were performed to distinguish the defect area from the normal areas including calyx, stem, and glaring on the apple surface image. All threshold values of the image were examined to reveal the defect area of pretreated filter images. Results: The developed operation methods were [image (720 nm) - image (900 nm)]/image (700 nm) for bruise detection and [image (740 nm) - image (900 nm)]/image (590 nm) for scab detection, which revealed 81% and 90% recognition ratios, respectively. Conclusions: Our results showed several optimal wavelengths and image processing methods to detect Fuji apple surface defects such as bruises and scabs.