• 대한수의학회지
• /
• 제49권2호
• /
• pp.127-133
• /
• 2009

Salmonella enterica subsp. enterica serovar gallinarum (S. gallinarum) is the agent of fowl typhoid, and the 9R vaccine is a commercial live vaccine for the prevention of fowl typhoid. The aim of this study was to assess the safety and immunogenicity of different brands of S. gallinarum 9R vaccine used in commercial laying chickens in Korea. All 9R strains originated from three different brands showed the same pattern in the biochemical and serological properties, and pulsed field gel electrophoresis (PFGE) profile. But, there was a difference in rhamnose fermentaion, agglutination with Salmonella group $D_1$ antiserum and PFGE pattern between 9R vaccine strain and field S. gallinarum isolates. In laboratory and field trials for assesment of safety and immunogenicity of 9R vaccine, all of the three 9R vaccines showed the same safety in commercial laying chickens. In addition, there was a significant difference between the vaccinated and unvaccinated control groups in mortality and the re-isolation rate of the challenge strain from the tissues (p < 0.05), and no difference by the brands of 9R vaccine. The results from this study indicated that all three different brands of S. gallinarum 9R vaccine showed highly protection against mortality and organ invasion in commercial laying chickens exposed to virulent strains of S. gallinarum.

• 대한임상검사과학회지
• /
• 제50권3호
• /
• pp.359-369
• /
• 2018

의료 관련 감염을 예방하기 위한 필수적 방법은 일관성이 있는 감염감시 시스템을 구축하고 효율적인 감시 통제를 수행하기 위해 신뢰할 수 있는 상황에 대해 진단을 향상시켜나가는 것이다. 또한 의료 종사자의 손과 의복 및 장비는 환자 관리 및 환경과 접촉하여 병원체가 오염되는 요인이다. 병원체를 가진 시설 표면(예: 침대 레일, 침대 옆 탁자), 음용수, 냉각탑용수, 내시경기구, 급식위생, 공기매개, 멸균검사, 내독소검사, 및 의료 장비를 포함한 의료 환경의 오염은 일반적으로 발생한다. 또한 이러한 감염원을 활동 감시를 통해 MLST, PFGE의 기법으로 역학분석을 수행한다. 따라서 HAI 예방을 위한 환경 감시배양 검사는 환자의 안전과 감염원의 차단을 향상시킬 뿐만 아니라 국가의 감염관리 시스템을 통제하여 최적의 효율적인 감염관리 예방을 가능케 하고 국가의 감염관리 시스템의 안전을 향상시킨다. 결론적으로 감시배양 검사의 표준화를 통해 실효성 있는 감염관리체계에 이바지하고 감염관리 전문인력으로서의 전문성을 확보하고자 한다. 이를 통해 표준화 마련의 일차적인 목표는 의료관련 감염을 줄이고 국가적 의료관리 체계를 향상시키는데 있다.

• International Journal of Naval Architecture and Ocean Engineering
• /
• 제12권1호
• /
• pp.376-386
• /
• 2020

The aim of this study was to develop a new efficient strategy that uses the Vector form Intrinsic Finite-element (VFIFE) method to conduct the static and dynamic analyses of marine pipes. Nonlinear problems, such as large displacement, small strain, and contact and collision, can be analyzed using a unified calculation process in the VFIFE method according to the fundamental theories of point value description, path element, and reverse motion. This method enables analysis without the need to integrate the stiffness matrix of the structure, because only motion equations of particles established according to Newton's second law are required. These characteristics of the VFIFE facilitate the modeling and computation efficiencies in analyzing the nonlinear dynamic problem of flexible pipe with large deflections. In this study, a three-dimensional (3-D) dynamical model based on 3-D beam element was established according to the VFIFE method. The deep-sea flexible pipe was described by a set of spatial mass particles linked by 3-D beam element. The motion and configuration of the pipe are determined by these spatial particles. Based on this model, a simulation procedure to predict the 3-D dynamical behavior of flexible pipe was developed and verified. It was found that the spatial configuration and static internal force of the mining pipe can be obtained by calculating the stationary state of pipe motion. Using this simulation procedure, an analysis was conducted on the static and dynamic behaviors of the flexible mining pipe based on a 1000-m sea trial system. The results of the analysis proved that the VFIFE method can be efficiently applied to the static and dynamic analyses of marine pipes.

• 한국산업보건학회지
• /
• 제20권4호
• /
• pp.248-255
• /
• 2010

Airborne nanoparticle concentrations in three metrics (particle surface area concentration, particle number concentration, and particle mass concentrations) were measured by task in a laboratory making carbon nanotubes (CNTs) films using three direct reading instruments. Because of the conducted other researcher's experiment before the tasks, airborne nanoparticle surface area and number concentrations are the highest at the first time conducted weighing and mixing by sonication task, respectively. Because of the mist generated during mixing by sonication, the highest airborne nanoparticle surface area and PM1 concentrations were measured in the task among the total. Nanoparticle surface area concentrations at the researchers' breathing zones had high correlation (r=0.93, p<0.01) with those measured at an area in the laboratory. This result indicates that nanoparticles generated during the experiment contaminated the whole room air. When the experiment performed all the fume hoods weren't operated and making CNTs films task were conducted in the out of the fume hoods. In conclusion, researchers performing making CNTs film experiments were exposed to airborne nanoparticles generated during the experiment without adequate controls. We recommend that adequate controls should be implemented so that workers' exposures to airborne nanoparticle are limited to minimum levels.

• 국제강구조저널
• /
• 제18권5호
• /
• pp.1801-1817
• /
• 2018

This paper presents the numerical parametric analysis on the loading capacity of Channel purlins with screw-fastened sheeting, in which the effects of anti-sag bar and corrugated steel sheet on the ultimate capacity are studied. Results show that the setup of anti-sag bars can reduce the deformations and improve the ultimate capacity of C purlins. The traditional method of setting the anti-sag bars in the middle of the web is favorable. The changing of sheeting type, sheeting thickness and rib spacing has significant effects on the ultimate capacity of C purlins without anti-sag bars, compared with those with anti-sag bars. The proposed design formulas are relatively consistent with the calculations of EN 1993-1-3:2006, which is different from those of GB 50018-2002.

• 약학회지
• /
• 제47권2호
• /
• pp.104-109
• /
• 2003

The present paper reviews the notion and comparison of the Korea Food and Drug Administration(KFDA) general pharmacology and the International Conference on Harmonisation (ICH) safety pharmacology. General pharmacology or safety pharmacology is termed the study to determine the potential of a compound to induce adverse pharmacological effects. KFDA general pharmacology studies have been considered an important component in drug safety assessment and these were originally referred to those designed to examine effects other than the primary therapeutics effect of a drug candidate. The KFDA notified the Guideline for General Pharmacology in 1997. Safety pharmacology studies were focused on identifying adverse effects on physiological functions. In the ICH came into place S7A Safety Pharmacology Studies for Human Pharmaceuticals in 2001. A new chemical entity should be assessed for its side effects, initially in those physiological systems which are generally agreed to be the key systems that are essential for life; these "core system" include the central nervous system, cardiovascular system and respiratory system in safety pharmacology studies. These studies should be performed in compliance with Good Laboratory Practice (GLP).

• Annals of Laboratory Medicine
• /
• 제38권6호
• /
• pp.599-603
• /
• 2018

Frequencies of red blood cell (RBC) blood group antigens differ by ethnicity. Since the number of immigrants is increasing in Korea, RBC antigens should be assessed in children/youths with parents of different ethnicities to ensure safe transfusions. We investigated the frequency of RBC antigens, except for ABO and RhD, in 382 children and youths with parents having Korean and non-Korean ethnicities. Subjects were divided into those with ethnically Korean parents (Korean group; N=252) and those with at least one parent of non-Korean ethnicity (non-Korean group; N=130). The 37 RBC antigens were genotyped using the ID CORE XT system (Progenika Biopharma-Grifols, Bizkaia, Spain). The frequencies of the Rh (E, C, e, $hr^S$, and $hr^B$), Duffy ($Fy^a$), MNS ($Mi^a$), and Cartwright ($Yt^b$) antigens differed significantly between the two groups. Eight and 11 subjects in the Korean and non-Korean groups, respectively, exhibited negative expression of high-frequency antigens, whereas 14 subjects in the non-Korean group showed positive expression of low-frequency antigens. The frequency of RBC antigens has altered alongside demographic changes in Korea and might lead to changes in distribution of RBC antibodies that cause acute or delayed hemolytic transfusion reaction.

• 대한인간공학회지
• /
• 제31권5호
• /
• pp.657-670
• /
• 2012

Background: Today, numerous telematics technologies, i.e., technologies developed by integrating telecommunications with information processing, are applied in vehicles. One such developmental application of this technology to vehicles is to increase the safety or convenience of drivers by providing them with necessary information such as warnings and information on emergencies and traffic situations. However, under certain conditions, there is a high probability of traffic accidents if the driving workload is high. Nowadays, the navigation system is frequently used in the vehicles, this system provides various information including route to the driver. But, the existing navigation systems are not only considered a driver's reaction but also provide unilaterally to the information regardless of them. Such one-side information service type may miss important information to the driver. In addition, it sometimes interferes safety driving. Objective: To solve this problem, the intelligent navigation system needs to the providing way that it checks the driver's reactions after providing information. Namely, if the driver passes the information received from the navigation, then the intelligent system provides more loudly and more frequently. Method: Therefore, in this study we introduce the intelligent navigation system that it automatically controls modality type and its strength when the driver misses or overlooks the information for their safety and entertainment and we analyze the driver's cognitive responses about the modality type and its strength. Results: To evaluate the effectiveness of the proposed system, we analyzed the reaction time and driving workload for each type of the information, modality and its strength. Also we evaluated the users' subjective satisfaction and understanding based on a questionnaire.

• Safety and Health at Work
• /
• 제8권3호
• /
• pp.315-317
• /
• 2017

We present the case of a 45-year-old man with a history of benzene exposure who developed splenic marginal zone lymphoma. For 6 years, he had worked in an enclosed space cleaning instruments with benzene. He was diagnosed with splenic marginal zone lymphoma 19 years after retirement. During his time of working in the laboratory in the 1980s, working environments were not monitored for hazardous materials. We indirectly estimated the cumulative level of past benzene exposure using job-exposure matrices and technical assumptions. Care must be taken in investigating the relevance of occupational benzene exposure in the occurrence of indolent B-cell lymphoma. Because of the long latency period and because occupational measurement data do not exist for the period during the patient's exposure, the epidemiological impact of benzene exposure may be underestimated.

• 대한의생명과학회지
• /
• 제26권3호
• /
• pp.201-209
• /
• 2020

The effect of mulberry leaves and yacon tuber extracts (MYE) on antioxidant was tested in this study. The present study investigated the in vivo effects of the anti-oxidative effect of MYE on catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px), and thiobarbituric acid reactive substances (TBARS). The seven-day acclimation of the mice was divided into six groups: Normal diet group (NOR), high fat diet group (HFD), high fat diet with 0.5% hydroxycitric acid group diet group for positive group (HHCA), high fat diet with 1% mulberry leaf and 1% yacon diet group (MYE-1), high fat diet with 3% mulberry leaf and 3% yacon group (MYE-3) and high fat diet with 5% mulberry leaf and 5% yacon group (MYE-5). The effect of serum antioxidant in the catalase of MYE-1, MYE-3, and HHCA comparing to HFD by 31.0%, 27.7% and 45.2%, respectively (P<0.05~0.01). The effect on hepatic antioxidant in the catalase of HFD was significantly increased 3.7 (77.3%) times than that of NOR (P<0.01). But, the activities of catalase were decreased significantly in MYE-1, MYE-3, MYE-5 and HHCA by 21.7%, 24.2%, 24.9%, and 28.8% compared to HFD, respectively. GSH-Px was significantly decreased in MYE-1, MYE-3, MYE-5 and HHCA by 15.5%, 37.1%, 23.4%, and 23.7% compared to HFD, respectively (P<0.05). The activities of CAT, SOD, GST, GSH-Px, and TBARS were more significantly decreased in MYE-1 and MYE-3 than those of HFD and HHCA. MYE have shown significant effects on anti-oxidative function against high fat diet.