Annals of Laboratory Medicine

  • 제38권6호
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  • Pages.599-603
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  • 2018
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  • 2234-3806(pISSN)
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  • 2234-3814(eISSN)
대한진단검사의학회 (Korean Society for Laboratory Medicine)
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Frequency of Red Blood Cell Antigens According to Parent Ethnicity in Korea Using Molecular Typing

  • Shin, Kyung-Hwa (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Lee, Hyun-Ji (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Kim, Hyung-Hoi (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Hong, Yun Ji (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Park, Kyoung Un (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Min Ju (The Division of Human Blood Safety Surveillance, Korea Centers for Disease Control and Prevention) ;
  • Kwon, Jeong-Ran (Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention) ;
  • Choi, Young-Sil (Division of Laboratory Diagnosis Management, Korea Centers for Disease Control and Prevention) ;
  • Kim, Jun Nyun (The Division of Human Blood Safety Surveillance, Korea Centers for Disease Control and Prevention)
  • 투고 : 2017.11.13
  • 심사 : 2018.06.22
  • 발행 : 2018.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Frequencies of red blood cell (RBC) blood group antigens differ by ethnicity. Since the number of immigrants is increasing in Korea, RBC antigens should be assessed in children/youths with parents of different ethnicities to ensure safe transfusions. We investigated the frequency of RBC antigens, except for ABO and RhD, in 382 children and youths with parents having Korean and non-Korean ethnicities. Subjects were divided into those with ethnically Korean parents (Korean group; N=252) and those with at least one parent of non-Korean ethnicity (non-Korean group; N=130). The 37 RBC antigens were genotyped using the ID CORE XT system (Progenika Biopharma-Grifols, Bizkaia, Spain). The frequencies of the Rh (E, C, e, $hr^S$, and $hr^B$), Duffy ($Fy^a$), MNS ($Mi^a$), and Cartwright ($Yt^b$) antigens differed significantly between the two groups. Eight and 11 subjects in the Korean and non-Korean groups, respectively, exhibited negative expression of high-frequency antigens, whereas 14 subjects in the non-Korean group showed positive expression of low-frequency antigens. The frequency of RBC antigens has altered alongside demographic changes in Korea and might lead to changes in distribution of RBC antibodies that cause acute or delayed hemolytic transfusion reaction.

키워드

과제정보

연구 과제 주관 기관 : Korea Centers for Disease Control and Prevention

참고문헌

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피인용 문헌

  1. Red Blood Cell Alloimmunization in Korean Patients With Myelodysplastic Syndrome and Liver Cirrhosis vol.39, pp.2, 2018, https://doi.org/10.3343/alm.2019.39.2.218
  2. Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency vol.29, pp.6, 2018, https://doi.org/10.1111/tme.12643