• Title/Summary/Keyword: lRE

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Study of 188Re(V)-DMSA for Treatment of Cancer: Radiolabeling and Biodistribution (암 치료를 위한 188Re(V)-DMSA에 관한 연구: 방사성동위원소 표지와 생체내 분포)

  • Kim, Young Ju;Jeong, Jae Min;Chang, Young Soo;Lee, Dong Soo;Chung, June-Key;Lee, Myung Chul;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.1
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    • pp.81-88
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    • 1998
  • The purpose of this study was to examine the radiolabeling and biodistribution of $^{188}Re(V)$-DMSA as a therapeutic cancer radiopharmaceutical. We made a DMSA kit($NaHCO_3$ 1.5 mg, meso-2,3-dimercaptosuccinic acid 1.0 mg, L(+)-ascorbic acid 0.7 mg, $SnCl_2{\cdot}2H_2O$ 0.34 mg, pH 2.9) for labeling with $^{188}Re$. In this kit, $^{188}ReO_4{^-}$ 5 mCi/2 ml added and boiled at $100^{\circ}C$ for 3 hr in water bath. The final pH adjusted to 7.5 with 7% $NaHCO_3$ solution. We checked the labelling efficacy with TLC-SG(n-butanol : acetic acid : $H_2O$ = 3 : 2 : 3) and examined the stability both in room temperature and in serum at $37^{\circ}C$. Biodistribution(1, 3, 13, 24, 48 hr) of $^{188}Re(V)$-DMSA compound was evaluated in Sarcoma 180 tumor-bearing mice. Each labeling efficiency and stability at room temperature for 48 hours was over 98% and 95%, respectively. The stability in serum were 82%(6 hr) and 85%(48 hr). Tumor uptake of $^{188}Re(V)$-DMSA in Sarcoma 180-bearing mice were $0.66{\pm}0.15%$(1 hr), $0.51{\pm}0.10%$(3 hr), $0.19{\pm}0.05%$(24 hr) and $0.13{\pm}0.02%$(48 hr). These result are consistent with those of $^{99m}Tc(V)$-DMSA which were reported previously. In conclusion, $^{188}Re(V)$-DMSA may be a useful therapeutic radiopharmaceutical for treating some cancers and metastatic bone lesion.

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Effects of Extraction Methods on the Antioxidative Activity of Artemisia sp. (추출 방법에 따른 쑥 추출물의 항산화 활성)

  • Kang, Kyoung-Myoung;Lee, Shin-Ho
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.8
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    • pp.1249-1254
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    • 2013
  • The effect of extraction methods, such as reflux extraction (RE), autoclave extraction (AE), low temperature high pressure extraction (LTPE) and ultrasonification extraction (USE) on antioxidant activity of various species of Artemisia (Artemisia capillaris T., Artemisia princeps P., Artemisia annua L.) was investigated. The extraction yield of RE and AE was higher than other methods tested for all Artemisia. The total polyphenol and flavonoid content of Artemisia sp. extracts from RE was highest of the extraction methods tested. The total polyphenol and flavonoid content of A. capillaris T. extracted by RE was 260.82 mg GAE/g and 11.52 mg RHE/g, respectively. The A. capillaris T. extract showed higher DPPH and ABTS radical scavenging activity than that of the other tested Artemisia sp. Nitrite scavenging activity and superoxide dismutase (SOD)-like activity of various extracts from RE was 45.48% and 68.29% (A. capillaris T.), 45.73% and 61.43% (A. princeps P.), and 44.25% and 58.19% (A. annua L.), respectively. The RE method was the most effective method for extracting antioxidant substances from various A. capillaris T. compared with AE, LTPE and USE. These results suggest that extracts of Artemisia sp. from RE can be used as bioactive and functional materials in the food industry.

Ginsenoside Content of North American Ginseng (Panax quinquefolius L. Araliaceae) in Relation to Plant Development and Growing Locations

  • Jackson, Chung Ja C.;Dini, Jean-Paul;Lavandier, Clara;Faulkner, Harold;Rupasinghe, H.P. vasantha;Proctor, John T.A.
    • Journal of Ginseng Research
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    • v.27 no.3
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    • pp.135-140
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    • 2003
  • North American ginseng (Panax quinquefolius L.) was analysed for total ginsenosides and ten major ginsenosides (R$_{0}$ , Rb$_1$, Rb$_2$, Rc, Rd, Re, Rf, Rg$_1$, pseudoginsenoside F$_{11}$ and gypenoside XVII), and variations in ginsenoside content with age of plant (over a four-year-period) and geographic location (Ontario versus British Columbia) were investigated. In the roots the total ginsenoside content increased with age up to 58-100 mgㆍg$^{-1}$ dry weights in the fourth year, but in leaves it remained constant over time. Roots and leaves, moreover, had different proportions of individual ginsenosides. The most abundant ginsenosides were Rb$_1$ (56mgㆍg$^{-1}$ for Ontario; 37mgㆍg$^{-1}$ for British Columbia) and Re (21mgㆍg$^{-1}$ for Ontario; 15 mgㆍg$^{-1}$ for British Columbia) in roots, and Rd (28-38 mgㆍg$^{-1}$ ), Re (20-25 mgㆍg$^{-1}$ ), and Rb$_2$ (13-19 mgㆍg$^{-1}$ ) in leaves. Measurable quantities of Rf were found in leaves (0.4-1.8 mgㆍg$^{-1}$ ) but not in roots or stems. Our results show that ginsenoside profiles in general, and Rf in particular, could be used for chemical fingerprinting to distinguish the different parts of the ginseng plant, and that ginseng leaves could be valuable sources of the ginsenosides Rd, Re, and Rb$_2$.

Trajectory Optimization and the Control of a Re-entry Vehicle during TAEM Phase using Artificial Neural Network (재진입 비행체의 TAEM 구간 최적궤적 설계와 인공신경망을 이용한 제어)

  • Kim, Jong-Hun;Lee, Dae-Woo;Cho, Kyeum-Rae;Min, Chan-Oh;Cho, Sung-Jin
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.37 no.4
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    • pp.350-358
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    • 2009
  • This paper describes a result of the guidance and control for re-entry vehicle during TAEM phase. TAEM phase (Terminal Aerial Energy Management phase) has many conditions, such as density, velocity, and so on. Under these conditions, we have optimized trajectory and other states for guidance in TAEM phase. The optimized states consist of 7 variables, down-range, cross range, altitude, velocity, flight path angle, vehicle's azimuth and flight range. We obtained the optimized reference trajectory by DIDO tool, and used feedback linearization with neural network for control re-entry vehicle. By back propagation algorithm, vehicle dynamics is approximated to real one. New command can be decided using the approximated dynamics, delayed command input and plant output, NARMA-L2. The result by this control law shows a good performance of tracking onto the reference trajectory.

Estimation of the Virtual Mass of Conical Nets using Circulating Water Channel (회류수조를 이요한 자루그물의 가상질량 추정)

  • 김현영
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.1
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    • pp.60-65
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    • 2000
  • The virtual mass of net is an important parameter in the analysis and control of net movement in the water. This experiment was performed with the purpose of getting a relation on the quantity of netting and virtual mass of trawl nets using the circulating water channel that can control flow speed. Twelve types of conical nets were examined. Resistance of the conical net at the steady and acceleration state was recorded as text on the personal computer through the tension meter and current meter. The results were obtained as follows ;1. Resistance(R) of the conical net is proportional to the degree of attack angle in the sam e amount of twine material.2. Coefficient of the resistance(Cd)could be defined by the following regression model as a function of Reynolds Number(Re). Cd=0.039Re-0.14743. Resistance(R) is proportional to TSA(Twine surface area) and defined as follows; R=21.398TSA-0.12194. Coefficient of virtual mass(CM) could be calculated by the following first order regression model. CM=37.557U-8.96845. Virtual mass is directly proportional to Volume of net(V) or d/l.

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Study on Anti-oxidant Activity of Four Kinds of Korea Herb Medicine Materials (4가지 한방 소재(행인, 호장근, 자초, 강황)의 항산화활성에 관한 연구)

  • Kim, Young-Hun;Lee, Su-Mi;Cheon, Soon-Ju;Jang, Min-Jung;Jun, Dong-Ha;Choi, Hyang-Ja;Cho, Woo-A;Lee, Jin-Tae
    • Journal of the Korean Society of Fashion and Beauty
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    • v.5 no.4
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    • pp.139-144
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    • 2007
  • There was an increasing interest that herbal medicine and natural material extracts were proved processes of antioxidant, cosmeceutical activity and the other effects. The aim of this study was to assess the antioxidant of extraction of four kinds from Prunus armeniaca L., Reynoutria elliptica, Curcuma aromatica, Lithospermum erythrorhizon. RE (Reynoutria elliptica) and CA (Curcuma aromatica) have good electron donating ability. The water and ethanol extract of RE at a 100 ppm concentration showed over 70%, the water extract at 500 ppm concentration showed 83% and the ethanol extract at 100 ppm concentration showed 86% of CA. Xanthine oxidase inhibition activity of the water extract of LE (Lithospermum erythrorhizon) at a 1,000 ppm concentration showed over 44%, on the other hand, RE showed in all lowest effect and there was no inhibition activity of a couple more extracts. In the measurement of nitrite scavenging activity, all extracts showed highly scavenging activity. Especially the water and ethanol extract of RE showed over 99% at 500 ppm, also LE showed over 40% at 10 ppm concentration.

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The Effects of Bastnasite Nitrate Fertilizer on the Growth of Creeping Bentgrass (질산희토비료가 크리핑벤트그래스의 생육에 미치는 영향)

  • Kim, Young-Sun;Ham, Suon-Kyu;Jeon, Seong-Jin
    • Asian Journal of Turfgrass Science
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    • v.25 no.1
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    • pp.89-93
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    • 2011
  • This study was conducted to evaluate the effects of bastnasite nitrate fertilizer (BNF) on the growth of creeping bentgrass. Fertilizer treatments were designed as follows; non-fertilizer (NF), control (CF; compound fertilizer), RE-l (CF+0.3 $g{\cdot}m^{-2}$BNF), RE-2 (CF+0.5 $g{\cdot}m^{-2}$BNF), RE-3 (CF+1.0 $g{\cdot}m^{-2}$BNF) and RE-4 (0.5 $g{\cdot}m^{-2}$BNF). Every treatment was arranged in a randomized complete block design with three replications. In creeping bentgrass, turf qualities such as turf color index and chlorophyll index, shoot number, clipping dry weight and nutrients of tissue were measured. It was hardly affected by BNF application in investigation of chemical properties of the soil. By applying BNF, turf color index and chlorophyll index in RE-2 were increased 3.9% and 9.2% more than NF. As applied BNF on creeping bentgrass, shoot number was increased 9% in RE-4 more than NF and 22% in RE~2 more than CF. It was increased in N uptake and clipping dry weight of creeping bentgrass by supplying BNF. These results indicated that the BNF application promoted a turf qualities and a growth of creeping bentgrass by advancing N uptake and shoot number.

A Study on Computation of Optimal Basic Load of Rifle and Firearm Using Arena (ARENA를 이용한 최적 기본 휴대량 산정에 관한 연구)

  • Park, Ji-Won;Lee, Jae-Yeong;Park, Jung-Kap
    • Journal of the military operations research society of Korea
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    • v.34 no.2
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    • pp.1-26
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    • 2008
  • This study presents a new estimation of optimal amount of B/L for infantry rifles and artillery weapons which are currently using in Korean Army. To do that, we analyzed current concept of B/L and methodologies used to compute B/L before, and re-calculate optimal amount of B/L to solve some problems founded. We also applied ARENA simulation model to propose estimated values of optimal B/L. The proposed optimal B/L will certainly help to improve efficiency for wartime readiness in the future.

GPS L5 Acquisition Schemes for Rapid Code Phase Search and Fine Doppler Determination (GPS L5 신호에서 신속한 코드위상 재검색 및 정밀 도플러 결정 기법)

  • Joo, In-One;Choi, Seung-Hyun;Kim, Jae-Hyun;Shin, Chun-Sik;Lee, Sang-Uk;Kim, Jae-Hoon
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.17 no.4
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    • pp.17-24
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    • 2009
  • According to the GPS modernization, L5 is the third civilian GPS signal, broadcasts in a radio band reserved exclusively for aviation safety services. However, as the code length of GPS L5 is ten times longer than that of GPS L1, the acquisition processing time in GPS L5 takes longer than that of L1. This characteristics make the code phase detected initially change and cause the tracking loop to unlock. In order to overcome this problem, this paper proposes L5 acquisition schemes for the rapid code phase re-search and the fine doppler determination. The feasibility of the proposed scheme is demonstrated through the simulation results.

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Optimum Soil Incorporation Time of Chinese Milk Vetch(Astragalus sinicus L) for its Natural Re-seeding and Green Manuring of Rice in Gyeongnam Province, Korea

  • Kim, Sang-Yeol;Oh, Seong-Hwan;Hwang, Woon-Ha;Choi, Kyung-Jin;Oh, Byeong-Gen
    • Journal of Crop Science and Biotechnology
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    • v.11 no.3
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    • pp.193-198
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    • 2008
  • To develop a natural re-seeding technology, the optimum soil incorporation time of Chinese milk vetch(CMV) plant residues, seed persistence in soil, biomass production and subsequent rice yield were determined from 2005 to 2007 in rice with CMV green manure in southern Korea. Generally, insufficient seedling stand was regenerated with CMV incorporation to the soil at 20 and 25 days after flowering(DAF), while high regeneration of greater than 400 seedlings per $m^2$ was observed at 35 and 40 DAF. High re-seeding stand of CMV incorporated at 35 DAF or later was related with high seed viability and heavy seed weight. Appreciable number of CMV seeds remained 4 month after burial in soil and a good number of CMV seedlings regenerated from this seed bank at rice harvest time in the fall. Based on the relationships among re-seeding number of CMV plants, seed weight and seed viability, CMV plants should be incorporated into the soil 35 DAF(May 30) or later when CMV seeds were sufficiently matured. The natural re-seeding stand for the 3-year trials was stable ranging from 437 to 700 plants per $m^2$ and the biomass production was sufficient to supply nitrogen for rice growth. The use of re-seeding CMV plant can produce similar rice yield like that of rice without CMV green manure.

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