• The Korean Journal of Physiology and Pharmacology
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• 제17권6호
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• pp.479-484
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• 2013

Given the CYP3A4 and CYP3A5's impact on the efficacy of drugs, the genetic backgrounds of individuals and populations are regarded as an important factor to be considered in the prescription of personalized medicine. However, genetic studies with Korean population are relatively scarce compared to those with other populations. In this study, we aimed to identify CYP3A4/5 polymorphisms and compare the genotype distributions among five ethnicities. To identify CYP3A4/5 SNPs, we first performed direct sequencing with 288 DNA samples which consisted of 96 Koreans, 48 European-Americans, 48 African-Americans, 48 Han Chinese, and 48 Japanese. The direct sequencing identified 15 novel SNPs, as well as 42 known polymorphisms. We defined the genotype distributions, and compared the allele frequencies among five ethnicities. The results showed that minor allele frequencies of Korean population were similar with those of the Japanese and Han Chinese populations, whereas there were distinct differences from European-Americans or African-Americans. Among the pharmacogenetic markers, frequencies of $CYP3A4^*1B$ (rs2740574) and $CYP3A5^*3C$ (rs776742) in Asian groups were different from those in other populations. In addition, minor allele frequency of $CYP3A4^*18$ (rs28371759) was the highest in Korean population. Additional in silico analysis predicted that two novel non-synonymous SNPs in CYP3A5 (+27256C>T, P389S and +31546T>G, I488S) could alter protein structure. The frequency distributions of the identified polymorphisms in the present study may contribute to the expansion of pharmacogenetic knowledge.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4885-4892
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• 2016

Background: Chinese and Korean Americans have lower colorectal cancer (CRC) screening rates than other racial/ ethnic groups, which may be explained by a low level of CRC knowledge and a high level of misconceptions. This study explores the role of knowledge in CRC screening among these groups. Methods: Chinese (N=59) and Korean (N=61) Americans older than 50 were recruited from the Washington D.C. Metropolitan area. They completed a detailed survey and participated in focus groups to discuss their knowledge on CRC and CRC screening. Seventeen physicians, community leaders, and patient navigators participated in key informant interviews. Using a mixed methods approach, data were analyzed quantitatively and qualitatively. Results: Participants lacked knowledge about CRC and CRC screening. More than half did not know that screening begins at age 50 and there are several types of tests available. More than 30% thought CRC screening was not necessary if there were no symptoms or there was nothing they could do to prevent CRC. Focus group findings suggested understanding about CRC was limited by an inadequate source of linguistically and culturally relevant health information. For example, many participants considered CRC a western condition mainly caused by unhealthy diet. This led to under-estimations about their susceptibility to CRC. Knowledge was positively associated with self-reported screening. Participants who had higher knowledge scores were more likely to report ever having had a colonoscopy and confidence in ability to have CRC screening. Conclusions: Mixed-methods analysis provides multi-faceted perspectives on CRC knowledge and its influence on screening. Study findings can help inform interventions to increase CRC screening among Chinese and Korean Americans.

• Diabetes and Metabolism Journal
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• 제42권6호
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• pp.488-495
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• 2018

Background: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. Methods: This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. Results: Thigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. Conclusion: Thigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.

• Nutrition Research and Practice
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• 제14권3호
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• pp.286-297
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• 2020

BACKGROUND/OBJECTIVES: This study compared the perception of customers from Korea and the U.S. on the attributes of different formats of menu labeling The specific objectives were 1) to compare the customers' perceived usefulness, ease-of-understanding, clarity, and attractiveness of different formats of menu labeling between Korea and the U.S.; and 2) to compare the customers' use intention to different formats of menu labeling between Korea and the U.S. SUBJECTS/METHODS: A survey was conducted in Korea and the U.S. The participants were allocated randomly to view 1 of the 7 restaurant menus that varied according to the following types of menu labeling formats: (type 1) kcal format, (type 2) traffic-light format, (type 3) percent daily intake (%DI) format, (type 4) kcal + traffic-light format, (type 5) kcal + %DI format, (type 6) traffic-light + %DI format, and (type 7) kcal + traffic-light + %DI format. A total of 279 Koreans and 347 Americans were entered in the analysis. An independent t-test and 1-way analysis of variance were performed. RESULTS: Koreans rated type 4 format (kcal + traffic light) the highest for usefulness and attractiveness. In contrast, Americans rated type 7 (kcal + traffic light + %DI) the highest for usefulness, ease-of-understanding, attractiveness, and clarity. Significant differences were found in the customers' perceived attributes to menu labeling between Korea and the U.S. Americans perceived higher for all the 4 attributes of menu labeling than Koreans. CONCLUSIONS: The study is unique in identifying the differences in the attributes of different formats of menu labeling between Korea and the U.S. Americans rated the most complicated type of menu labeling as the highest perception for the attributes, and showed a higher use intention of menu labeling than Koreans. This study contributes to academia and industry for practicing menu labeling in different countries using different formats.

• 사회복지연구
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• 제40권3호
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• pp.181-211
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• 2009

본 연구는 사회인지직업이론 (Social Cognitive Career Theory)을 근거로, 동양계 미국인의 문화적응도 (levels of acculturation)와 이민 세대 (family immigration status)에 따라 주변인들의 불인정 (disapproval by significant others)으로 인한 진로선택의 어려움과 부모의 진로에 대한 관여도 (parental involvement)가 달라진다는 가설을 검증하였다. 사회조사연구로 설계되었으며 370명의 동양계 미국사회복지사의 자료를 분석하였다. 연구결과, 이민세대에 따라 진로선택에 관련하여 부모의 관여도와 주변인들의 불인정으로 인한 진로어려움이 달라지는 것으로 나타났다. 그러나 문화적응도는 부모의 진로 관여도와 주변인들의 불인정으로 인한 진로선택의 어려움에 유의미하게 영향을 미치지 않는 것으로 나타났다. 연구결과를 바탕으로 진로선택행동에 영향을 미치는 문화적 요인들을 고려한, 동양계 미국인들을 위한 진로상담에 대한 함의가 논의되었다.

• 한국영양학회:학술대회논문집
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• 한국영양학회 1999년도 춘계학술대회 초록
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• pp.97-98
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• 1999

• 동아시아식생활학회지
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• 제23권3호
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• pp.265-272
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• 2013

In order to globalize Korean foods successfully, it is necessary to understand foreigners' attitudes about ethnic foods and how foreigners perceive Korean foods. It would be valuable to survey the degree of interest from foreigners when purchasing Korean foods. Thus, a survey was performed on the most common tourists in Korea, the Japanese, Chinese and Americans. 313 respondents completed the survey on ethnic foods (16 questions), purchasing intention of Korean foods (3 questions), and socio-demographic conditions (9 questions). Factor analysis and reliability analysis were conducted to identify the indicators of attitudes toward ethnic foods. Correlation analysis was conducted to confirm the relation between attitudes toward ethnic foods and Korean food purchasing intention. From the results of factor analysis, 5 factors emerged from the 13 out of 16 questions; and were labeled new food seekers, ethnic food seekers, familiarity seekers, new taste seekers and challenge seekers. Items were analyzed to determine the differences according to nationality by using the ANOVA, and it showed that Americans have the highest Korean food purchasing intentions. The regression analysis indicated that attitude factors on ethnic foods, new foods and new taste seekers are strongly related to Korean food purchase intentions.

• 한국의류학회지
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• 제17권3호
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• pp.367-379
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• 1993

The objectives of this study were to classify the contents of clothing image preferences of Korean and American students, and to examine how clothing image preferences vary according to sex role identity, sex, and culture. A woman's clothing image preference inventory and the Bem Sex Role Inventory were administered to 127 Korean students and 116 American students. Sex role idendity was classified into androgynous, masculine, feminine, and undifferentiated type. 1. Four segments of woman's clothing image preference derived by factor analysis : F. 1 'splendid-plain' ; F. 2 'feminine-masculine' ; F. 3 'casual-formal' ; F. 4 'classic-contemporary'. 2. Americans prefered splendid image more than did Koreans. Androgynous-typed males liked splendid image most among American male subjects. 3. There was interaction effect between sex and culture on feminine-masculine image preference. In Korean students, males liked feminine image much more than did females. Masculine-typed females liked masculine image most among American female subjects. 4. Koreans prefered casual image more than did Americans. 5. There was interaction effect between sex role identity, sex, and culture($4{\times}2{\times}2$) on classic-contemporary image preference. Feminine-typed females liked classic image most among Korean female subjects. 6. Korean males especially prefered luxurious image least. Korean females contemporary most, American males sexy most, American females fashionable most among four subject groups. That is, differences on clothing image preferences were found according to sex role identity, sex, and culture.

• 음성과학
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• 제10권3호
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• pp.157-173
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• 2003

The purpose of this experimental study is to investigate and compare the. vowel lengths of English diphthongs and low vowels among native-English-speaking Americans with Korean college students from the Chungnam and Gyungnam provinces. Eight words and sixteen sentences were uttered five times by twenty five subjects from three groups; 1) Chungnam dialect speakers, 2) Gyungnam dialect speakers and 3) five native-English-speaking Americans. Acoustic features (duration) were measured from sound spectrograms made by the PC Quire. Results showed that the vowel lengths of English diphthongs and low vowels between native English speakers and Korean collegians of Chungnam and Gyungnam provinces were different. Comparing the average length of English diphthongs of Korean collegians with those of American natives, we can see that native English speakers tend to pronounce the English diphthongs shorter than Korean collegians do. However, native English speakers tend to pronounce the English low vowels longer than Korean collegians do. In this study we also tried to find out the differences of English diphthongs and low vowel lengths in relation to their utterance positions among American natives and Chungnam and Gyungnam dialect speakers. By the results of this experiment, we observed a lengthening effect in the three groups. However, in the pronunciation of American natives, a lengthening effect of English vowels was more clearly observed, especially in the pronunciation of English diphthongs.

• International Journal of Human Ecology
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• 제5권2호
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• pp.123-134
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• 2004

A convenience samples of Korean-Canadian/American adults who lived in Vancouver, San Hose and Los Angeles areas for over 10 years, were studied in 2000. Total of 130 adults were analyzed by immigration age. The age of immigration age was divided into 3 groups: the young group immigrated at 25 or before, the middle group immigrated at 26 to 40, and the old group immigrated at over 40. Their average length of residence in Canada and the U.S. was a little longer than 20 years. The dietary behavior patterns were similar among 3 groups, except co-eaters and dining-out frequency, and the Korean-Canadians/Americans seemed to be more home-based, family-tightened and traditional patterns than Koreans in Korea. They liked Korean traditional basic dishes, but their children liked a-la-carte ones and immigrants at early 20's showed similar food preferences as young generations. The attitudes of dietary acculturation for themselves and for their children were high. Since immigrating at age 26 to 40 years old rather than 20's or over 40's, showed stronger acculturation attitudes even with no significance and revealed significantly differences in some dietary behaviors and food preferences, it is recommended that immigration age should be considered when planning dietary foodservices at nursing care systems for Korean Canadians/Americans.