• 한국도서관정보학회지
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• 제38권2호
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• pp.31-50
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• 2007

이 논문에서는 1984년부터 2003년까지 200년에 걸쳐 MEDLINE과 CINAKL. IPA 등 3개 서지데이터베이스에 수록된 간염에 관한 분야의 문헌의 증가추세를 계량과학적으로 분석하였다. 이 기간 동안MEDLINE은 최대인 75,750건의 레코드를 수록하였으며, CINAHL, IPA의 순이었다. 특정지식영역의 연간문헌증가율은 동일하지 않으며, 연간증가율을 측정하기 위해서는 RGR을 적용하는 것이 아주 적합한 것으로 나타났다. RGR은 감소추세를 보였는데, 다만 1985년과 1997년에 성장률에서 약간의 변동이 있었다. 대학과 기업, 연구기관들은 RGR 및 Dt와 관련한 성과에서 성장추세와 감소추세, 변동추세 등의 결과에서 혼재된 양상을 보여주었다. 간염연구는 논문수와 페이지수의 측면에서 연단위로 RGR과 Dt를 산정했을 때는 다양한 양상을 보여주었다.

• 대한임상검사과학회지
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• 제44권4호
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• pp.210-215
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• 2012

Hepatitis virus infection is one of the major problems in Korea. To establish preventive measures for hepatitis A and B virus infection, study on sero-positivity of serum anti-HAV (aHAV) and anti-HBs (aHBs) is needed. The aim of this study was to analyze the sero-positivity and related factors of aHAV and aHBs. We analysed the sero-positivity of serum aHAV and aHBs using ICA (Immunochromatography Assay) method from 102 university students and employees and questionnaire survey was obtained characteristics, vaccination history, past history test, knowledge and information sources of the study subjects. Overall sero-positivity rates of serum aHAV and aHBs were 20.6% and 52.9%, respectively. The sero-positivity rate of aHBs was significantly different by gender (M, 34.9%; F,66.1%) and that of aHAV was significantly different by age (20 age group, 2.7%; 30 age group, 14.3%; 40 age group, 70%; 50 age group, 91.7%). Overall sero-positivity rates of serum aHAV and aHBs by vaccination history rates were 4.9% and 43.1%, respectively. Overall sero-positivity rates of serum aHAV and aHBs by past history test were 10.8% and 52.9%, respectively. Sero-positivity rates of serum aHAV was low in university students. The results of this study could be used effectively as a basic data for establishing effective preventive measures for hepatitis A including vaccination.

• 한국학교보건학회지
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• 제15권2호
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• pp.183-191
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• 2002

This study is aimed at offering basic data about prevention of Hepatitis B virus and infection control to dental hygiene students who will work mostly at dental offices which are characteristically exposed to a high risk of HBV infection. For this study, surveyed were 188 sophomores and juniors of the dental hygiene department who volunteered to undergo the tests of HBsAg and HBsAb. The examination of the blood collected from the samples and analysis of their perception about hygiene resulted in following conclusion: Positive HBsAg Four was found in 4 testees(2.1%) while 118(62.8%) revealed positive HBsAb. Juniors showed higher positive rate in HBsAg whereas sophomores had higher positive rate in HBsAb. But such difference has statistically no significance. Generally, students seemed to pay little attention to HBV, judging from the survey of their perception about the present state of HBsAg and HBsAb(p>0.05), conduct of infection(p<0.05), completion of 3 requested vaccinations(p>0.05), and formation of antibody(p>0.05). With regard to the infection routes of HBV, most students(92.4%) replied "through blood", which is statistically insignificant, though. Next ratio goes to the reply "through contaminated injectors". This reply came more from sophomores than from juniors, a difference which is statistically significant(p<0.05). The lowest rate of possible infection(29.2%) was thought to be "through breast-feeding of a positive mother"(p<0.05). In general, it turned out that sophomores had more knowledge about the infection routes of HBV than juniors. In terms of clinical history among family members, 6(3.1%) reported that some of their family members are currently suffering from a liver complaint, 3(1.6%) replied their family members were once afflicted, and 4(2.1%) said their members died of hepatitis. Except 10(4.7%), all the surveyees replied that their states of health are better than normal. Generally, sophomores are healthier than juniors except for the very health case, a difference which is statistically of no value.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.4953-4960
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• 2013

Primary liver cancer is one of the most common cancers at the global level, accounting for half of all cancers in some undeveloped countries. This disease tends to occur in livers damaged through alcohol abuse, or chronic infection with hepatitis B and C, on a background of cirrhosis. Various cancer-causing substances are associated with primary liver cancer, including certain pesticides and such chemicals as vinyl chloride and arsenic. The strong association between HBV infection and liver cancer is well documented in epidemiological studies. It is generally acknowledged that the virus is involved through long term chronic infection, frequently associated with cirrhosis, suggesting a nonspecific mechanism triggered by the immune response. Chronic inflammation of liver, continuous cell death, abnormal cell growth, would increase the occurrence rate of genetic alterations and risk of disease. However, the statistics indicated that only about one fifth of HBV carries would develop HCC in lifetime, suggesting that individual variation in genome would also influence the susceptibility of HCC. The goal of this review is to highlight present level of knowledge on the role of viral infection and genetic variation in the development of liver cancer.

• 한국미생물·생명공학회지
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• 제51권2호
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• pp.135-146
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• 2023

Viral oncology is focused on understanding the relationship between cancer and viruses, which are known to play a role in the development of certain types of cancer. Approximately 15-20% of human cancers are believed to be caused by oncogenic viruses, and as a result, there is significant interest in understanding how these viruses contribute to cancer development. There are several viruses that have been linked to cancer, including human papillomavirus, hepatitis B and C virus, Epstein-Barr virus, human T-cell lymphotropic virus type 1, Kaposi's sarcoma-associated herpesvirus, and Merkel cell polyomavirus. Each of these viruses is associated with different types of cancer, and the mechanisms by which they contribute to cancer development are diverse. This article discusses these mechanisms as well as current and future strategies for preventing and treating virus-associated cancers with the goal of presenting a thorough review of the current state of knowledge in viral oncology and to highlight the importance of continued research in this field.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4765-4771
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• 2014

Background: Patients with chronic liver diseases (CLD) may have compromised health related quality of life (HRQoL). Hepatitis B virus (HBV) infection has long been the leading cause of CLD including liver cancer and cirrhosis. Knowledge on different symptom profiles of CLD should help in development of comprehensive treatment and patient care plans. Objective: To access the facets of HRQoL in chronic liver diseases throughout their spectrum of severity. Materials and Methods: A cross-sectional study was conducted in the First Affiliated Hospital of Kunming Medical University in Yunnan Province of China. Both out- and inpatients undergoing treatment protocols for different HBV related liver disease states were consecutively collected from December 2012 to June 2013. ANOVA was used to compare the mean scores of EQ-5D and chronic liver disease questionnaire (CLDQ) among 5 disease groups. The relationship between demographic variables predicting global CLDQ scores and the domains of CLDQ was analysed. Results: A total of 1040 patients including 520 without complications, 91 with compensated cirrhosis, 198 with decompensated cirrhosis, 131 with HCC and 100 with liver failure were recruited. All domains of CLDQ, the means of EQ-5D value and EQ VAS exhibited significant decline with worsening of disease severity from uncomplicated HBV to liver failure. The multivariate regression demonstrated the reduction of mean scores of CLDQ domain at advanced stage. Patients with liver failure and HCC had more HRQoL impairment than other disease states. No effect of patient gender was found. Patient age was associated with 'fatigue' and 'worry' domains (p=0.006; p=0.004) but not with other domains and global scores of CLDQ and ED-5D. Conclusions: The HRQoL in chronic hepatitis B patients is greatly affected by disease states. Care for HBV-related diseases should consider not only the outcomes of treatment strategies but also improvement in patient wellbeing.

• 한국임상약학회지
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• 제21권3호
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• pp.280-291
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• 2011

Vaccines are products for immunization which can provoke antibodies by eliciting immune reponses without causing disease and have played an important role in preventing fatal and contagious diseases as well as H1N1 influenza. They are classified by two following categories; lived attenuated vaccine and killed vaccine and currently commonly using vaccines are BCG, diphtheria, tetanus, mumps, measles, rubella, polio, Haemophilus influenza type b, hepatitis B, influenza etc. All vaccines must be used correctly to reach optimal therapeutic goals and also informed well to patients to decrease potential problems. In order to do, pharmacists must have good knowledge of vaccines. The purpose of this study is to evaluate the necessity of vaccine education for pharmacists and develop a vaccine leaflet for patient counseling. We have performed a survey with questionnaire for a total of 176 pharmacists and nurses(hospital pharmacists, n=65; community pharmacists, n=50; hospital nurses, n=61) from January 27th to March 12th, 2010. The questionnaire includes items about vaccine education and counseling and 12 quizzes to evaluate responders' knowledge of vaccines. We used the SPSS(Version 12. for windows) program to analyze the data. In results, 94.9% of all responders said they had not been educated on vaccines. And only 1.1% of all responders said they know about vaccines enough to counsel patients. Pharmacists who have an experience recommending vaccines to other people are 21.7%. On the other hand, nurses who have an experience recommending vaccines to other people are 55.7%(p=0.000). The mean number of correct answers at the 12 quizzes are followings; hospital pharmacist, 8.1; community pharmacist, 6.1, hospital nurses, 6.2(p=0.000). A vaccine leaflet for patient counseling is developed with several references. In conclusion, due to no opportunity of vaccine education, pharmacists have no confidence to counsel patients and lack of knowledge of vaccine. But importance of vaccine's role is increasing, pharmacists should counsel patients in vaccination. So they need vaccine education and a vaccine leaflet will be helpful for their counseling.

• Journal of Yeungnam Medical Science
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• 제24권2호
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• pp.137-147
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• 2007

배경 : 검사결과의 판독과 보고는 진단검사의학과에서 시행해야 할 업무이지만 일일 발생하는 검사건수의 방대함으로 쉽게 접근하기 어려움이 있어 검사결과의 판독과 해석을 할 수 있는 보조 프로그램의 개발이 필요하다. 따라서 저자는 판독 프로그램을 개발하여 검사항목이 적으며, 묶음 검사항목으로 되어 있는 건강검진자를 대상으로 임상 적용시의 문제점과 보완점을 알아보고자 하였다. 재료 및 방법 : 연관성이 있는 검사항목을 기준으로 각 검사결과에 따른 rule-based expert 시스템을 개발하여 2007년 8월 본원 건강증진센터를 방문한 535명을 대상으로 검증하였다. 룰의 구성은 "if-then"로 구성하였으며, 즉 검사결과가 조건에 맞는 경우 미리 입력되어 있는 판독문구가 출력되도록 하였다. 결과 : 50.5%에서 해석적 보고가 필요한 것으로 나타났다. 고지혈증이 34%, 빈혈관련 질환이 8.0%, 뇨검사에서 9.9%, 종양표지자가 4.7%, 갑상선 장애가 7.7%, B형간염표지자에서 4.7%, 혈당 관련 질환에서 4.3%, 등으로 나타났으며, 이는 실제 추적검사를 시행한 환자 수(49명, 9.1%) 보다 상당히 높게 나타났다. 이는 해석적 보고가 단순히 검사항목에 대한 검증으로 대상자의 임상적 소견을 감안하지 않아 더 높은 비율로 나타난 것으로 보인다. 결론 : 임상의에 보고하기 전에 시행하는 검사의 판독은 검사실내의 정도관리적 측면에서도 도움이 되며, 임상의가 최종 진단전 고려해야 할 질환 등을 감별함으로써 보다 질적인 측면에서 향상된 정보를 제공함으로써 입원 및 외래 내원 환자에 적용하면 치료 등에 도움이 될 수 있을 것으로 생각된다.

• 한국치위생학회지
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• 제9권1호
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• pp.45-58
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• 2009

The purpose of this study was to examine the recognition level related to the infection prevention in dental medical institute in dental hygienists and to offer basic data of enhancing the knowledge education in dental hygienists on the infection prevention according to it. As a result of collecting and analyzing data by using the self-administered questionnaire on April 27, 2008 targeting 230 dental hygienists who are working at hospitals and clinics in P,K region, the following conclusions were obtained. 1. Dental hygienists' recognition on hospital-virus treatment method was indicated to be averagely 1.20 out of 3-point perfection. 2. The recognition on infection was indicated to be averagely 2.64 out of 4-point perfection. The statistically significant difference was shown with the appearance of periodical health examination(t=-2.42, p<.05) and by infection-education experience(t=2.28, p<0.05). 3. The recognition on an infection disease was indicated to be averagely 4.38 out of 8-point perfection. The significant difference(t=3.52, p<0.05) was shown depending on task in charge. 4. The recognition on the infection prevention in dental treatment institute was indicated to be averagely 4.89 out of 7-point perfection. The recognition on the infection prevention of dental treatment institute in dental hygienists, who work for general hospital, was indicated to be the highest. Accordingly, it was considered to be required an effort for dental hygienists, other dental-medical practitioners, and patients to be able to treated safely by enhancing the recognition level on infection prevention in dental hygienists and by maximally reducing exposure to infection in dental medical institute.

• 치위생과학회지
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• 제7권1호
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• pp.1-7
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• 2007

이 연구는 치과 진료실에서 치과위생사의 감염예방 실태를 파악하여 치과위생사가 감염예방을 실천하는데 기초 자료로 제공하고자 한다. 연구 대상은 2005년 10월과 11월에 인천경기도회와 서울시회 보수교육에 참여한 치과위생사로 하였으며, 감염 예방에 관한 설문조사를 자기기입방식으로 시행하였다. 그 결과는 다음과 같다. 1. 감염예방 교육경험은 "있다"로 응답한 자가 72명(42.9%)이었고, "없다"고 응답한 자가 96명(57.1%)이었고 감염예방 교육경로를 보면 "근무병원 자체 교육을 통해서"가 42명(58%)으로 가장 많았다. 2. 손상 경험은 "있다"로 응답한 자가 147명(87.5%)이었고 "없다"로 응답한 자가 21명(12.5%)이었으며, 손상 경험이 있는 대상자 147명의 전체 연 평균 손상 횟수는 7.7회였다. 손상을 입힌 기구 명으로는 "explorer"가 125(75%)명으로 가장 많았다. 3. 감염성 질환에 감염된 경험은 "있다"로 응답한 자가 6명(3.6%)이었는데 질환으로는 "B형 간염"이 4명으로 가장 많았고, "풍진" 1명, "결핵" 1명이었다. 4. 실천 점수가 높은 문항은 "2. 나는 진료 후에 손을 씻는다(1.86점)", "7. 나는 국소 마취 후 마취주사바늘 뚜껑을 덮는다(1.86점)", "20. 나는 폐기물을 분리수거하여 적출물처리업자에게 위탁 한다(1.85점)"이었으며, 실천 점수가 낮은 문항은 "16. 나는 진료복을 하루에 한번 갈아입는다(0.24점)"와 "감염성 환자 진료 후에는 진료복을 매번 세탁 한다(0.52점)"이었다. 5. 지식도가 가장 높은 문항은 "1. 치과 진료를 하는 동안에 전염은 감염원, 전염방법, 전염경로, 감염되기 쉬운 숙주에 의해 좌우 된다(0.95점)" 이었으며 지식도가 가장 낮은 문항은 "5. HBV(B형간염)는 95oC에서 5분 이상 가열해야 파괴 된다(0.27점)"이였다. 6. 조직관련 요인 점수가 가장 높은 문항은 "나는 필요한 경우 마스크, 장갑 등의 보호 장구가 항상 이용 가능하다(0.89점)"이었으며 가장 점수가 낮은 문항은 으로 "내가 일하는 곳에는 감염과 관련된 위험한 상황에 노출되었을 때 참고할 수 있는 지침서가 있다(0.33점)" 이었다. 7. 진료환경에서 세면대와 진료실의 거리는 "1미터 미만"이 116명(69.0%), 소독실과 진료실의 거리는 "2미터 미만"이 77명(45.8%)으로 가장 많았으며 보호 장구 구비 현황은 마스크(일회용) 168명(100%), 일회용 장갑(라텍스) 167명(99.4%)으로 대부분 구비되어 있었다. 반면 안면 보호대는 응답자수가 108(64.3%)명으로 가장 적었다. 소독, 멸균기에서는 autoclave가 있다고 응답한 자가 165명(98.2%)이었다.