Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.12.4765

Dynamics and Liver Disease Specific Aspects of Quality of Life Among Patients with Chronic Liver Disease in Yunnan, China  

Che, Yan-Hua (Breast Disease Center, The First Peoples Hospital of Kunming)
You, Jing (The First Affiliated Hospital of Kunming Medical University)
Chongsuvivatwong, Virasakdi (Epidemiology Unit, Faculty of Medicine, Prince of Songkla University)
Li, Li (Department of Hepatobiliary Surgery, The First Peoples Hospital of Kunming)
Sriplung, Hucha (Epidemiology Unit, Faculty of Medicine, Prince of Songkla University)
Yan, Yuan-Zhi (The First Affiliated Hospital of Kunming Medical University)
Ma, Si-Jia (The First Affiliated Hospital of Kunming Medical University)
Zhang, Xiaoli (The First Affiliated Hospital of Kunming Medical University)
Shen, Ting (The First Affiliated Hospital of Kunming Medical University)
Chen, He-Min (The First Affiliated Hospital of Kunming Medical University)
Rao, Shao-Feng (The First Affiliated Hospital of Kunming Medical University)
Zhang, Ru-Yi (The First Affiliated Hospital of Kunming Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.12, 2014 , pp. 4765-4771 More about this Journal
Abstract
Background: Patients with chronic liver diseases (CLD) may have compromised health related quality of life (HRQoL). Hepatitis B virus (HBV) infection has long been the leading cause of CLD including liver cancer and cirrhosis. Knowledge on different symptom profiles of CLD should help in development of comprehensive treatment and patient care plans. Objective: To access the facets of HRQoL in chronic liver diseases throughout their spectrum of severity. Materials and Methods: A cross-sectional study was conducted in the First Affiliated Hospital of Kunming Medical University in Yunnan Province of China. Both out- and inpatients undergoing treatment protocols for different HBV related liver disease states were consecutively collected from December 2012 to June 2013. ANOVA was used to compare the mean scores of EQ-5D and chronic liver disease questionnaire (CLDQ) among 5 disease groups. The relationship between demographic variables predicting global CLDQ scores and the domains of CLDQ was analysed. Results: A total of 1040 patients including 520 without complications, 91 with compensated cirrhosis, 198 with decompensated cirrhosis, 131 with HCC and 100 with liver failure were recruited. All domains of CLDQ, the means of EQ-5D value and EQ VAS exhibited significant decline with worsening of disease severity from uncomplicated HBV to liver failure. The multivariate regression demonstrated the reduction of mean scores of CLDQ domain at advanced stage. Patients with liver failure and HCC had more HRQoL impairment than other disease states. No effect of patient gender was found. Patient age was associated with 'fatigue' and 'worry' domains (p=0.006; p=0.004) but not with other domains and global scores of CLDQ and ED-5D. Conclusions: The HRQoL in chronic hepatitis B patients is greatly affected by disease states. Care for HBV-related diseases should consider not only the outcomes of treatment strategies but also improvement in patient wellbeing.
Keywords
HBV; chronic liver disease; liver cancer; cirrhosis; quality of life;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tongsiri S (2009). "The Thai population-based preference scores for EQ-5D health states [Internet]. Bangkok: HITAP." A
2 Ware J, Kosinski M, Keller S (1994). SF-36 physical and mental health summary scales: A user's manual. Boston, MA: The Health Institute, New England Medical Center.
3 WHO (2012). "international classification of diseases (ICD)." Retrieved 2013-12-26, from http://www.who.int/ classifications/icd/en/
4 Xincai H, Hua Zh, Yan L, et al (2012). Psychometrics of the chronic liver disease questionnaire for patients with posthepatic B cirrhosis. Chin J Hepatol, 20, 8621-7.
5 Younossi Z, Boparai N, McCormick M, et al (2001). Assessment of utiliutilities and health-related quality of life in patients with chronic liver disease. Gastroenterol, 96, 579-583.
6 Chong CA, Gulamhussein A, Heathcote EJ, et al (2003). Healthstate utilities and quality of life in hepatitis C patients. Am J Gastroenterol, 98, 630-8.   DOI
7 Beasley RP, Hwang LY, Lin CC, et al (1981). Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet, 2, 1129-33.
8 Brooks R (1996). EuroQol: the current state of play. Health Policy, 37, 53-72.   DOI   ScienceOn
9 Chinese Society of Hepatology and Chinese Society of Infectious Diseases, C. M. A. (2011). The guideline of prevention and treatment for chronic hepatitis B (2010 version) J ClinHepatol, 27, 1-11.
10 Cordoba J, Flavia M, Jacas C, et al (2003). Quality of life and cognitive function in hepatitis C at different stages of liver disease. J Hepatol, 39, 231-8.   DOI   ScienceOn
11 The EuroQol Group (1990). EuroQol-a new facility for the measurement of health-related quality of life. Health Policy, 16, 199-208.   DOI   ScienceOn
12 Ghany MG, Strader DB, Thomas DL, et al (2009). Diagnosis, Management, and Treatment of Hepatitis C: An Update. Hepatology, 49, 1335-74.   DOI   ScienceOn
13 Lam ET, Lam CL, Lai CL, et al (2009). Health-related quality of life of Southern Chinese with chronic hepatitis B infection. Health Qual Life Outcomes, 7, 52.   DOI   ScienceOn
14 Lee WM. (1997). Hepatitis B virus infection. N Engl J Med, 337, 1733-45.   DOI   ScienceOn
15 Lesmana LA, Leung NW, Mahachai V, et al (2006). Hepatitis B: overview of the burden of disease in the Asia-Pacific region. Liver Int, 26, 3-10.   DOI   ScienceOn
16 Younossi ZM, Boparai N, Price LL, et al (2001). Health-related quality of life in chronic liver disease: the impact of type and severity of disease. Am J Gastroenterol, 96, 2199-205.   DOI   ScienceOn
17 Marchesini G, Bianchi G, Amodio P, et al (2001). Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology, 120, 170-8.   DOI   ScienceOn
18 Arguedas MR, DeLawrence TG, McGuire BM (2003). Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis. Dig Dis Sci, 48, 1622-6.   DOI   ScienceOn
19 R Core Team (2013). "R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria."
20 Younossi ZM, Guyatt G, Kiwi M, et al (1999). Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease. Gut 45, 295-300.   DOI   ScienceOn
21 Ministry of Public Health of P.R.C. (2011) "The guideline of prevention and treatment for primary liver cancer (PLC) (2011 version) Chinese Clinical Oncology, 16, 929-46.
22 Ong JP, Younossi ZM (2005). Approach to the diagnosis and treatment of non-alcoholic fatty liver disease. Clin Liver Dis, 9, 617-34.   DOI   ScienceOn
23 Rodrigue JR, Baz MA (2006). Are there sex differences in healthrelated quality of life after lung transplantation for chronic obstructive pulmonary disease? J Heart Lung Transplant, 25, 120-5.   DOI
24 Sobhonslidsuk A, Silpakit C, Kongsakon R, et al (2004). Chronic liver disease questionnaire: translation and validation in Thais. World J Gastroenterol, 10, 1954-7.   DOI
25 Pettersen KI, Reikvam A, Rollag A, et al (2008). Understanding sex differences in health-related quality of life following myocardial infarction. Int J Cardiol, 130, 449-56.   DOI
26 Guyatt GH, Feeny DH, Patrick DL (1993). Measuring healthrelated quality of life. Ann Intern Med, 118, 622-9.   DOI   ScienceOn