• 제목/요약/키워드: ketone body

검색결과 40건 처리시간 0.022초

Genetic parameter estimation for milk β-hydroxybutyrate and acetone in early lactation and its association with fat to protein ratio and energy balance in Korean Holstein cattle

  • Ranaraja, Umanthi;Cho, KwangHyun;Park, MiNa;Kim, SiDong;Lee, SeokHyun;Do, ChangHee
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제31권6호
    • /
    • pp.798-803
    • /
    • 2018
  • Objective: The objective of this study was to estimate the genetic parameters for milk ${\beta}$-hydroxybutyrate (BHBA), acetone (Ac), fat protein ratio (FPR), and energy balance (EB) using milk test day records and investigate the effect of early lactation FPR and EB on milk ketone body concentrations. Methods: Total 262,940 test-day records collected from Korea Animal Improvement Association during the period of 2012 to 2016 were used in this study. BHBA and Ac concentrations in milk were measured by Fourier transform infrared spectroscopy (FTIR). FPR values were obtained using test day records of fat and protein percentage. EB was calculated using previously developed equation based on parity, lactation week, and milk composition data. Genetic parameters were estimated by restricted maximum likelihood procedure based on repeatability model using Wombat program. Results: Elevated milk BHBA and Ac concentrations were observed during the early lactation under the negative energy balance. Milk FPR tends to decrease with the decreasing ketone body concentrations. Heritability estimates for milk BHBA, Ac, EB, and FPR ranged from 0.09 to 0.14, 0.23 to 0.31, 0.19 to 0.52, and 0.16 to 0.42 respectively at parity 1, 2, 3, and 4. The overall heritability for BHBA, Ac, EB and FPR were 0.29, 0.32, 0.58, and 0.38 respectively. A common pattern was observed in heritability of EB and FPR along with parities. Conclusion: FPR and EB can be suggested as potential predictors for risk of hyperketonemia. The heritability estimates of milk BHBA, Ac, EB, and FPR indicate that the selective breeding may contribute to maintaining the milk ketone bodies at optimum level during early lactation.

경주마(競走馬)의 혈액화학성상(血液化學性狀)에 관한 연구 II. 혈액화학치(血液化學値) (Studies on the blood chemical properties in racehorses II. Blood chemical values)

  • 강정부
    • 대한수의학회지
    • /
    • 제28권2호
    • /
    • pp.307-310
    • /
    • 1988
  • This experiment was carried out to provide the data of blood chemistry in use of application to clinical diagnosis in racehorses. Blood was collected from 30 racehorses(♀ 17, ♂ 13). Calcium, inorganic phosphorus, blood glucose, blood urea nitrogen, cholesterol, bilirubin, fibrinogen and ketone body in serum were analyzed as follows. 1. The values of calcium and inorganic phosphorus were maintained a certain level without much variation regardless of sex and species, Ca/P ratio was in the range of 3.13~3.35. 2. The value of blood glucose was 60 mg/100ml, Age and sex of racehorses make no difference in the value. 3. The value of blood urea nitrogen and total cholesterol showed a tendency to increase according to the age. Total cholesterol value was somewhat higher in male than in female. 4. The value of total bilirubin showed a tendency to increase according to the age. There was no difference between sexes in the value. 5. The value of fibrinogen showed no apparent difference with age and sex. 6. Ketone body was negative in all of the cases. 7. There was no variation in the species of the racehorses.

  • PDF

Preparation of $^{99m}Tc$ Ferric Hydroxide Macroaggregates for Lung Perfusion Studies

  • Kim, Young-Hwan;Kim, Young-Sup;Kim, Young-Kuk
    • Nuclear Engineering and Technology
    • /
    • 제4권4호
    • /
    • pp.327-330
    • /
    • 1972
  • 낮은 방사능의 $^{99m}$ Mo으로부터 methyl ethyl ketone으로 추출하여 제조된 Na $^{99m}$ TcO$_4$를 가지고 폐검진에 사용되고 있는 $^{99m}$ Tc Ferric Hydroxide Macroaggregates를 제조하였으며 여러 pH 범위에서 입자의 크기와 수가 변하는 모양을 검토하였고 pH 6-7에서 평균입자의 크기가 scanning에 가장 적당한 20~60$\mu$이었다. 토끼와 인체에 주사하여 좋은 곁과를 얻었다.

  • PDF

Displacement of scan body during screw tightening: A comparative in vitro study

  • Kim, JungHan;Son, KeunBaDa;Lee, Kyu-Bok
    • The Journal of Advanced Prosthodontics
    • /
    • 제12권5호
    • /
    • pp.307-315
    • /
    • 2020
  • PURPOSE. The purpose of this study was to evaluate the occurrence of displacement while tightening the screw of scan bodies, which were compared according to the material type. MATERIALS AND METHODS. Three types of scan bodies whose base regions were made up of polyether ether ketone (PEEK) material [Straumann Group, Dentium Group, and Myfit (PEEK) Group] and another scan body whose base region was made up of titanium material [Myfit (Metal) Group] were used (15 per group). The reference model was fabricated by aligning the scan body library on the central axis of the implant, and moving this position by the resin model. The screws of the scan bodies were tightened to the implant fixture with torques of 5 Ncm, 10 Ncm, and a hand tightening torque. After the application of the torque, the scan bodies were scanned using a laboratory scanner. To evaluate the vertical, horizontal, and 3-dimensional (3D) displacements, a 3D inspection software program was used. To examine the difference among groups, one-way analysis of variance and Tukey's HSD post hoc test were used (α=.05). RESULTS. There were significant differences in 3D, vertical, and horizontal displacements among the different types of scan bodies (P<.001). There was a significantly lower displacement in the Straumann group than in the Myfit (PEEK) and Dentium groups (P<.05). CONCLUSION. The horizontal displacement in all groups was less than 10 ㎛. With the hand tightening torque, a high vertical displacement of over 100 ㎛ occurred in PEEK scan bodies (Myfit and Dentium). Therefore, it is recommended to apply a tightening torque of 5 Ncm instead of a hand tightening torque.

소양인(少陽人) 양격산화탕(凉膈散火湯)과 인동등지골피탕(忍冬藤地骨皮湯) 및 숙지황고삼탕(熟地黃苦蔘湯)이 Alloxan 투여(投與) 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響) (Effects of Soyangin Yangkyuksanwhatang(少陽人凉膈散火湯), Soyangin Yangkyuksanwhatang Indongduengjigolpitang(忍冬藤地骨皮湯) and Sookjiwhanggosamtang(熟地黃苦蔘湯) on the Alloxan-Induced diabetic Rats)

  • 최병일;송일병
    • 사상체질의학회지
    • /
    • 제10권2호
    • /
    • pp.513-532
    • /
    • 1998
  • In order to investigate the effect of the Soyangin Yangkyuksanwhatang, Indongduengjigolpitang and Sookjiwhanggosamtang that are the model prescriptions for diabetic soyangin. The contents of serum glucose, insulin, total triglyceride and urine glucose, ketone-body and urine volumn and body-weights were mesured on the Alloxan-Induced diabetic Rats. The following results have been measured. 1. Yangkyuksanwhatang, Indonduengjigolpitang and Sookjiwhanggosamtang showed significant decreases on the serum glucose and particulruy Sookjiwhanggosamtang decreased significantly. 2. The contents of serum insulin on the Alloxan-Induced diabetic Rats comparing with normal group were increased in Yangkyuksanwhatang and Indongduengjigolpitang with no significance but Sookjiwhanggosamtang showed a significant increase on the serum insulin. 3. The contents of serum triglyceride were decreased in three groups, but Indongduengjigolpitang showed the significant decrease and others did not. 4. The contents of serum total cholesterol were signicantly decreased In indongduengjigolpitang but Yangkyuksanwhatang and Sookjiwhanggosamtang did not. 5. The contents of urine glucose simillary decreased in three groups. 6. The contents of urine ketone-body were not changed comparing with control group in Yangkyuksanwhatang and Indongduengjigolpitang groups, but Sookjiwhanggosamtang group showed some increase. 7. The urine volume were significantly decreased in Yangkyuksanwhatang, but Indongduengjigolpitang and Sookjiwhanggosamtang showed the decrease of urine volume with no significance. 8. Body weights were regained comparing with control group, but only Indongduengjigolpitang showed significant increase. According to the above results, Yangkyuksanwhatang, Indongduengjigolpitang and Sookjiwhanggosamtang had the effect for hyperglycemia, particulary Indongduengjigolpitang was assumed as having the effect for hyperlipemia and weight-loss induced by D. M.. Therefore, by this experiments it can be concluded that Yangkyuksanwhatang, indongduengjigolpitang and Sookjiwhanggosamtang recorded in "DongYi Soose Bowon" have the effect for soyangin diabetics.

  • PDF

케톤음료를 보충한 저탄수화물·고지방식이 섭취가 치매고위험 노인의 인지기능 및 신체활동 능력 변화에 미치는 영향 (Effects of Low-carbohydrate and High-fat Diet Supplemented with Ketogenic Drink on Cognitive Function and Physical Performance in the Elderly at High Risk for Dementia)

  • 김은지;박정식;최원선;박유경
    • 대한지역사회영양학회지
    • /
    • 제24권6호
    • /
    • pp.525-534
    • /
    • 2019
  • Objectives: Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer's disease, in which ketone bodies are used as the only and effective alternative energy source of glucose. This study examined the effects of a low-carbohydrate and high-fat (LCHF) diet supplemented with a ketogenic nutrition drink on cognitive function and physical activity in the elderly at high risk for dementia. Methods: The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated. Results: Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05). Conclusions: We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.

Effects of Starvation on Lipid Metabolism and Gluconeogenesis in Yak

  • Yu, Xiaoqiang;Peng, Quanhui;Luo, Xiaolin;An, Tianwu;Guan, Jiuqiang;Wang, Zhisheng
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제29권11호
    • /
    • pp.1593-1600
    • /
    • 2016
  • This research was conducted to investigate the physiological consequences of undernourished yak. Twelve Maiwa yak ($110.3{\pm}5.85kg$) were randomly divided into two groups (baseline and starvation group). The yak of baseline group were slaughtered at day 0, while the other group of yak were kept in shed without feed but allowed free access to water, salt and free movement for 9 days. Blood samples of the starvation group were collected on day 0, 1, 2, 3, 5, 7, 9 and the starved yak were slaughtered after the final blood sample collection. The liver and muscle glycogen of the starvation group decreased (p<0.01), and the lipid content also decreased while the content of moisture and ash increased (p<0.05) both in Longissimus dorsi and liver compared with the baseline group. The plasma insulin and glucose of the starved yak decreased at first and then kept stable but at a relatively lower level during the following days (p<0.01). On the contrary, the non-esterified fatty acids was increased (p<0.01). Beyond our expectation, the ketone bodies of ${\beta}$-hydroxybutyric acid and acetoacetic acid decreased with prolonged starvation (p<0.01). Furthermore, the mRNA expression of lipogenetic enzyme fatty acid synthase and lipoprotein lipase in subcutaneous adipose tissue of starved yak were down-regulated (p<0.01), whereas the mRNA expression of lipolytic enzyme carnitine palmitoyltransferase-1 and hormone sensitive lipase were up-regulated (p<0.01) after 9 days of starvation. The phosphoenolpyruvate carboxykinase and pyruvate carboxylase, responsible for hepatic gluconeogenesis were up-regulated (p<0.01). It was concluded that yak derive energy by gluconeogenesis promotion and fat storage mobilization during starvation but without ketone body accumulation in the plasma.

케톤식이로 발생한 체중감소 및 내당능장애에 침치료 효과 (Effects of Acupuncture Treatment on Weight Loss and Glucose Intolerance Induced by a Ketogenic Diet)

  • 고희재;김동주;김승남
    • Korean Journal of Acupuncture
    • /
    • 제36권4호
    • /
    • pp.274-280
    • /
    • 2019
  • Objectives : This preliminary study investigated the effect of acupuncture treatment on short-term ketogenic diet-induced weight loss and glucose intolerance in mice. Methods : Six-week old male C57BL/6J mice were randomly assigned to 3 groups: normal, KD, and KD+ACU. All the mice except normal group were fed with ketogenic diet formula for 7 weeks and mice in KD+ACU group received acupuncture treatment three times a week. Body weights were measured three times a week, and glucose level was measured on week 1,3,5, and 7. Ketone level was measured on week 3,5, and 7. Results : Ketogenic diet showed short-term weight loss effect, however, acupuncture treatment did not affect on the weight loss. Ketone level was increased in KD fed mice compared to normal diet fed mice and the level was decreased in KD+ACU group on week 3. However, the change was not significantly different compared to KD group on week 7. Glucose intolerance was improved in KD+ACU group compared to KD group. Conclusions : Acupuncture treatment was effective in relieving glucose intolerance, and the results suggest that combining acupuncture treatment with ketogenic diet may complement each therapeutic intervention by improving glucose intolerance but not effecting on weight loss. This study provides meaningful evidence as a preliminary study of acupuncture treatment on ketogenic diet.

한우(韓牛)의 혈액내(血液內) Total Ketone body의 정상치(正常値)에 관(關)한 연구(硏究) (A Study on the Blood Total Ketones and Acetone of Korean Cattle)

  • 김영홍
    • 대한수의학회지
    • /
    • 제8권2호
    • /
    • pp.121-124
    • /
    • 1968
  • For 8 months, from January to August, 1967, the author made a stuffy of blood total ketones and of korean cattle in different sexes and age groups in winter and summer. The results were summarized as follows : 1. The mean values of blood total ketones and acetone in Korean cattle were $2.31{\pm}0.18mg/dl$ and $0.76{\pm}0.10mg/dl$ in female and $2.35{\pm}0.19mg/dl$ and $0.74{\pm}0.12mg/dl$ in male respectively. 2. The mean values of blood total ketones and acetone during winter season were 2.39mg/dl and 0.84mg/dl in female, and 2.38mg/dl and 0.84mg/dl in male respectively. 3. No statistical significance was recognized among the sexes, the age groups and the seasons by F-distribution. 4. The mean values of blood total ketone and acetone during summer season were 2.25mg/dl and 0.67mg/dl in female, and 2.32mg/dl and 0.64mg/dl in male respectively.

  • PDF

인삼백호탕(人蔘白虎湯)이 Alloxan으로 유발(誘發)된 mouse의 당뇨병성(糖尿病性) 신증(腎症)에 미치는 영향(影響) (The Effects of Insambackhotang on Mouse with Diabetic Nephropathy Induced by Alloxan)

  • 김용성;김철중;성현제
    • 한국한의학연구원논문집
    • /
    • 제5권1호
    • /
    • pp.17-25
    • /
    • 1999
  • To investigate recovery effects of Insambackhotang, which have been used clinically in diabetes therapny, on kidney failure of a diabetes-induced mouse by Alloxan administration, body and kidney weight changes of mice, BUN, creatinine, glucose and MDA level in serum, MDA level in kidney tissue. 1. A hyperglycemia(250-400mg/dl) mouse induced by Alloxan(75mg/kg) showed significant decline of kidney function: increase of BUN and creatinine in serum, excretion of glucose, protein, ketone in urine were observed at 4 days after the treatment. 2. Increase of the mouse body and kidney weight and a ratio of the kidney/body weight of Insambackhotang treated group as compared to the control group was significantly inhibited. 3. The BUN, creatinine level in serum of Insambackhotang treated group as compared to the control group were significantly inhibited. 4. The MDA level in serum and kidney tissue of Insambackhotang treated group as compared to the control group were significantly inhibited.

  • PDF