• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5319-5323
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• 2015

Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.

• 종양간호연구
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• 제7권1호
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• pp.3-13
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• 2007

Purpose: The purpose of this study was to identify the relationship of fatigue and functional status in patients with cancer. Method: The data were collected from August, 15 to October, 10, 2005. The subjects were recruited from three university hospitals and two general hospitals in B, U, and S cities in Korea. Fatigue was measured using the Fatigue Scale for Cancer Patients, and Functional Status was measured using the Karnofsky Performance Status Index. Result: 1) The mean score of fatigue was $79.72{\pm}21.25$(range: 26-130), and the mean score of functional status was $79.33{\pm}13.02$. 2) There were significant differences in the scores of fatigue by sex, age, marital status, employment, major care-giver, pain, and period after diagnosis. 3) There were significant differences in the scores of functional status by employment, major care-giver, pain, stage of cancer, period after diagnosis, and type of cancer. 4) There was a significant negative correlation between fatigue and functional status (r= -.472, p= .000). Conclusion: Increase in fatigue was associated with decrease in functional status in patients with cancer. Nurses must assess fatigue and functional status when caring for the cancer patients, and provide nursing intervention to relieve fatigue and to improve functional status.

• Tuberculosis and Respiratory Diseases
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• 제45권1호
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• pp.68-76
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• 1998

연구배경: 비소세포성 폐암이 수술이 불가능한 국소 병변일 경우 외부 방사선 치료를 받거나 항암치료와 병행하기도 한다. 그러나 방사선치료후 재발한 경우 특히 재발 부위가 통일한 경우는 외부방사선 치료를 다시 받을 수 없다. 이런 환자의 경우 재발로 인한 증상이 있을 경우 외부 방사선 조사 여부와 상관없이 기관지내 고선량율 근접치료는 치료의 대안이 될수 있다. 본연구에서는 치료후 기관지내로 재발한 비소세포성 폐암 환자 26명을 대상으로 기관지내 고선량율 근접조사치료를 시행하여 효과를 보았다. 연구방법: 대상환자는 비소세포성 폐암으로 치료후 재발한 26명이고 기관지 내시경율 통해 방사선 투시하에 카테타를 삽입하여 종양부위에 설치하고 $^{192}Ir$ HDR 후부하 기구(Remote afterloading unit : Gammamed, Germany)를 연결하였다. 컴퓨터로 정확한 조사위치를 정하고 깊이 10mm로 설정하고 조사량은 500cGY로 매주 간격으로 3회 시행하였다. 조사시간은 10~15분 정도 였다. 치료 효과를 판정하기 위하여 기관지 내시경하 폐색정도, 치료전과 치료후 4주에 단순 흉부 X-선 촬영, 증상과 징후의 접수에 따른 비교, Karnofsky performance scale (KPS)을 비교하였다. 결 과: 치료후 기관지 폐색은 26명중 11명(42%)에서 호전되었고 13명(50%)에서 변화없었으며, 2명(8%)에서 악화되었다. 흉부 X-선상 기관지 폐색으로 인한 무기폐는 환자 15명에서 관찰되었고 이들중 5명(33%)에서 호전되었고, 1명(7%)에서 오히려 악화되었으며 9명(60%)에서 변화없었다. 환자들이 주로 호소하는 증상은 객혈, 호흡곤란, 기침이었으며 객혈은 10명중 5명(50%)에서 증상호전을 보였고, 4명(40%)에서 변화없었으며, 1명(10%)에서 악화되었다. 호흡곤란은 치료후 8명중 5명(62%)에서 호전되었고, 2(25%)명에서 변화없었으며, 1명(13%)에서 악화되었다. 18명의 환자가 호소하던 기침은 치료후 10명(56%)에서 호전되었으며, 7명(38%)에서 변화없었고 1명(6%)에서 악화되었다. 전체적인 수행능력을 알아보는 Karnofsky performance scale은 치료전 평균 76.4점에서 77.6점으로 상승하였다. 결 론: 기관지내 고선량율 근접 조사치료는 기관지내로 재발한 폐암 환자의 증상을 완화시키고 합병증도 적고, 환자들도 외래에서 짧은 시간에 치료 받을 수 있어 효과적이다.

• 대한한방내과학회지
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• 제42권5호
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• pp.746-759
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• 2021

Objectives: This study assessed the effect of a combination of Korean medicine and immunotherapy on three papillary thyroid cancer patients following thyroidectomy. Methods: The three patients who underwent thyroidectomy received Korean medical treatments, including acupuncture, moxibustion, pharmacopuncture, and immunotherapy. To evaluate the patients, symptoms were measured using the Numerical Rating Scale (NRS) and Karnofsky Performance Status Scale (KPS). Blood tests, including thyroid function tests, were conducted during treatment. Results: After treatment, postoperative pain and general weakness were gradually alleviated. Conclusions: These cases provide evidence that treatment with a combination of Korean medicine and immunotherapy can have substantial benefits for postoperative complications following thyroidectomy.

• 임상간호연구
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• 제22권2호
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• pp.194-204
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• 2016

Purpose: The purpose of this study was to identify physiological functional status and unmet care needs among patients with chronic pulmonary disease, colorectal cancer, and strokes after discharge. Methods: A crosssectional study was conducted with 224 patients diagnosed with aforementioned diseases from January to July in 2014 in two different tertiary hospitals in Seoul and its suburban area. Physiological functional status and unmet care needs were collected using Karnofsky Performance Status (KPS) Scale and Problems After Discharge Questionnaire-English version(PADQ-E) respectively. Data were analyzed using SPSS/WIN 21.0 program. Results: Patients with chronic pulmonary disease and colorectal cancer showed a low level of physiological functional status (mean: 77.20 and 77.60 out of 100 respectively) and a high level of unmet care needs (mean 2.23 and 2.63 out of 4 respectively). Stroke patients showed a high level of unmet care needs in the category of 'counseling', 'physical complaints', and 'instructions'. Physiological functional status was significantly associated with unmet care needs in all three patient groups and it showed a significant effect on unmet care needs in patients with stroke. Conclusion: The results showed that patients after discharge were still having insufficient functional status and various unmet care needs. The results of this study suggest a development of nursing care service for patients with chronic diseases after discharge.

• 생물정신의학
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• 제16권2호
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• pp.112-120
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• 2009

Objectives : Depression is a common psychiatric disorder in cancer patients. The Brief Edinburgh Depression Scale(BEDS), which is an abbreviated version of the Edinburgh Depression Scale, may serve as a useful tool in screening for the depression in patients with the medical illnesses. This report investigated the reliability and validity of the Korean Version of the BEDS(K-BEDS) for the depression in cancer patients. Methods : One-hundred cancer patients were enrolled in this study. All subjects completed the K-BEDS, the Hospital Anxiety Depression Scale(HADS), and the Karnofsky Performance Status Scale(KPSS). Reliability, validity and Receiver Operating Characteristic(ROC) curve analysis measures were assessed. Results : The K-BEDS showed good internal consistency(Cronbach ${\alpha}$=0.77) and test-retest reliability(0.94, p<0.001). All item-total correlations were above 0.3. Also, it revealed moderate correlation with the depression subscale of the HADS(r=0.617), but no correlation with the KPSS. Exploratory factor analysis produced only one factor, accounting for 47.1% of the total variance. The most valid cutoff value to screen for depression was a total score of 5 on the K-BEDS, which showed sensitivity of 62.5% and specificity of 86.4% with a positive predictive value of 4.60 and a negative predictive value of 0.43.

• 여성건강간호학회지
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• 제12권1호
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• pp.53-60
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• 2006

Purpose: This study aimed to explore changes in symptom distress and functional status in gynecologic cancer patients during the entire treatment cycles of chemotherapy. Methods: A prospective and longitudinal study with repeated measures was designed. Symptom Distress Scale and Karnofsky Performance Status Index were included in a daily log developed for self-administration. A total of 39 patients with a mean age of 48.4 years participated. Results: The levels of symptom distress and functional status changed significantly over the six cycles. Symptom distress kept increasing until its peak at the fourth cycle, while the functional status scored lowest at the first cycle, then it improved as the cycle repeated. In each cycle, symptom distress was marked higher during the first 6 days accompanying poor functional status. However, both changes did not recover completely until the end of each cycle. Conclusion: Nursing assessment and intervention need to be provided based on these changing patterns to help cancer patients cope and adjust successfully during the long treatment period. Further studies are needed to examine the impact of the major symptoms on psychological responses, quality of life, and outcomes of the cancer treatments.

• Journal of Korean Neurosurgical Society
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• 제65권3호
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• pp.469-478
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• 2022

Objective : Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression of chordomas over the past 10 years. Methods : We retrospectively reviewed 50 patients who underwent surgery at Tianjin Huanhu Hospital between 2010 and 2020 and were pathologically diagnosed with chordomas. Tumor resection was performed within the maximum safe range in all patients; the extent of resection was evaluated by imaging; and the incidence of complications, recurrence or progression, and overall survival were assessed. Results : Fifty patients were divided into the low-risk group (LRG) and high-risk group (HRG) based on the cranial chordoma grading system (CCGS). The Karnofsky Performance Scale scores and gross total resection rate of the LRG were significantly higher than those of the HRG (p<0.05). The incidence of complications and mortality in the LRG were lower than those of HRG. The analysis of cumulative survival and cumulative recurrence free survival/progression free survival (RFS/PFS) showed no statistical differences in the extent of resection for survival, recurrence, or progression. Univariate and multivariate analyses showed that Ki-67 was significantly associated with tumor recurrence and was an independent hazard factor (p=0.02). Conclusion : The CCGS can help neurosurgeons anticipate surgical outcomes. Pathological results are important in evaluating the possibility of tumor recurrence, and postoperative radiotherapy improves overall survival and RFS/PFS.

• 대한한방내과학회지
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• 제39권4호
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• pp.814-821
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• 2018

Thyroid cancer is one of the most common cancers in Korea, and thyroidectomy is the first-line treatment. Hypoparathyroidism is a common complication of thyroidectomy and can cause symptoms such as numbness, spasm, and anxiety, but these issues have seldom been reported in the Korean medical literature. The present case was a 53-year-old thyroid cancer patient who complained of numbness caused by hypoparathyroidism, general weakness, fatigue, and postoperative pain after total thyroidectomy. The patient was treated with Korean medicine treatment, including herbal medicine, acupuncture, cupping, and moxibustion, and her changes in clinical symptoms were measured with a numeric rating scale (NRS), the Karnofsky performance status scale (KPS), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). After treatment, her clinical symptoms were improved, leading to an improvement in her quality of life. Therefore, Korean medicine may be effective in the treatment of thyroid cancer patients who experience numbness caused by hypoparathyroidism, general weakness and fatigue after total thyroidectomy.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4609-4614
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• 2016

Purpose: To evaluate the therapeutic effects of copper reduction on angiogenesis-related factors in patients with glioblastoma multiforme treated by gamma knife radiosurgery. Materials and Methods: In the present block randomized, placebo-controlled trial, fifty eligible patients with a diagnosis of glioblastoma multiforme who were candidates for gamma knife radiosurgery were randomly assigned into two groups to receive daily either 1gr penicillamine and a low copper diet or placebo for three months. The intervention started on the same day as gamma knife radiosurgery. Serum interleukin-6 (IL-6), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), vascular endothelial growth factor (VEGF) and copper levels were measured at baseline and after the intervention. The serum copper level was used as the final index of compliance with the diet. In order to control probable side effects of intervention, laboratory tests were conducted at the beginning, middle and end of the study. Results: The patients had a mean age and Karnofsky Performance Scale of 43.7 years and 75 respectively. Mean serum copper levels were significantly reduced in intervention group. Mean survival time was 18.5 months in intervention group vs. 14.9 in placebo group. VEGF and IL-6 levels in the intervention group were also significantly reduced compared to the placebo group and $TNF-{\alpha}$ increased less. Conclusions: It seems that reducing the level of copper in the diet and dosing with penicillamine leads to decline of angiogenesis-related factors such as VEGF, IL-6 and $TNF-{\alpha}$. Approaches targeting angiogenesis may improve survival and can be used as a future therapeutic strategy.