Browse > Article
http://dx.doi.org/10.7314/APJCP.2015.16.13.5319

Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients  

Atalay, Tugay (Department of Neurosurgery, School of Medicine, Bozok University)
Ak, Hakan (Department of Neurosurgery, School of Medicine, Bozok University)
Celik, Bahattin (Department of Neurosurgery, School of Medicine, Harran University)
Gulsen, Ismail (Department of Neurosurgery, School of Medicine, Yuzuncu Yil University)
Seckin, Hakan (Department of Neurosurgery, Lokman Hekim Private Hospital)
Tanik, Nermin (Department of Neurology, School of Medicine, Bozok University)
Albayrak, Sedat Baki (Department of Neurosurgery, School of Medicine, Suleyman Demirel University)
Bavbek, Murad (Department of Neurosurgery, School of Medicine, Yildirim Beyazit University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.13, 2015 , pp. 5319-5323 More about this Journal
Abstract
Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.
Keywords
Oligodendroglioma; ki-67 index, microvascular density; karnofsky performance scale; CD34 staining;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Ahmed N, Bhurgri Y, Sadiq S, et al (2007). Pediatric brain tumours at a tertiary care hospital in Karachi. Asian Pac J Cancer Prev, 8, 399-404.
2 Allam A, Radwi A, El Weshi A, et al (2000). Oligodendroglioma: an analysis of prognostic factors and treatment results. Am J Clin Oncol, 23, 170-5.   DOI
3 Cairncross G, Macdonald D, Ludwin S, et al (1994). Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol, 12, 2013-21.
4 Coleman KE, Brat DJ, Cotsonis GA, et al (2006). Proliferation (MIB-1 expression) in oligodendrogliomas: assessment of quantitative methods and prognostic significance. Appl Immunohistochem Mol Morphol, 14, 109-14.   DOI
5 Coons SW, Pearl DK (1998). Mitosis identification in diffuse gliomas: implications for tumor grading. Cancer, 82, 1550-5.   DOI
6 Engelhard HH, Stelea A, Mundt A (2003). Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis. Surg Neurol, 60, 443-56.   DOI
7 Fortin D, Cairncross GJ, Hammond RR (1999). Oligodendroglioma: an appraisal of recent data pertaining to diagnosis and treatment. Neurosurgery, 45, 1279-91.   DOI
8 Gheytanchi E, Mehrazma M, Madjd Z (2014). Expression of Ki-67, p53 and VEGF in pediatric neuroblastoma. Asian Pac J Cancer Prev, 15, 3065-70.   DOI   ScienceOn
9 Haroon S, Hashmi AA, Khurshid A, et al (2013). Ki67 index in breast cancer: correlation with other prognostic markers and potential in pakistani patients. Asian Pac J Cancer Prev, 14, 4353-8.   DOI
10 Heegaard S, Sommer HM, Broholm H, et al (1995). Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer, 76, 1809-13.   DOI
11 Heesters MA, Koudstaal J, Go KG, et al (1999). Analysis of proliferation and apoptosis in brain gliomas: prognostic and clinical value. J Neurooncol, 44, 255-66.   DOI
12 Kayaselcuk F, Zorludemir S, Gumurduhu D, et al (2002). PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade. J Neurooncol, 57, 115-21.   DOI
13 Louis DN, Ohgaki H, Wiestler OD, et al (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol, 114, 97-109.   DOI
14 Miller CR, Dunham CP, Scheithauer BW, et al (2006). Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas. J Clin Oncol, 24, 5419-26.   DOI
15 Reis-Filho JS, Faoro LN, Carrilho C, et al (2000). Evaluation of cell proliferation, epidermal growth factor receptor, and bcl-2 immunoexpression as prognostic factors for patients with World Health Organization grade 2 oligodendroglioma. Cancer, 88, 862-9.   DOI
16 Ocal I, Avci A, Cakalagaoglu F, et al (2014). Lack of correlations among histopathological parameters, Ki-67 proliferation index and prognosis in pheochromocytoma patients. Asian Pac J Cancer Prev, 15, 1751-5.   DOI
17 Olson JD, Riedel E, DeAngelis LM (2000). Long-term outcome of low-grade oligodendroglioma and mixed glioma. Neurol, 54, 1442-8.   DOI
18 Quon H, Hasbini A, Cougnard J, et al (2010). Assessment of tumor angiogenesis as a prognostic factor of survival in patients with oligodendroglioma. J Neurooncol, 96, 277-85.   DOI
19 Scerrati M, Roselli R, Iacoangeli M, et al (1996). Prognostic factors in low grade (WHO grade II) gliomas of the cerebral hemispheres: the role of surgery. J Neurol Neurosurg Psychiatry, 61, 291-6.   DOI
20 Schiffer D, Dutto A, Cavalla P, et al (1997). Prognostic factors in oligodendroglioma. Can J Neurol Sci, 24, 313-9.   DOI
21 Shaw EG, Scheithauer BW, O'Fallon JR, et al (1992). Oligodendrogliomas: the Mayo Clinic experience. J Neurosurg, 76, 428-34.   DOI
22 Vaquero J, Zurita M, Coca S, et al (2000). Prognostic significance of clinical and angiogenesis-related factors in low-grade oligodendrogliomas. Surg Neurol, 54, 229-34.   DOI
23 Weidner N, Carroll PR, Flax J, et al (1993). Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol, 143, 401-9.
24 Zahir ST, Vakili M, Navabii H, et al (2014). Clinicopathological findings and five year survival rates for patients with central nervous system tumors in Yazd, Iran. Asian Pac J Cancer Prev, 15, 10319-23.
25 Wharton SB, Hibberd S, Eward KL, et al (2004). DNA replication licensing and cell cycle kinetics of oligodendroglial tumours. Br J Cancer, 91, 262-9.
26 Yates JW, Chalmer B, McKegney FP (1980). Evaluation of patients with advanced cancer using the Karnofsky performance status. Cancer, 45, 2220-4.   DOI