• 한국방사선학회논문지
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• 제16권1호
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• pp.45-51
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• 2022

본 연구는 Chest CT에서 Care Dose 4D+Care kV System을 사용하여 촬영할 때와 CARE DOSE 4D 기능만을 사용했을 때, 그리고 Care Dose 4D와 관전압을 각각 80 kVp, 100 kVp, 120 kVp, 140 kVp로 변화를 주고 검사했을 때의 DLP값과 팬텀의 입사표면선량, 화질을 비교하여 최소의 선량으로 가장 최상의 화질을 유지할 수 있는 방법을 찾아보고자 하였다. DLP값은 Chest Care Dose 4D + Care kV semi 100으로 촬영하였을 때 6.727%, Chest Care Dose 4D + Care kV 로 촬영하였을 때 6.481% 감소하는 것으로 나타났다. Chest Non을 기준으로 입사표면선량에서 Chest Care Dose 4D + Care kV semi 100으로 검사하였을 때 16.519%, Chest Care Dose 4D + Care kV 로 검사하였을 때 15.705% 감소하는 것으로 나타났다. 영상의 화질에 대한 비교에서 Chest Non과 비교해서 Care Dose 4D + Care kV를 포함한 모든 촬영조건에서 SNR값과 CNR값을 비교한 결과 P>0.05로 유의한 차이가 없는 것으로 나타났다. Chest CT에서 Chest Care Dose 4D + Care kV를 사용해서 촬영한 결과 수동으로 kV와 mAS를 조정해서 얻은 최상의 조건의 결과 값과 비슷하게 피폭선량이 감소한 것으로 나타났으며, 영상의 SNR과 CNR에서도 유의한 차이가 없는 것으로 나타났다. Chest Care Dose 4D + Care kV 기능을 사용한다면 영상의 화질을 유지하면서 환자피폭을 줄일 수 있는 좋은 방법이라 생각된다.

• 대한디지털의료영상학회논문지
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• 제11권2호
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• pp.101-107
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• 2009

With the recent development of diagnosis using radiation and increasing demand of the medical treatment, we need to minimize radiation exposure dose. So, This is the method which reduce patient dose by measuring surface dose of radiographic change factor and by comparing theoretical and actual dose, when we take an X-ray which is generally used. By changing the factor of kV, mAs, FSD, whose range is 60 to 120 kV, 20 to 100 mAs, 80 to 180 cm, we compared theoretical surface dose with actual surface dose calculated by the simple calculation program, Bit system, and NDD-M method As a result, when kV and mAs were higher, theoretical surface dose and actual surface dose were more increased. but the higher FSD was, the more decreased surface dose was. According to this, the error were measured about 0.1 to 0.2 mGy in low dose part and about 0.7 to 1.5 mGy in high dose part. Therefore, this shows that theoretical surface dose calculation method is more correct in low dose part than in high dose part. In conclusion, we will have to make constant efforts which can reduce patient and radiographer's exposure dose, studying methods which can predict patient's radiation exposure dose more exactly.

• Journal of Radiation Protection and Research
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• 제30권4호
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• pp.161-165
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• 2005

The gamma-ray dose rates in air at 233 locations in Korea have been determined. The contribution to the gamma-ray dose rates in air due to the presence of $^{232}Th-series,\;^{238}U-series\;and\;^{40}K$ is as follows: 47.3% $(36\;nGyh^{-1})\;^{232}Th-series$ 14.5% $(11\;nGyh^{-1})\;^{238}U-series$ and 38.2% $(29\;nGyh^{-1})\;^{40}K$. The mean gamma-ray dose rate theoretically derived from $^{232}Th-series,\;^{238}U-series\;and\;^{40}K\;was\;76{\pm}17\;nGyh^{-1}$. This corresponds to an annual effective dose of $410\;{\mu}Sv$ and an annual collective dose of 18900 person-Sv for all provinces under study. The results have been compared with other global radiation dose.

• Journal of Radiation Protection and Research
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• 제41권3호
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• pp.291-300
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• 2016

Background: It is necessary to assess radiation dose to workers due to inhalation of airborne particulates containing naturally occurring radioactive materials (NORM) to ensure radiological safety required by the Natural Radiation Safety Management Act. The objective of this study is to develop an internal dose assessment procedure for workers at industries using raw materials containing natural radionuclides. Materials and Methods: The dose assessment procedure was developed based on harmonization, accuracy, and proportionality. The procedure includes determination of dose assessment necessity, preliminary dose estimation, airborne particulate sampling and characterization, and detailed assessment of radiation dose. Results and Discussion: The developed dose assessment procedure is as follows. Radioactivity concentration criteria to determine dose assessment necessity are $10Bq{\cdot}g^{-1}$ for $^{40}K$ and $1Bq{\cdot}g^{-1}$ for the other natural radionuclides. The preliminary dose estimation is performed using annual limit on intake (ALI). The estimated doses are classified into 3 groups ( < 0.1 mSv, 0.1-0.3 mSv, and > 0.3 mSv). Air sampling methods are determined based on the dose estimates. Detailed dose assessment is performed using air sampling and particulate characterization. The final dose results are classified into 4 different levels ( < 0.1 mSv, 0.1-0.3 mSv, 0.3-1 mSv, and > 1 mSv). Proper radiation protection measures are suggested according to the dose level. The developed dose assessment procedure was applied for NORM industries in Korea, including coal combustion, phosphate processing, and monazite handing facilities. Conclusion: The developed procedure provides consistent dose assessment results and contributes to the establishment of optimization of radiological protection in NORM industries.

• 대한방사선기술학회지:방사선기술과학
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• 제32권3호
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• pp.299-306
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• 2009

MDCT의 시간분해능 향상과 등방성 해상능(isotrophic resolution) 영상의 획득, 그리고 지능적인 심전도 동조를 바탕으로 하여 심혈관 질환의 효과적인 진단검사로 인정받고 있는 후향적 심전도 동조화(retrospective ECG gating) 하의 coronary CT angiography는 상대적으로 많은 환자선량을 제공함으로 인해 우수한 진단방법으로서의 장점을 반감시키고 있다. 이에 각 장치 제조사에서는 환자선량을 감소시키는 방법의 연구가 활성화되어 왔으며, 이의 일환으로 지능적인 cardiac dose modulation 기술과 전향적 심전도 동조화(prospective ECG gating)를 사용한 sequential scan이 도입되고 있다. 이에 본 연구에서는 64 채널 MDCT에서 54 kg, 163 cm인 여성 인체모형팬텀을 대상으로 하고 형광유리선량계를 사용하여 후향적 심전도 동조화 하의 coronary CT angiography 프로토콜에서 환자선량의 정량적 평가와 환자선량 감소를 위해 본원에서 선택적으로 적용하고 있는 5가지 검사 프로토콜을 적용하였을 경우의 effective dose와 중요 부위의 organ dose를 측정 비교하여 다음과 같은 결과를 얻었다. 1) Dose modulation없이 120 kVp와 210 mAs의 노출조건으로 retrospectively ECG gated helical scan으로 시행한 conventional coronary CT angiography 프로토콜의 effective dose는 17.8 mSv였으며, 심장의 organ dose는 103.8 mGy였다. 2) 관전압을 120 kVp에서 100 kVp로 낮추었을 경우 effective dose는 11.0 mSv로 conventional coronary CT에 비해 38.2%가 감소하였으며, 심장은 67.3 mGy로 45.2%가 감소하였다. 3) Cardiac dose modulation을 적용한 경우 effective dose는 13.3 mSv로 conventional coronary CT에 비해 25.3%가 감소하였으며, 심장은 80.0 mGy로 22.9%가 감소하였다. 4) 100 kVp의 저관전압과 cardiac dose modulation을 적용한 경우 effective dose는 8.1 mSv로 conventional coronary CT angiography에 비해 54.5%가 감소하였으며, 심장은 49.5 mGy로 52.3%가 감소하였다.

• 한국의학물리학회지:의학물리
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• 제28권3호
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• pp.111-121
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• 2017

Verification of dose distribution is an essential part of ensuring the treatment planning system's (TPS) calculated dose will achieve the desired outcome in radiation therapy. Each measurement have uncertainty associated with it. It is desirable to reduce the measurement uncertainty. A best approach is to reduce the uncertainty associated with each step of the process to keep the total uncertainty under acceptable limits. Point dose patient specific quality assurance (QA) is recommended by American Association of Medical Physicists (AAPM) and European Society for Radiotherapy and Oncology (ESTRO) for all the complex radiation therapy treatment techniques. Relative and absolute point dose measurement methods are used to verify the TPS computed dose. Relative and absolute point dose measurement techniques have a number of steps to measure the point dose which includes chamber cross calibration, electrometer reading, chamber calibration coefficient, beam quality correction factor, reference conditions, influences quantities, machine stability, nominal calibration factor (for relative method) and absolute dose calibration of machine. Keeping these parameters in mind, the estimated relative percentage uncertainty associated with the absolute point dose measurement is 2.1% (k=1). On the other hand, the relative percentage uncertainty associated with the relative point dose verification method is estimated to 1.0% (k=1). To compare both point dose measurement methods, 13 head and neck (H&N) IMRT patients were selected. A point dose for each patient was measured with both methods. The average percentage difference between TPS computed dose and measured absolute relative point dose was 1.4% and 1% respectively. The results of this comparative study show that while choosing the relative or absolute point dose measurement technique, both techniques can produce similar results for H&N IMRT treatment plans. There is no statistically significant difference between both point dose verification methods based upon the t-test for comparing two means.

• Journal of Radiation Protection and Research
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• 제38권4호
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• pp.179-184
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• 2013

The biological effects of radiation are dependent on the dose rate and dose of radiation. In this study, effects of dose and dose rate using whole body radiation on plasma cytokines and blood count from male BALB/c mice were evaluated. We examined the blood and cytokine changes in mice exposed to a low (3.49m Gy $h^{-1}$) and high (2.6 Gy $min^{-1}$) dose rate of radiation at a total dose of 0.5 and 2 Gy, respectively. Blood from mice exposed to radiation were evaluated using cytokine assays and complete blood count. Peripheral lymphocytes and neutrophils decreased in a dose dependent manner following high dose rate radiation. The peripheral lymphocytes population remained unchanged following low dose rate radiation; however, the neutrophils population increased after radiation. The sera from these mice exhibited elevated levels of flt3 ligand and granulocyte-colony-stimulating factor (G-CSF), after high/low dose rate radiation. These results suggest that low-dose-rate radiation does not induce blood damage, which was unlike high-dose-rate radiation treatment; low-dose-rate radiation exposure activated the hematopoiesis through the increase of flt3 ligand and G-CSF.

• 혜화의학회지
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• 제22권1호
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• pp.171-184
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• 2013

Single-and repeated-dose toxicities of Compound K (CK) were evaluated according to Toxicity Test Guidelines of Korea Food and Drug Administration using Sprague-Dawley rats. For single-dose toxicity study, CK was dissolved in drinking water, orally administered and examined for 14 days. As results, CK up to a dose of 5,000 mg/kg, the limited dose, neither induced death, clinical signs and necropsy findings, nor affected body weight gain and organ weights, in which 10% lethal dose could not be estimated. Based on the results of single-dose toxicity test, CK was administered at doses of 500, 1,000 or 2,000 mg/kg for 28 days for the evaluation of repeated-dose toxicity. All doses including the limited dose (2,000 mg/kg) of CK did not cause any abnormalities of rats, including mortality, clinical signs, body weight gain, feed/water consumption, necropsy findings, organ weights, hematology, blood biochemistry. Rather, high doses (1,000 - 2,000 mg/kg) of CK reduced the serum levels of alanine transaminase (ALT), aspartate transaminase (AST), creatinine phosphokinase (CPK), lactate dehydrogenase (LDH) and triglycerides, in addition to an increase in glucose, indicative of protective effects on hepatic and muscular injuries. Thus, both maximum tolerable dose (MTD) and no observed adverse effect level (NOAEL) were not determined. The results indicate that long-term intake of high-dose CK might not induce general adverse effects.

• Imaging Science in Dentistry
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• 제40권1호
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• pp.15-23
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• 2010

Purpose : This study was designed to compare the effective doses from low-dose and standard-dose multi-detector CT (MDCT) scanning protocols and evaluate the image quality and the spatial resolution of the low-dose MDCT protocols for clinical use. Materials and Methods : 6-channel MDCT scanner (Siemens Medical System, Forschheim, Germany), was used for this study. Protocol of the standard-dose MDCT for the orthodontic analysis was 130 kV, 35 mAs, 1.25 mm slice width, 0.8 pitch. Those of the low-dose MDCT for orthodontic analysis and orthodontic surgery were 110 kV, 30 mAs, 1.25 mm slice width, 0.85 pitch and 110 kV, 45 mAs, 2.5 mm slice width, 0.85 pitch. Thermoluminescent dosimeters (TLDs) were placed at 31 sites throughout the levels of adult female ART head and neck phantom. Effective doses were calculated according to ICRP 1990 and 2007 recommendations. A formalin-fixed cadaver and AAPM CT performance phantom were scanned for the evaluation of subjective image quality and spatial resolution. Results : Effective doses in ${\mu}Sv$ ($E_{2007}$) were 699.1, 429.4 and 603.1 for standard-dose CT of orthodontic treatment, low-dose CT of orthodontic analysis, and low-dose CT of orthodontic surgery, respectively. The image quality from the low-dose protocol were not worse than those from the standard-dose protocol. The spatial resolutions of both standard-dose and low-dose CT images were acceptable. Conclusion : From the above results, it can be concluded that the low-dose MDCT protocol is preferable in obtaining CT images for orthodontic analysis and orthodontic surgery.

• 한국방사선학회논문지
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• 제11권3호
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• pp.109-115
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• 2017

본 연구의 목적은 128 MDCT(Multi-detector computed tomography)의 CareDose 4D 선량감소 효과와 임상적 유용성을 평가하고자 시행되었다. Phantom과 임상 복부 검사 연구라는 두 가지 방법을 통해 128 MDCT CareDose 4D 시스템 적용 전후의 피사체 피폭선량과 영상 평가를 실시하였다. Phantom 연구에서는 CareDose 4D 적용 전후의 두 그룹에 대하여 중앙과 3, 6, 9, 12시의 방향으로 ROI(Region of interest)를 위치시켰고, 임상 연구에서는 간의 각 8구획에 대하여 CareDose 4D 적용 전 후 두 그룹에 대하여 ROI를 위치하여 CT Number, Noise, DLP(Dose length product)선량을 측정하였다. 측정결과 Phantom 및 임상연구에서 CT Number는 적용 전 후 값에 차이가 없었고(p>.05), 선량관련 CTDIvol(CT dose index volume) 측정값 및 유효선량은 CareDose 4D 적용 후가 낮았다 (p<.05). 결론적으로 CareDose 4D를 사용하면 영상의 화질을 저하시키지 않고 최적의 영상정보를 획득하면서 환자 선량이 감소되는 효과를 얻을 수 있다.