• BMB Reports
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• 제57권8호
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• pp.375-380
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• 2024

Early proatherogenic inflammation constitutes a significant risk factor for atherogenesis development. Despite this, the precise molecular mechanisms driving this pathological progression largely remain elusive. Our study unveils a pivotal role for the microRNA miR-328-5p in dampening endothelial inflammation by modulating the stability of JUNB (JunB proto-oncogene). Perturbation of miR-328-5p levels results in heightened monocyte adhesion to endothelial cells and enhanced transendothelial migration, while its overexpression mitigates these inflammatory processes. Furthermore, miR-328-5p hinders macrophage polarization toward the pro-inflammatory M1 phenotype, and exerts a negative influence on atherosclerotic plaque formation in vivo. By pinpointing JUNB as a direct miR-328-5p target, our research underscores the potential of miR-328-5p as a therapeutic target for inflammatory atherosclerosis. Reintroduction of JUNB effectively counteracts the anti-atherosclerotic effects of miR-328-5p, highlighting the promise of pharmacological miR-328-5p targeting in managing inflammatory atherosclerosis.

• 한국건축시공학회지
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• 제4권3호
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• pp.125-131
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• 2004

Nowadays, it seems we are in the high time of construction design because development of construction technology widen the option of construction exterior closing materials and deepen the high-tech construction method with all various materials. When we see the flow of construction market, the mainstream is the high-rise intelligent building, which makes the best use of the small midtown area efficently. Therefore, Alum curtain wall is becoming the main material of exterior construction, the concept of which is changing from just a simple window frame to an outer wall which has comprehensive function and capability. As we think of the importance of Curtain wall as a comprehensive outer wall, We should do thorough technical examination and verification at the stage of construction design and plan of carrying out construction.

• Journal of Welding and Joining
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• 제24권1호
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• pp.88-92
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• 2006

Laser-rotating arc hybrid welding was introduced by combining $CO_2$ laser and rotating gas metal arc welding. While the arc rotation enhances the weld pool motion, it reduces the undercut formation which is one of most critical weld defects in the conventional laser-arc hybrid welding. This research investigated the bead characteristics according to the welding parameters such as frequency of rotation, welding voltage, shielding gas composition and interspacing distance between laser and we. The welding parameters were selected to reduce spatter generation and ensure sound weld beads fur bead welding and butt welding with various joint gaps. Gap bridging ability was improved, such that the sound weld beads were achieved for butt joint with up to 2mm joint sap, with no adjustment of CTWD(Contact tip-to-workpiece distance) and electrode diameter.

• Structural Engineering and Mechanics
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• 제86권3호
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• pp.417-430
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• 2023

As the key part in the reinforced concrete column-steel beam (RCS) frame, the beam-column joints are usually subjected the axial force, shear force and bending moment under seismic actions. With the aim to study the seismic behavior of RCS joints with and without RC slab, the quasi-static cyclic tests results, including hysteretic curves, slab crack development, failure mode, strain distributions, etc. were discussed in detail. It is shown that the composite action between steel beam and RC slab can significantly enhance the initial stiffness and loading capacity, but lead to a changing of the failure mode from beam flexural failure to the joint shear failure. Based on the analysis of shear failure mechanism, the calculation formula accounting for the influence of RC slab was proposed to estimate shear strength of RCS joint. In addition, the finite element model (FEM) was developed by ABAQUS and a series of parametric analysis model with RC slab was conducted to investigate the influence of the face plates thickness, slab reinforcement diameter, beam web strength and inner concrete strength on the shear strength of joints. Finally, the proposed formula in this paper is verified by the experiment and FEM parametric analysis results.

• International journal of advanced smart convergence
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• 제8권4호
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• pp.154-160
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• 2019

In this paper, we propose the miniaturization size of wearable Range of Motion(ROM) and a system that can be connected with smart devices in real-time to measure the joint movement range dynamically. Currently, the ROM of the joint is directly measured by a person using a goniometer. Conventional methods are different depending on the measurement method and location of the measurement person, which makes it difficult to measure consistently and may cause errors. Also, it is impossible to measure the ROM of joints in real-life situations. Therefore, the wearable sensor is attached to the joint to be measured to develop a miniaturize size ROM device that can measure the range of motion of the joint in real-time. The sensor measured the resistance value changed according to the movement of the joint using a load cell. Also, the sensed analog values were converted to digital values using an Analog to Digital Converter(ADC). The converted amount can be transmitted wireless to the smart device through the wearable sensor node. As a result, the developed device can be measured more consistently than the measurement using the goniometer, communication with IoT-based smart devices, and wearable enables dynamic observation. The developed wearable sensor node will be able to monitor the dynamic state of rehabilitation patients in real-time and improve the rapid change of treatment method and customized treatment.

• 대한의용생체공학회:의공학회지
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• 제28권6호
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• pp.744-749
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• 2007

Kinematic and kinetic analysis has been performed for Soft Golf swings utilizing realistic three dimensional computer simulations based on three dimensional motion tracking data. Soft Golf is a newly developed recreational sport in South Korea aimed to become a safe and easy-to-learn sport for all ages. The advantage of Soft Golf stems from lighter weight of the club and much larger area of the sweet spot. This paper tries to look into kinematic and kinetic aspects of soft golf swings compared to regular golf swing and find the advantages of lighter Soft Golf clubs. For this purpose, swing motions of older aged participants were captured and kinematic analysis was performed for various kinematic parameters such as club head velocity, joint angular velocity, and joint range of motions as a pilot study. Kinetic analysis was performed by applying kinematic data to computer simulation models constructed from anthropometric database and the measurements from the participants. The simulations were solved using multi-body dynamics solver. Firstly, the kinematic parameters such as joint angles were obtained by solving inverse dynamics problem based on motion tracking data. Secondly, the kinetic parameters such as joint torques were obtained by solving control dynamics problem of making joint torque to follow pre-defined joint angle data. The results showed that mechanical loadings to major joints were reduced with lighter Soft Golf club.

• Nuclear Engineering and Technology
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• 제56권5호
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• pp.1667-1671
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• 2024

This paper presents a neutron/gamma detector based on a micropixel avalanche photodiode and a plastic scintillator that monitors the status of the accelerator-driven intense resonance neutron source (IREN) facility by measuring the neutron/gamma intensity in the target hall. The electronics of the neutron/gamma detector has been designed and developed. The size of the plastic scintillator was selected to be 3.7 × 3.7 × 30 mm³ due to the sensitive area of the MAPD. The experimental results demonstrated a dependence between the count rate of the detector and the frequency of the accelerator. The detector is sensitive to intermediate and fast neutrons. The minimum detectable energy was determined to be 200 keV using Cs-137 point gamma source. The maximum counting rate of the detector from TTL out is about 2.2⋅10⁶ counts/sec, but for analogue output it is about 2⋅10⁷ counts/sec. The detector can not allow discriminating neutrons and gamma rays by charge integration method.

• 한국군사과학기술학회지
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• 제23권2호
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• pp.106-114
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• 2020

NCW which is shaping favorable conditions with obtaining initiative through superiority in C2 and information sharing is critical to the result of the war in a modern warfare. An important requirement to attain superiority through an effective networking in a war-environment is to apply QoS to ensure priority in supporting critical mission and services. In order to obtain an effective NCOE through JCS-led QoS support, standard doucments have been reviewed and analyzed to understand the current level of technology and development. In addition, QoS-related policy documents which is currently being applied by the ROK armed forces have been analyzed to substantiated the JCS-led QoS model and propose the directions of development and enhancement required in the realm of technology, policy and system.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1991년도 추계학술대회
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• pp.48-53
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• 1991

The discrete cosine transform (DCT)-based progressive and hierarchical coding schemes developed by the International Standardization Organization (ISO) Joint Photographic Experts Groups (JPEG) are implemented and evaluated for the application of medical image communication. For a series of head sections of magnetic resonance images, a compression ratio of about 10 is obtained by the algorithm without noticeable image degradation.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.777-780
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• 2005

The bench of cut-slope is necessary to stabilizing. But it is possible to be a weak zone in slope. When a small scale failure is occurred in a bench, it influence a large scale failure of slope. So when it is found out any unstable factor, weathering of rock, a direction of joint in a bench, if the bench is reinforced suitably, the holly failure is prevented in cut-slope