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Anti-obesity Effects of Sparassis crispa on High-fat Diet-induced Obese Mice (고지방식이로 유도한 비만 흰쥐에 대한 꽃송이 버섯의 항비만 효과)

  • Lee, Mi Ra;Hou, Jing Gang;Begum, Shahnaz;Wang, Yun Bo;Oh, Deuk Sil;Wi, An Jin;Yoon, Byung Sun;Sung, Chang Keun
    • Journal of Life Science
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    • v.24 no.9
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    • pp.952-958
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    • 2014
  • The present study investigated the anti-obesity effects of Sparassis crispa (SC) on mice fed a high-fat (HF, 45 kcal% fat) diet. Mice were fed either a normal control diet and an HF diet or an HF diet supplemented with SC (1%, 3%, and 5%) for 12 weeks. The consumption of an HF diet compared to the NC group resulted in increases in body weight, the food efficiency ratio (FER), retroperitoneal and subcutaneous fat weights, cholesterol and triglyceride levels, fecal fat, and liver lipids. However, the administration of SC significantly decreased body weight gain, food intake, FER, cholesterol and triglyceride levels, and liver lipids in a dose-dependent manner. In particular, treatment with 5% SC significantly reduced the occurrence of fatty liver deposits and steatosis, which are associated with the increased adipocyte size in mice fed an HF diet. Therefore, these results suggested that dietary supplementation with SC exerts anti-obesity effects and could be used as a functional food to control obesity.

NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization

  • Liu, Qihui;Tian, Yuan;Zhao, Xiangfeng;Jing, Haifeng;Xie, Qi;Li, Peng;Li, Dong;Yan, Dongmei;Zhu, Xun
    • Molecules and Cells
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    • v.38 no.10
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    • pp.886-894
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    • 2015
  • Macrophages are divided into two subpopulations: classically activated macrophages (M1) and alternatively activated macrophages (M2). BCG (Bacilli Calmette-$Gu{\acute{e}}rin$) activates disabled $na{\ddot{i}}ve$ macrophages to M1 macrophages, which act as inflammatory, microbicidal and tumoricidal cells through cell-cell contact and/or the release of soluble factors. Various transcription factors and signaling pathways are involved in the regulation of macrophage activation and polarization. We discovered that BCG-activated macrophages (BAM) expressed a new molecule, and we named it Novel Macrophage Activated Associated Protein 1 (NMAAP1). 1 The current study found that the overexpression of NMAAP1 in macrophages results in M1 polarization with increased expression levels of M1 genes, such as inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-${\alpha}$), Interleukin 6 (IL-6), Interleukin 12 (IL-12), Monocyte chemoattractant protein-1 (MCP-1) and Interleukin-1 beta (IL-$1{\beta}$), and decreased expression of some M2 genes, such as Kruppel-like factor 4 (KLF4) and suppressor of cytokine signaling 1 (SOCS1), but not other M2 genes, including arginase-1 (Arg-1), Interleukin (IL-10), transforming growth factor beta (TGF-${\beta}$) and found in inflammatory zone 1 (Fizz1). Moreover, NMAAP1 overexpression in the RAW264.7 cell line increased cytotoxicity against MCA207 tumor cells, which depends on increased inflammatory cytokines rather than cell-cell contact. NMAAP1 also substantially enhanced the phagocytic ability of macrophages, which implies that NMAAP1 promoted macrophage adhesive and clearance activities. Our results indicate that NMAAP1 is an essential molecule that modulates macrophages phenotype and plays an important role in macrophage tumoricidal functions.

Effect of Phytohormones and Chemical Inhibitors on Pathogenesis-related Genes Identified by Differential Hybridization in Rice Suspension Culture Cells

  • Kim, Sang-Gon;Wu, Jing-Ni;Wang, Yiming;White, Ethan E.;Choi, Young-Whan;Kim, Keun-Ki;Choi, In-Soo;Kim, Yong-Cheol;Kim, Sun-Hyung;Kang, Kyu-Young;Kim, Sun-Tae
    • The Plant Pathology Journal
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    • v.26 no.4
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    • pp.386-393
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    • 2010
  • In order to study disease resistance mechanisms in rice against the rice blast fungus Magnaporthe grisea, we screened fungal elicitor-responsive genes from rice suspension-cultured cells treated with fungal elicitors employing differential hybridization (DH). By DH screening, 31 distinct rice clones were isolated and a majority of them were full-length cDNAs encoding pathogenesisrelated (PR) genes. Sixteen of the 31 genes were upregulated at 4, 8, and 12 h following fungal elicitor treatment. To elucidate the effect of signal molecules and biotic elicitors on the regulation of rice defense genes, we further characterized the transcriptional expression patterns of representative isolated PR genes; OsGlu1, OsGlu2, OsTLP, OsRLK, and OsPR-10, following treatment with fungal elicitor, phytohormones, cycloheximide, and inhibitors of protein phosphorylation. Jasmonic acid (JA) induced transcriptional expression of OsGlu1, OsTLP, and OsRLK, but not of OsGlu2 and OsPR-10 at any of the tested time points. Salicylic acid (SA) and abscisic acid weakly induced the expression of OsTLP and OsRLK. SA showed an antagonistic effect with fungal elicitor and JA. Cycloheximide suppressed all these genes upon elicitor treatment, except for OsGlu2. Staurosporine only induced the expression of OsRLK. Application of calyculin A strongly induced OsRLK expression, but suppressed the expression of OsGlu2. Our study yielded a number of PR genes that play a role in defense mechanisms against the rice blast fungus, as well as contribute towards the elucidation of crosstalk between phytohormones and other modifications during defense signaling.

Acupuncture Treatment in Feline Horner's Syndrome: Case Report (고양이 Horner's syndrome에 대한 침치료(針治療) 증예보고(症例報告))

  • Hsu, Chin-Yuan;Hsu, Chin-ling;Hsu, Chin-Hwang;Liao, Jim-Cai;Chueh, Hao-Jen;Cheng, Han-Wen;Jun, Hyeong-Kyou;Kim, Duck-Hwan
    • Journal of Veterinary Clinics
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    • v.24 no.2
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    • pp.214-217
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    • 2007
  • A about 2-month- old, mixed female cat was referred to Yeon Chang Veterinaly Clinic in Taiwan. Because this patient was wandering cat, precise history was not blown. At first admission, miosis, ptosis and protrusion of the nictitating membrane was observed in the right sided eye, and also slight miosis was found in the left sided eye. The patient was diagnosed into feline HS. Oculo-AP and injection-AP with dexamethasone were applied to this patient. Oculo-AP at Shang Jiao regions of both eyes was done for 10 minutes. In addition, injection-AP with dexamethasone (0.2 ml/acupoint) at BL01-Jing Ming, BL02-Zan Zhu and ST01-Cheng Qi. After AP treatment, prolapse of the nictitating membrane was amazingly disappeared and pupil was dilatated at session 1. Ocular findings at session 2 (one day after session 1) were maintained with nearly normal state. Accordingly, the present patient was a case with feline HS that showed favorable therapeutic effect by AP treatment.

Theory Study and Work of Ohaeng-Hwa Acupuncture (오행화침법(五行和鍼法)의 이론적 고찰 및 운용)

  • Sim, Sung-Heum;Kam, Cheol-Woo;Lee, Byung-Gwon;Kim, Jin-Young;Baek, Sang-In;Son, Ho-Young
    • Korean Journal of Acupuncture
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    • v.26 no.4
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    • pp.119-133
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    • 2009
  • Objectives : The object of this study is to report on the theory of Ohaeng-Hwa Acupuncture Therapy. Methods : The theory of Ohaeng-Hwa Acupuncture Therapy(OHAT; 五行和針法) is a part of the Five Elements Theory unique to Korea. This research Classic of Difficulty Issues-Nan Jing review Ohaeng-Hwa Acupuncture Therapy. Results : OHAT, created and developed by Jae-hoon Song, integrates the victor-vanquished as well as the son-mother relationship of the Five Elements of breakdown and restoration of balance between yin and yang. And also, it provides resources and data on The seventy fifth Nan(75難), The sixty ninth Nan(69難) of Classic of Difficulty Issues - Nan Jin 75, 69. OHAT establishes objectiveness and accuracy of diagnosis based upon the traditional method and procedure of pulse taking. In OHAT, a person's state of illness is diagnosed by applying the comparative examination of the palpitation of the pulse. It is the fact that the pulse varies according to the state, and that OHAT treatment has proven the positive results by using the victor-vanquished relationship on The Nan Jin 75. On the basis of this, it is necessary to add the sixty ninth Nan(69難), to research the theory of the generation of the Five Element. Conclusions : Ohaeng-Hwa Acupuncture is very effective in treating the wide range of illness, and thus it has gained an increasing attention of many scholars and practitioners in the field of traditional Korean oriental medicine. However, it is the first theoretical attempt to the clinical research and scientific methodology of Ohaeng(Five) Ohaeng-Hwa Acupuncture, and more active Ohaeng-Hwa Acupuncture R&D is being conducted nationwide.

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Design and Implementation of the Management System of Cultivation and Tracking for Agricultural Products using USN (유비쿼터스 센서 네트워크를 이용한 농산물 재배관리 및 이력추적 시스템의 설계 및 구현)

  • Yoo, Nam-Hyun;Song, Gil-Jong;Yoo, Ju-Hyun;Yang, Su-Yeong;Son, Cheol-Su;Koh, Jing-Wang;Kim, Won-Jung
    • Journal of KIISE:Computing Practices and Letters
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    • v.15 no.9
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    • pp.661-674
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    • 2009
  • Recently, there has been much research and many attempts to enhance converged information technology services using new technology such as ubiquitous sensor networks (USN) in medical, environmental, industrial, and logistic areas. There has also been much research and various attempts to apply this new technology to agricultural areas. However, applications to the agricultural areas should be considered differently against the same areas such as medical, environmental, industrial, and logistics. Therefore, this paper suggests that an agricultural cultivating management and traceability system. This system is a unified system that supports the processes sowing seeds through selling agricultural products to consumers. Farmers can be provided with an effective calendar for cultivation and weather information in real time as well as the monitoring of the growth of farm products on the farm in real time using this system. Farmers can also control all equipment installed on the farm directly or remotely and the equipment can be controlled automatically when the measured values such as temperature and humidity deviate from the decent criteria which are set by farmers or this system. Additionally, the reliability for and the better quality of the agricultural products can be improved because farmers can use this unified system to cover all processes from sowing seeds to selling to consumers.

Knowledge of Cervical Cancer Screening among Health Care Workers Providing Services Across Different Socio-economic Regions of China

  • Di, Jiang-Li;Rutherford, Shannon;Wu, Jiu-Ling;Song, Bo;Ma, Lan;Chen, Jing-Yi;Chu, Cordia
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.6
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    • pp.2965-2972
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    • 2016
  • Background: China carries a heavy burden of cervical cancer (CC) and substantial disparities exist across regions within the country. In order to reduce regional disparities in CC, the government of China launched the National Cervical Cancer Screening Program in Rural Areas (NCCSPRA) in 2009. Critical to the success of the program are the health care workers who play a pivotal role in preventing and managing CC by encouraging and motivating women to use screening services and by providing identification and treatment services. This study aimed to assess cervical cancer knowledge among these health care workers at the county level in maternal and child health (MCH) hospitals across different socio-economic regions of China. Materials and Methods: A cross-sectional survey was conducted and self-administered questionnaires were sent to all health care workers (a total of 66) providing cervical cancer screening services in 6 county level MCH hospitals in Liaoning, Hubei and Shaanxi provinces, representing eastern, central and western regions of China; 64 (97.0%, 64/66) of the workers responded. ANOVA and Chi-square test were used to compare the knowledge rate and scores in subgroups. Results: The knowledge level of the respondents was generally low. The overall combined knowledge rate was 46.9%. The knowledge rates for risk factors, prevention, clinical symptoms, screening and diagnostic tests and understanding of positive results were 31.3%, 37.5%, 18.1%, 56.3% and 84.4%, respectively. Statistically significant differences in scores or rates of CC knowledge were seen across the different regions. The total and sectional scores in the less developed regions were statistically significantly lower than in the other regions. Conclusions: The majority of the health care workers who provide CC screening service in NCCSPRA at county level MCH hospitals do not have adequately equipped with knowledge about CC. Given the importance of knowledge to the program's success in reducing CC burden in rural women in China, efforts are needed to improve the knowledge of health care workers, especially in less developed regions.

Robust Feature Extraction Based on Image-based Approach for Visual Speech Recognition (시각 음성인식을 위한 영상 기반 접근방법에 기반한 강인한 시각 특징 파라미터의 추출 방법)

  • Gyu, Song-Min;Pham, Thanh Trung;Min, So-Hee;Kim, Jing-Young;Na, Seung-You;Hwang, Sung-Taek
    • Journal of the Korean Institute of Intelligent Systems
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    • v.20 no.3
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    • pp.348-355
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    • 2010
  • In spite of development in speech recognition technology, speech recognition under noisy environment is still a difficult task. To solve this problem, Researchers has been proposed different methods where they have been used visual information except audio information for visual speech recognition. However, visual information also has visual noises as well as the noises of audio information, and this visual noises cause degradation in visual speech recognition. Therefore, it is one the field of interest how to extract visual features parameter for enhancing visual speech recognition performance. In this paper, we propose a method for visual feature parameter extraction based on image-base approach for enhancing recognition performance of the HMM based visual speech recognizer. For experiments, we have constructed Audio-visual database which is consisted with 105 speackers and each speaker has uttered 62 words. We have applied histogram matching, lip folding, RASTA filtering, Liner Mask, DCT and PCA. The experimental results show that the recognition performance of our proposed method enhanced at about 21% than the baseline method.

Obesity-Associated Metabolic Signatures Correlate to Clinical and Inflammatory Profiles of Asthma: A Pilot Study

  • Liu, Ying;Zheng, Jing;Zhang, Hong Ping;Zhang, Xin;Wang, Lei;Wood, Lisa;Wang, Gang
    • Allergy, Asthma & Immunology Research
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    • v.10 no.6
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    • pp.628-647
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    • 2018
  • Purpose: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. Methods: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin $(IL)-1{\beta}$, -4, -5, -6, -13, and tumor necrosis factor $(TNF)-{\alpha}$, and serum was detected for leptin, adiponectin and C-reactive protein. Untargeted gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolic profiles in sputum, serum and peripheral blood monocular cells (PBMCs) were analyzed by orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and pathway topology enrichment analysis. The differential metabolites were further validated by correlation analysis with body composition, and clinical and inflammatory profiles. Results: Body composition, asthma control, and the levels of $IL-1{\beta}$, -4, -13, leptin and adiponectin in obese asthmatics were significantly different from those in lean asthmatics. OPLS-DA analysis revealed 28 differential metabolites that distinguished obese from lean asthmatic subjects. The validation analysis identified 18 potential metabolic signatures (11 in sputum, 4 in serum and 2 in PBMCs) of obese asthmatics. Pathway topology enrichment analysis revealed that cyanoamino acid metabolism, caffeine metabolism, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, pentose phosphate pathway in sputum, and glyoxylate and dicarboxylate metabolism, glycerolipid metabolism and pentose phosphate pathway in serum are suggested to be significant pathways related to obese asthma. Conclusions: GC-TOF-MS-based metabolomics indicates obese asthma is characterized by a metabolic profile different from lean asthma. The potential metabolic signatures indicated novel immune-metabolic mechanisms in obese asthma with providing more phenotypic and therapeutic implications, which needs further replication and validation.

The status quo and developing measurement of water reuse in China

  • Li, Wei;Li, Jing;Wang, Yiwen;Zhong, Yuxiu;Liu, Hongxian;Li, Peilei
    • Proceedings of the Korea Water Resources Association Conference
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    • 2015.05a
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    • pp.228-228
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    • 2015
  • Water reuse plays significant role in water saving and water environmental protection, and it helps alleviate the shortage of water resources. China's water reuse was put into practice since 1980s by means of pilot and promotion in National Fifth-year Plan and other strategies. The effects of water reuse is beneficial in both economic, social and environmental aspects. But some shortcomings still undermine future development of water reuse in China. To overcome and boost water reuse, Ministry of Water Resources conducted a successive survey across China. The aim of this study is to demonstrate the current condition of water reuse in China in construction, funds, legislation, planning, policy aspects, to summarize problems and its reasons underneath, to make suggestions for further development. Basically, in 2010, China's water reuse is 2.83 billion cubic meters and the utilization rate is 10.35%. Water reuse in China has four major characteristics: the first one is water reuse differences in amount occur national-widely and North of China has the main percentage as 47.3%; the second one is water reuse is mainly in environment maintenance (42.1%) and industry cooling (29.8%); the third one is funds for water reuse station and pipe construction is main in non-fiscal budget which take percentage as 56.8%; the fourth one is progresses of administrative system, political system, price management, standard system and technologies go rapidly recently. The problems of water reuse such as lack in water reuse station, delay in pipe constriction and limits on water reuse amount still exist due to some reasons. As a think tank of Ministry of Water Resources, we give some suggestions: firstly, water reuse needs to be integrated with traditional water resources allocation; secondly, public budgets need to be strengthened and income mechanism should also be constructed; thirdly, water resources integrated administrative of city and county should be boosted and roles as water reuse need to be clear and precise; fourthly, national, provincial and regional water reuse planning should be made in time; fifthly, regulations on water reuse should be programmed as soon as possible.

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