• 한국재료학회지
• /
• 제32권1호
• /
• pp.14-22
• /
• 2022

To improve light absorption ability in the visible light region and the efficiency of the charge transfer reaction, Pd nanoparticles decorated with reduced TiO₂ nanotube photocatalyst were synthesized. The reduced TiO₂ nanotube photocatalyst was fabricated by anodic oxidation of Ti plate, followed by an electrochemical reduction process using applied cathodic potential. For TiO₂ photocatalyst electrochemically reduced using an applied voltage of -1.3 V for 10 min, 38% of Ti⁴⁺ ions on TiO₂ surface were converted to Ti³⁺ ion. The formation of Ti³⁺ species leads to the decrease in the band gap energy, resulting in an increase in the light absorption ability in the visible range. To obtain better photocatalytic efficiency, Pd nanoparticles were decorated through photoreduction process on the surface of reduced TiO₂ nanotube photocatalyst (r10-TNT). The Pd nanoparticles decorated with reduced TiO₂ nanotube photocatalyst exhibited enhanced photocurrent response, and high efficiency and rate constant for aniline blue degradation; these were ascribed to the synergistic effect of the new electronic state of the TiO₂ band gap energy induced by formation of Ti³⁺ species on TiO₂, and by improvement of the charge transfer reaction.

• Journal of Nutrition and Health
• /
• 제55권2호
• /
• pp.250-262
• /
• 2022

Purpose: Elevated iodine intake is related to a higher prevalence of subclinical hypothyroidism (SCH). We investigated the short-term effect of dietary iodine restriction on thyroid function in patients with SCH with high iodine intakes. Methods: The iodine levels in 64 SCH patients with serum TSH levels from 4.0 to 10.0 mIU/L and normal serum fT4 levels (n = 64) were assessed using 24-hour urine iodine test results and iodine intake levels calculated using a semi-quantitative food frequency questionnaire. Dietary iodine restriction was not recommended for patients with an iodine intake in the normal range (group A, n = 13), but seaweed restriction was recommended for patients with high iodine intakes (group B, n = 33). Thyroid functions and iodine levels were rechecked after three months. Another eighteen patients were prescribed thyroid hormone replacement therapy according to clinical criteria. Results: Median baseline iodine intake for the 64 patients was 290.61 ㎍/day, and median 24-hour urine iodine was 33.65 µmol/g of creatinine. The major source of dietary iodine was seaweed, which accounted for 72.2% of median baseline intake. Urine iodine and calculated iodine intake levels were positively correlated with serum TSH levels (p < 0.001 and p = 0.027, respectively), and calculated iodine intakes were significantly correlated with urine iodine levels (p = 0.001). In group B, iodine restriction significantly decreased urine iodine (p = 0.042) and TSH levels (p = 0.004), and conversion to euthyroid status was achieved in 16 of the 33 patients (48.5%). Conclusion: Iodine intake and urine iodine levels are correlated with thyroid function in SCH patients, and dietary iodine restriction can aid functional thyroid recovery in patients with elevated iodine intakes.

• 한국인터넷방송통신학회논문지
• /
• 제22권1호
• /
• pp.121-126
• /
• 2022

본 연구는 변형된 힐버트 커브 프랙탈 모노폴 구조를 단순화하여 육각형 대칭 패턴을 가지면서 모노폴 형태로 구현한 안테나에 대한 것이다. 힐버트 커브 프랙탈 모노폴 구조를 단순화하여 소형화했을 뿐 아니라 성능 개선을 모색하기 위해 복사기 구조를 육각형 대칭 패턴으로 구현했다. 기판 유전체의 비유전율은 4.7이며, 미앤더 형태로 대칭 구조를 갖는 총 선로길이는 59 mm이다. 안테나의 크기는 10 mm × 10 mm × 0.8 mm이고, 선폭은 0.4 mm이다. 안테나 측정 지그의 크기는 64 mm × 21 mm × 1 mm이다. 공진주파수는 1.57 GHz 이고, 주파수 범위는 1.51 ~ 1.615 GHz이다. 주파수대역폭은 105 MHz이다. 안테나 이득은 YZ-plane의 측정이득은 2.32 dBi 이고, XZ-plane의 경우 -1.03 dBi를 얻었다. 결과적으로 육각형 대칭 패턴 프랙탈 구조를 이용하여 안테나 소형화를 이루었으며, 복사기 구조 변화로 안테나 성능 개선이 용이함을 확인했다.

• 한국임상수의학회지
• /
• 제39권4호
• /
• pp.149-155
• /
• 2022

The aim of this study was to compare the mechanical properties of 0.6 and 0.8 mm cerclage wires with the 1.0 mm cerclage wire in the twist, single-loop, double-loop, double-wrap, and loop/twist knot methods. Six stainless steel cerclage wires of various diameters in different knot methods were tied round a customized jig mounted on a load testing machine. The initial tension, initial stiffness, and yield load were evaluated. The failure mode of each cerclage was observed. For each wire size, the double-loop, double-wrap, and loop/twist knots showed significantly greater initial stiffness, and yield load than those seen with twist and single-loop knots. The single-loop knot showed the least initial stiffness regardless of the diameter. As the cerclage wire diameter increased, the cerclage tended to show significantly greater initial stiffness, and yield load. Failure modes varied depending on the knot configurations. Single-loop knots of smaller-diameter wires less than 1 mm had similar or lower initial tension, initial stiffness, and yield load than a twist knot. Owing to the variance in mechanical properties, the clinical application of the knot type should depend on the diameter of the cerclage wire.

• 한국초전도ㆍ저온공학회논문지
• /
• 제8권1호
• /
• pp.9-14
• /
• 2006

Sample preparation plays a critical role in microstructure analysis using TEM. Although TEM specimen has been usually prepared by jet-polishing or Ar-ion beam milling technique. these methods could not be applied to YBCO CC which is composed of IBAD or RABiTS substrates, several buffet layers, and YBCO superconducting layer because of big difference in mechanical strengths between the metallic phase and oxide phases. To obtain useful cross-sectional information such as interface between the phases or second phases in YBCO CC, it is prerequisite to secure the large area of thin section in the cross-sectional direction. The superconducting layer or the buffer layers are relatively weak and fragile compared to the metallic substrate such as Ni-5wt%W RABiTS of Hastelloy-based IBAD, and preferential removal of weak ceramic phases during polishing steps makes specimen preparation almost impossible. Tripod polisher and small jig were home-made and employed to sample preparation. The polishing angle was maintained <$1^{\circ}$ throughout the polishing steps using 2 micrometers attached to the tripod plate. TEM specimens with large and thin area could be secured and used for RABiTS/IBAD substrate analyses. In some cases, additional Ar-beam ion milling with low beam current and impinging angle was used for less than 30 sec. to remove debris or polishing media attacked to the specimens.

• 대한두개안면성형외과학회지
• /
• 제24권1호
• /
• pp.18-23
• /
• 2023

Background: When performing reduction of zygomatic arch fractures, locating the inward portion of the fracture can be difficult. Therefore, this study investigated the discrepancy between the locations of the depression on the soft tissue and bone and sought to identify how to determine the inward portion of the fracture on the patient's face. Methods: We conducted a retrospective review of chart with isolated zygomatic arch fractures of type V in the Nam and Jung classification from March 2013 to February 2022. For consistent measurements, a reference point (RP), at the intersection between a vertical line passing through the end point of the root of the ear helix in the patient's side-view photograph and a transverse line passing through the longest horizontal axis of the external meatus opening, was established. We then measured the distance between the RP and the soft tissue depression in a portrait and the bone depression on a computed tomography (CT) scan. The discrepancy between these distances was quantified. Results: Among the patients with isolated zygomatic arch fractures, only those with a fully visible ear on a side-view photograph were included. Twenty-four patients met the inclusion criteria. There were four types of discrepancies in the location of the soft tissue depression compared to the bone depression: type I, forward and upward discrepancy (7.45 and 3.28 mm), type II, backward and upward (4.29 and 4.21 mm), type III, forward and downward (10.06 and 5.15 mm), and type IV, backward and downward (2.61 and 3.27 mm). Conclusion: This study showed that discrepancy between the locations of the depressions on the soft tissue and bone exists in various directions. Therefore, applying the transverse and vertical distances measured from a bone image of the CT scan onto the patient's face at the indicated RP will be helpful for predicting the reduction location.

• Journal of Interdisciplinary Genomics
• /
• 제5권2호
• /
• pp.35-41
• /
• 2023

Background: Ca²⁺ signaling plays a vital role in neuronal signaling and altered Ca²⁺ homeostasis in Parkinson's disease (PD). Overexpression of αSYN significantly promote the Ca²⁺-Calmodulin (CaM) activity and subsequent nuclear translocation of nuclear factor of activated T cells (NFAT) transcription factor in dopaminergic neurons of midbrain. However, the exact role of Ca²⁺-CaM and NFAT in PD pathology is yet to be elucidated. Methods: We designed the CaM-NFAT-oligodeoxynucleotide (ODN), a synthetic short DNA containing complementary sequence for NFAT transcription factor and CaM mRNA. Then, the effect of CaM-NFAT-ODN on 1-methyl-4-phenylpyridinium (MPP⁺)-mediated neurotoxicity was investigated in mimic PD model in vitro. Results: First, the expression of αSYN and CaM was strongly increased in substantia nigra (SN) of PD and the expression of tyrosine hydroxylase (TH) was strongly increased in control SN. Additionally, the expression of apoptosis marker proteins was strongly increased in SN of PD. Transfection of CaM-NFAT-ODN repressed CaM and pNFAT, the target genes of this ODN in rat embryo primary mesencephalic neurons. It also reduced ERK phosphorylation, a downstream target of these genes. These results demonstrated that CaM-NFAT-ODN operated successfully in rat embryo primary mesencephalic neurons. Transfection of CaM-NFAT-ODN repressed TH reduction, αSYN accumulation, and apoptosis by MPP⁺-induced neurotoxicity response through Ca²⁺ signaling and mitogen-activated protein kinases (MAPK) signaling. Conclusion: Synthetic CaM-NFAT-ODN has substantial therapeutic feasibility for the treatment of neurodegenerative diseases.

• 센서학회지
• /
• 제33권2호
• /
• pp.112-116
• /
• 2024

Gas-sensor technology for volatile organic compounds (VOC) biomarker detection offers significant advantages for noninvasive diagnostics, including rapid response time and low operational costs, exhibiting promising potential for disease diagnosis. Colorimetric gas sensors, which enable intuitive analysis of gas concentrations through changes in color, present additional benefits for the development of personal diagnostic kits. However, the traditional method of visually monitoring these sensors can limit quantitative analysis and consistency in detection threshold evaluation, potentially affecting diagnostic accuracy. To address this, we developed a machine vision platform based on metal-organic framework (MOF) for colorimetric gas sensor arrays, designed to accurately detect disease-related VOC biomarkers. This platform integrates a CMOS camera module, gas chamber, and colorimetric MOF sensor jig to quantitatively assess color changes. A specialized machine vision algorithm accurately identifies the color-change Region of Interest (ROI) from the captured images and monitors the color trends. Performance evaluation was conducted through experiments using a platform with four types of low-concentration standard gases. A limit-of-detection (LoD) at 100 ppb level was observed. This approach significantly enhances the potential for non-invasive and accurate disease diagnosis by detecting low-concentration VOC biomarkers and offers a novel diagnostic tool.

• Journal of Interdisciplinary Genomics
• /
• 제6권1호
• /
• pp.6-13
• /
• 2024

Background: ABO typing is crucial for ensuring safe blood transfusion and is commonly performed by examining antigen-antibody interactions. Determining ABO blood group can be difficult when dealing with ABO discrepancy and ABO subgroups. ABO genotyping may be necessary to resolve ABO discrepancy. ABO genotyping primarily involves direct sequencing, with the possibility of using other molecular methods. Methods: PCR and direct sequencing of exons 6 and 7 were performed for total 108 samples from June 2010 to December 2019. Also, other molecular methods including cloning sequencing and short tandem repeat analysis were carried out just in case. Sequencing data were compared with allele information of blood group antigen mutation databases. Results: The predominant causal allele among 108 ABO discrepant cases was cis-AB01, with 28 cases. This was followed by rare ABO alleles (B309, B306, A204, Bw29, and Ax01) with 14 cases, and blood chimera with 5 cases. Five new alleles were identified during the investigation. Conclusion: This study reaffirms that cis-AB is the most common cause of inherited ABO discrepancies, and cis-AB01 is the most prevalent cis-AB allele in the Korean population, also in the southeastern region. In addition, we discovered five new alleles and five blood chimeras by adopting sequencing analysis and additional molecular techniques to resolve ABO discrepancies, which provide regional data on rare alleles. This study presents rare and new ABO alleles and blood chimeras identified over a ten-year period at two major university hospitals in Southeastern Korea.

• 한국지진공학회논문집
• /
• 제28권3호
• /
• pp.129-139
• /
• 2024

In this study, the SBC system, a new mechanical joint method, was developed to improve the constructability of precast concrete (PC) beam-column connections. The reliability of the finite element analysis model was verified through the comparison of experimental results and FEM analysis results. Recently, the intermediate moment frame, a seismic force resistance system, has served as a ramen structure that resists seismic force through beams and columns and has few load-bearing walls, so it is increasingly being applied to PC warehouses and PC factories with high loads and long spans. However, looking at the existing PC beam-column anchorage details, the wire, strand, and lower main bar are overlapped with the anchorage rebar at the end, so they do not satisfy the joint and anchorage requirements for reinforcing bars (KDS 41 17 00 9.3). Therefore, a mechanical joint method (SBC) was developed to meet the relevant standards and improve constructability. Tensile and bending experiments were conducted to examine structural performance, and a finite element analysis model was created. The load-displacement curve and failure pattern confirmed that both the experimental and analysis results were similar, and it was verified that a reliable finite element analysis model was built. In addition, bending tests showed that the larger the thickness of the bolt joint surface of the SBC, the better its structural performance. It was also determined that the system could improve energy dissipation ability and ductility through buckling and yielding occurring in the SBC.