• International Journal of Oral Biology
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• 제36권1호
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• pp.7-11
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• 2011

Ursolic acid is a triterpenoid compound present in many plants. This study examined the antimicrobial activity of ursolic acid against mutans streptococci (MS) isolated from the Korean population. The antimicrobial activity was evaluated by the minimum inhibitory concentration (MIC) and time kill curves of MS. The cytotoxicity of ursolic acid against KB cells was tested using an MTT assay. The $MIC_{90}$ values of ursolic acid for Streptococcus mutans and Streptococcus sobrinus isolated from the Korean population were $2 {\mu}g$/ml and $4 {\mu}g$/ml, respectively. Ursolic acid had a bactericidal effect on S. mutans ATCC $25175^T$ and S. sobrinus ATCC $33478^T$ at > $2 \;{\times}\; MIC (4 {\mu}g$/ml) and $4 \;{\times}\; MIC (8 {\mu}g$/ml), respectively. Ursolic acid had no cytotoxic effect on KB cells at concentrations at which it exerted antimicrobial effects. The results suggest that ursolic acid can be used in the development of oral hygiene products for the prevention of dental caries.

• Structural Engineering and Mechanics
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• 제75권1호
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• pp.33-47
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• 2020

In this paper the dynamic behavior of an isolated building subjected to idealized near-fault pulses is investigated. The building is represented with a simple 2-DOF model. Both linear and non-linear behavior of the isolation system is considered. Using dimensional analysis, in conjunction with closed form mathematical idealized pulses, appropriate dimensionless parameters are defined and self-similar curves are plotted on dimensionless graphs, based on which various conclusions are reached. In the linear case, the role of viscous damping is examined in detail and the existence of an optimum value of damping along with its significant variation with the number of half-cycles is shown. In the nonlinear case, where the behavior of the building depends on the amplitude of the excitation, the benefits of dimensional analysis are evident since the influence of the dimensionless 𝚷-terms is easily examined. Special consideration is given to the normalized strength of the non-linear isolation system that appears to play a complex role which greatly affects the response of the 2-DOF. In the last part of the paper, a comparison of the responses to idealized pulses between a linear fixed-base SDOF and the respective isolated 2-DOF with both linear and non-linear damping is conducted and it is shown that, under certain values of the superstructure and isolation system characteristics, the use of an isolation system can amplify both the normalized acceleration and displacement of the superstructure.

• International Journal of Oral Biology
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• 제35권4호
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• pp.191-195
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• 2010

Oleanolic acid is a natural triterpenoid that exists widely in foods and some medicinal herbs. The purpose of this study was to determine the antimicrobial activity of oleanolic acid against Streptococcus mutans strains isolated from a Korean population. Antimicrobial activity against these bacteria was evaluated by minimal inhibitory concentration (MIC) and time kill curves. The tolerance of human gingival fibroblasts and human periodontal ligaments to oleanolic acid was tested using a methyl thiazolyl tetrazolium (MTT) assay. The $MIC_{90}$ value of oleanolic acid for both S. mutans and S. sobrinus isolated from Koreans was 8 ${\mu}g/ml$. Oleanolic acid showed bactericidal effects against S. mutans ATCC $25175^T$ and S. sobrinus ATCC $33478^T$ at $1\;{\times}\;MIC$ ($8{\mu}g/ml$) and had no cytotoxic effects against KB cells at this dose. The results suggest that oleanolic acid could be useful in the future development of oral hygiene products for the prevention of dental caries.

• 한국안광학회지
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• 제6권1호
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• pp.149-153
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• 2001

LiF:Mg, Cu, Na, Si TL 물질의 열자극발광을 온도대 파장대 발광강도의 3차원으로 측정하여 분석하였다. 온도대 발광강도곡선(glow curve)은 각 온도에서 파장별 발광강도데이터를 적분하여 구성하였고, 이를 분석하여 트랩에 관계되는 여러가지 파라미터들을 결정하였다. 발광곡선의 분석은 일반차 모델의 TL 강도 표현식을 기본함수로 하여 컴퓨터화된 발광곡선 분해(Computerized Glow Curve Deconvolution: CGCD)기법을 이용하였고, 그 결과 LiF:Mg, Cu, Na, Si TL 물질의 열자극발광곡선은 정점온도 333 K, 374 K 426 K, 466 K, 483 K 그리고 516 K를 갖는 6개의 개별적인 발광곡선들로 구성되어 있음을 확인하였다. 주 피크(main peak)인 456 K 발광곡선에 대하여 활성화에너지는 2.06 eV, 발광차수는 1.05로 밝혀졌다. 발광스펙트럼 분석결과 LiF:Mg, Cu, Na, Si TL 물질은 3개의 재결합준위 1.80 eV, 2.88 eV 그리고 3.27 eV를 가지는 것으로 판명되었다. 이 중 약 2.88 eV 준위가 지배적이고 다음으로 3.27eV 준위에서 발광이 일어나며 1.80 eV 준위는 극히 미약하나 분명한 존재를 확인하였다.

• 대한기계학회논문집
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• 제17권9호
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• pp.2271-2279
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• 1993

In the case of life prediction on the structures and machines after long service, it is natural to consider a degradation problems. Most of degradation data form practical structures are isolated data obtained at the time of periodical inspection or repair. From such data, it may be difficult to obtain the degradation curve available and necessary for life prediction. In this paper, for the purpose of obtaining a degradation curves, developed the simulate degradation method and fatigue test and Charpy impact test were conducted on the degraded, simulate degraded and recovered materials. Fatigue life prediction were conducted by using the relationship between fracture transition temperature (DBTT : vTrs) obtained from the Charpy impact test through the degradation process and fatigue crack growth constants of m and C obtained from the fatigue test.

• Journal of Power Electronics
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• 제8권1호
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• pp.60-73
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• 2008

In this paper a three-phase ac-to-dc resonant converter with high input power factor and isolated output is proposed. To improve the input power factor of the converter, high frequency current is injected into the input of the three-phase diode bridge rectifier. It is injected through an impedance network consisting of a series of L-C branches from the output of the high frequency three-phase inverter. A narrow switching frequency variation is required to regulate the output voltage. A design example with different design curves is illustrated along with the component ratings. Experimental verification of the converter is performed on a prototype of 3 kW, 1000 V output, operating above 300 kHz. Experimental results confirm the concept of the proposed converter. Narrow switching frequency variation is required to regulate the output voltage.

• The Korean Journal of Physiology and Pharmacology
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• 제4권2호
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• pp.105-111
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• 2000

Stimulation of muscarinic receptors by carbachol (CCh) in the circular smooth muscle of the guinea pig gastric antrum causes muscle contraction. In the present study, muscarinic receptor subtype controlling the muscle contraction in response to CCh was studied using putative muscarinic receptor antagonists. Isometric force of the isolated circular muscle strips was measured in an organ bath. CCh contracted the muscle in a dose-dependent way, and each of the three muscarinic receptor antagonists, 4-diphenylacetoxy- N-methylpeperdine methiodide (4-DAMP), methoctramine and pirenzepine shifted the concentration- response curves to the right without significantly reducing the maximum force. The affinities of the muscarinic antagonists $(pA_2\;values)$ obtained from Schild plot analysis were 10.15, 7.05 and 6.84 for 4-DAMP, methoctramine and pirenzepine, respectively. These results suggest that the $M_3-subtype$ mainly mediate the muscle contraction in response to CCh in guinea pig gastric antrum.

• 대한화학회지
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• 제57권1호
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• pp.52-62
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• 2013

The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II) and cerium (IV) with deprotonated enrofloxacin leads to the formation of the neutral or cationic mononuclear complexes. The isolated solid complexes have been characterized with physicochemical and spectroscopic techniques and thermogravimeteric analyses. The spectroscopic data indicate that the enrofloxacin ligand is on the deprotonated mode acting as bidentate ligand coordinated to the metal ions through the ketone oxygen and a carboxylato oxygen and the metal ions completed the coordination number with water molecules. The thermal decomposition mechanisms proposed for enrofloxacin and their metal complexes were discussed. The activation energies, $E^*$, enthalpies, ${\Delta}H^*$, entropies, ${\Delta}S^*$ and Gibbs free energies, ${\Delta}G^*$, of the thermal decomposition reactions have been derived from thermogravimetric (TG) and differential thermogravimetric (DTG) curves, using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. The antimicrobial activity has been evaluated against six different microorganisms.

• Structural Engineering and Mechanics
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• 제8권3호
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• pp.299-310
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• 1999

One problem with base isolators of the sliding type is that their dynamic responses are nonlinear, which cannot be solved in an easy manner, as distinction must be made between the sliding and non-sliding phases. The lack of a simple method for analyzing structures installed with base isolators is one of the obstacles encountered in application of these devices. As an initial effort toward simplification of the analysis procedure for base-isolated structures, an approach will be proposed in this paper for computing the equivalent damping for the resilient-friction base isolators (R-FBI), based on the condition that the sum of the least squares of errors of the linearized response with reference to the original nonlinear one is a minimum. With the aid of equivalent damping, the original nonlinear system can be replaced by a linear one, which can then be solved by methods readily available. In this paper, equivalent damping curves are established for all ranges of the parameters that characterize the R-FBI for some design spectra.

• 대한토목학회논문집
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• 제9권3호
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• pp.75-88
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• 1989

본(本) 연구(硏究)에서는 도로기하구조(道路幾何構造) 개량(改良)이 발생(發生)하게 될 performance 분석(分析) 모형(模型)을 최근(最近) 기법(技法)을 통하여 개발(開發)하였고 그 절차상(節次上)의 산정(算定) 과정(過程)을 전산화(電算化)하여 GUCAM(Geometric-specific User Cost Analysis Moded)을 개발(開發)하였다. GUCAM과 HIAP 모형간(模型間)의 비교(比較)를 위하여 지방부(地方部) 2차선도로(車線道路)를 4차선도로(車線道路)로 확장하는 현장(現場) 자료(資料)를 입력(入力)하였다. 그 결과(結果) GUCAM이 도로(道路)의 기하구조개량(幾何構造改良)에 보다 실제적(實際的)이고 민감하게 반응(反應)하는 것으로 나타났으며 그 이유는 도로(道路)의 평면곡선(平面曲線)과 구배를 반영하는 절차(節次) 개선(改善)하였기 때문인 것으로 판단되었다. 향후의 과제(課題)로는 GUCAM이 아직도 한 평면곡선(平面曲線)이나 구배의 개량(改良)을 충분히 고려하지 못하고 있는 점을 생각하여 이에 대한 보다 정확(正確)한 performance 분석(分析)에 관한 연구(硏究)가 될 것이다.