• Corrosion Science and Technology
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• 제20권3호
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• pp.143-151
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• 2021

In this study, optimal shot peening process conditions were investigated for improving the cavitation erosion resistance of gray cast iron under a marine environment. Shot peening was performed with variables of injection pressure and injection time. The durability was then evaluated through cavitation erosion test which was conducted according to the modified ASTM G-32 standard. The tendency of cavitation erosion damage according to shot peening process condition was investigated through weight loss rate, surface and cross-sectional analysis of the specimen before and after the test. As a result, the shot peening process condition that could minimize cavitation erosion was when the injection pressure was the lowest and when the injection time was the shortest. This was because the flake graphite exposed on the gray cast iron surface could be easily removed under such condition. Therefore, the notch effect can be prevented by surface modification. In addition, the cavitation erosion damage mechanism of gray cast iron was discussed in detail.

• Toxicological Research
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• 제31권4호
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• pp.347-354
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• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• 한국자기학회지
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• 제14권5호
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• pp.174-179
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• 2004

고주파 회로에서 발생하는 전도 노이즈의 흡수율을 측정하는 방안의 하나로 50 $\Omega$ 특성 임피던스의 마이크로스트립 선로를 제작하고, 순철 압분체로 구성되는 자기손실재의 전력 흡수율 측정을 통하여 측정 및 해석 방법의 타당성을 제시하였다 제작된 마이크로스트립 선로는 S$_{11}$ < -60 dB, S$_{21}$=0 dB의 반사/투과 특성을 보여 전도 노이즈 흡수율 측정에 이상적인 전송특성을 보였다. Attrition milling에 의해 순철 압분체를 제작하고, 이를 고무와 혼합하여 두께 1mm정도의 복합재 sheet를 제작하였다. 이 재료를 마이크로스트립 선로에 장착한 결과 2～8 GHz대역에서 전력흡수율이 80% 이상인 대역저지 필터와 유사한 특성을 얻을 수 있었다. 주파수, 흡수 sheet 크기에 따른 노이즈 흡수율에 관한 분석을 통하여, 노이즈 흡수율에 주된 영향을 주는 인자는 자기손실임을 제안하였다.

• Animal cells and systems
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• 제6권2호
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• pp.171-180
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• 2002

Nitric oxide has high affinity for iron, and thus it can cause intracellular iron loss. We tested the idea that intracellular iron can be the primary target of NO toxicity by comparing the signaling mechanisms involved in cell death caused by iron depletion and that caused by NO. Treatment of HL-60 cells with a NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP), decreased the intracellular iron level rapidly as that observed with the iron chelator deferoxamine (DFO). Iron chelators such as DFO and mimosine could induce death of human leukemic HL-60 cells by a mechanism requiring activation of p38 kinase, c-Jun N-terminal kinase, caspase-3 and caspase-8. DFO and SNAP also caused release of cytochrome c from mitochondria. Inhibition of p38 kinase by a selective inhibitor, SB203580, abolished the NO and DFO-induced cell death, release of cytochrome c, and activation of caspase-3 and caspase-8, thus indicating that p38 kinase lies upstream in the cell death processes. In a parallel situation, the cells that are sensitive to NO showed similar sensitivity to DFO. Moreover, simultaneous addition of ferric citrate, an iron-containing compound, inhibited the SNAP and DFO-induced activation of caspases and also blocked the NO-mediated cell cycle arrest at $G_1$ phase. Collectively, our data implicate that the NO-induced cell death of tumor cells including HL-60 cells is mediated by depletion of iron and further suggest that activation of p38 kinase lies upstream of cytochrome c release and caspase activation involved in this apoptotic process.

• 한국주조공학회지
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• 제10권1호
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• pp.31-42
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• 1990

The full mould casting process in one of the newly developed techniques which has many advantages. Unbonded sand mould has been prepared for the major mould and $CO^2$ gas mould has been used occasionally for comparison. Patterns were built up with expanded polystyrene and coated with three different materials. Silica, graphite and zircon were used for the coating layer. The effects on fluidity and temperature loss of molten metals were investigated. The molten metals were Al-5% Si alloy, Cu-30% Zn alloy and gray iron of approximately 4.0% of carbon equivalent. Experimental variables were runner section area, superheat, sprue height, coating materials, coating thickness and apparent density of EPS pattern. The effects of coating materials on fluidity and temperature loss of the molten metals during transient pouring are summarized as follows : As runner section area, superheat and sprue height increased, fluidity increased. Temperature loss decreased as runner section area and sprue height increased. However, reversed effects were observed in the case of superheat increment. The coating materials decreased the fluidity of each alloy in the order of silica, graphite and zircon. Zircon brought to the highest temperature loss among the coating materials used. The fluidity increased in the order gray iron, Cu-30% Zn and Al-5% Si alloy while temperature loss in the reverse order. Especially in case of reduced pressure process, the fluidity was increased apparently. Al-5% Si alloy showed the lowest temperature loss among the alloys. The increment of the apparent density of EPS pattern resulted in the fluidity decrease and temperature loss increase. The relation between fluidity and temperature loss of each alloy can be expressed by the following equation within the coating thickness limit of 0.5-1.5㎜. F^*={\frac{a}{T^*-b}}-c$ where, $F^*$ : fluidity in the Full mould, $T^*$ : temperature loss in the mould. a : parameter for full mould. b, c : constants.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• 제5B권3호
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• pp.238-242
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• 2005

In this paper, a surface permanent magnet motor made of the Soft Magnetic Composites (SMC) is analysed using the 3-D finite element method. By comparing with the motor made of the silicon steel sheets, the usefulness of the SMC for the eddy current loss is clarified quantitatively.

• 대한치과보존학회:학술대회논문집
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• 대한치과보존학회 2003년도 춘계학술대회
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• pp.260-261
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• 2003

• 한국자기학회지
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• 제22권1호
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• pp.23-26
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• 2012

정현파 자속밀도 조건에서 연자성 재료의 교류자기손실을 측정하기 위한 새로운 방법을 제시하였다. 본 방법은 입력전압파형을 결정짓기 위해 통상 이용하는 $H_i(B_i)$곡선대신 $V_{in}$(B)곡선을 이용함으로서 자기장, 자속밀도 그리고 입력전압간의 위상차를 고려할 필요가 없이 직접 입력전압파형을 얻을 수 있어 프로그램이 간편하게 되는 장점을 가지고 있었다. 개발된 측정방법의 유효성을 1 kHz, 10 kHz 주파수에서 페라이트 코어로 확인할 수 있었다.

• Molecules and Cells
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• 제40권12호
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• pp.976-985
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• 2017

Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood development, however, remain elusive. Here, we found that iron homeostasis is critical for differentiation of Drosophila blood cells in the larval hematopoietic organ, called the lymph gland. Supplementation of an iron chelator, bathophenanthroline disulfate (BPS) results in an excessive differentiation of the crystal cell in the lymph gland. This phenotype is recapitulated by loss of Fer1HCH in the intestine, indicating that reduced levels of systemic iron enhances crystal cell differentiation. Detailed analysis of Fer1HCH-tagged-GFP revealed that Fer1HCH is also expressed in the hematopoietic systems. Lastly, blocking Fer1HCH expression in the mature blood cells showed marked increase in the blood differentiation of both crystal cells and plasmatocytes. Thus, our work suggests a relevance of systemic and local iron homeostasis in blood differentiation, prompting further investigation of molecular mechanisms underlying iron regulation and cell fate determination in the hematopoietic system.

• Journal of Electrical Engineering and Technology
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• 제9권1호
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• pp.121-126
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• 2014

The accurate determination of induction motor efficiency depends on the estimation of the five losses of stator and rotor copper loss, iron loss, mechanical loss and stray load loss. As the mechanical and stray load losses are not calculated by electro-magnetic analysis, the values of these two losses are very important in induction motor design. In this paper, the values of mechanical loss and stray load loss are proposed through investigating testing data from commercial products of three phase induction motors under 37kW. If the values of this paper are applied to motor design, the accuracy of design and analysis can be improved. The losses of motors are obtained by using load and no-load test results following IEC 60034-2-1 standard.