• 생약학회지
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• 제16권3호
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• pp.160-164
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• 1985

Ajuga multiflora Bunge is a perennial herb in the family of Labiatae. The iridoid glycoside was isolated from the ethylacetate fraction and the n-butanol fraction of the plant. The structure of the substance was identified as 8-O-acetylharpagide by UV, IR, NMR spectra and several chemical reactions.

• Natural Product Sciences
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• 제19권3호
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• pp.227-230
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• 2013

One new iridoid glycoside, 10-p-dihydrocoumaroyl-6-${\alpha}$-hydroxygeniposide (1), and six known iridoid glycoside derivatives, 10-p-dihydrocoumaroyl deacetylasperuloside (2), asperulosidic acid methylester (3), asperuloside (4), asperulosidic acid (5), deacetylasperuloside (6), and scandoside (7) were isolated from the methanolic extract of the whole plant of Galium verum var. asiaticum Nakai (Rubiaceae) through repeated column chromatography. Their chemical structures were characterized by spectroscopic analysis. This is the first report of the characterization of compounds 1 - 7 from this plant.

• 생약학회지
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• 제27권2호
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• pp.87-90
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• 1996

An iridoid glycoside was isolated from the roots of Phlomis umbrosa and identified as sesamoside on the basis of spectroscopic evidence.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.247-247
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• 1994

Acteoside는 일명 Verbascoside로 불리우는 Phenylpropanoid glycoside에 속하는 화합물로 이미 보고되어진 생리활성으로는 Cytotoxic effect, Anti bacterial effect, Immunosuppressive effect, C-AMP Phospaestrase의 저해활성등 여러가지 생리활성이 보고되어 있다. 저자등은 마주송이풀의 성분을 규명하는 가운데 acteoside가 주성분임을 확인하게 되었고 이 식물이 한의서에서 관절염등에 사용되어 진다는 점에서 소염활성을, 식물을 건조할때 흑색으로 변하는데 착안하여 iridoid glycoside의 존재가 추정되어 iridoid glycoside의 일반 생리활성인 담즙분비 촉진작용과 간장보호 작용을 검색하던 중 phenylpropanoid glycoside인 acteoside에서도 담즙분비촉진 작용과 간장보호작용의 지견을 얻었기에 보고하고자 한다.

• 생약학회지
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• 제17권2호
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• pp.129-133
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• 1986

Antimicrobial activities of aucubin, an iridoid glycoside, were investigated. Gram-positive bacterium, S. aureus appeared to be more sensitive to aucubin's aglucone, aucubigenin than Gram-negative, E. coli did. Antimicrobial activities produced by aucubigenin may result in part from the inhibition of RNA and protein biosyntheses in bacterial cells. The conversion of aucubin iridoid glycoside into aucubigenin, an aglucone, appears to be a prerequisite step to exhibit the antimicrobial activities.

• Natural Product Sciences
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• 제18권3호
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• pp.195-199
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• 2012

Nine iridoid glycoside derivatives were elucidated from the methanolic extract of the aerial parts of Galium spurium (Rubiaceae) through repeated column chromatography. Their chemical structures were characterized as 10-O-trans-p-coumaroylscandoside (1a), 10-O-cis-p-coumaroylscandoside (1b), 10-O-trans-p-coumaroyl-10-O-deacetyldaphylloside (2), 10-O-cis-p-coumaroyl-10-O-deacetyldaphylloside (3), asperulic acid methylester (4), asperuloside (5), asperulosidic acid (6), scandoside (7), and deacetyl asperulosidic acid (8) by spectroscopic analysis. This is the first report of the characterization of compounds 1a, 1b, 2, 3 and 7 from this plant.

• 생약학회지
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• 제11권1호
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• pp.15-23
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• 1980

A new iridoid glucoside was isolated from the whole plant of Ajuga spectabilis Nakai (Jaran-cho; Labiatae). This compound was obtained as white plate-like crystal and named as Jaranidoside. It has a molecular formula $C_{17}H_{26}O_{12}$ and mp $128{\sim}130^{\circ}C$. The structure of the Jaranidoside was assumed from data of chemical reactions and PMR specturum of the compound. To determine the most favorable conformation, informations on the proton coupling and chemical shift were used. Jaranidoside exhibited a stimulating activity on smooth muscle and cardiac muscle. No antimicrobial activity on five microorganism strains was observed.

• 생약학회지
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• 제16권2호
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• pp.99-104
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• 1985

To investigate a possible biological activity of iridoid glucosides, six compounds, aucubin, catalpol, gardenoside, geniposide, rehmannioside and swertiamarin, were studied in relation with their potential influences in RNA and protein biosyntheses in murine tumor cell, sarcoma 180, in vitro. Protein biosynthesis was slightly inhibited by aucubin, gardenoside and swertiamarin. Degree of inhibition of RNA biosynthesis by those iridoid appeared to be more sensitive than that of protein biosynthesis. When aucubin was pretreated with ${\beta}-glucosidase$ to produce its genin form and the sarcoma 180 cells were exposed to this aucubigenin, the protein and RNA biosyntheses in the cells were profoundly inhibited. The results indicate that a biologically active from of iridoid compounds is the hydrolytic products of glycoside, i.e. genin form. It is also suggested that sarcoma 180 cells used in the experiments appear to lack of ${\beta}-glucosidase$, since the inhibitory actions of iridoid glucosides were so slight that those glucosides were not hydrolysed by the enzyme to their genin forms.

• 생약학회지
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• 제13권3호
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• pp.106-111
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• 1982

Melampyrum roseum Max. is an annual herb in Scrophulariaceae plants. The materials were collected in Kyeongi-Do in 1980. The BuOH extract was evaporated under reduced pressure. The residue was column chromatographed over silica gel with benzene-MeOH (8 : 1) as an eluent and it gave the amorphus powder. Compound I has a molecular formula $C_{17}H_{26}O_{10}$ and it was identified as mussaenoside by chemical data, UV, IR, NMR spectra and compared with the authentic sample of mussaenoside tetraacetate.

• Archives of Pharmacal Research
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• 제28권10호
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• pp.1156-1160
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• 2005

An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-O-ben-zoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed $63.3{\pm}2.0,\;62.2{\pm}1.6,\;and\;63.8{\pm}1.5\%$ inhibition, respectively, at a concentration of 20 ${\mu}g/mL$.