• Progress in Medical Physics
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• v.15 no.2
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• pp.100-104
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• 2004

The detector size effect due to the spatial response of detectors is a critical source of inaccuracy in clinical dosimetry that has been the subject of numerous studies. Conventionally, the detector response kernel contains all the information about the influence that the detector size has on the measured beam profile. Various analytical models for this kernel have been proposed and studied in theoretical and experimental works. Herein, a method to simply determine the detector response kernel using the Monte Carlo simulation and convolution theory has been proposed. Based on this numerical method, the detector response kernel for a Farmer type ion chamber embedded in a water phantom has been obtained. The obtained kernel shows characteristics of both the pre-existing parabolic model proposed by Sibata et al. and the Gaussian model used by Garcia-Vicente et al. From this kernel and deconvolution technique, the detector size effect can be removed from measurements for 6MV, 10${\times}$10 $\textrm{cm}^2$ and 0.5${\times}$10 $\textrm{cm}^2$photon beams. The deconvolved beam profiles are in good agreements with the measurements performed by the film and pin-point ion chamber, with the exception of in the tail legion.

• Journal of Sensor Science and Technology
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• v.7 no.3
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• pp.163-170
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• 1998

An ion energy spectrometer which has the $45^{\circ}$ parallel electrostatic deflection plate was designed and constructed for measuring ion temperature in high temperature plasma. The energy calibration and the energy resolution were studied in detail for a hydrogen ion at the $0.24{\sim}1.92\;keV$ energy using electrostatic accelerator with a duoplasmatron ion source. The voltage of the deflection plate was linearly increased for the decreased ion detector position at the constant ion energy and decreased for the increased ion energy at the fixed ion detector position. The inclination of the deflection plate voltage to the ion energy was between 0.92 and 1.61, and linearly decreased for the increased the ion detector position. The measured energy resolution, which is $4.2%\;{\sim}\;11.6%$ in this experiment region, was improved for the increased ion dector position and ion energy. The relative efficiency was increased for the decreased the ion detector position. The ion energy spectrum of the DC plasma in the multi-purpose plasma generator was measured using this equipment. The ion temperature was 203-205 eV at the discharge voltage 320 V, discharge current 1.7 A.

• Proceedings of the Korean Society of Medical Physics Conference
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• 1999.11a
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• pp.372-375
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• 1999

We have developed a new heavy ion CT detector system for the use of a fan beam. The system consists of two sets of a position sensitive detector and an energy detector. The calibration runs were carried out using a $\^$12/C beam of 1mm in diameter with the energies of 290 MeV/u, 254.5 MeV/u, and 215.8 MeV/u. The spatial resolution of 1.1 mm and the energy resolution of about 1％ were achieved.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.3
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• pp.161-167
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• 1997

Determination of several cationic surfactants in cosmetics has been investigated. Reverse phase ion pair chromatography was used to identify and quantitate cationic surfactants. Cationic surfactants analyzed in this experiment were cetylpyridium chloride, stearyltrimetylammonium chloride, bezalkonium chloride, benzyldicethylcetylammonium chloride, and bihenyltrimethyl ammonium chloride. The separation was achieved on a reverse phase coumn with 10mM HCl-acetonitrile eluent. In this condition, the most of cationic surfactants with exception of CPC and CTAC respectively with suppressed conductivity detector and UV detector connected in series. The calibration curves obtained by plotting the peak areas of the cationic surfactants were linear at levels ranging from 0.005 to 0.1% correlation coefficient, r=0.9988. The detection limits were 1 to 5ppm in sample solution. The average recoveries of cationic surfactants added to hair treatment cream and hair rinse in three to five experiments were 96.7 105.2% and relative standard deviations were 1.1-3.8%. The case that there were CPC and CTAC in same solution was also tested. CPC and CTAC which couldn't be separated on reverse phase column were quantitated with suppressed conductivity detector and UV detector connected in series. Recovery of CPC and CTAC were 101.6 and 89.2% respectively. The proposed method was applied to the determination of cationic surfactants in commercial hair treatment cream.

• Progress in Medical Physics
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• v.1 no.1
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• pp.91-95
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• 1990

The solid state detector system was constructed using commercially available rectifier diode for the assessment of quality assurance in radiotherapy. Dosimetry system which consists of the electrometer and the water phanton was used for measuring small field size scanning. The measured results, which had linearity in accordance with variation of radiation dose for gamma-ray of Co- 60 and 6 and 10MV photons of linear accelerator, showed quite linear characteristics within 1% error. The percent depth dose of 10MV photon of Mevatron KD linear accelerator was measured in small field size using diode, and the results were compared with that of using ion chambers. The results show that the difference of percent depth dose between the value of diode and that of ion chamber was negligible in large field size. However, in small size less than 4$\times$4cm, the difference of percent depth dose estimated by diode and ion chamber was 4.7% by extrapolation to 0$\times$0cm. Considering the smaller volume of diode than that of ion chamber, it might be more reliable to use diode for estimating percent depth dose. Above results suggest that diode can be used for routine check such as beam profile, flatness, symmetry and energy

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.107.1-107.1
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• 2014

We have developed and commercialize a time-of-flight - medium energy ion scattering spectrometry (TOF-MEIS) system (model MEIS-K120). MEIS-K120 adapted a large solid acceptance angle detector that results in high collection efficiency, minimized ion beam damage while maintaining a similar energy resolution. In addition, TOF analyzer regards neutrals same to ions which removes the ion neutralization problems in absolute quantitative analysis. A TOF-MEIS system achieves $7{\times}10^{-3}$ energy resolution by utilizing a pulsed ion beam with a pulse width 350 ps and a TOF delay-line-detector with a time resolution of about 85 ps. TOF-MEIS spectra were obtained using 100 keV $He^+$ ions with an ion beam diameter of $10{\mu}m$ with ion dose $1{\times}10^{16}$ in ordinary experimental condition. Among TOF-MEIS applications, we report the quantitative compositional profiling of 3~5 nm CdSe/ZnS QDs, As depth profile and substitutional As ratio of As implanted/annealed Si, Ionic Critical Dimension (CD) for FinFET, Direct Recoil (DR) analysis of hydrogen in diamond like carbon (DLC) and InxGayZnzOn on glass substrate.

• Archives of Pharmacal Research
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• v.28 no.10
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• pp.1190-1195
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• 2005

The objective of this study was to develop an assay for mequitazine (MQZ) for the study of the bioavailability of the drug in human subjects. Using one mL of human plasma, the pH of the sample was adjusted and MQZ in the aqueous phase extracted with hexane; the organic layer was then evaporated to dryness, reconstituted and an aliquot introduced to a gas chromatograph/mass spectrometer (GC/MS) system with ion-trap detector. Inter- and intra-day precision of the assay were less than 15.1 and $17.7{\%}$, respectively; Inter- and intra-day accuracy were less than 8.91 and $18.6{\%}$, respectively. The limit of quantification for the current assay was set at 1 ng/mL. To determine whether the current assay is applicable in a pharmacokinetic study for MQZ in human, oral formulation containing 10 mg MQZ was administered to healthy male subjects and blood samples collected. The current assay was able to quantify MQZ levels in most of the samples. The maximum concentration ($C_{max}$ was 8.5 ng/mL, which was obtained at 10.1 h, with mean half-life of approximately 45.5 h. Under the current sampling protocol, the ratio of $AUC_{t{\rightarrow}last}$ to $AUC_{t{\rightarrow}{\infty}}$ was $934{\%}$, indicating that the blood collection time of 216 h is reasonable for MQZ. Therefore, these observations indicate that an assay for MQZ in human plasma is developed by using GC/MS with ion-trap detector and validated for the study of pharmacokinetics of single oral dose of 10 mg MQZ, and that the current study design for the bioavailability study is adequate for the drug.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1371-1374
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• 1997

We had developed the on-line environmental monitoring system which has installed around Kori Nuclear Power Plants and will be taken the place of the existing system. The system consists of a main computer and 11 sets of radiation monitoring post equipments. Nal(Tl) scintillation detectro was adopted in addition to ion-chamber detector and implemented with DCU(Dose Conversion Unit) and SCA(Single Channel Analyzer). Compared with the existing system, it has revised feature in the radiation measurements which are detection of artificial radioactivity and 2-ways of the radiatiion detectors. The field test trsults show that the developed radiation detecting equipments can measure environmental radiation withn 5.0% of the theoretical value.

• Nuclear Engineering and Technology
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• v.50 no.5
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• pp.751-757
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• 2018

In this article, a UV sensor that is an appropriate tool for fire detection has been designed and constructed. The structure of this UV sensor is an air-filled single-wire detector that is able to operate under normal air condition. A reflective CsI photocathode is installed at the end of the sensor chamber to generate photoelectrons in the ion chamber. An electric current is produced by accelerating photoelectrons to the anode in the electric field. The detector is able to measure the intensity of the incident UV rays whenever the current is sufficiently high. Therefore, the sensitivity coefficient of this sensor is found to be $7.67{\times}10^{-6}V/photons/sec$.

• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.123-129
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• 2006

A method determining the plasma concentration of clotiazepam was developed by using gas chromatography/mass spectrometry with an ion-trap detector and was validated for applying pharmacokinetics to human volunteers orally taken 5 mg dose of clotiazepam. The detection limit was 1 ng/ml and the limit of quantitation was 5 ng/mt. Intraday reproducibility and accuracy bias % were less than 8.2 and 10.2% with inter-day variations for those being within 7.0 and 13.8%, respectively. The recovery of clotiazepam was higher than 87%. The principal pharmacokinetic parameters were determined from the plasma concentration-time plot by non-compartmental or two-compartmental analysis. In non-compartmental analysis, the elimination half-life of 10.4 hr and the area under the curve of 651.3 ng hr/ml were determined, and the maximal concentration (158.6 ng/ml) in the plasma was obtained at 0.56 hr post-dose. The developed method can be appropriate to apply pharmacokinetics and bioequivalence of clotiazepam.