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Effectiveness of Botulinum Toxin A in Treatment of Frey's Syndrome (Frey 증후군의 치료에 있어서 보툴리눔 독소 A형의 유용성)

  • Kim, Kook Hyun;Park, Eun Soo;Youn, Chang Won;Lee, Young Mann;Kim, Yong Bae
    • Archives of Craniofacial Surgery
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    • v.10 no.2
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    • pp.114-119
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    • 2009
  • Purpose: Several therapeutic approaches have been introduced and tried to treat Frey syndrome following parotidectomy. However they were not proved as an effective treatment. A new therapeutic modality using botulinum toxin injections was presented previously by several study groups. But, the duration of the demonstrated positive effect was essentially unknown so far. The purpose of this clinical investigation is to demonstrate the effectiveness of Botulinum toxin type A(BTXA) in patients with Frey syndrome. Methods: For this study, 12 patients were treated, They were assessed with the Minor's iodine-starch test and interviewed before and after treatment. Botulinum toxin is injected with $1.0cm^2$ apart into the skin where symptoms of Frey's syndrome has manifestated. The patients were classified according to the concentration of botulinum toxin and dosage of botulinum toxin. Results: The outcome measures were the time of reappearance of gustatory sweating(subjective study), and the results of an Minor's iodine-starch test(objective study) of 3 weeks, 3 months, 6 months, 9 months, 12 months after treatment. This treatment was effective in all groups of patients. The concentrations and the amount of dosages did not affect the treatment. But high concentration produced faster effectiveness in subjective. Conclusion: Botulinum toxin type A(BTXA) for Frey syndrome is easy, convenient and effective withouts severe complication. And the patients has no difficulty and limitation in their life.

Changes in Retrogradation Degree of Nonwaxy Rice Cooked at Different Pressure and Stored in Electric Rice Cooker (압력 취반 백미의 전기밥솥 보온중 노화도의 변화)

  • Park, Seok-Kyu;Ko, Yong-Duck;Choi, Ok-Ja;Shon, Mi-Yae;Seo, Kwon-Il
    • Korean Journal of Food Science and Technology
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    • v.29 no.4
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    • pp.705-709
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    • 1997
  • Changes in retrogradation degree of nonwaxy milled rice cooked at different pressure and stored in electric rice cooker at $74^{\circ}C$ were investigated. The moisture contents of nonwaxy milled rice cooked at $1.0{\sim}1.9\;atm\;and\;1.2{\sim}1.5$ water/rice ratio were $59.9{\sim}64.3%$. When nonwaxy milled rice was cooked at high pressure, X-ray diffraction patterns of cooked rice exhibited the V-type having nearly no crystallinity. Retrogradation peak of cooked rice from DSC thermogram was observed in the temperature range of $41.9{\sim}62.4^{\circ}C$ and was not appeared in cooked rice above 1.5 atm. During storage at cooker for 24 hr, retrogradation enthalpy of cooked rice was increased and retrogradation peak was not appeared above 1.7 atm. In cooking and storage of cooked rice, retrogradation degree measured by ${\alpha}-amylase-iodine$ method in high pressure gelatinized samples was lower than that in low pressure gelatinized ones.

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Variation of Microfibril Angle Within Stems of Three Commercial Softwoods Grown in Korea (국내산 주요 침엽수 3종의 수간 내 마이크로피브릴 경사각의 변이)

  • Eun, Dong-Jin;Kim, Nam-Hun
    • Journal of the Korean Wood Science and Technology
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    • v.36 no.4
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    • pp.77-83
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    • 2008
  • Radial and axial variations of microfibril angle (MFA) within stems of three commercial softwoods (Pinus densiflora, Pinus koraiensis and Pinus rigida) grown in Korea were examined by iodine crystal deposition method. The average MFA were $16.4^{\circ}$ in Pinus densiflora, 14.4, in Pinus koraiensis, and $26.2^{\circ}$ in Pinus rigida, respectively. The MFA in earlywood and latewood decreased with age to about 15~20 years, and then remained almost constant. The MFA of latewood was slightly smaller than that of earlywood. The MFA in the three species was a little smaller at the base of stem and decreased slightly with increasing tree height, but no significant difference by height was identified only in earlywood of Pinus rigida. Consequently, it was considered that the MFA could be an useful index for identifying juvenile wood and adult wood of Pinus densiflora, Pinus. koraiensis and Pinus rigida.

A DYNAMIC SIMULATION OF THE SULFURIC ACID DECOMPOSITION PROCESS IN A SULFUR-IODINE NUCLEAR HYDROGEN PRODUCTION PLANT

  • Shin, Young-Joon;Chang, Ji-Woon;Kim, Ji-Hwan;Park, Byung-Heung;Lee, Ki-Young;Lee, Won-Jae;Chang, Jong-Hwa
    • Nuclear Engineering and Technology
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    • v.41 no.6
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    • pp.831-840
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    • 2009
  • In order to evaluate the start-up behavior and to identify, through abnormal operation occurrences, the transient behaviors of the Sulfur Iodine(SI) process, which is a nuclear hydrogen process that is coupled to a Very High Temperature Gas Cooled Reactor (VHTR) through an Intermediate Heat Exchanger (IHX), a dynamic simulation of the process is necessary. Perturbation of the flow rate or temperature in the inlet streams may result in various transient states. An understanding of the dynamic behavior due to these factors is able to support the conceptual design of the secondary helium loop system associated with a hydrogen production plant. Based on the mass and energy balance sheets of an electrodialysis-embedded SI process equivalent to a 200 $MW_{th}$ VHTR and a considerable thermal pathway between the SI process and the VHTR system, a dynamic simulation of the SI process was carried out for a sulfuric acid decomposition process (Second Section) that is composed of a sulfuric acid vaporizer, a sulfuric acid decomposer, and a sulfur trioxide decomposer. The dynamic behaviors of these integrated reactors according to several anticipated scenarios are evaluated and the dominant and mild factors are observed. As for the results of the simulation, all the reactors in the sulfuric acid decomposition process approach a steady state at the same time. Temperature control of the inlet helium is strictly required rather than the flow rate control of the inlet helium to keep the steady state condition in the Second Section. On the other hand, it was revealed that the changes of the inlet helium operation conditions make a great impact on the performances of $SO_3$ and $H_2SO_4$ decomposers, but no effect on the performance of the $H_2SO_4$ vaporizer.

Electron Microscopy and Magnetic Properties of Tetra(n-butyl) ammonium salts of $[Ni(dmbit)_2]^1- (dmbit^2-:C_7H_2S_5$:2-thiobenzo[d]-1,3-dithiole-5,6-dithiolate;$dmbbip^{2-}:C_{12}H_{16}S_4$:1,2-bis(isopropylthio)benzene-4,5-dithiolat

  • No, Dong Yeon;Gang, Mi Jeong;Lee, Ha Jin;Kim, Jong Hyeon;Choe, Jin Ho
    • Bulletin of the Korean Chemical Society
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    • v.17 no.1
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    • pp.46-50
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    • 1996
  • Monoanionic nickel(Ⅲ) complexes, [Ni(dmbit)2]1- and [Ni(dmbbip)2]1- where dmbit2- and dmbbip2- denote 2-thiobenzo[d]-1,3-dithiole-5,6-dithiolate and 1,2-bis(isopropylthio)benzen-4,5-dithiolate, respectively, have been synthesized by the iodine oxidation of dianionic complexes. In the scanning electron microscopic(SEM) images, these complexes show the well-grown two-dimensional layered structures which are clearly comparable to the dianionic ones with three-dimensional structures. Magnetic susceptibilities of nickel(Ⅲ)complexes are fitted well with the two-dimensional Heisenberg antiferromagnet model of S=1/2 system resulting in the spin-exchange parameters (|J|/k) of 11.4 K and 0.45 K, respectively. The weaker magnetic interaction in [Ni(dmbbip)2]1- is resulted from the bulky isopropyl groups on the periphery of dmbbip ligand. EPR measurements for [Ni(dmbit)2]1- give the signal with axial symmetry and the anisotropic g-values for low-spin nickel(Ⅲ) (g//=2.158, g =2.030,gav=2.074 at 300 K; g//=2.162, g =2.038, gav=2.080 at 77 K). It is therefore concluded that nickel(Ⅱ) is oxidized to nickel(Ⅲ), rather than dmbit2- and dmbbip2- ligands are, by the iodine oxidation. The paramagnetic Ni(Ⅲ) would be located in the axial symmetry(D4h) with the electronic configuration of (dxz2dyz2dz22dxy1dx2-y20).

The strategies for the supplementation of vitamins and trace minerals in pig production: surveying major producers in China

  • Yang, Pan;Wang, Hua Kai;Li, Long Xian;Ma, Yong Xi
    • Animal Bioscience
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    • v.34 no.8
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    • pp.1350-1364
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    • 2021
  • Objective: Adequate vitamin and trace mineral intake for pigs are important to achieve satisfactory growth performance. There are no data available on the vitamin and trace mineral intake across pig producers in China. The purpose of this study was to investigate and describe the amount of vitamin and trace minerals used in Chinese pig diets. Methods: A 1-year survey of supplemented vitamin and trace minerals in pig diets was organized in China. A total of 69 producers were invited for the survey, which represents approximately 90% of the pig herd in China. Data were compiled by bodyweight stages to determine descriptive statistics. Nutrients were evaluated for vitamin A, vitamin D, vitamin E, vitamin K, thiamine, riboflavin, vitamin B6, vitamin B12, pantothenic acid, niacin, folic acid, biotin, choline, copper, iron, manganese, zinc, selenium, and iodine. Data were statistically analyzed by functions in Excel. Results: The results indicated variation for supplemented vitamin (vitamin A, vitamin D, vitamin E, vitamin K, vitamin B12, pantothenic acid, niacin, and choline) and trace minerals (copper, manganese, zinc, and iodine) in pig diets, but most vitamins and trace minerals were included at concentrations far above the total dietary requirement estimates reported by the National Research Council and the China's Feeding Standard of Swine. Conclusion: The levels of vitamin and trace mineral used in China's pig industry vary widely. Adding a high concentration for vitamin and trace mineral appears to be common practice in pig diets. This investigation provides a reference for supplementation rates of the vitamins and trace minerals in the China's pig industry.

Safety of Administering Intravenous CT Contrast Agents Repeatedly or Using Both CT and MRI Contrast Agents on the Same Day: An Animal Study

  • Heejin Bae;Hyewon Oh;Ga Bin Park;Yong Eun Chung
    • Korean Journal of Radiology
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    • v.25 no.3
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    • pp.257-266
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    • 2024
  • Objective: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study. Materials and Methods: Fifty-six Sprague-Dawley male rats were equally divided into eight groups: negative control, positive control (PC) with single-dose administration of CT contrast agent, and additional administration of either CT or MR contrast agents 2, 4, or 24 hours from initial CT contrast agent injection. A 12 µL/g of iodinated contrast agent or a 0.47 µL/g of gadolinium-based contrast agent were injected into the tail vein. Serum levels of blood urea nitrogen, creatinine, cystatin C (Cys C), and malondialdehyde (MDA) were measured. mRNA and protein levels of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated. Results: Levels of serum creatinine (SCr) were significantly higher in repeated CT contrast agent injection groups than in PC (0.21 ± 0.02 mg/dL for PC; 0.40 ± 0.02, 0.34 ± 0.03, and 0.41 ± 0.10 mg/dL for 2-, 4-, and 24-hour interval groups, respectively; P < 0.001). There was no significant difference in the average Cys C and MDA levels between PC and repeated CT contrast agent injection groups (Cys C, P = 0.256-0.362; MDA, P > 0.99). Additional doses of MR contrast agent did not make significant changes compared to PC in SCr (P > 0.99), Cys C (P = 0.262), and MDA (P = 0.139-0.771) levels. mRNA and protein levels of KIM-1 and NGAL were not significantly different among additional CT or MR contrast agent groups (P > 0.05). Conclusion: A sufficient time interval, probably more than 24 hours, between repeated contrast-enhanced CT examinations may be necessary to avoid deterioration in renal function. However, conducting contrast-enhanced MRI on the same day as contrast-enhanced CT may not induce clinically significant kidney injury.

Effects of the Thyroid Function on the Adrenal Gland, Hypophysis and Gonads in the Guinea Pigs. 1 Effects of the Thyroid Function on the Adrenal Gland in the Guinea Pigs (Guinea pig의 갑상선기능(甲狀腺機能)이 부신(副腎), 뇌하수체(腦下垂體) 및 생식선(生殖腺)에 미치는 영향(影響) I. Guinea pig의 갑상선(甲狀腺)이 부신(副腎)에 미치는 영향(影響))

  • Lee, Kang Wook;Lee, Kyu Sung;Cheong, Young Chai
    • Korean Journal of Veterinary Research
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    • v.8 no.2
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    • pp.110-116
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    • 1968
  • The mature guinea pigs were grouped as indicated in the table 1. Radio-active iodine(I-131)in dose of 4.5mci, was administered to the experimental groups. The animals were killed for examination in 1, 7, 14, 28, 42, and 55 days after the administration the radio-active iodine. The thyroid and adrenal glands were observed histologically. The results obtained were as follows; 1. One day after the administration, thyroid epithelial cells were abnormally enlarged. After seven days, specimens taken from the middle of the thyroid showed that the follicles and epithelial cells were changing to fibrous tissue, however, some follicles still remained in the verge of the thyroid. Follicles were not observed after fourteen days. After twenty-eight days, the follicles had all changed to fibrous tissue, and had lost their function. 2. The size of the zonas gromerulosa of adrenal cortex epually, in both male and female, showed slight fluctuation in size with no tendency to be changed. 3. Among the zones of the adrenal glands, zona fasciculata showed marked changes. Zona fasciculata was atrophied in Process of time. In females, it was atrophied significantly(P<0.05) after fourteen days, and highly significant (P<0.01) in twenty-eight and fifty-six days after the administration of radioactive iodine. In males, it also decreased significantly(P<0.05) in seventy-eight days and highly significant(P<0.01) in forty-two and fifty-six days after the administration. 4. The size of the Zona reticularis of adrenal cortex in the females increased significantly (P<0.05) in twenty-eight days after the administration. In males, it showed slight fluctuation until twenty-eight days, but it increased significantly(P<0.05) in forty-two and fifty-six days after the administration. 5. The size of the adrenal medulla increased significantly(P<0.05) in twenty-eight and forty-two days in females. It was increased significantly(P<0.05) in fourth-two days and high significantly(P<0.01) in fifty-six days after the administration.

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A preliminary study to determine the order of the latent fingerprint deposition on thermal paper - A short term study - (감열지상 잠재지문의 남겨진 순서결정에 대한 예비적 연구 - 단기연구 -)

  • Lim, Dong-A;Ok, Yun-Seok;Heo, Bo-Reum;Choi, Sung-Woon
    • Analytical Science and Technology
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    • v.30 no.5
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    • pp.279-286
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    • 2017
  • Determination of the order of latent fingerprints deposition on the surface of thermal paper, often found in crime scenes, is related to the study of time course and aging of fingerprints and can provide additional information in criminal investigations. A preliminary study was performed to determine the deposition order of fingerprints left with two different conditions of deposition pressure and time (in seconds) after 1 day intervals for 7 days on thermal paper (receipt and fax thermal paper) using an iodine fuming method. The resultant images of the visualized fingerprints were analyzed with densitometric image analysis to measure the changes in the areas of the ridges, which can be correlated to the deposition order. No significant variation was found with the different types of thermal paper. The average areas of the friction ridges increased gradually or were similar to the values from day 1 for 3 days, and then a continual decrease was shown from day 4 through day 7. The area values from day 6 and day 7 were less than half of those from day 1. Furthermore, the test with overlapped fingerprints showed the possibility of differentiation between fingerprints that are 1-3 and 6-7 days old based on the clarity visible to the naked eye. Additional experiments with the deposition conditions can prove that the current method is valuable for the determining the order of fingerprint deposition on thermal paper.

Comparison of Urine Iodine/Creatinine ratio between Patients following Stringent and Less Stringent Low Iodine Diet for Radioiodine Remnant Ablation of Thyroid Cancer (갑상선암의 방사성요오드치료를 위한 저요오드식이 방법 차이에 따른 소변 중 요오드/크레아티닌 비의 비교)

  • Roh, Jee-Ho;Kim, Byung-Il;Ha, Ji-Su;Chang, Sei-Joong;Shin, Hye-Young;Choi, Joon-Hyuk;Kim, Do-Min;Kim, Chong-Soon
    • Nuclear Medicine and Molecular Imaging
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    • v.40 no.6
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    • pp.322-326
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    • 2006
  • A low iodine diet (LID) for $1{\sim}2$ weeks is recommended for patients who undergoing radioiodine remnant ablation. However, the LID educations for patients are different among centers because there is no concrete recommendation for protocol of LID. In this investigation, we compared two representative types of LID protocols performed in several centers in Korea using urine iodine to creatinine ratio (urine I/Cr). Methods: From 2006, April to June, patients referred to our center for radioiodine remnant ablation of thyroid cancer from several local hospitals which had different LID protocols were included. We divided into two groups, stringent LID for 1week and less stringent LID for 2 weeks, then measured their urine I/Cr ratio with spot urine when patients were admitted to the hospital. Results: Total 27 patients were included in this investigation (M:F=1:26; 13 in one-week stringent LID; 14 in two-week less stringent LID. Average of urine I/Cr ratio was $127.87{\pm}78.52{\mu}g/g$ in stringent LID for 1 week, and $289.75{\pm}188.24{\mu}g/g$ in less stringent LID for 2 weeks. It was significantly lower in stringent LID for 1 week group (p=0.008). The number of patients whose urine I/Cr ratios were below $100{\mu}g/g$ was 6 of 13 in stringent LID for 1 week group, and 3 of 14 in less stringent LID for 2 weeks group. Conclusion: Stringent LID for 1 week resulted in better urinary I/Cr ratio in our investigation compared with the other protocol. However it still resulted in plenty of inadequate range of I/Cr ratio, so more stringent protocol such as stringent LID for 2 weeks is expected more desirable.