• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3319-3323
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• 2012

Objective: The results from the published studies on the association between prohibitin 3' untranslated region C > T gene polymorphism and cancer risk are conflicting. This meta-analysis was performed to evaluate the relationship with cancer susceptibility overall, and to explore whether the T allele or TT genotype could become a predictive marker for cancer risk. Methods: Association studies were identified from the databases of PubMed, Embase, and Cochrane Library as of March 1, 2012, and eligible investigations were synthesized using the meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Six investigations were identified for the analysis of association between the prohibitin 3' untranslated region C > T gene polymorphism and cancer risk, covering of 1,461 patients with cancer and 1,197 controls. There was a positive association between the T allele and cancer susceptibility (OR=1.20, 95% CI: 1.03-1.39, P=0.02), and CC homozygous might play a protective role (OR=0.80, 95% CI: 0.68-6.11, P=0.95). In the sub-group analysis, prohibitin 3' untranslated region C > T gene polymorphism and cancer risk appeared associated with the risk of breast cancer, but not ovarian cancer. Conclusions: Our results indicate that T allele is a significant genetic molecular marker to predict cancer susceptibility and CC genotype is protective, especially for breast cancer. However, more investigations are required to further clarify the association of the prohibitin 3' untranslated region C > T gene polymorphism with cancer susceptibility.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.1015-1021
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• 2014

This study aimed at summarizing published study findings on the diagnostic value of rectal bleeding (RB) and informing clinical practice, preventive interventions and future research areas. We searched Medline and Embase for studies published by September 13, 2013 examining the risk of colorectal cancer in patients with RB using highly inclusive algorithms. Data for sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and positive predictive value (PPV) of RB were extracted by two researchers and analyzed applying Meta-Disc (version 1.4) and Stata (version 11.0). Methodological quality of studies was assessed according to QUADAS. A total of 38 studies containing 5,626 colorectal cancer patients and 73,174 participants with RB were included. The pooled sensitivity and specificity were 0.47 (95% CI: 0.45-0.48) and 0.96 (95% CI: 0.96-0.96) respectively. The overall PPVs ranged from 0.01 to 0.21 with a pooled value of 0.06 (95% CI: 0.05-0.08). Being over the age of 60 years, change in bowel habit, weight loss, anaemia, colorectal cancer among first-degree relatives and feeling of incomplete evacuation of rectum appeared to increase the predictive value of RB. Although RB greatly increases the probability of diagnosing colorectal cancer, it alone may not be sufficient for proposing further sophisticated investigations. However, given the high specificity, subjects without RB may be ruled out of further investigations. Future studies should focus on strategies using RB as an "alarm" symptom and finding additional indications to justify whether there is a need for further investigations.

• Journal of Korean Society for Geospatial Information Science
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• v.19 no.3
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• pp.91-98
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• 2011

Road signs are part of the traffic facilities intended to guide drivers to their destinations in a safe and comfortable manner. Due to the creation of new routes, changes to the old routes, and the deterioration of road signs, road signs do require efforts to do ongoing field investigations and put the results in a database. The purpose of this study was to propose methodologies to do field investigations and build a database for road signs efficiently. For that purpose, a mobile mapping system was designed for field investigations. The designed mobile mapping system was comprised of three cameras to produce image information about road signs, GPS/IMU/DMI to obtain information about the position and attitude of a vehicle, and a laser scanner to generate information about the locations of road signs and routes. Also proposed in the study was a procedure to automatically detect the areas of road signs in the road signs images and recognize their characters.

• 전기의세계
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• v.14 no.1
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• pp.5-12
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• 1965

In the designs of the sensitive electronic devices such as phase sensitive detector, X-ray diffractometer, and neutron diffractometers, we must take into account the geometrical factors in a coil systems and extraneous stray fields. Input wave forms in such a sensitive electronic devices are often altered by the influence of these factors. Since the magnitude of the stray fields is generally very small, this affection may be removed by applying a good shielding but it is not ease to remove the affection from a geometrical factor. This affection must be however calculated by the theoretical methods and analytical solution in the equation of these factors. The fundamental purpose of this paper lie in the theoretical calculations and practical measurements of the geometrical factor in the coil systems, finite solenoid, and four point prove. In the heoretical calculations, the geometrical factors in the coil systems were calculated by applying the elliptic functions and in the contact points were calculated by applying the elliptic functions and in the contact points were calculated by applying the eigen functions and the infinite series. The measurements were carried out by using the sensitive electronic device made from author's design, as shown in the Fig. 9. The result of this work has verified the essential correctness of theoretical investigations and measuring techniques of geometrical factors on the design of sensitive electronic devices. It also has several advantages such that: (1) all the data obtained may give effective data to designer to work on the field of sensitive electronic devices or microelectronic devices, (2) it has evidently explained the characteristics of electrical investigations and physical definition, and has removed the conventional error of geometrical factors in the coil systems and contact points.

• Wind and Structures
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• v.22 no.2
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• pp.253-272
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• 2016

The paper concerns with the method and results of wind tunnel investigations of the Strouhal number (St) of a stationary iced cable model of cable-supported bridges with respect to different angles of wind attack. The investigations were conducted in the Climatic Wind Tunnel Laboratory of the Czech Academy of Sciences in $Tel{\check{c}}$. The methodology leading to the experimental icing of the inclined cable model was prepared in a climatic section of the laboratory. The shape of the ice on the cable was registered by a photogrammetry method. A section of an iced cable model with a smaller scale was reproduced with a 3D printing procedure for subsequent aerodynamic investigations. The St values were determined within the range of the Reynolds number (Re) between $2.4{\cdot}10^4$ and $16.5{\cdot}10^4$, based on the dominant vortex shedding frequencies measured in the wake of the model. The model was oriented at three principal angles of wind attack for each of selected Re values. The flow regimes were distinguished for each model configuration. In order to recognize the tunnel blockage effect the St of a circular smooth cylinder was also tested. Good agreement with the reported values in the subcritical Re range of a circular cylinder was obtained. The knowledge of the flow regimes of the airflow around an iced cable and the associated St values could constitute a basis to formulate a mathematical description of the vortex-induced force acting on the iced cable of a cable-supported bridge and could allow predicting the cable response due to the vortex excitation phenomenon.

• 한국지구물리탐사학회:학술대회논문집
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• 1999.08a
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• pp.21-36
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• 1999

Recently resistivity survey is widely used for site investigations in the field of civil engineering. Since such application area requires accurate interpretation tools especially in the area of complicated geology and rough terrain topography, we developed a three-dimensional (3-D) resistivity inversion code, which can reconstruct real earth structures. Furthermore, the inversion code gives resolution-enhanced images by applying the ACB(Active Constraint Balancing) method. With the help of this inversion code, 3-D resistivity survey is now used as new techniques for site investigations in civil engineering problem. By imaging the 3-D resistivity distribution, we could get useful informations such as depth distribution of basement rock, distribution of weak zone, fractures and cavities which is crucial to civil engineers.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.30 no.1
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• pp.42-44
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• 2019

Hashimoto's encephalopathy (HE) is a rare and underdiagnosed neuropsychiatric illness. We present the case of a 17-year-old girl who was admitted to a tertiary-care psychiatric center with acute onset psychosis and fever. Her psychotic symptoms were characterized by persecutory and referential delusions, as well as tactile and visual hallucinations. Her acute behavioral disturbance warranted admission and treatment in a psychiatric setting (risperidone tablets, 3 mg/day). She had experienced an episode of fever with a unilateral visual acuity defect approximately 3 years before admission, which was resolved with treatment. Focused clinical examination revealed an enlarged thyroid, and baseline blood investigations, including thyroid function test results were normal. Abnormal laboratory investigations revealed elevated anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels (anti-TPO of 480 IU/mL; anti-TG of 287 IU/mL). Results of other investigations for infection, including cerebrospinal fluid examination, electroencephalography, and brain magnetic resonance imaging were normal. She was diagnosed with HE and was treated with intravenous corticosteroids (methylprednisolone up to 1 g/day; tapered and discontinued after a month). The patient achieved complete remission of psychotic symptoms and normalization of the anti-thyroid antibody titers. Currently, at the seventh month of follow-up, the patient is doing well. This case highlights the fact that in the absence of well-defined clinical diagnostic criteria, a high index of suspicion is required for early diagnosis of HE. Psychiatrists need to explore for organic etiologies when dealing with acute psychiatric symptoms in a younger age group.

• Journal of the Korean Society of Safety
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• v.34 no.1
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• pp.62-69
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• 2019

Korean shipbuilding companies have taken many efforts for safety over the years by developing Health, Safety & Environment (HSE) Management Systems, Procedures, Training, and studying Programs for prevention of incidents. As a result, the shipbuilding industry has succeeded in reducing overall injury rates. Nevertheless, the industry also noticed that incident rates are still not at zero and more importantly, serious injuries and fatalities are still occurring. One factor that may be attributing to this is the lack of managing potential severity during incident investigations, most incident investigations are implemented based on the actual result. Generally, each shipbuilding company develops their customized incident investigation programs and these are also commonly being focused on actual result. This study aimed to develop a shift in strategy toward safety to classify the criteria of potential severity from any incidents and manage that to prevent any recurrence or causing any serious injuries or fatalities in the shipbuilding industry. Several global energy companies have already developed potential severity management tools and applied them in their incident investigations. In order to verify the necessity of improvement for current systems, a case study and comparative analysis between a domestic shipbuilding company and several global energy companies from foreign countries was implemented and comparison of two incident investigation cases from specific offshore projects was conducted to measure the value of a potential severity system. Also, a checklist was established from the data of fatalities and serious injuries in recent 5 years that occurred in Korea shipbuilding industry and a proposal to verify high potential incidents in the incident investigation process and comparative analysis between the assessment by appling proposed checklist and the assessment from a global energy company by using their own system was implemented. As a measure to prevent any incidents, it is required to focus on potential severity assessment during the incident investigation rather than to only control actual result. Hence, this study aims to propose a realistic plan which enables to improve the existing practices of incident investigation and control in the shipbuilding industry.

• Journal of the Society of Disaster Information
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• v.17 no.3
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• pp.403-414
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• 2021

Purpose: The purpose of this study is to provide the effective safety management system to prevent similar chemical accidents through accident investigations. Method: Chemical accident prevention and response management systems at the central and local government levels were reviewed, Also, statistical data of chemical accidents occurred in the last 5 years were analyzed. In particular, Two accidents with high accident risk were analyzed. Result: Chemical accidents that have occurred in the last 5 years were analyzed to occur in the order of hydrochloric acid, sulfuric acid, and nitric acid, and concrete safety management improvement measures were derived through investigations of two causes. Conclusion: In this study, we proposed safety management plans in terms of technical and management aspects. The results of this study are expected to be used as effective in preventing and managing chemical accidents.

• The Korean Journal of Pain
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• v.35 no.2
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• pp.140-151
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• 2022

Background: Essential oils are of great interest for their analgesic and anti-inflammatory properties. We aimed to study the content of the essential oil of the Origanum vulgare of the Armenian highlands (OVA) in different periods of vegetation and to investigate its antinociceptive and anti-inflammatory effects in mice (in vivo) and cytotoxic action in cultured cells (in vitro). OVA essential oil was extracted from fresh plant material by hydro-distillation. Methods: For OVA essential oil contents determination the gas chromatography-mass spectrometry method was used. Formalin and hot plate tests and analysis of cell viability using the methyl-thiazolyl-tetrazolium (MTT) assay were used. Results: The maximal content of β-caryophyllene and β-caryophyllene oxide in OVA essential oil was revealed in the period of blossoming (8.18% and 13.36%, correspondently). In the formalin test, 4% OVA essential oil solution (3.5 mg/mouse) exerts significant antinociceptive and anti-inflammatory effects (P = 0.003). MTT assay shows approximately 60% cytotoxicity in HeLa and Vero cells for 2.0 µL/mL OVA essential oil in media. Conclusions: The wild oregano herb of Armenian highlands, harvested in the blossoming period, may be considered as a valuable source for developing pain-relieving preparations.