• Title/Summary/Keyword: inversions

Search Result 77, Processing Time 0.024 seconds

A Cytogenetic Analysis of Inversion as a Type of Structural Chromosome Aberration in Prenatal Diagnosis

  • Hwang, Si-Mok;Kwon, Kyoung-Hun;Jo, Yoon-Kyung;Yoon, Kyung-Ah
    • Biomedical Science Letters
    • /
    • v.15 no.4
    • /
    • pp.363-368
    • /
    • 2009
  • One of the frequent occurrences in rearrangements is chromosome inversion. Pericentric inversion is considered to be the variant of normal karyotype. We investigated the karyotypes of 1195 cases being referred to prenatal diagnosis using standard GTG banding for karyotype preparation. The chromosomal analysis revealed a total of 15 (1.26%) inversions. The characteristics of inversion type [(inv(4), inv(8), inv(9), inv(11)) were investigated on the basis of chromosomal analyses of fetuses and their parents. The results from chromosomal examination of the parents, whose fetuses were diagnosed as inversion, show that either parent might be the carrier. Inversion in human chromosome is commonly seen in normal humans and the frequency estimated to be 1 to 2% in general population and the exact amount of this phenomenon is still unclear. These results indicate that inv(8), inv(9), and inv(11) are phenotypically normal. However these may often cause clinical problems in offspring of the carrier, such as fetal wastage repeated spontaneous abortions and infertility with unknown mechanisms related to sex. We describe an inversion of human chromosome and its clinical correlation with human genetic disease.

  • PDF

Thorpe Scale Analysis using CTD Observations on the Continental Slope of the Southwestern East Sea (동해 남서부 해역의 대륙사면에서 Thorpe 규모(scale)를 이용한 연직 난류 확산계수 추정)

  • Seo, Seongbong;Park, Young-Gyu;Park, Jae-Hun;Jeong, Hee-Dong
    • Ocean and Polar Research
    • /
    • v.37 no.2
    • /
    • pp.107-117
    • /
    • 2015
  • Thorpe scale analysis was performed using two sets of 25-hour-long hourly CTD data. Raw density profiles collected on the continental slope of the southwestern East Sea were post-processed to reduce instrument noises and measurement errors. Density inversions were detected by applying the overturn ratio test proposed by Gargett and Garner (2008). The value of $K_z$ below the main thermocline estimated with the Osborn parameterization was $5.3{\times}10^{-4}(1.1{\times}10^{-4})m^2s^{-1}$ and that with the Shih parameterization was $5.9{\times}10^{-5}(2.4{\times}10^{-5})m^2s^{-1}$during the spring (neap) tidal period. This result suggests that internal tides can enhance vertical mixing in the observation region.

A Study on Inversion at Leeward Side of High-rise Building in Winter (동절기 고층건물 풍하면의 기온역전에 관한 연구)

  • Zheng, Hai-Yan;Jin, Wen-Cheng;Oh, Sung-Nam;Lee, Kyoo-Seock
    • Journal of Environmental Impact Assessment
    • /
    • v.19 no.6
    • /
    • pp.583-590
    • /
    • 2010
  • To determine nocturnal inversion characteristics at the leeward side of high-rise building, air temperature data were observed at 10 minute interval from February 22, 2010 to April 15, 2010. The observed data were compared, analyzed and examined to illustrate air temperature differences between the roof (XAR) and surface (XAG) of X apartment. The wind speed, wind direction and precipitation data were also observed at XAR and YJL (Yangjae Stream) sites at the same time. After the analysis, the maximum nocturnal inversion was observed by $4.0^{\circ}C$ at 3:40, 3:50, 4:10 on February 24th 2010, at that time the weather condition was clear and weak wind. Air temperature inversions at the leeward side of high-rise building were observed on whole day in wintertime and air temperature inversion intensity was also higher than other nearby area (SMG).

A Prenatal Case of Paracentric Inversion of Chromosome 18, inv(18)(q21.1q22)

  • An, Gye-Hyeong;Kim, Moon Young;Kim, Min Hyoung;Kim, Yun Young;Choi, Kyu Hong;Kwak, Dong Wook;Park, So Yeon;Lee, Bom Yi;Park, Ju Yeon;Ryu, Hyun Mee
    • Journal of Genetic Medicine
    • /
    • v.9 no.2
    • /
    • pp.101-103
    • /
    • 2012
  • Paracentric inversion of chromosome 18 is a rare cytogenetic abnormality. The vast majority of paracentric inversions are harmless and the offspring of paracentric inversion carriers have only slightly elevated risks for unbalanced karyotypes. However, various clinical phenotypes are seen due to breakpoint variation or recombination. We report a prenatally detected case of familial paracentric inversion of chromosome 18, inv(18)(q21.1q22), with normal clinical features.

Karyotypes, DNA Values and Nuclear Sizes of Several Scups (Teleostomi : Perciformes) (돔류(類) 몇종(種)의 염색체(染色體), DNA함량(含量)과 핵(核)의 크기에 관한 연구(硏究))

  • Kim, Dong-Soo;Jeon, Im-Gi;Lee, Jong-Kwan
    • Korean Journal of Ichthyology
    • /
    • v.1 no.1_2
    • /
    • pp.35-41
    • /
    • 1989
  • An examination of the karyotypes, DNA values and nuclear sizes of three scups was undertaken as part of the study of cytogenetical evolution of order Perciformes. The chromosome number 2n=48 was the same in all three species but the numbers of chromosome arm were not identical. The distribution of genome size and nuclear volumes among species was continuous ranging from 1.287 pg and $20.78\;{\mu}m^3$ for Pagrus major down to 1.237 pg and $20.56\;{\mu}m^3$ for Acanthopagrus schlegeli. Above results indicate the possible role of pericentric inversions in the karyotypic evolution of these species.

  • PDF

Improved full-waveform inversion of normalised seismic wavefield data (정규화된 탄성파 파동장 자료의 향상된 전파형 역산)

  • Kim, Hee-Joon;Matsuoka, Toshifumi
    • Geophysics and Geophysical Exploration
    • /
    • v.9 no.1
    • /
    • pp.86-92
    • /
    • 2006
  • The full-waveform inversion algorithm using normalised seismic wavefields can avoid potential inversion errors due to source estimation required in conventional full-waveform inversion methods. In this paper, we have modified the inversion scheme to install a weighted smoothness constraint for better resolution, and to implement a staged approach using normalised wavefields in order of increasing frequency instead of inverting all frequency components simultaneously. The newly developed scheme is verified by using a simple two-dimensional fault model. One of the most significant improvements is based on introducing weights in model parameters, which can be derived from integrated sensitivities. The model-parameter weighting matrix is effective in selectively relaxing the smoothness constraint and in reducing artefacts in the reconstructed image. Simultaneous multiple-frequency inversion can almost be replicated by multiple single-frequency inversions. In particular, consecutively ordered single-frequency inversion, in which lower frequencies are used first, is useful for computation efficiency.

Inversion Analysis of Magnetotelluric Data Acquired in Geothermal Area of Seokmo Island (석모도 지열지대 자기지전류 탐사 자료의 역산 해석)

  • Lee, Seong-Kon;Park, In-Hwa;Chung, Yong-Hyun;Lee, Tae-Jong
    • Journal of the Korean earth science society
    • /
    • v.32 no.6
    • /
    • pp.654-664
    • /
    • 2011
  • A field campaign of magnetotelluric (MT) and audio-frequency MT (AMT) survey was done at 36 measurement points as a complementary for the previous 44 MT measurements completed during the period of 2005-2006. The purpose of additional MT survey is to investigate the possible fracture system in Seokmo Island, which is conceived to be crucial in accumulation and migration of geothermal hot spring in this area. We have done 2D and 3D inversions of overall MT and AMT data distributed on a grid to interpret subsurface of extended area. The inversion results reveal that at least two major faults are imaged in the inversion results, one of which is in NNE-SWW with steep dip, and another is in E-W direction.

Comparison of Coronal Electron Density Distributions from MLSO/MK4 and SOHO/UVCS

  • Lee, Jae-Ok;Lee, Kyung-Sun;Lee, Jin-Yi;Jang, Soojeong;Kim, Rok-Soon;Cho, Kyung-Suk;Moon, Yong-Jae
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.42 no.2
    • /
    • pp.85.2-85.2
    • /
    • 2017
  • The coronal electron density is a fundamental and important physical quantity in solar physics for estimating coronal magnetic fields and analyzing solar radio bursts. To check a validation of coronal electron density distributions (CEDDs) from polarized brightness (pB) measurements with Van de Hulst inversions, we compare CEDDs derived from a polarized brightness (pB) observation [MLSO/MK4 coronameter] and one spectroscopic observation [SOHO/UVCS]. For this, we consider data observed in 2005 with the following conditions: (1) the observation time differences from each other are less than 1 minutes; and (2) O VI doublet (O VI $1031.9{\AA}$ and $1037.6{\AA}$) is well identified. In the pB observation, the CEDDs can be estimated by using Van de Hulst inversion methods. In the spectroscopic observation, we use the ratio of radiative and collisional components of the O VI doublet to estimate the CEDDs. We find that the CEDDs obtained from pB measurements are higher than those based on UVCS observations at the heights between 1.6 and 1.8 Rs (${\times}1.9$ for coronal streamer, 1.2 ~ 1.8 for background corona, and 1.5 for coronal hole), while they are lower than those based on UVCS at the heights between 1.9 and 2.6 Rs (${\times}0.1{\sim}0.6$ for coronal streamer, 0.5 ~ 0.7 for background corona, and 0.6 for coronal hole). The CEDDs of coronal streamers are higher than those of background corona at the between 1.6 and 2.0 Rs: ${\times}1.2{\sim}2.4$ for MK4 and 1.5 ~ 1.9 for UVCS.

  • PDF

DEVELOPMENT AND VALIDATION OF LAND SURFACE TEMPERATURE RETRIEVAL ALGORITHM FROM MTSAT-1R DATA

  • Hong, Ki-Ok;Kang, Jeon-Ho;Suh, Myoung-Seok
    • Proceedings of the KSRS Conference
    • /
    • 2008.10a
    • /
    • pp.293-296
    • /
    • 2008
  • Land surface Temperature (LST) is a very useful surface parameter for the wide range of applications, such as agriculture, numerical and climate modelling community. Whereas operational observation of LST is far from the needs of application community in the spatial Itemporal resolution and accuracy. So, we developed split-window type LST retrieval algorithm to estimate the LST from MTSAT-IR data. The coefficients of split-window algorithm were obtained by means of a statistical regression analysis from the radiative transfer simulations using MODTRAN 4 for wide range of atmospheric profiles, satellite zenith angle and lapse rate conditions including the surface inversions. The sensitivity analysis showed that the LST algorithm reproduces the LST with a reasonable quality. However, the LST algorithm overestimates and underestimates for the strong surface inversion and superadiabatic conditions especially for the warm temperature, respectively. And the performance of LST algorithms is superior when satellite zenith angle is small. The accuracy of the retrieved LST has been evaluated with the Moderate Resolution Imaging Spectroradiometer (MODIS) LST data. The validation results showed that the correlation coefficients and RMSE are about 0.83${\sim}$0.98 and 1.38${\sim}$4.06, respectively. And the quality of LST is significantly better during night and winter time than during day and summer. The validation results showed that the LST retrieval algorithm could be used for the operational retrieval of LST from MTSAT-IR and COMS(Communication, Ocean and Meteorological Satellite) data with some modifications.

  • PDF

Comparison of the Electrocardiographic Characteristics of Junior Athletes and Untrained Subjects

  • Park, Sang Ku;Kang, Ji-Hyuk
    • Korean Journal of Clinical Laboratory Science
    • /
    • v.44 no.3
    • /
    • pp.136-141
    • /
    • 2012
  • The hearts of highly trained athletes show morphologic and electrocardiographic (ECG) changes that suggest the presence of cardiovascular disease, including sinus bradycardia, a striking increase in precordial R-wave or S-wave voltages, ST segment depression, and T-wave inversions. Despite a number of previous observational surveys, the determinants of abnormal ECG patterns in trained athletes remain largely unresolved. In this study, we compared the electrocardiographic characteristics of athletes to determine any sensitive indicators. Comparison between ECG patterns and cardiac physiology was performed in 21 junior athletes and 25 untrained subjects with no signs of cardiac disease. Sinus bradycardia was detected in a subset of athletes but not statistically significant between the athletes ($69.9{\pm}11.1bpm$) and the control ($72.7{\pm}9.9bpm$) group. The mean values of the PR and QTc intervals in the athletes' group were $149.2{\pm}15.4ms$ and $402.3{\pm}28.8ms$, respectively. Also, there were no significantly differences between control group and the athletes' group. In addition, the athletes demonstrated a spectrum of alterations in the 12-lead ECG pattern, including marked increase in precordial R-wave or S-wave voltages ($$SV_1+RV_5{\geq_-}35mm$$, 23.8%), QRS duration ($${\geq_-}90ms$$, 90.5%), suggestive of left ventricular hypertrophy. However, left axis deviation, ST segment depression, and T-wave changes in V5, V6 were not observed in either the athletes or control group. Our findings suggest that sinus bradycardia, precordial R-wave or S-wave voltages, and QRS duration seem to be more sensitively detected in athletes than in control group. Further researches on the electrocardiographic patterns of athletes should be carried out to improve the sensitivity and specificity of diagnostic criteria.

  • PDF