• Asian Pacific Journal of Cancer Prevention
• /
• 제15권23호
• /
• pp.10085-10089
• /
• 2015

Background: The insulin-like growth factor (IGF) system comprises a group of proteins that play key roles in regulating cell growth, differentiation, and apoptosis in a variety of cellular systems. The aim of this study was to investigate the role of insulin-like growth factor binding protein 3 (IGFBP3) in hepatocellular carcinoma. Materials and Methods: Expression of IGF2, IGFBP3, and PTEN was analyzed by qRT-PCR. Lentivirus vectors were used to overexpress IGFBP3 in hepatocellular carcinoma cell (HCC) lines. The effect of IGFBP3 on proliferation was investigated by MTT and colony formation assays. Results: Expression of IGF2, IGFBP3, and PTEN in several HCC cell lines was lower than in normal cell lines. After 5-aza-2'-deoxycytidine/trichostatin A treatment, significant demethylation of the promoter region of IGFBP3 was observed in HCC cells. Overexpression of IGFBP3 induced apoptosis and reduced colony formation in HUH7 cells. Conclusions: Expression of IGF2, IGFBP3, and PTEN in several HCC cell lines was lower than in normal cell lines. After 5-aza-2'-deoxycytidine/trichostatin A treatment, significant demethylation of the promoter region of IGFBP3 was observed in HCC cells. Overexpression of IGFBP3 induced apoptosis and reduced colony formation in HUH7 cells.

• 대한정형도수물리치료학회지
• /
• 제11권1호
• /
• pp.1-10
• /
• 2005

Objectives: To compare the efficacy of two types specific exercise intervention (deep and superficial abdominal muscle exercises) in the treatment of patients with chronic low back pain (CLBP). Design: A randomized, comparative, repeated-measures. Subjects: Twenty-four patients with CLBP (at least for 3 months), mean $age{\pm}SD=51.58{\pm}16.21$ (yrs). Methods: Twenty-four patients with this condition were assigned randomly to two treatment groups. Both first and second group underwent 3 weeks specific exercise treatment program. The first group specific trained for the deep abdominal muscles. The second group specific trained for the superficial abdominal muscles. Results: After intervention, the first group showed a statistically significant reduction in pain intensity and functional disability levels (p<.05). The second group showed no significant change in these parameters after intervention (p>.05). Conclusions: According to results, a "deep abdominal muscle exercises" treatment approach appears more effective than a "superficial abdominal muscle exercises" treatment in patients with CLBP.

• Tuberculosis and Respiratory Diseases
• /
• 제38권3호
• /
• pp.245-249
• /
• 1991

Surgical intervention for pumlmonary tuberculosis has been controverted for last several decades. Although it is widely held that the chemotherapy is the best modality for treatment of pulmonary tuberculosis, surgical intervention has still some roles in well elected circumstance. At the National Kongju Tuberculosis Hospital in Korea, we performed a retrospective case Cohort study through the regular follow-up of 463 cases, who underwent the surgical intervention for pulmonary tuberculosis between January 1986 and April 1990. The results were as follows: 1) The male to female ratio was 1.8:1 and 84.4% of the patients were between 20 and 49 years of age. 2) According to the NAT classification, 6 cases (1.3%) were minimal, 216 (46.7%) moderately advanced and 241 (52%) far advanced. 3) One hundred and thirty four cases (28.9%) had the treatment history of 5 to 10 years and 129 cases (27.9%) of 3 to 4 years. 4) As for the pathologic entities, 172 cases (37.1%) had the totally destroyed lung and 137 (29.6%) destroyed lobe or segment. 5) A total of 238 cases (51.4%) underwent pneumonectomy and 153 (33.0%) lobectomy. 6) As the post-operative complications, 21 cases (4.5%) had empyema and 11 (2.4%) bleeding. The rate of complication after pneumonectomy and lobectomy was 5.8% and 3.2%, respectively. 7) Six cases (1.3%) died post-operatively. 8) Out of 238 cases with pre-operative positivity for AFB, 212 achieved the negative conversion, its rate being 89.1%. It follows from these results that although it has a limit, surgical intervention may play an important role in treating some patients with pulmonary tuberculosis.

• 대한감각통합치료학회지
• /
• 제11권1호
• /
• pp.1-9
• /
• 2013

목적 : 본 연구는 구강활동을 병행한 감각통합치료가 발달장애 아동의 호흡과 구강협응능력에 미치는 효과를 알아보고자 하였다. 연구 방법 : 연구대상은 G시에 거주하는 만 6세 7개월의 남아로, 발달장애 진단을 받았다. 연구는 2012년 11월부터 2013년 2월까지 실시하였다. 실험은 개별실험연구 중 AB디자인을 사용하였다. 실험과정은 기초선(A) 3회기, 중재(B) 16회기이었다. 기초선 기간 동안에는 감각통합치료를 실시하였고, 중재기간동안에는 감각통합치료에 구강활동을 병행하여 실시하였다. 호흡기능은 폐활량 측정계로 측정하였으며, 구강협응능력은 "파타카(pataka)"를 10회 반복할 때 소요된 시간을 초단위로 측정하였다. 결과 : 아동의 호흡과 구강협응능력은 기초선과 비교하여 중재기간 동안 유의하게 증가하였다. 결론 : 구강활동을 병행한 감각통합치료가 아동의 호흡과 구강협응능력 향상에 긍정적이었다.

• 사물인터넷융복합논문지
• /
• 제9권3호
• /
• pp.45-53
• /
• 2023

본 연구는 간호학과 재학 중인 3학년을 대상으로 이압요법이 지각된 스트레스와 수면의 질에 미치는 효과를 확인하기 위한 비동등성 플라시보 대조군 전후설계이다. 연구의 대상자는 K대학교에서 처치군 30명, 대조군 30명, 총 60명을 선정하여 2022년 3월 2일부터 4월 26일까지 8주간 자료를 수집하였다. 처치군은 귀의 반응점(신문, 심, 시상)에 압봉 스티커를 부착하여 1일 3회 이압을 적용하였고, 플라시보 대조군은 동일한 기간에 동일한 방법으로 귀의 반응점(고관절, 무릎, 발목)에 적용하였다. 자료는 SPSS 23.0 프로그램을 이용하여 처치군과 플라시보 대조군의 시점별 지각된 스트레스와 수면의 질은 independent t-test, 경과에 따른 종속변수의 변화는 repeated measures ANOVA로 분석하였다. 처치군의 지각된 스트레스 점수는 중재 4주 후 2.28점, 중재 8주 후 2.07점으로 유의하게 감소하였고, 수면의 질 점수는 중재 4주 후 3.37점, 중재 8주 후 4.02점으로 유의하게 증가하여 시간이 경과함에 따라 지속 효과가 있는 것으로 확인되었다.

• 한국전문물리치료학회지
• /
• 제27권1호
• /
• pp.63-69
• /
• 2020

Background: Stroke recovery is a long and complex process. Successful stroke recovery seems to be strongly associated with patients' high motivation and committed participation. Patients' motivation is a key determinant of successful rehabilitation outcomes, but it is difficult in defining and measuring. Patients' participation is defined as the degree or extent to which subjects take part in rehabilitation activities and can be measured by observable behavior. Objects: The purpose of this study was to investigate the impact of patients' level of participation in rehabilitation on functional outcomes in patients with stroke. Methods: Forty post-stroke inpatients participated in this study. The level of rehabilitation participation was measured by the Hopkins Rehabilitation Engagement Rating Scale (HRERS). Other measures used for the evaluation were the Rivermead Mobility Index (RMI) and Korean version of the Modified Barthel Index (K-MBI). Overall measurements were made at early intervention and late intervention. Spearman correlation and multiple regression were used to measure the relationships between HRERS, RMI, and K-MBI. Results: The correlation found between HRERS total scores at early intervention and RMI total scores of late intervention was above moderate (r = 0.607, p < 0.01). RMI total scores at early intervention (p < 0.000), HRERS total scores at early intervention (p < 0.001), and disease duration (p < 0.003) were significant predictors of RMI total scores at late intervention. Conclusion: The level of participation at early intervention was associated with improvement in mobility. The level of mobility at early intervention, disease duration, and patients' participation at early intervention were important determinants of functional outcome. These findings suggest that patients' participation should be encouraged in order to achieve successful stroke recovery.

• Clinical and Experimental Pediatrics
• /
• 제65권2호
• /
• pp.98-107
• /
• 2022

Background: Various interventions have been tested to prevent or treat childhood obesity in South Korea. However, the overall effect of those interventions is unclear, as very few reviews and meta-analyses were specific to Korean children and adolescents. Purpose: We aimed to examine the overall effect of obesity interventions among Korean children and adolescents, while also examining differences by sex, age group, baseline weight category, intervention duration, number of intervention components, and type of intervention components. Methods: A meta-analysis was conducted for all intervention studies sampling Korean children and adolescents, with at least one control group and one month of follow-up, published between January 2000 and August 2020. Cohen d was calculated as an effect size for treatment effect, using the standardized difference between intervention group's body mass index (BMI) change and control group's BMI change. Results: The final sample included 19 intervention studies with 2,140 Korean children (mean age, 12.2 years). Overall, interventions were strongly favored over their controls (d=1.61; 95% confidence interval [CI], 1.12-2.09). The subgroup analysis showed that interventions with at least one physical activity component (d=2.43; 95% CI, 1.63-3.24) were significantly better than those that did not include physical activity (d=0.02; 95% CI, -0.26 to 0.31). Conclusion: Type of intervention component appeared important, though no differential association was observed by sex, age, baseline weight category, intervention duration, and number of intervention components. Korean and non-Korean interventions may be substantively different. Additional studies are needed to understand why and how Korean interventions differ from non-Korean interventions.

• 동의신경정신과학회지
• /
• 제20권3호
• /
• pp.261-271
• /
• 2009

Objectives : This study was performed to report the effect of music-listening intervention and relaxation for somatoform disorder. Methods : A 51 year-old female patient suffered from several somatic symptoms without identifiable physical cause. We saw her symptoms were related to her psychological factors. We applied music-listening intervention and relaxation besides Korean traditional medical treatment to make her be aware of her psychological condition such as inner conflict and know symptoms are related to her psychological condition. Results : After the music-listening intervention and relaxation, the patient revealed her unrecognized hidden feelings and emotions and got some insights about herself. Then somatic symptoms such as dysesthesia and urinary frequency and anxiety were decreased considerably. Conclusions : These results suggest that the music-listening intervention and relaxation can be effective on improvement of soma to form disorder.

• 지역사회간호학회지
• /
• 제22권3호
• /
• pp.342-354
• /
• 2011

Purpose: This study was to estimate the effectiveness of an intervention program using the trans-theoretical model on the stages of change, the process of change, decisional balance, self-efficacy, the levels of medication adherence, and blood pressure difference. Methods: A similar experiment was conducted using a nonequivalent control group pre- and post-test design. The study subjects were 108 hypertensive patients. The program was administered to the experimental group while educational materials were given to the control group. Descriptive analysis, 2-test, t-test, and repeated measures ANOVA were used with SPSS 17.0 to analyze collected data. Results: After treatment with this program, the experimental group showed stage of change ($x^2=52.917$, p<.001), cognitive (F=13,528, p<.001), behavioral process of change (F=10.808, p<.001), benefits (F=5.569, p=.012), loss of medication adherence (F=15.661, p<.001), self-efficacy (F=5.407, p=.011), levels of medication adherence (F=51.442, p<.001). Conclusion: There was a significant improvement in the experimental group who participated in the TTM medication adherence intervention program. Given that this intervention program motivated and stimulated hypertensive patients to adhere to the prescribed medications, the TTM medication adherence intervention program is expected to be an effective and practical intervention method for health improvement.

• 기본간호학회지
• /
• 제24권1호
• /
• pp.18-29
• /
• 2017

Purpose: The purpose of this study was to develop an algorithm for nursing care after percutaneous coronary intervention in order to improve patients' safety and prevent complications, because percutaneous coronary intervention is becoming a common treatment for coronary artery diseases. Methods: By reviewing related literatures and interviewing nurses, items and paths that were to be used in the algorithm for nursing care after percutaneous coronary intervention were drawn up and a draft algorithm was developed. The final algorithm was determined based on the results of the evaluation performed after clinical application. Results: According to the outcome after allowing nurses to apply the revised algorithm with 11 patients, suitability on items composing the algorithm were highly rated whereas promptness was lowly rated. Although the patients (n=11) to whom the algorithm was applied complained of less back pain (p=.001) and discomfort (p=.026) compared to the patients (n=17) to whom the algorithm was not applied, no significant difference in bleeding complication was found. Conclusion: The findings in the study support the clinical utilization of the algorithm for nursing care after percutaneous coronary intervention as the use of this algorithm reduced back pain and discomfort without increasing bleeding complications at the femoral puncture site.