• Restorative Dentistry and Endodontics
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• 제20권1호
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• pp.342-350
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• 1995

To determine the factors which affect the flow of dentinal fluid through cat dentinal tubules in vivo, the flow of fluid was measured by observing the movement of the fat droplets of dilute milk in a glass capillary with a microscope connected to the monitor. After measuring the exposed area of dentin, hydraulic conductances of dentin were calculated. The mean pressure which stoped the outward flow of dentinal fluid was 9.5mmHg. The hydraulic conductance of dentin under the condition of pulp exposed was increased by 21 % from that under the condition of dentin exposed. Under the conditions of pulp cut and pulp removed, the hydraulic conductances of dentin were increased by 22 % and 31 % respectively from that under the condition of dentin exposed. These results show that the direction and rate of dentinal fluid flow in cat dentin is affected mainly by the hydrostatic pressure of interstitial fluid of pulp tissue in the state of low compliance. Both of the osmotic effect produced by the protein constituents of interstitial fluid across the odontoblast tell layer and the change of interstitial fluid pressure produced by the state of the microcirculation of the pulp also affect the direction and rate of dentinal fluid in some degree.

• 센서학회지
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• 제17권2호
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• pp.120-126
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• 2008

Glucose concentrations in the interstitial fluid were measured based on optical spectroscopy. Prediction of glucose concentrations was made using partial least squares regression and accuracy improvement was achieved by data preprocessing as well as by selecting an optimal wavelength region. For this purpose, artificial interstitial fluid samples were prepared where their glucose levels varied between 0 and 10 g/dl. Infrared spectral regions where glucose absorption lies were investigated. A region of 1000 - 1500 $cm^{-1}$ produced the best accuracy among the regions of 1000 - 1500 $cm^{-1}$, 4000 - 4545 $cm^{-1}$1 and 5500 - 6500 $cm^{-1}$. Further accuracy improvement in 1000 - 1500 $cm^{-1}$ was achieved by selecting specific wavelength bands based on a loading vector analysis method. For the samples whose glucose concentrations ranged between 0 and 0.5 g/dl, SEP= 0.0266 g/dl and R =0.9863 were achieved with 1000 - 1500 $cm^{-1}$. However, the loading vector optimized band of 1002 - 1095 $cm^{-1}$ reduced the prediction error up to 47 % (SEP =0.0125 g/dl and R=0.9970).

• Journal of the Optical Society of Korea
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• 제13권2호
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• pp.279-285
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• 2009

Prediction of glucose concentration in the interstitial fluid (ISF) based on mid-infrared absorption spectroscopy was examined at the glucose fundamental absorption band of 1000 - 1500/cm (10 - 6.67 um) using multi-component analysis. Simulated ISF samples were prepared by including four major ISF components. Sodium lactate had absorption spectra that interfere with those of glucose. The rest NaCl, KCl and $CaCl_2$ did not have any signatures. A preliminary experiment based on Design of Experiment, an optimization method, proved that sodium lactate influenced the prediction accuracy of glucose. For the main experiment, 54 samples were prepared whose glucose and sodium lactate concentration varied independently. A partial least squares regression (PLSR) analysis was used to build calibration models. The prediction accuracy was dependent on spectrum preprocessing methods, and Mean Centering produced the best results. Depending on calibration sample sets whose sodium lactate had different concentration levels, the standard error prediction (SEP) of glucose ranged $17.19{\sim}21.02\;mg/dl$.

• Tuberculosis and Respiratory Diseases
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• 제53권2호
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• pp.127-135
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• 2002

배 경 :특발성 간질성 폐렴은 만성적 염증과 폐 섬유화가 특징적인 병이다. clara cell 10 kD protein(CC10)은 기관지 상피세포에서 만들어지는 강력한 항염 작용을 가진 것으로 알려진 단백질이다. 따라서, CC-10은 특발성 간질성 폐렴 환자의 염증 조절자로서의 역할을 기대할 수 있다. 본 연구에서는 폐 섬유화의 정도와 기관지 폐포 세척액 내의 CC-10 발현 사이의 연관성을 알아 보고자 하였다. 방 법 : 29명의 환자와 10명의 대조군에서 기관지 폐포 세척이 시행되었으며, 세척액을 이용하여, 정량적 Western blot 분석을 시행하였다. 각각의 band의 RI (relative intensity)를 산출하여, 환자의 진단, 기관지 폐포 세척액 내의 염증 세포 분율, 방사선학적 폐 섬유화의 정도와 비교하였다. 결과 : 환자군 ($77.5{\pm}75.8%$)과 대조군 ($70.7{\pm}39.8%$)의 RI 값에는 유의한 차이가 없었다 (p>0.05). 그리고, 통상형 간질성 폐렴 환자의 폐섬유화의 정도 및 기관지 폐포 세척 액 내의 염증 세포 분율에 따라서도 RI 값에 유의한 차이가 없었다 (p>0.05). 결 론: 통상형 간질성 폐렴 환자의 폐 섬유화 정도와 기관지 폐포 세척 액내의 CC-10 농도는 관련이 없다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.1078-1080
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• 2002

The pressure variation of interstitial fluid is one of the most important factors in bone physiology. In order to understand the role of interstitial fluid and the biomechanical interactions between fluid and solid constituents within bone, poroelastic theory was applied. The purpose of this study is to describe the behavior of calf vertebral trabecular bone composed of the porous solid trabeculae and the viscous bone marrow by using a commercial finite element analysis program based on the poroelasticity. In this study, the model was numerically tested for 5 different strain rates, i. e., 0.001, 0.01, 0.1, 1.0, and 10 per second. The material properties of the calf vertebral trabecular bone were utilized from the previous experimental study. Two asymptotic poroelastic response, the drained and undrained deformation, were predicted. From the predicted results for the simulated five strain rate, it was found that the pore pressure generation has a linearly increasing behavior when the strain rate is the highest at 10 per second, other wise it showed a nonlinear the strain rate Increased. Based on the results of the present study, it was suggested that the calf vertebral trabecular bone could be modeled as a porous material and its strain rate dependent material behavior could be predicted.

• 대한두경부종양학회지
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• 제16권1호
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• pp.9-13
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• 2000

Objectives: To determine the tumor interstitial fluid pressure(TIFP) in patients with head and neck cancerand predict radiotherapy outcome.Materials and Methods: In 12 biopsy proven primary head and neck cancer patients with accessible by direct inspection and palpation, and of sufficient thickness(>1cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy using a modified wick-in-needle technique. Tumor size was measured clinically and radiologically. Results: The mean preradiotherapy TIFP was 23.4mmHg. Preradiotherapy TIFP had significant relationship with tumor size(p=0.0009). Preradiotherapy TIFP was not different between complete response group and partial or less response group(p=0.114). Radiotherapy outcome was not different between group with above and group with below average TIFP(p=0.09). Conclusion: The mean TIFP was elevated with 23.4mmHg before radiation therapy. Preradiotherapy TIFP had significant relationship with tumor size. It is not definitive that TIFP could be prognostic indicator of radiation response.

• 대한한의학원전학회지
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• 제23권1호
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• pp.11-13
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• 2010

In this article, the concept of body fluid is explained in three aspects: the word meaning of body fluid, the origins of the definitions of the body fluid concept and the connotation and extension of body fluid. Investigating data about the time Hwangjenaegyeong(黃帝內經) was written, the author discovers that the meaning of "Aek(液)" is clear, but there are still questions about the meaning of "Jin(津)". The concept of body fluid derived from observation of life phenomenon and ancient philosophy on the "water". The concept of body fluid should be expressed as that body fluid is a general term for all normal liquids in the body. Within the meridians, as the composition of blood components; outside the meridians, constituting the intrinsic body fluids of various organs and tissues. This is the main part of body fluid, coming from diet, constituting the human body and maintaining human life activities, playing the roles of moistening and nourishing various of organs and tissues of the body. In addition, Interstitial fluid, all kinds of normal liquid secretion and metabolic products, such as sweat, tears, nasal discharge, saliva, slobber, gastric juice, intestinal fluid, urine, joint fluid, latex and so on, both belong to body fluid.

• Tuberculosis and Respiratory Diseases
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• 제52권4호
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• pp.419-424
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• 2002

경금속 진폐증에 속하는 거대세포 간질성 폐렴은 경금속을 사용한 절삭, 연마의 과정 중 발생하는 분진을 흡입하여 발생하는 것으로 알려져 있으나 이러한 직업력이 불분명한 증례를 개흉생검술을 통해 진단하였기에 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제68권4호
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• pp.226-230
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• 2010

Androgen deprivation therapy, which is the standard treatment for metastatic prostate cancer, includes nonsteroidal antiandrogenic drugs, such as flutamide, nilutamide and bicalutamide. Of them, bicalutamide rarely induces interstitial pneumonia. We report a case of bicalutamide-induced interstitial pneumonia. A 68-year old male diagnosed with prostate cancer and multiple bone metastases presented with dry cough and low grade fever for 3 days. He had taken bicalutamide (50 mg/day) for 13 months. High resolution computed tomography revealed ground glass opacity in his right upper lung. The laboratory studies showed no eosinophilia in the serum and bronchoalveolar lavage fluid. Despite the use of antimicrobial agents for 2 weeks, the extent of the lung lesions increased to the left upper and right lower lung. He had no environmental exposure, collagen vascular disease and microbiological causes. Under the suspicion of bicalutamide-induced interstitial pneumonia, bicalutamide was stopped and prednisolone (1 mg/kg/ day) was initiated. The symptoms and radiologic abnormalities were resolved with residual minimal fibrosis.

• Tuberculosis and Respiratory Diseases
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• 제48권2호
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• pp.260-267
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• 2000

거대세포성 간질성 폐렴은 경금속 도구를 이용한 절삭, 연마공정에서 발생하는 경금속 분진을 흡입하여 발생하는 산업성 폐질환으로 알려져 있다. 저자들은 이러한 특징적인 경금속분진에 대한 노출력이 없이 발생하였던 거대세포성 간질성 폐렴을 수술적 폐생검과 폐조직내 금속 함유량 분석을 통해 진단하였기에 보고 하는 바이다.