Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

Bicalutamide-induced Interstitial Lung Disease

전립선 암에서 Bicalutamide 사용으로 생긴 간질성 폐질환 1예

  • Kim, Yang-Kyun (Department of Pulmonary and Critical Care Medicine, East-West Neo Medical Center, Kyung Hee University School of Medicine) ;
  • Kim, Yee-Hyung (Department of Pulmonary and Critical Care Medicine, East-West Neo Medical Center, Kyung Hee University School of Medicine) ;
  • Lee, Jae-Jin (Department of Hematology and Oncology, East-West Neo Medical Center, Kyung Hee University School of Medicine) ;
  • Choi, Cheon-Woong (Department of Pulmonary and Critical Care Medicine, East-West Neo Medical Center, Kyung Hee University School of Medicine) ;
  • Yoo, Jee-Hong (Department of Pulmonary and Critical Care Medicine, East-West Neo Medical Center, Kyung Hee University School of Medicine) ;
  • Park, Myung-Jae (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Medical Center, Kyung Hee University School of Medicine) ;
  • Kang, Hong-Mo (Department of Pulmonary and Critical Care Medicine, Kyung Hee University Medical Center, Kyung Hee University School of Medicine)
  • 김양균 (경희대학교 의과대학 동서신의학병원 호흡기내과학교실) ;
  • 김이형 (경희대학교 의과대학 동서신의학병원 호흡기내과학교실) ;
  • 이재진 (경희대학교 의과대학 동서신의학병원 혈액종양내과학교실) ;
  • 최천웅 (경희대학교 의과대학 동서신의학병원 호흡기내과학교실) ;
  • 유지홍 (경희대학교 의과대학 동서신의학병원 호흡기내과학교실) ;
  • 박명재 (경희대학교 의과대학 경희의료원 호흡기내과학교실) ;
  • 강홍모 (경희대학교 의과대학 경희의료원 호흡기내과학교실)
  • Received : 2009.10.21
  • Accepted : 2009.11.19
  • Published : 2010.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Androgen deprivation therapy, which is the standard treatment for metastatic prostate cancer, includes nonsteroidal antiandrogenic drugs, such as flutamide, nilutamide and bicalutamide. Of them, bicalutamide rarely induces interstitial pneumonia. We report a case of bicalutamide-induced interstitial pneumonia. A 68-year old male diagnosed with prostate cancer and multiple bone metastases presented with dry cough and low grade fever for 3 days. He had taken bicalutamide (50 mg/day) for 13 months. High resolution computed tomography revealed ground glass opacity in his right upper lung. The laboratory studies showed no eosinophilia in the serum and bronchoalveolar lavage fluid. Despite the use of antimicrobial agents for 2 weeks, the extent of the lung lesions increased to the left upper and right lower lung. He had no environmental exposure, collagen vascular disease and microbiological causes. Under the suspicion of bicalutamide-induced interstitial pneumonia, bicalutamide was stopped and prednisolone (1 mg/kg/ day) was initiated. The symptoms and radiologic abnormalities were resolved with residual minimal fibrosis.

Keywords

References

  1. Camus P, Fanton A, Bonniaud P, Camus C, Foucher P. Interstitial lung disease induced by drugs and radiation. Respiration 2004;71:301-26. https://doi.org/10.1159/000079633
  2. Pfitzenmeyer P, Foucher P, Piard F, Coudert B, Braud ML, Gabez P, et al. Nilutamide pneumonitis: a report on eight patients. Thorax 1992;47:622-7. https://doi.org/10.1136/thx.47.8.622
  3. Azuma T, Kurimoto S, Mikami K, Oshi M. Interstitial pneumonitis related to leuprorelin acetate and flutamide. J Urol 1999;161:221. https://doi.org/10.1016/S0022-5347(01)62106-2
  4. Shioi K, Sakai N, Yoshida M, Nakamura M. Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer. Hinyokika Kiyo 2005;51:211-4.
  5. Shioi K, Yoshida M, Sakai N. Interstitial pneumonitis induced by bicalutamide and leuprorelin acetate for prostate cancer. Int J Urol 2003;10:625-6. https://doi.org/10.1046/j.1442-2042.2003.00705.x
  6. Mayaud C, Fartoukh M, Parrot A, Cadranel J, Milleron B, Akoun G. Drug-associated interstitial lung disease: a diagnostic challenge. Rev Pneumol Clin 2005;61:179-85. https://doi.org/10.1016/S0761-8417(05)84810-2
  7. Ben-Noun L. Drug-induced respiratory disorders: incidence, prevention and management. Drug Saf 2000;23:143-64. https://doi.org/10.2165/00002018-200023020-00005
  8. Ellis SJ, Cleverley JR, Muller NL. Drug-induced lung disease: high-resolution CT findings. AJR Am J Roentgenol 2000;175:1019-24. https://doi.org/10.2214/ajr.175.4.1751019
  9. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. CA Cancer J Clin 1999;49:8-31. https://doi.org/10.3322/canjclin.49.1.8
  10. Dahele M, Brade A, Pearson S, Bezjak A. Stereotactic radiation therapy for inoperable, early-stage non-smallcell lung cancer. CMAJ 2009;180:1326-8. https://doi.org/10.1503/cmaj.081291
  11. Kim TH, Cho KH, Pyo HR, Lee JS, Zo JI, Lee DH, et al. Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimensional conformal radiation therapy for lung cancer. Radiology 2005;235:208-15. https://doi.org/10.1148/radiol.2351040248
  12. Koenig TR, Munden RF, Erasmus JJ, Sabloff BS, Gladish GW, Komaki R, et al. Radiation injury of the lung after three-dimensional conformal radiation therapy. AJR Am J Roentgenol 2002;178:1383-8. https://doi.org/10.2214/ajr.178.6.1781383
  13. Ikezoe J, Takashima S, Morimoto S, Kadowaki K, Takeuchi N, Yamamoto T, et al. CT appearance of acute radiation-induced injury in the lung. AJR Am J Roentgenol 1988;150:765-70. https://doi.org/10.2214/ajr.150.4.765
  14. Cleverley JR, Screaton NJ, Hiorns MP, Flint JD, Muller NL. Drug-induced lung disease: high-resolution CT and histological findings. Clin Radiol 2002;57:292-9. https://doi.org/10.1053/crad.2001.0792